12 research outputs found
A laboratory-adapted HCV JFH-1 strain is sensitive to neutralization and can gradually escape under the selection pressure of neutralizing human plasma
No full textViral replication and neutralization of hepatitis C viruses (HCV) have been studied using the infectious molecular clone JFH-1. By passaging JFH-1 in hepatoma cells in the absence or presence of HCV neutralizing antibodies (nAbs), we investigated the molecular mechanisms of cell-culture adaptation and sensitivity to nAbs. The cell culture-adapted JFH-1 virus (JFH-1-CA) became more sensitive to nAbs than its parental virus. Sequence analysis revealed that the predominant viruses in the JFH-1-CA population carried two mutations in their envelopes (1414T and V293A). Plasma that could neutralize JFH-1-CA was found in 2 of 7 HCV-infected individuals who have cleared the virus in blood. Plasma 226233 with a higher 50% neutralization titer was used for in vitro selection of neutralization resistant viruses. Under the increasing selection pressure of plasma 226233, the neutralizing sensitivity of JFH-1-CA decreased gradually. Two mutations (T414I and P500S) in envelope were found in all but one sequenced clones in the viral population after eight rounds of selection. Interestingly, the cell-culture adapted mutation I414T reverted back to the wild-type residue (1414) under the selection pressure. By introducing mutations at positions 414 and 500 into the JFH-1 clone, we confirmed that the T414I mutation alone can confer neutralization resistance. The results of this current study suggest that nAbs are present in a subset of HCV-infected individuals who have cleared the virus in blood. Our data also provide the first evidence that, the E2 residue P500, located within a previously identified highly conserved polyclonal epitope, may be a target for neutralizing antibodies present in individual who have spontaneously resolved the HCV infection. Published by Elsevier B.V.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000311133800019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701VirologySCI(E)PubMed0ARTICLE1154-16116
Single cell genomics of uncultured marine alveolates shows paraphyly of basal dinoflagellates
No full textMarine alveolates (MALVs) are diverse and widespread early-branching dinoflagellates, but most knowledge of the group comes from a few cultured species that are generally not abundant in natural samples, or from diversity analyses of PCR-based environmental SSU rRNA gene sequences. To more broadly examine MALV genomes, we generated single cell genome sequences from seven individually isolated cells. Genes expected of heterotrophic eukaryotes were found, with interesting exceptions like presence of proteorhodopsin and vacuolar H+-pyrophosphatase. Phylogenetic analysis of concatenated SSU and LSU rRNA gene sequences provided strong support for the paraphyly of MALV lineages. Dinoflagellate viral nucleoproteins were found only in MALV groups that branched as sister to dinokaryotes. Our findings indicate that multiple independent origins of several characteristics early in dinoflagellate evolution, such as a parasitic life style, underlie the environmental diversity of MALVs, and suggest they have more varied trophic modes than previously thought
The social weaving of a reading atmosphere
No full textThis paper discusses how public library readers in Almeida Garrett, Porto, create a reading atmosphere, focusing on meanings associated with aural conditions. Through a qualitative, single case study, ethnographic and interview techniques were applied.
Readers’ actual practices and discourses, through a theoretical sample, and those of managers, staff and architects were analysed; a spatial analysis was conducted within the framework of social inequalities and power relations. The paper proposes the concept of reading atmosphere and suggests that its social production is based on a tacit, informal code of conduct in which some regular readers played an influential role. Some recommendations on service provision are made
Thermal stability and inactivation of hepatitis C virus grown in cell culture
No full textAbstract Background Hepatitis C virus (HCV) is a blood-borne flavivirus that infects many millions of people worldwide. Relatively little is known, however, concerning the stability of HCV and reliable procedures for inactivating this virus. Methods In the current study, the thermostability of cell culture-derived HCV (HCVcc, JFH-1 strain) under different environmental temperatures (37°C, room temperature, and 4°C) and the ability of heat, UVC light irradiation, and aldehyde and detergent treatments to inactivate HCVcc were evaluated. The infectious titers of treated viral samples were determined by focus-forming unit (FFU) assay using an indirect immunofluorescence assay for HCV NS3 in hepatoma Huh7-25-CD81 cells highly permissive for HCVcc infection. MTT cytotoxicity assay was performed to determine the concentrations of aldehydes or detergents at which they were no longer cytotoxic. Results HCVcc in culture medium was found to survive 37°C and room temperature (RT, 25 ± 2°C) for 2 and 16 days, respectively, while the virus was relatively stable at 4°C without drastic loss of infectivity for at least 6 weeks. HCVcc in culture medium was sensitive to heat and could be inactivated in 8 and 4 min when incubated at 60°C and 65°C, respectively. However, at 56°C, 40 min were required to eliminate HCVcc infectivity. Addition of normal human serum to HCVcc did not significantly alter viral stability at RT or its susceptibility to heat. UVC light irradiation (wavelength = 253.7 nm) with an intensity of 450 μW/cm2 efficiently inactivated HCVcc within 2 min. Exposures to formaldehyde, glutaraldehyde, ionic or nonionic detergents all destroyed HCVcc infectivity effectively, regardless of whether the treatments were conducted in the presence of cell culture medium or human serum. Conclusions The results provide quantitative evidence for the potential use of a variety of approaches for inactivating HCV. The ability of HCVcc to survive ambient temperatures warrants precautions in handling and disposing of objects and materials that may have been contaminated with HCV.</p
Biogeochemical processes at hydrothermal vents : microbes and minerals, bioenergetics, and carbon fluxes
No full textAuthor Posting. © The Oceanography Society, 2012. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 25, no. 1 (2012): 196–208, doi:10.5670/oceanog.2012.18.Hydrothermal vents are among the most biologically active regions of the deep ocean. However, our understanding of the limits of life in this extreme environment, the extent of biogeochemical transformation that occurs in the crust and overlying ocean, and the impact of vent life on regional and global ocean chemistry is in its infancy. Recently, scientific studies have expanded our view of how vent microbes gain metabolic energy at vents through their use of dissolved chemicals and minerals contained in ocean basalts, seafloor sulfide deposits, and hydrothermal plumes and, in turn, how they catalyze chemical and mineral transformations. The scale of vent environments and the difficulties inherent in the study of life above, on, and below the deep seafloor have led to the development of geochemical and bioenergetic models. These models predict habitability and biological activity based on the chemical composition of hydrothermal fluids, seawater, and the surrounding rock, balanced by the physiological energy demand of cells. This modeling, coupled with field sampling for ground truth and discovery, has led to a better understanding of how hydrothermal vents affect the ocean and global geochemical cycles, and how they influence our views of life on the early Earth and the search for life beyond our own planet.Research for
this paper was supported by the National
Science Foundation (NSF) Division
of Ocean Sciences grants 0732611 for
JFH, 0926805 and 1038055 for JAB,
and 1038055 for BMT; and by the
University of Missouri Research Board
for KLR
Antibodies Targeting Novel Neutralizing Epitopes of Hepatitis C Virus Glycoprotein Preclude Genotype 2 Virus Infection.
