1,720,968 research outputs found
A response to the Vancouver call for action: addressing the needs of early career scientists in radiation protection
No full textEarly career researchers, professionals, and scientists (ECRs) are essential to the future of radiation protection, a field that increasingly relies on interdisciplinary collaboration and innovation. In line with the principles outlined in the Vancouver Call for Action for Radiation Protection Researchers, an ICRP (International Commission on Radiological Protection) initiative, this article explores the current landscape for ECRs through the lens of survey data, initiative outcomes, and the establishment of the Early Career in Radiation Protection Network (ECRad). Drawing on a Europe-wide survey of 47 ECRs, the study identifies key areas of concern: while there is strong intrinsic motivation to remain in the field, perceived feasibility is often hampered by job insecurity, fragmented institutional support, and lack of structured mentorship. Although most respondents participate in existing networks such as ICRP, EURADOS, and IRPA, many reported unmet expectations, particularly in mentorship, sustained peer interaction, and accessible professional development. The formation of the RadoNorm Early Career Researcher Council (ECRC) responded directly to these gaps, demonstrating that self-organized, ECR-led initiatives can significantly enhance a sense of belonging and interdisciplinary engagement. However, structural barriers - such as time, funding, and short-term project support - persist, echoing the Vancouver Call for Action's call for improved education, training, and retention. In conclusion, while considerable progress has been made in addressing the needs of ECRs in radiation protection, gaps that threaten the long-term vitality of the field remain. The findings affirm the urgency of coordinated action among institutions, networks, and funding bodies to invest in and empower the next generation of radiation protection professionals.Funding
Open Access funding enabled and organized by Projekt DEAL.
The authors would like to especially thank the respondents of the ECRad survey for investing their time and sharing their honest opinion. Special thanks also go out to Balázs Madas, Andrzej Wojcik and members of the PIANOFORTE consortium for their continued support and advise on obtaining funding to organize events
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Development of a new method for the detection of vanadium complexes bound to DNA, using Agarose Gel Electrophoresis
No full textDissertação de mest., Qualidade em Análises, Faculdade de Ciências e Tecnologia, Univ. do Algarve, 2012Existem apenas alguns métodos disponíveis para o estudo da ligação de metais ao ADN. Estes são baseados em técnicas espectroscópicas, que podem apenas ser utilizadas quando determinados cromóforos quer da molécula de ADN ou dos complexos metálicos estão directamente envolvidos na ligação de metais ao ADN.
O objectivo deste projecto foi desenvolver um novo método que pode ser utilizado para detectar a ligação de um metal de transição ao ADN, utilizando Electroforese em gel de agarose (EGA). O método tem sido estudado para complexos de vanádio, mas pode ser adaptado para quaisquer metais de transição susceptíveis de sofrer reacções de tipo Fenton. O novo método envolve a adição ao gel de agarose de ácido tereftálico (TPA), um indicador bem conhecido para os radicais hidroxilo. Embebendo o gel desenvolvido em peróxido de hidrogénio, a presença de vanádio será revelada por uma reacção do tipo Fenton que irá gerar radicais hidroxilo e irá hidroxilar TPA em 2-hidroxi-TPA, uma molécula altamente fluorescente. Bandas electroforéticas contendo vanádio podem então ser fotografadas e analisadas utilizando um sistema de imagem.
A metodologia envolveu quatro passos:
1. Um estudo preliminar do sistema utilizando a EGA.
2. O desenvolvimento do método para a quantificação dos complexos de vanádio baseado no mesmo sistema de reacção utilizando amostras aquosas.
3. Desenvolvimento do método em soluções aquosas com uma matriz semelhante à de agarose.
4. Aplicação em géis de agarose.
Os resultados preliminares foram mal sucedidos para detectar a presença de vanádio em géis de agarose. Concluiu-se que para ser usado um sistema de imagem, o método requer a utilização de um filtro (464 ± 40) nm. Foram efectuados mais testes utilizando um espectrofluorímetro.
Quando se utilizou um concentrado peroxide (~ 9M), a intensidade máxima de fluorescência de 2-OH-TPA formado diminuiu ao longo do tempo. Com um peróxido menos concentrado (1,8 mM) foi obtida uma boa sensibilidade. O LOD (limite de detecção) determinado para o vanádio foi de 4,1 μM.
O sistema foi depois testado num sistema aquoso com galactose. O sistema tem uma boa gama de trabalho, até 300 μM na presença de 0,50% de galactose. A sensibilidade diminuiu significativamente na presença de galactose. O LOD determinado para o vanádio foi de 5,4 μM.
O sistema foi finalmente testado em géis de agarose. Houve alguma dificuldade em assegurar a homogeneidade da preparação, necessária para um estudo espectrofluorimétrico. Num gel onde a homogeneidade foi conseguida, foi observada uma banda de emissão muito fraca na região do espectro onde o complexo 2-hidroxi-TPA emite. A sensibilidade obtida nesta preparação foi muito baixa.
Não foi possível completar os testes em EGA devido à falta de tempo disponível para este trabalho. No entanto, os resultados em solução aquosa mostram que o método é viável e pode proporcionar uma boa sensibilidade quando aplicado em matrizes EGA, desde que o método para a preparação de gel seja optimizado
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Use of molecularly imprinted polymers for enrichment of phosphopeptides and alpha-Synuclein, and the mass spectrometric analyses of alpha-Synuclein in human brains
No full textAlpha-Synuclein (Syn) ist ein putativer Biomarker der Parkinson-Krankheit (PK). Aggregierte Syn werden als Lewy-Körperchen (LK) bezeichnet und sind in der Gehirnregion ein Kennzeichen für die PK. Phosphoryliertes Syn ist die häufigste Form in LK. Die Konzentration von Syn in Körperflüssigkeiten wie z.B. in der Cerebrospinalflüssigkeit ist sehr gering und liegt unter der Nachweisgrenze für die Massenspektrometrie (MS)-analyse. In dieser Arbeit wurden molekular geprägte Polymere (MIPs) für die Anreicherung von Syn und anderen Phosphopeptiden verwendet. Mit Hilfe der MIPs konnten sowohl Syn aus Human Embryonic Kidney (HEK)- als auch Phosphopeptide aus dem HeLa-Zelllysat angereichert werden. Außerdem wurde die MS-basierte Methode zur Quantifizierung der Syn-Konzentration in humanen Gehirn erfolgreich etabliert. Mit Hilfe der neu etablierten Methode konnte der Massenanteil von Syn im humanen Gehirn auf 0,3% bestimmt werden
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