82 research outputs found

    Advanced characterisation of pulmonary hypertension: Assessment of right ventricular diastolic function and pulmonary artery wave reflection

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    © 2016 Dr Stuart David MurchPulmonary hypertension is the net haemodynamic consequence of a wide variety of underlying pathologies. As disease progresses, right ventricular systolic dysfunction may develop. However, by the time this occurs, prognosis is poor. Like the situation in the left ventricle, chronically increased right ventricular afterload first leads to right ventricular hypertrophy and hypothetically, diastolic dysfunction. Although there is some evidence from animal models for this, human data is limited. Theoretically, the identification of right ventricular diastolic dysfunction may assist in the earlier diagnosis of pulmonary hypertension. This thesis provides evidence that right ventricular diastolic dysfunction does exist in the setting of pulmonary hypertension, that it occurs earlier than systolic dysfunction, and that it can be identified by invasive pressure measurement in the right ventricular cavity. Although echocardiography provides a useful way to assess left ventricular diastolic function, data presented here will show that currently available echocardiographic measurement of right ventricular diastolic function may not be sensitive enough to detect abnormal function. The secondary hypothesis tested is that a pressure/time analysis of pulmonary wave reflection can provide additional information in the assessment of patients with pulmonary hypertension. Data suggests that a metric of wave reflection, the pulmonary augmentation index, is closely associated with standard measures of right ventricular afterload, and therefore may not add value. However, the time to wave reflection is related to the site of obstruction in the pulmonary circulation and could theoretically assist in identifying disease aetiology

    Cognitive Resources Engaged in the Comprehension of Iconic Gestures

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    v, 31 p.The field of gesture research has experienced tremendous growth in recent years. Research has shown that gesturing while speaking improves communication, making the speaker more efficient at conveying his or her message, as well as offering benefits to working memory. Most of the research in this area has focused on how producing gestures aids the speaker's working memory, the present study investigates how seeing gesture aids comprehension of a spoken message and what aspects of working memory are involved in comprehending these messages. We gathered useable data from 74 participants (25 males, 49 females) between the ages 18 and 62 (M= 35.8 years) through Amazon's mechanical turk (mTurk). MTurk is an online service that allows researchers to post surveys and experiments, called "hits" that are open to "workers" who complete surveys for a small monetary reward. For the experiment participant's completed 12 trials, with each trial being made up of a memory task and a comprehension task. Results indicated that seeing gestures improved participant's recall for verbal, but not spatial, information on the memory task, but that there was no difference for performance on the comprehension task between the gesture and non-gesture conditions. Any benefit for verbal recall gained by seeing gesture was not offset by losses in spatial recall

    U.S. Government Printing Office

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    This pamphlet, 7¼ x 5, presents the contrasting stories of the two Navy flyers mentioned in the subtitle. George W. Noble did everything right in life, and was well beloved. Mugger Murch was hated by everyone. On one small point, their studied contrast flips. Mugger remembers to turn on his IFF and use the numbers of the day, while beloved George forgets to turn on his IFF and to enter the numbers of the day. Poor George is now dead because we shot him down! Navaer 00-80L=1. Believe it or not, this publication is marked restricted

    Mapping the Cyberbiosecurity Enterprise

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    This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac

    Mapping the Cyberbiosecurity Enterprise

    No full text
    This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac

    Real Estate piece on 27 dream islands available in Maine including Oak Islan

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    Real Estate piece on 27 dream islands available in Maine including Oak Island near North Haven; Outer Goose & Goose Nubble Islands in Addison; Harbor Island in Bucks Harbor, Brooksville; Ram Island and Scraggle Point in St. George; Ram Island at the mouth of Machias Bay; Gooseberry Island in Kittery; Middle Hardwood in Jonesport; Davis Island in St. George; Chance Island in Machiasport; Scabby Island chain in Machiasport; Lower Birch Islands in Addison; Narrows Island & Bar Island in Harrington; Norton Island in Addison; Fisherman\u27s Island near Beals; Nautilus Island in Brooksville; Joe\u27s Island in Friendship; Brown Island in Nicatous Lake; White\u27s Island in Big Lake, Washington County; Ram Island in Saco Bay; Hanneman Island in Big Lake, Greenville; Birch Island in Moosehead Lake, Greenville; Murch Island in George\u27s Pond, Franklin; Phoebe Island in Sebec Lake, Piscataquis; Burnt Island in Saint George Lake, Liberty; Genthner Island in Pemaquid Pond, Nobleboro; Chasse Island in Wadleigh Pond, Lymna; and Foster Island in Narraguagus Bay, Harrington