No full textCurrently, there is no effective vaccine to prevent hepatitis C virus (HCV) infection, partly due to our insufficient understanding of the virus glycoprotein immunology. Most neutralizing antibodies (nAbs) were identified using glycoprotein immunogens, such as recombinant E1E2, HCV pseudoparticles or cell culture derived HCV. However, the fact that in the HCV acute infection phase, only a small proportion of patients are self-resolved accompanied with the emergence of nAbs, indicates the limited immunogenicity of glycoprotein itself to induce effective antibodies against a highly evolved virus. Secondly, in previous reports, the immunogen sequence was mostly the genotype of the 1a H77 strain. Rarely, other genotypes/subtypes have been studied, although theoretically one genotype/subtype immunogen is able to induce cross-genotype neutralizing antibodies. To overcome these drawbacks and find potential novel neutralizing epitopes, 57 overlapping peptides encompassing the full-length glycoprotein E1E2 of subtype 1b were synthesized to immunize BALB/c mice, and the neutralizing reactive of the induced antisera against HCVpp genotypes 1-6 was determined. We defined a domain comprising amino acids (aa) 192-221, 232-251, 262-281 and 292-331 of E1, and 421-543, 564-583, 594-618 and 634-673 of E2, as the neutralizing regions of HCV glycoprotein. Peptides PUHI26 (aa 444-463) and PUHI45 (aa 604-618)-induced antisera displayed the most potent broad neutralizing reactive. Two monoclonal antibodies recognizing the PUHI26 and PUHI45 epitopes efficiently precluded genotype 2 viral (HCVcc JFH and J6 strains) infection, but they did not neutralize other genotypes. Our study mapped a neutralizing epitope region of HCV glycoprotein using a novel immunization strategy, and identified two monoclonal antibodies effective in preventing genotype 2 virus infection
Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior
No full textAlcohol abuse adversely affects the lives of millions of people worldwide. Deficits in synaptic transmission and in microglial function are commonly found in human alcohol abusers and in animal models of alcohol intoxication. Here, we found that a protocol simulating chronic binge drinking in male mice resulted in aberrant synaptic pruning and substantial loss of excitatory synapses in the prefrontal cortex, which resulted in increased anxiety-like behavior. Mechanistically, alcohol intake increased the engulfment capacity of microglia in a manner dependent on the kinase Src, the subsequent activation of the transcription factor NF-κB, and the consequent production of the proinflammatory cytokine TNF. Pharmacological blockade of Src activation or of TNF production in microglia, genetic ablation of Tnf, or conditional ablation of microglia attenuated aberrant synaptic pruning, thereby preventing the neuronal and behavioral effects of the alcohol. Our data suggest that aberrant pruning of excitatory synapses by microglia may disrupt synaptic transmission in response to alcohol abuse.This work was financed by FEDER -Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 -Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior in the framework of the project POCI-01-0145-FEDER-030647 (PTDC/SAU-TOX/30647/2017) in TS lab. The projects FEDER Portugal (Norte-01-0145-FEDER-000008000008—Porto
Neurosciences and Neurologic Disease Research Initiative at I3S, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); FCOMP-01-0124-FEDER-021333) and FCT (PTDC/MED-NEU/31318/2017) supported work in JBR lab. CCP and RS hold employment contracts financed by national funds through FCT – Fundação para a Ciência e a Tecnologia, I.P., in the context of the program-contract described in paragraphs 4, 5 and 6 of art. 23 of Law no. 57/2016, of August 29, as amended by Law no. 57/2017 of July 2019. TC is supported by FCT (SFRH/BD/117148/2016). RLA was supported by FCT
(PD/BD/114266/2016). AM was supported by FCT (IF/00753/2014). Author contributions: RS, TS, and JBR designed the project. RS, JFH, CCP, TOA, JTM, RLA, TC, CS, and AM performed experiments. RS, TS, and JBR co-supervised the study. RS and JBR wrote the original draft. RS, CCP, TS, and JBR reviewed and edited
the manuscript. TS and JBR acquired funding
Heterogeneous Os isotope compositions in the Kalatongke sulfide deposit, NW China: the role of crustal contamination
No full textRe-Os isotope compositions of mantle-derived magmas are highly sensitive to crustal contamination because the crust and mantle have very different Os isotope compositions. Crustal contamination may trigger S saturation and thus the formation of magmatic Ni-Cu-(PGE) sulfide deposits. The ∼287-Ma Kalatongke norite intrusion of NW China are hosted in carboniferous tuffaceous rocks and contain both disseminated and massive sulfide mineralization. The Re-Os isotope compositions in the intrusion are highly variable. Norite and massive sulfide ores have γ Os values ranging from +59 to +160 and a Re-Os isochron age of 239 ± 51 Ma, whereas disseminated sulfide ores have γ Os values from +117 to +198 and a Re-Os isochron age of 349 ± 34 Ma. The variability of Os isotope compositions can be explained as the emplacement of two distinct magma pulses. Massive sulfide ores and barren norite in the intrusion formed from the same magma pulse, whereas the disseminated sulfide ores with more radiogenic Os isotopes formed from another magma pulse which underwent different degrees of crustal contamination. Re-Os isotopes may not be suitable for dating sulfide-bearing intrusions that underwent variable degrees of crustal contamination to form magmatic sulfide deposits. © 2012 The Author(s).published_or_final_versionSpringer Open Choice, 28 May 201
0003
No full textDAILY PALO ALTO THUS,MONDAY. NOV. ai. i-»i.
