24,604 research outputs found
Factors related to meaning of life in Taiwanese women treated with in vitro fertilization.
No full textWill biological agents supplant systemic glucocorticoids as the first-line treatment for thyroid-associated ophthalmopathy?
No full textIn this article, the two authors present their opposing points of view concerning the likelihood that glucocorticoids will be replaced by newly developed biological agents in the treatment of active, moderate-to-severe thyroid-associated ophthalmopathy (TAO). TAO is a vexing, disfiguring and potentially blinding autoimmune manifestation of thyroid autoimmunity. One author expresses the opinion that steroids are nonspecific, frequently fail to improve the disease and can cause sometimes serious side effects. He suggests that glucocorticoids should be replaced as soon as possible by more specific and safer drugs, once they become available. The most promising of these are biological agents. The other author argues that glucocorticoids are proven effective and are unlikely to be replaced by biologicals. He reasons that while they may not uniformly result in optimal benefit, they have been proven effective in many reports. He remains open minded about alternative therapies such as biologicals but remains skeptical that they will replace steroids as the first-line therapy for active, moderate-to-severe TAO without head-to-head comparative clinical trials demonstrating superiority. Despite these very different points of view, both authors are optimistic about the availability of improved medical therapies for TAO, either as single agents or in combination. Further, both agree that better treatment options are needed to improve the care of our patients with active moderate-to-severe TAO
Transporte con Astra en TJ-II
Full text linkEl informe describe la adaptaci??n del sistema num??rico de transporte ASTRA al c??lculo de plasmas del dispositivo TJ-II. En primer lugar se aproxima la geometr??a y se comparte un modelo sencillo de transporte con otros dos c??digos de c??lculo (PROCTR, PRETOR-Stellarator) para compararlos con ASTRA. A continuci??n se ejemplifican dos de las facetas de ASTRA motivo de su inclusi??n como herramienta de c??lculo para los plasmas del TJ-II: el transporte interpretativo y el predictivo. El primero consiste en la estimaci??n de los coeficientes de transporte a partir de datos experimentales, siendo tres descargas del TJ-II las usadas con este prop??sito. La faceta predictiva se ilustra mediante un modelo capaz de incluir consistentemente la din??mica de barreras de transporte. El informe incluye este modelo en el lenguaje propio de ASTRA para ilustrar su uso
Nonlinear buckling of microfabricated thin annular plates
No full textAnnular plate structures are commonly used in MEMS devices, particularly in pumps and valves. In MEMS applications, large nonlinear deflections are routinely achieved. In this paper, the nonlinear buckling of a thin elastic annular plate under a compressive radial force acting in the plane of the plate is considered. Although the critical loads at which buckling starts can be determined by solving a linear eigenvalue problem, the large deflection behavior of a buckled plate beyond the critical loads can be described by the nonlinear theory proposed by von Kármán. The buckling loads of the annular plate for various boundary conditions are calculated and the post-buckling behaviors are examined. Interestingly, the buckling of an annular plate exhibits a supercritical pitchfork bifurcation. Thus, the post-buckling behavior is stable and will not collapse catastrophically. Several design implications for microfabricated structures, in particular microvalves, are also given
The value of silence
No full textThis is an electronic version of the article published in Theatre Journal, 54(1):85-94, 2002 March. The published article is available at http://muse.jhu.edu/journals/theatre_journal/v054/54.1eng.pdfEng, David L.The Value of Silence.Theatre Journal, 54,(1):85-94, 2002.DOI: 10.1353/tj.2002.000
Testing of workpiece TJ.19-PI.33