    U.S. Government Printing Office

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    This pamphlet, 7¼ x 5, is second in a series. The first, from the same year, presented The Sad Tale of George W. Noble and Mugger Murch. This number presents the story of Sack-Time Charlie. Charlie as a civilian had ballooned through getting no exercise, eating too much, and drinking coffee, soft drinks, and worse. Basic training and flying school shaped him up, and he became an ace. But he did not attend to exercise and to learning how to swim. Though he downed many Japs, he began to balloon again, got downed by a zero, was beaten to the raft by the now-downed Jap who had downed him, and was lucky to be saved. Charlie really learns his lesson when he draws the assignment of accompanying the captain on shore leave but cannot row the boat when the motor conks out. The captain, who has had to do the rowing, soon assigns Charlie training, various exercises, and swimming lessons. This time, it all takes, and Charlie shows that he really is a smart cookie. Navaer 00-80L-2. Believe it or not, this publication, like the first number, is marked restricted! If there is some top-secret information here, I certainly missed it

    The voice of the child in private law proceedings: time to rethink the approach

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    Based on a presentation to the Court Service Family Law Seminar in October 2009, this article focuses on the needs of those children and young people caught up in the stresses of private law disputes, drawing on the research findings of the 10 year (1996-2006) Cardiff University Children in Divorce Research Programme. The author asserts that in the present economic crisis most of these children will receive less priority than those children subject to public law proceedings, commenting that in the context of the coming election and potential cuts in public expenditure it is possible that in future the government may expect families themselves to pay for their involvement with the family justice system in private family law proceedings. The article covers the consequences for the family justice system of the aftermath of recession, key messages from the Cardiff Children in Divorce Research Programme, how to accommodate the messages for reform which emerged from the research interviews with children and their parents, and the challenge for the recently announced comprehensive review of the family justice system

    Seamless Transitions in Film and Video

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    abstract: Inspired by the great film editor Walter Murch, and his book In the Blink of an Eye, I decided to take a deep dive into understanding one powerful filmmaking technique: seamless transitions. I started by studying the impressive work of professional directors and editors and then applied the information I learned in practice to ultimately boil the technique down to its essence and understand how to make seamless transitions regularly in my own creative work. As film editing is my major and career path, the choice to present the culmination of my study in practice in the form of a video-essay felt natural and appropriate for this project

    “The ones you sent”: American veterans and legacies of the Vietnam War

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    This dissertation analyzes prominent political mobilizations of Vietnam War veterans between the 1960s and the post-9/11 U.S. military interventions to reveal how their organizing efforts have been fundamentally informed by the social and institutional relationship between the Vietnam-era military and the nation that sent it to war. The existing literature on the Vietnam War’s legacies often underscores the historical influence of political elites and the explanatory value of popular culture to the extent that it elides less prominent historical actors. By contrast, this dissertation provides a more contested and contingent narrative of the Vietnam War’s repercussions by demonstrating how veterans mobilized the different lessons they derived from their experiences to engage their society. Rather than relying primarily on analysis of the speeches of political officials, or the films and music of commercial artists, this social historical study is grounded in sources produced by veterans—their own oral history interviews, correspondence, organizational papers, public statements, and literary production—to expose their attempts to communicate the consequences of their war experiences to their fellow Americans. It reveals connections between ideologically disparate political projects, and traces the ways that those efforts have influenced changes in American ideas about military service since the Vietnam War. Exploring veterans’ attempts to build communities and engage the larger society, this study argues that while political ideology often divided veterans, the social context of their military service generated common concerns. Most significantly, military manpower policies that buffered the war’s impositions on middle-class domestic life contributed to a perception among veterans that Americans at home were disengaged from the burdens of the war they fought. While the troubling implications of U.S. intervention in Vietnam turned popular opinion against the war by the late 1960s, Americans responded with quiet, conflicted apprehension more than active opposition. Veterans often interpreted the consequent silence as indifference, and this observation compelled them to come to terms with their war experiences in a position of social and moral distance from their society. This social estrangement contradicted prevalent assumptions that war was a matter of exigency that entailed shared sacrifice. Vietnam War veterans’ ideological diversity reflected their need to give individualized meaning to their experiences, given the limits of their society’s collective assimilation of the war’s consequences. Yet the ideas and activism that drove their mobilizations in the decades since the 1960s reflected in different ways a common yearning for social and moral reciprocity that was rooted in the inequities of the Vietnam War mobilization, and which remains pertinent to the contemporary relationship between the armed forces and the society it serves.Ph.D.Includes bibliographical reference
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