—IU pslo Blto glmcg
ass******'"*— —-- in.M ul las.
^"^nf*?* nn-iU-smtatG iwmpaky
KAIL SUBSCaiPTIOK KATL
trsytsi* '
LET KLEIN
Make you a garment.
Harris* Homespuns-, In all the latest
shades of Brown.
i tm^tymmmm. Hi aha, Can-'.a
am. w. BiMKlSS W.,
EDITOBa
MONDAY. NOVEMBEB :i. 1M0 I
Our "Want Ads
Do the Business
This department ot Ths Dally Times Is highly SBPCB—faL II
brine* results. We could Mil you many trws stories to prove IL
A Sssayrsl* man lost a gold watch oa the train near Palo Alto.
He pat an sd 1b this paper on tb* chance that aoroa Palo Alto
person might have found It. It ws* toand by s Pacific Grove lady
wbo saw Uie ad In Tha Times aad restored ths watch. geWag
10 rrsssid. H yon want anytlilng srhalever. try s want ad.
eaa r**j>cisco-i.tl
A B***U9M
What** th* ma
Alto** As a metier
.S rRIKIft.
Hcf *■"•" *****
of habit we bub-
Choice Turkeys for
Thanksgiving
FROM
Iw E E KS!
e -_ *
Is s
Poultry Ranch
i ■* "'■ ■■' ■ *-* ""~ *
Hamilton 'Avenue, Palo Alto •
s
*
Phone 774x
Wanted—Sunny room and board
for an elderly lady in a German
home Direct answer* to Mr*. M.
Steven*, box 414, Redwood City.
ll-2l-6t
Wanted—Elderly lady wjahes position In family; experienced nurse
and good housekeeper; day, week or
month. 316 High atreet. 11*15-1-—
Wanted—Position by Japane**
schoolboy. Address Box J. Tiroes
ofnee. ll-15-st*-
Japansc ablo-bodlcd boy wants
jio--iii.it. will take any kind of
work. Box J, Times office. H-1S-61
Wanted—Bookkeeping, clerical or
prl.uU' secretary work foe evenings,
by experienced man. Box A. Times
offlee. U-14-lw
For Rent—-Sunny furnished front
rooms; reasonable. >J7 Emerson.
i i-i ;■-,;;
Lets ef Nerve.
rBrmefs Son-liy f.iber __„
*7L*iszr^^
B*-l know. He Jnil
v0"!T * al.eirt t0 brt« ****»**&
London Telegraph. -mcil-
A B.Mr atetlve.
"T*s, be played tbe last two *-*.
wltb * broken wrist-** *Cnj
"Heroism, afar**
"Not at *IL h* ma afraid to -us.
his uaderstudy a thaoeJ^ZJ***
Plain Dealer. -*-m»laad
For Rent—Sunny flat of four
rooms, kitchen partly rurnlshed, at
ItT Channlng arena*; 11. Apply j-j. ii-.-.. a.
200 Homer avenue. 11-16-lta
CARR COMPANY
"^-Sr^^Sg--**-
For Rent—Furnished flat, six
rooms; pantry, laundry, bath; adults
prelerred. Mrs. Wyckoff, :<: Homer avenue. 11-14-lW*
For
rooms,
bath.
Rent—Two sunny 'root
with kitchen end private
2GS Lytton avenue. 11-2-lm*
For Rent—Nice sunny rooms, tor*
nlshed for housekeeping. Rata*
reasonable. 454 Hamilton avenu*.
10-2 6-1 m
FOR SALa.
ee**s****************e*********s***ss*********s
iii.- out the word*. She's all right!
The fact 1* that Palo Alio Is funda- '
-mentally right, bat Bred* an agile. -,
methodical, .optimistic com mere I il ■.MMM^^^aM*^™*^™«M*w**^*^^^"^'^*^^^-**»*»»«****'
bead—not one man. but n group of [does nothing but pay his dues haji the matter No doubt the employes
men to begin planning right nnw-no ritht ,„ kick If the organization woudl be very grateful If rondltlons
how to make tb* roost of our ad- -, moribund. The work to be done ronuld be changed so tbey could be
vantages. The town ha* been dor- -,, (OT ■*-•#*- firm's benent. and every com fort* ble.
niruil long enough. ,irr[1 ,..,„,, h*-lt> 11 "long or It won't. "A CITIZEN AND CLOSE 0B-
l..* done If the members stay away ' SERVER."
from race'lngs It is equivalent io *
voting definitely against, a Joint lll-ACKIiril-V HAS THE
united movement for better eondl- LAIG1I OX COUNT."
