3,030 research outputs found
Buckling design of stringer-stiffened conical shells in compression
No full textThe buckling strength of conical shells subjected to axial compression may be increased by means of meridional stiffeners (stringers). Unlike stiffened cylinders, only limited research has been carried out and no design provisions exist for stringer-stiffened cones. In this paper, a design procedure for such cones is developed based on an equivalent cylinder approach. Design criteria for both local (shell panel) and global (stiffened panel) buckling modes are proposed. In the absence of experimental results, a numerical parametric study is then presented to assess the design proposal. By using finite-element models, linear and nonlinear analyses are performed to quantify critical design aspects and to calibrate buckling strength predictions derived from the design proposal
Viewer-, Author-, and Ownership in the Work of Andrea Zittel
No full textAndrea Zittel invites others to collapse the distinctions between artist, viewer, and collaborator by interacting with her usable works. This thesis explores the process of interacting with Zittel\u27s works, and how it affects viewer-, author- and ownership
Inhibition of histone deacetylase 3 via RGFP966 facilitates unusually accurate cue memory for excitatory and inhibitory cue-reward associations
No full textEpigenetic mechanisms are key for regulating long-term memory (LTM) and are known to exert control on memory formation in multiple systems of the adult brain, including the sensory cortex. One epigenetic mechanism is chromatin modification by histone acetylation. Blocking the action of histone de-acetylases (HDACs) that normally negatively regulate LTM usually by repressing transcription, has been shown to enable memory formation. Indeed, HDAC inhibition appears to facilitate memory by altering the dynamics of gene expression events for consolidation, however less understood is how molecular-level consolidation processes alter subsequent memory for enhanced storage or retrieval. Here we used a sensory perspective to investigate from a behavioral-level whether the characteristics of memory formed with HDAC inhibitors are different from naturally-formed memory. One possibility is that HDAC-inhibition enables memory to form with greater sensory detail than normal. Because the auditory system undergoes learning-induced remodeling that provides substrates for sound-specific LTM, we aimed to identify behavioral effects of HDAC-inhibition on memory for specific sound features using a standard model of auditory associative cue-reward learning. We found that three systemic post-training treatments of an HDAC3-inhibitor (RGPF966, Abcam Inc.) in rats in the early phase of training facilitated auditory discriminative learning, and increased the specificity for acoustic frequency formed in memory of both excitatory (CS+) and inhibitory (CS-) associations for at least 2 weeks. The findings support that epigenetic mechanisms act on the sensory acuity and precision of memory, which can be revealed by studying the sensory aspects of long-term associative memory formation with HDAC inhibitors
Fine morphology of the myrmecophilous larva of Paussus kannegieteri (Coleoptera: Carabidae: Paussinae: Paussini). Corresponding author
No full textFIGURES 13–18. Paussus kannegieteri third instar larva: 13, thorax, left lateral view; 14, thorax, dorsal view; 15, mesothoracic spiracle; 16, metathoracic spiracle-like structure; 17, mesothoracic leg, anterolateral view; 18, apex of metathoracic leg with lanceolate setae, posterolateral view. CO = coxa, ls = lanceolate setae, m = membrane, ME = mesonotum, MT = metanotum, pe = peritreme, PR = pronotum, un = claw. Scale bars: Figs. 13–14 = 500 µm; Fig. 15 = 10 µm; Fig. 16 = 20 µm; Fig. 17 = 200 µm; Fig. 18 = 50 µm.Published as part of Giulio, Andrea Di, 2008, Fine morphology of the myrmecophilous larva of Paussus kannegieteri (Coleoptera: Carabidae: Paussinae: Paussini), pp. 37-50 in Zootaxa 1741 on page 44, DOI: 10.5281/zenodo.18152
Chemotherapy-induced mucositis: the role of the gastrointestinal microbiome and toll-like receptors