No full textTema završnog rada obrađena je kompiliranjem teorijskih saznanja i eksperimentalnog ispitivanja tvrdoće. Teorijskim dijelom pojašnjena je tvrdoća te su istaknute promjene u svojstvima metala koje su u korelaciji s tvrdoćom. Uz samo pojašnjenje tvrdoće, analiziraju se čvrstoća i granica razvlačenja metala, puzanje, žilavost i plastičnost materijala. Opisani su postupci ispitivanja tvrdoće materijala: ispitivanje tvrdoće paranjem (Mohsova metoda i Martensov postupak), ispitivanje tvrdoće utiskivanjem (Brinellova metoda, Vickersova metoda, Rockwellova metoda, Knoopova metoda, UltrasonicContactImpedance metoda i Through-indenterViewing metoda) te metoda odskoka (Poldijeve postupak, Shoreov postupak i ispitivanje tvrdoće duroskopom). Praktičnim dijelom je obuhvaćena analiza rezultata ispitivanja tvrdoće strojnog dijela TJ.19-Pl.33.The theme of the final work was elaborated by compilation of theoretical knowledge and experimental hardness testing. Theoretical part explains hardness and changes in hard metal correlation properties. Along with hardness clarification, strength and bandwidth of metal, cracking, toughness and plasticity of the material are analysed. Hardness testing (Mohs method and Martens method), hardness testing by injection (Brinell's method, Vickers method, Rockwell method, Knoop's method, UltrasonicContactImpedance method and Through-indenterViewing method) and discard method (Poldy's procedure, Shore's procedure and hardness test hardness) are described in the paper.The practical part covers the analysis of TJ.19-P.33 hardness test results
Anhydrous Alum Inhibits α-MSH-Induced Melanogenesis by Down-Regulating MITF via Dual Modulation of CREB and ERK
Full text linkMelanogenesis, the intricate process of melanin synthesis, is central to skin pigmentation and photoprotection and is regulated by various signaling pathways and transcription factors. To develop potential skin-whitening agents, we used B16F1 melanoma cells to investigate the inhibitory effects of anhydrous alum on melanogenesis and its underlying molecular mechanisms. Anhydrous alum (KAl(SO4)2) with high purity (>99%), which is generated through the heat-treatment of hydrated alum (KAl(SO4)2·12H2O) at 400 °C, potentiates a significant reduction in melanin content without cytotoxicity. Anhydrous alum downregulates the master regulator of melanogenesis, microphthalmia-associated transcription factor (MITF), which targets key genes involved in melanogenesis, thereby inhibiting α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis. Phosphorylation of the cAMP response element-binding protein, which acts as a co-activator of MITF gene expression, is attenuated by anhydrous alum, resulting in compromised MITF transcription. Notably, anhydrous alum promoted extracellular signal-regulated kinase phosphorylation, leading to the impaired nuclear localization of MITF. Overall, these results demonstrated the generation and mode of action of anhydrous alum in B16F1 cells, which constitutes a promising option for cosmetic or therapeutic use
El uso del software HistCite para identificar artículos significativos en búsquedas por materias en la Web of Science
Full text linkHistCiteTM is a large-scale computer tool for mapping science. Its power of visualization combines
the production of historiographs on the basis of the analysis of co-citations of documents, with the
use of bibliometrics specific indicators. The objective of this article is, to present the advantages of
the new bibliometrics configuration of HistCiteTM (2004) when identifying articles to analyze the
histograms that produces HistCiteTM, in terms of cumulative advantage and aging of the citations
to do a comparative study of the results of HistCiteTM, in its indicators of amplitude and recognition.
Also is examined its treatment of the sampling problems, by formalizing the question of
Kendall
El "añadido" castellano del TJ 1 o las mal llamadas "prosiflcaciones"
Full text linkThe author suggests to give the name of "addition" to the first twenty-five Cantigas de Santa María, written in prose, of the Ms TJ l. The author thinks that these additions do not come neither from Alfonso X nor from his surrouindings. They should have been added when the cultural reader was different and did not know the language of Galice. What proves this is the fact that the person who wrote this "addition" obtained information from another sources in some miracles (numbers 2 and 3) and those of praise are a theological gloss.El autor propone que se llame "añadido" a las hasta ahora denominadas prosificaciones castellans de las primeras veinticinco cantigas de Santa María del Ms TJ l. Él entiende que no se deben a Alfonso X, ni a su entorno. Que debieren ser añadidas en un tiempo en que el lector cultural era distinto y desconocía el gallego. Esto lo demuestra en cuanto el responsable del tal "añadido" acude a fuentes distintas en algunos milagros (números 2 y 3) y las de loor son una glosa teológica
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