, 3- for Rent—Armory hall. Apply
#i For Bale—Fresh, choice almonds, to W. F. Sewell at Armory or
• 'this season's crop. In small or large! Clark* Congdon. 130 University
J' Quantltl**, 15 rants pound. J. A.I avenue. 1-17-U.
Dickson. 251 Emerson. ll-lS-lw*
When ihe Panama-Pacillc International exposition comes to Ssn
Francl»co, as now seems certain.
Then- will be a doien cities and
-towns within fifty mile* of San ,-on
Francisco whlcb'will make a bid for
th* new business. The nearest ar-^
besl towns will have a chance to In-
-crease their jKtpulatlon from 1*> to
SOU) per cent In ten years. Palo Alto
-with lis points 'of saperiortty.
.should enjoy a Splendid growth.
Plans should bo worked out Im*
aieiiiu.il-,>■ to make the attraction*
nt Palo Alto known and to welcome -,,.,,■ o(
n*.« arrivals when they come. Plans
are ben>g consider*] for a hole).rmi-raged to go to work lor the gen- Mi
These should be cncouriiged. In*: ersl D*;neflt or be allowed to dlsban-1 lb
the organisation and quit pretend
It*c-sl*rtn-f Promptly d^
Phone SleX
John E. Newton
llousecleanlng, Window
(leaning. Gardening. Etc,
Promptly attended ts. '
Box 258. Palo Alto.
Parisian Dyeing and
Cleaning Company
For_ Rent—Alt*_ Halt, on thej French Diy "-rgntss asd Dys,,
For Sals— Fine resident** ot *er-'-h|rt noor 0, th* SlmklnB bonding.! latest Psrtalas
en rooms, corner lot 150 fort •tiuar* u available tor Bmall maetlnga Hi
on main slreet of Lo* Gato*. besutl-. ream 0f 1.50 per meeting En-
ful grounds, with fruit, ornamental qU|re Tim** office 5-T-tr
trees and flo|krs. Price S5.000.
Will trade r*o» Palo Alto property.
Mortgaga for ft.OOO throe years at
6 per cent can remain. Address
Box 8. Times offlc*. l-12-tf
For Sale—Baby carriage for
17.50; cost new |16. ITS Lytton.
1-30-U
PBsa tin BIB tor Auto
Took Him tn Jail.
That
The -November masting ol tbe Will
chamber or commerce will be held
nt the City hall tomorrow night.
Every business house In town Hiding to Jail In an automobile at
should bare a representative there. tb« expense or the county and th*
Every member of tbe executive com- presentation ol a hill to the board
tnltter should be there- personally of KUiiervlsor*' finance r-omtnllteo, ol
«r,*end tn hi* resignation. The of- which the ii reused Ir chairman,
fleers named above as the executive the latest bit or Irony
business ■ community way io ihe aurrace lo
were elected, and should be en- Supervisor
For Sale—Wlbdow cards mark***
"For 8*1*" can be had at Tim** office at fi cents each.
For Sale
For Rant—Window card* marked
"For Rent" or "Furnished Rooms"
or "Rooms and Board" caa I - h*d
at Times offlee. 5 cants each.
MIBCE^IsAXKOUS.
Vou- tree package Conkey's Laying Tonic and Poultry Book are
here. Call before they're gone. M.
C. Ford. 11-22,23,*'.
Mrs. W. F. Miller, ladles' tailoring nnd dre*sm*klng. Terms reasonable. 22Ii Bryant slreet.
11-21-lm*
bay
le» will -.n-li In-.ri-i- near th*
. Tbey should be drawi
Palo Alto If JHXslble. Minor prob-
Irni d.-niaud - attention from tb*
soiled business Interests.
The natural comments! head in
■Ibis city 1* the chamber of commerce. romj-O'ed of "fifty firms doing business here. This body Is
* ,?uaipet*nt to meet the needs of th-*
pr***eni situation. The executive
committee 1* composed »* follow*
J. V. I'arttlnson. •-Iinlrmau.
**. W. B. Allen.
M. A. Ilarhan.
* C. J. f'sn-j.
Jolm Dutineld.
C. H. DowiiliiL*
W. H. Kr'.ly.
lag that tbey hat
port
the general i
V Mem
Thei
Philanthropist Wants
Society for P. C. C.
SAYS f'LEHKS r,\NNOT HOP
LIVELY EXOI'GII Tt> KEEP
U.lltM WITIHH'T KIRK.
We hare a common It atlon pleading for a society lor the prevention
or crueltj io clerks. There are
mime Jol« apparently where the era-
■ -,i ri'it stir around lively
enough to keep warm without a
llr-. the contribution roads as fot
I nd t ft*.
that sill no' Inr-re-t.
rrotti 1300 to II -v-o.j
>*ar» If thl*
!*»■ -ro-x-t-saor^. an
begin a systematic pi
nilgti this winter.