No full textAlimentary mucositis is a major clinical problem. Patients with mucositis are at significantly increased risk of infection and are often hospitalized for prolonged periods. More importantly, these patients often have to undergo reductions in their cytotoxic therapy, which may lead to reduced survival. Unfortunately, there are very limited therapeutic options for mucositis and no effective prevention. The human gut microbiome is receiving increased attention as a key player in the pathogenesis of alimentary mucositis with recent literature suggesting that changes in bacteria lead to mucositis. The bacteria which are found throughout the gut are tightly regulated by the toll-like receptor (TLR) family which currently has 13 known members. TLRs play a critical role in gut homeostasis and bacterial regulation. Furthermore, TLRs play a critical role in the regulation of nuclear factor kappa B, a key regulator of alimentary mucositis. However to date, no research has clearly identified a link between TLRs and alimentary mucositis. This critical literature review seeks to correct this.Daniel W. Thorpe, Andrea M. Stringer and Rachel J. Gibso
Trusted Tales: Creating Authenticity in Literary Representations from Ex-Yugoslavia
No full textThis research deals with questions of authority and authenticity and how they are expressed, constructed, and appropriated within the Anglophone book market. It considers the body of literature written about ex-Yugoslavia since the 1990s Balkan conflicts by exiled writers from the region which has entered the international literary canon. Books’ routes from original publishers into English translation are discussed through practices of trust, one of the crucial social devices underpinning their exchange. Within these cross-cultural processes, the role of cultural brokers is crucial. Symbolic and cultural resources are specifically mobilised through their powerful author brands.
By exploring authenticity in the context of book publishing, I further look at how ideas and practices of community are employed and negotiated by writers and those who promote their books. My field is multi-sited and fluid, reflecting how different individual and national positions are enacted and performed through strategies ranging from unconscious dispositions to deliberate intentions. This research thus brings together ideas of the author as an authentic, representative voice together with exile as a position that grants them a new lease of relevancy in the post-socialist context.
Although ex-Yugoslav books occupy a ‘high end’ niche of the UK market, constrained by commercial as well as political, cultural, and institutional forces, in public discourse ideas of the ‘free market’ and ‘free speech’ are mobilised to produce various types of modernisation narratives. The (post)socialist production of literature is perceived as having to ‘evolve’ into a capitalist model: this would allow not only healthy competition and consumer choice but guarantee an individual writer ‘free speech’ as a basic human right. Therefore, the most general question this research raises is what kind of foreign literature gets translated into English, under what socio-cultural conditions and which politics of representation it serves within the project of world literature
Selection of housekeeping genes for gene expression studies in a rat model of irinotecan-induced mucositis
No full textBackground/Aims: Mucositis is the term used to describe damage caused by chemotherapy to mucous membranes of the alimentary tract. RT-PCR has recently been utilised to determine the molecular events that occur in mucositis. As this method relies on the use of a validated endogenous control, this study aims to validate commonly used housekeeping genes in an irinotecan-induced mucositis model.
Methods: Rats were administered irinotecan and sacrificed at different time points, in particular 1, 24, 72 and 144 h following treatment. Histopathological damage was assessed by haematoxylin and eosin staining. RT-PCR was used to evaluate the expression of 11 housekeeping genes. Expression stability was determined by the Normfinder program. Matrix metalloproteinase 2 was used as a target gene to validate the appropriateness of the top-ranking housekeeping gene.
Results: For normalisation to multiple housekeeping genes, the most stable combination across all time points in the jejunum was Ywhaz/UBC and in the colon UBC/β-actin. SDHA and GAPDH were the most variable genes in the jejunum and colon where they were 4.4 and 3.2 fold upregulated following irinotecan, respectively.