*"--*an;. financial lo*, EaAerprl * '.'■
r->w means future prosperity.* Brl
itome member* of-thl* ehatsha I
B! "itiiniereo. ..\.-n of tin- cwcutit-r. «
t immlttea*. find fsult with- th.- A
. s hleifmerit* ot the organisation. In a
this Ihey find fault with themselves i,
and with-uearly evirry huMlncss man «
hart. The qiM-sthiti for every man (wi
-> s*k 1* not whit'la ihe rhaml*f>r: There s>
' -ommerce doing* but -'What can.comfort rxlaUna
■"ae chamber o* romtn*re*',dO If I nrrount of the
s-rsiinally attend the inci-tlnKs?" remedied, and why not
Tit*, man who **tay-i" away and offlefr or humane soelet
12,"SO—5 acres, all out In alfal-
work Its! fa. good stand; 3 acres of the best
esse of.rarleUes of apples: good C-room
£ Blackburn of San house, bsrn and chicken house;
-it counly. recently Indicted by close In. Will take a 2,000
s.i*! Francisco grsnd Jury on a Cottajte In part exchange. Balance
charge of accepting a bribe. TbUJcan stand oa mortgage,
■situation cxme to light yeslerday.j 17.000—16 1-2 acres, all bearing
■when R. E; Bowie, owner-of ih* orchard; good E-rooro house, new
machlfls, pr***nutd a hill to th* barn, well, mill and tank; clo«e tt*
-s-elerk of the board ror 5,250—10 acres at Mountain
from Redwood City to tbe Black- view; J."1« will
of the board declHrs*d the bill an buy this Inside of one week. After
.rage on the community, and :t - that/it can't be bought for less than
lively Hit will ae-j 1.-..0OO. and perhaps not for that.
igb the Apply to
J. a DALEY
10-29-lm -tW
Axle cutting, horse clipping. Ids*
Idence phone 406L: business phot
ID*! Monte stables) >l
IN VALID CARRUOI AND 1
AMIU'LANCK caa b* fOBBd at j
th* Beoepe stables, comer ]
Hamlltoa ave. and Ems-sea 3
st. Phon* 14J; offlc* phet-s '
176; resldeoc* phon* ST], ]
GEO. W. "lTNNBrr, Proprietor, j
Week's Poaltry Ranch
win supply yonr table with eaetes
ll-2i-lm-'| mllk-fBttsasd pssltry. dr*****r aBd
Get your roof repaired and int-1 ******** ***** ts oook asd ashrant
tera cleaned beroro the rains by *n' to yosr door. Order over pbos* T74I
experienced roof repairer. Loavot Raseh located oa Hamlltoa axaas.
orders at Backus' paint store, 212Ja4_ p-ia .,to
University avenue. Phone 43KJ^^
Palo Atto. 11-14-*!'
Order your turkey for Thanksgiving of L. II. Barker, 12 Boyce •«*-
te; telephone 341. 11-14-lw
Lost—On Bryant stroot or Channlng avenue, bunch of keys. Return to Times office. Reward.
11 -i »*3t
l,o*l—Wednesday, between Lytton school and Boyco avenuu. stunll
silver watch and lob. Phone 5I7X.
Reward. 11-21-31*
Jt HI- A FEW HOUR BAHGAIM
In o tie-motion eoIlapBlbr* go-carts;
nest, esmfortsbl*. durabi*
Sole agents for tbe fsmosa OA-
I-OR10 FntBLIlU COOKERS sad
VI i»m Pimm SHADES.
W, F. PennebaKer's
SM Emersoa Ht.. opposlta P. 0.
He Promised.
Sutton—No. 1 nut *|--ire Ihe in one)
... very well, but I'll lend II to you If yoo
Lo* Al-j promise otvt to keep it too long. Gar-
boy—II! und'Tluke to speud every pen-
ny ot It before tnnionmr,- Wiislllug.
Ionian.
«*I..*MK)
|ti> IAJAN
.Voald It nol be well for the 10-
U-srd ol health U> InvmtlRBte
lltlnn* nn to comfori and health
niplove* working In Palo AlloT'l-i exin-et'ed Ihat
1 do yow find some of ihe plae«jrompsny It on Us way thi
■="ii«i with the doors closed 1 county machinery,
wiih heat mi as to comfortable.] ,
le others per*!-*.'In keeping thej m San Frtin.-iNco nt Ih* promt
■1 side open apd no hea» except, date there -r* -j.-.-.-n new school*
: la *hut ap In s tm-foot office'in the course of construction at va-
c-e|i the proprietor or mnnager' rlou. points In Ihe city. This lit* a
m, uhllt the rest of the people good nlgn or the city's prosperity,
l'1-..d ln'the -tore are frer-xlng" 1
•o be a condition of un- It 1* one of the alwurdlii--- of ih-
Palo Alto, on]po*toSlre that stamps shall
.Street,
hat should be;
9
t
•
• You Have a
i
ga, iii*- lii.f'TT of any concern
0
^
ot be
il the general delivery witutou.
eieu though the general deliver*
cl«rk may be at leisure and th'
*'atnp - at thr
money ordet atudow or Ihe regis-
Iry window. Such a rule Is n'l
right when ii 'acllllat** the publl<
srriit-,- ^ ^1 any other time Ir 1.
rid Imi Ion-.
THE DEAREST GIFT.
A Path.!.-. Incident In tha L.fe ef Robert Brown, og.
A young Atasericau woman was Harding one day In an Italian railway
.-ouch. Hie onlj- other occapaqt of the
romparifiiDnt -hdhu an elderly gentle-
Ri«ht to Know
Mr.
hj -Mr and Mp
im .I'linti...
Ark.
lyes and Cecil Me.
f its J lor* to Sans.*-
were • litertalncd ._
Pbilbrcok on their! but durJinr Hi
The Philbrook-.l ."* „„..,„.,,
OlMerrlns
y*ang woman In :'.,
which they were |
niso that It wa*
experleiieisl irarele
Jects m;il pljee* of
From *.enrry the
<d to book* mid in
thing stiggesiesl tn
ran one of Ellz.iln-
Inn's sonaet*. wlil-T
Sbe WBB a-.ti-oL.il.
bus* t lu
ll.*
:.-re«i of tb*
.-:■ through
■i mid seeing
ht, the more
Hied out ob-
- whom yoa entm*t yonr money, ***
We want to'tell yos why we ran safely pay O per cent aad Bs*
at the same time allow you to withdraw yonr money on thirty 0
9 days* notice at any time; sHo why we hare bras sble to do ao 4ft
0 for IR years past aad why our tm*ine*a has grows antll we as
jfh bow have satisfied rastomers In almost rvrry state. as
•
• Palo Alto Mutual Building and Loan Association *
B, M IIWHAI.I. iil.irK. -Wniary.
• 257 UaWer-ltr Arease PALO ALTO *
Trlaisl.an. ITS. S
**» ' *
■: ': -.'1 drift*
I bora, until some-
fIn* jot-tig Ameri-
li It-irn-tt Brown-
she ijuotrd.
J and abssbed bail mtide no reply,
r (In* ride sat look.
I lie window, hav-
•lien tbe very exits rompaalon.
1 nlatjon where the
lesve the csr she
Ing apparently lor
who are well known here, are de- i-tence of hi* irav
Hghtful hosts and the visitors thor-: As they ncinsl |
oughly enjoyed the day. j young* lady was t
■ i ssld timidly:
Spiteful *"I fear. tir. that 1 have offended y(oo.
"Ves.- said Ibe enaiged girl. -Dick ' *i****P* y-^do not like Mrs. Brownie Tcry methm!Im!. He gives me , I lug** poetry,
kl** shea lie i-oiiium ami two wben In
goes away."
■Tbat'B.always been bl* Wi
torned her dearest friend. Tt
lots of v-lrls c-niiiment on 11."*
Thus Jl luippen-t that (bey t
speak to each olher.
Found—Blsek *nd white terrier
wlih collar and chain attached.
Owner can claim, the un* on bp-
nlylng to '.■■■ Scott street snd on
th* payment'for this ad. 11-21-St
The man slowly turned ujwu her
tear dimmed eyes, and In a voice full of
etnotlo* be said:
"Madam, thst sonnet I* the Bweetest,
j as IU singer wa* the dearest, gift God
I ever fare to me."
in was Ron-
sBpBBlss*.
I Het. traveling 1
! ert l*TOWBlas.-V'
Dr. Stefan von Hedry, rec-jntly
uppolatsd attache of the Austrian
embassy, will arrive in Ne wYork oa
the Carmaala on November 2«th.
Fetding the Fi»h.
Dlsguslnl ri-ticmi-irt leinptylng his ;
ball Into Hi.- stream)--Hanged If I'll
wait on you nay longer: Hi-re, help '
j-ourselves -Life,
A. W. MILLS
REAL ErtTATE
INSURANCE
319 University Ave.
I'hoae S46X.
The
"Doesn't yum
Ur*. Blnksr
"No. Indeed He hste* all cats el- ' |
cent a little kluy tbry have at bl* .
club."—Baltimore American.
A man
I Is a lamp 1
M. C. FORD !
(Successor to B. F .BELLI ■
WOOD, COAL.
nay. Grain, Ponltry Snppues. ,
Corner Hamilton and Ramona. '
Tetephone 60. j
1894=1910
Oldest Gioceiy Store in Palo
Alto,' known as the
House of
QUALITY, PROGRESS and
ACCOMMODATION
Earle fe Company
115 9 University Avenue
Phone 3
0006
No full textDAILY PALO ALTO TIMES, MU.NUAY, JANUARY 18. 1909
First
National Bank
Wants
Your
Business t
i
m
•
:
m
:
x
t
:
t
x
*
X
*
:
*
:
i
. aad win «xt.a* .—ry
• madatloa CBBlstafit wit* _
♦
♦ soand bsakla..
Capital
Surplus
5,200
orric>K8:
C. X Callds. Prssldsat.
Jaka Dadtald. Via. rrwMaaa.
Ell Kiss. Cs—r.
C. X. Jordaa, Ant Caaassr.
OIKBCTORS.
C. X Ctlld.
Jobs Dndfi.t*
C I. Smls*.
H W. Slm.ln.
.11 KlBS
Hr H L Wilbur
J. t l—Us
llttttttt.tt.t..tt«tltt*tt.
aomtaaa amcvdmuvt
num. 1 runHE WOMKX
Fancy
New Maine
corn!
2 Cans for 25c.
1.40 per dozen •
FULLER & CO. I
Phone 51
158 Uiv.rsity Ave. jj
■L*tJtnttttttttttt»*ttt«attt.
. Sacramento. Jan. IS.— Women
suffragists lifrt? In the Interest uf
the proposed amendment regarding
equst .ulTrsg** condemn tb*> meas-
ure which will be ititrui.ur*.*.] Itt tli.*
upper honse br Senator Sanford.
whereby sn attempt wtll be made to
shift ths burden of solvln« th* question lo the shoulders of the women
of the state, whteh they say will re-
cult In a delay of about four years,
so far as the final settle-mem Is concerned. Several of tbe leading; women will appear before the committee on constitutional am»ndnients
Tuesday afternoon to present argu-
111.-tits In favor of offering their
amendment to the voters at the
next election. Tho principal ad-
dresa will be made by Mrs, UllUn
Harris Coffin. Mrs. Helen Moore,
state organiser of the suffrage awo-
rlatlon. snd Mra. Elizabeth Low*
Watson of Santa Clara may also
speak.