Conclusions: For normalisation of irinotecan-induced mucositis gene expression studies, a combination of Ywhaz/UBC and UBC/β-actin should be used in the jejunum and colon, respectively. UBC is the most favourable if restricted to a single housekeeping gene across all time points.Noor Al-Dasooqi, Joanne M. Bowen, Rachel J. Gibson, Richard M. Logan, Andrea M. Stringer, Dorothy M. Keef
Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis
No full textBackground: Mucositis is a toxic side effect of anti-cancer treatments and is a major focus in cancer research. Pro-inflammatory cytokines have previously been implicated in the pathophysiology of chemotherapy-induced gastrointestinal mucositis. However, whether they play a key role in the development of radiotherapy-induced gastrointestinal mucositis is still unknown. Therefore, the aim of the present study was to characterise the expression of pro-inflammatory cytokines in the gastrointestinal tract using a rat model of fractionated radiotherapy-induced toxicity. Methods: Thirty six female Dark Agouti rats were randomly assigned into groups and received 2.5 Gys abdominal radiotherapy three times a week over six weeks. Real time PCR was conducted to determine the relative change in mRNA expression of pro-inflammatory cytokines IL-1β, IL-6 and TNF in the jejunum and colon. Protein expression of IL-1β, IL-6 and TNF in the intestinal epithelium was investigated using qualitative immunohistochemistry. Results: Radiotherapy-induced sub-acute damage was associated with significantly upregulated IL-1β, IL-6 and TNF mRNA levels in the jejunum and colon. The majority of pro-inflammatory cytokine protein expression in the jejunum and colon exhibited minimal change following fractionated radiotherapy. Conclusions: Pro-inflammatory cytokines play a key role in radiotherapy-induced gastrointestinal mucositis in the sub-acute onset setting.Zhi Yi Ong, Rachel J. Gibson, Joanne M. Bowen, Andrea M. Stringer, Jocelyn M. Darby, Richard M. Logan, Ann S.J. Yeoh, Dorothy M. Keef
The Influence of Radial Edge Constraint on the Stability of Stiffened Conical Shells in Compression
No full textUsing finite element analysis, the non-linear behaviour of thin stringer-stiffened cones under axial compression is studied. In particular, various alternatives in specifying edge conditions are presented and the sensitivity natives in specifying edge conditions are presented and the sensitivity of the response to the radial edge constraint is examined in detail. It is shown that both the initial stiffness and the limit load cart be severely reduced if radial edge displacements are not constrained and that, in this case, linear eigenvalue results can be misleading. Analogies are drawn between the cone and the more commonly encountered cylindrical shell. The implications of these results for experimental studies and for the development of design formulations are discussed
Data set for anomaly detection on a HPC system
No full text<p>This data set contains the data collected on the DAVIDE HPC system (CINECA & E4 & University of Bologna, Bologna, Italy) in the period March-May 2018.</p>
<p>The data set has been used to train a autoencoder-based model to automatically detect anomalies in a semi-supervised fashion, on a real HPC system.</p>
<p>This work is described in:</p>
<p>1) "Anomaly Detection using Autoencoders in High Performance Computing Systems", <a href="https://arxiv.org/search/cs?searchtype=author&query=Borghesi%2C+A">Andrea Borghesi</a>, <a href="https://arxiv.org/search/cs?searchtype=author&query=Bartolini%2C+A">Andrea Bartolini</a>, <a href="https://arxiv.org/search/cs?searchtype=author&query=Lombardi%2C+M">Michele Lombardi</a>, <a href="https://arxiv.org/search/cs?searchtype=author&query=Milano%2C+M">Michela Milano</a>, <a href="https://arxiv.org/search/cs?searchtype=author&query=Benini%2C+L">Luca Benini,</a> IAAI19 (proceedings in process) -- https://arxiv.org/abs/1902.08447</p>
<p>2) "Online Anomaly Detection in HPC Systems", <a href="https://arxiv.org/search/cs?searchtype=author&query=Borghesi%2C+A">Andrea Borghesi</a>, <a href="https://arxiv.org/search/cs?searchtype=author&query=Libri%2C+A">Antonio Libri</a>, <a href="https://arxiv.org/search/cs?searchtype=author&query=Benini%2C+L">Luca Benini</a>, <a href="https://arxiv.org/search/cs?searchtype=author&query=Bartolini%2C+A">Andrea Bartolini, </a>AICAS19 (proceedings in process) -- https://arxiv.org/abs/1811.05269</p>
<p>See the git repository for usage examples & details --> https://github.com/AndreaBorghesi/anomaly_detection_HPC</p>
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