WANTS
CLASSIFIED.
W.UfTKD. ~*
Wanted—Competent/ young lady
will act as ladles' maid at receptions,
dances, eic. Will serve refresh*
ments. Telephone "*\»L lS-So-lm*
Wanted—First-class practical oh
stetrical nurse wishes cases Box
,1004 Palo Alto l.-SO-lm**
Wanted—Young woman will
first-class laundry work and housework by the hour. Phone 5.3L.
1-4-3W*
Wanted—Olrl for general house*
work. Five-room cottage, three In
family, new* wpgmm Call 13-. balls
Wanted—Olrl for general house
work, small family; good wages
Call at 3*1 Waverley atreM. 1-1 2-1 *>
Want**d—Position aa practical
nurse or attendant on invalid or aa
housekeeper, by competent -young
woman. References exchanged
Phone 5>sV. Palo Alto. i-i*-lw«
I.--' — Friday night at Assembly
Hall, lady's black fur boa Keiurn
to Times office. lie ward l-ls-lt"
Found—-Lady's fttr. Ow**er call at
333 Waverley street and '"Identify
aame. l-U-.t
Our Dear Friend
The Merchant:
MAXINE ELLIOTT AND HER NEW THEATER.
stasia. Klli.-ii. bssslda* b*la* ratad *s aa* ol tb. uiost bsaatlral wobwsb
en Hi. at*—, la lh. ualy actraaa la Um world who ba* b*r own tbaatar. Tb*
aaw stasia* Kin..ii (tsaatar Ib Was. Thlnr-niBta ,tr—t, Msw Tort, wss
pl*ao.d br Ul*. Elliot, and ballt aodar h*r direction. Kb. Inv-attd a fortun*
In tt and own* lt IB i-ODBrtnarsblp wltb tn* Sbnb*rta Tba plsrbous* baa
many •&tlr*tr n*w lastar—. It la urobablj ta. tost!***, .b*at*r of Its bibs ta* world.
These Men Will Plan Reform in
Vote For Charter Prison Treatment
Th*
following votar. b.ve «x-
MKMIIKKH OK KTATK M—SS
«iik;kst b2.vi.om> iXHTrrt'-
i I, i\ Will I IK-I 11 IIMl.lls.
FOR TtR-tT.
Machine - Made
BREAD
AT
Stanford
Home Bakery
JOHN MC0L. Proprietor
US Uarretaitv Att. Wt Alto
For Rent—Rooms and tableboard'
for men. 55(1 Waverley street. Allj
home comforts i-i-im :.
For Bent—Unfnmlahed house alx<
rooms, three lots. barn. 50 bearing
fruit trees Address Rev W. Cohb.
«* Ho roar. H-U-lm*
Board and rooms, also "table board.
-.'.:. Lytton avenue. Also stable to
rent. l_*l-»lm
For Kent Furnished "double
front room and double back parlor,
with bath privileges. Is each. »S»
Emerson street. 12-Zt-tf
For Rent— Furnished "rooms by
day, week or month: housekeeping
rooms a .|*ect*!tv\ *S4 Hamilton. -
l-H-lw
Roams end board. 4.1 Hamilton
venue. l-ll-Jt*
For Bent—Cheap, three-room
house. Enquire Z?o Cbannfng avenue l-H-lw"
For Rent—Two newly furnished
housekeeping rooms. 12 a month:
three newl) furnished be-drix.'.... I*
a month. Stanton. 11 5 Everett.
■ i?*,jy.!B__
For Rent Nl..- attic rooms, two
windows In each room: ladles preferred. Box C. Times office. 1-1&-Ct*
FOR KALE.
ett.fi t ttt t ttttotf* •■•»••■'t#
Palo Alto
Cash Marie*.* g
3TS I nhe-r-11 j Atenoe.
Phowe 331.
Dealers tn Salt and 3m*k*d
Meets, Poultry of all kinds, j*
Everything new and clean
jj THOMPSON 4 UUR1M1>. ^
Iwiiiiuumm.inMssT
»».♦♦»»* »»»**■*»♦♦« »«****-»-
♦ -rt*-n*a -KMiit»ar*p. jiSL. o*v« r:
X l. * . THORPE
♦ Notary Pabllc
a Rem! Estate, In.tsn-sce. LOW-*,
♦ With Fnlveraity Realty Co..;
• t -.1 rim.-r.it>- Aremme.
* .-———_—___— — —.—.—..—.— __-__ . . . 4 .
tfjAttl********************
-w a v. tru. a. t a——is. j.
S COAL. WOOD, HAT,
/ GRAIN
1 BELL-RITCHIE CO.
s
*.
MltlltlWlWaWWWW
For Sale—Oak wood, atovewood.
four-root wood, wood far heaters:
II per cord, delivered. Peter Faber,
R. F. D. 3. Redwood City. Yard at
MIddlefteld road and San Franrls-
qutto creefc. t-10-tf
For Sale—A great bargain and
most be told, a business lot, fib*
112 1-2, Alma street between I'nt-
ti-rsttv and Hamilton avenues. Act
quickly. John F. Byibee. 101 Lytton- avenue. :i'-tf
r.ir Kale Will sell very cheap, -
new and modern six-room bungalow,
double fireplare. polished floors.
large sunnr porch, also summer
porch, concrete basement, (as' and
electricity: one and one-half blocks
from trolley car. The price l
surprise you: most any terms, 8e*
owner at 540 Embarradero road-
1-U-rW
For Bal^e—Cheap, few genuine
Nsvajo rugs. Klamath Indian blankets, rare furs, choice bedroom furniture. Mra. M Bottdeau.. Box .22.
Palo Alto. TwtaBhOTS lw4T. l"l_«_ll"
To Exchange Small frultranrfc
nicely located near good town for
Palo Alto property: or would sell
cheap for cash or part cash. ■ Address Box W. Times office 1-13-lw
MlhCKU-UrBOCS.
Twelve talking machines to be given
away, one with eacb I3S cash purchase. W. F. JPensebaker. &2t tn
ACCIDENTS will happen. -in
sure In tbe Maryland Casualty Company. Jobn F. Byxbee, agent, 101
Lytton avenae. corner Alma street-
Call and see my new office. 12-15-lm
press*J ih.lr Intention to vote fori
the charter. Not only have they an* [
thorlxed the use of their names, but
many of them have glveu expression:
to strong sentiments in favor of the:
proposed form of government. Oth-! Sacramento. Jan. U.—Plana for
er names will be added to the llat:« aweeplng change In California
tomorrow Those who may desire i I*aology are contained In a bill pre-
to be enrolled In this Hat are rs>j»*r,sd ■* **** ********** ot Governor
quested to so notify The Times of-! ******** *** members of the state
t>M: board of prison directors and lntro-
1 duced by Benalor Wolfe.
\ Tb* puriKise ot the bill la to keep
first termers between the ages of la
I and 30 away from the contamlnat-
1 log Influence of hardened convicts.
as well aa to prepare them ror another start In the world, by confining them to an Institution lo bt
known as the California state reformatory The Mil carries an appro-
; prlatlon of |2r.0,000 Tor the pur
chaae of land aod tbe construction
i or the new penal Institution.
Under tbe propoaed system per-
f sons between 16 and 30 who hsve
! been convicted of felony and who
; never have been In prison before
will receive no fixed sentence, but
merely a commitment lo the reformatory. If they prove Incorrigible,
' <hey are to be transferred to San
| Quentln or Folsotn. but If tbey
i prove trsctable and show evidence
' or penitence and reform they are to
' be paroled, and If tbe board of trua-
teea aee fit. absolutely released.
The bill provides for the purchase
or 100 aerea of land and the con
.atructlon of the reformatory by eon'
' vlet labor, aa far as feasible. The
rerormatory ta to be administered by
. a board of trustees consisting of Ave
men to be appointed by the governor io serve four years without pay.
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REVXOUW
Tbt* Is the l.iti.n.
Tbe I-nlted States postal author!-
j ties have reached ihe Hmtt In root-
lshnesa In postal restriction*, says
the t'klah Dispatch-Democrat.
* cording to the latest postal ruling
newapapers are barred from print-
| Ing the natnea or prlxewlnnera at
. card parties and at various contests
1 In lodgerooms. if the papers are to
ito through the malls. The Appeal
and the People's Cause, two papera
or Maryavllle. have recently been np
against It ror violating tha law. Tha
j flr.i paper named printed under the
heading "Twenty Tears Ago"* the
j reat.lt or a drawing or lots that took
'place In Sutter City In 1*88. and
' tb* postmasler announced that
' though the newa waa anctiyit he
[/would have to preclude It rrom the
) malls. Tbe other paper prlnted
iist of prlxewlnoers at a local card
] party and tbe namea of the man and
woman who woo at a mllk-dtioktng
jconleat at onr or the lodges.
. I The Prf.*-Democrat speaking
| Ironically or the decision, says:
The iMMiofflre haa given notice
' tbat nc* papers may phas through the
, ; malls that give results of any same
John Tlerney, the gateman rorjof tfatMre where nrt'ele* o|^¥ any
th* railroad company.' want to th*; value whatever are the prize*/- Pos-
9outhern Pacific boapltal fa Ban! albly this may prevent the newsps
_r*...ii,Ml' »,_.._., _,»,_-_ ha artll ham P*** trooi printing resultsor draw-
Frenclseo today, wher* h« win have, j-J- wb^ ^. ^Jfh of „upmnfl „
a amall cancertnia gi-trarth r*moT*d j appenate court judges draw lota ror
rrom hla Up. the long term and the short term,
Probably, too. It will be held a violation or poatal rulea ahould a newspaper print the atory ot tbe crucl-
Axton or Chriat. unless that part la
eliminated concerntng the caatlng or
lots for His raiment
Mrs- James Orr. of Mayfleld. re-
i timed from a ae van-months' trip to
England and Canada. She waa a*>
mpanled by ber daughter Elsie.
In the matter of hot air many a
man can beat bla own furnace.
be opened at alx o'clock or th* for*-
noon of aald day of election, aat
will be kept open until alx o'clock
of th* afternoon of said day. wb*n
tbe polls wll) be closed hy order Of
the Board of Trustees of tbe Town
of Palo Alto,
"fMAS D. MARX
"Prealdent or the Board or Trua-
t**a or th* Town of Palo Alto.
"Atteat:
"C. H. JORDAN. Town Clerk."
When You Are In
San Francisco
nsr*GO-
Valencia Theatre
*TM
. *x*e*i*ww*—*ftta fc4wt*t*,**c * r
Tak* s V.leacla Soaet car ts tbs sear. It's
Stir* atkiBt** nearer Third and Market lhaa FBI-
tmott Street- It'* ia* rimmat Tbaalr* Is th* wsst
SSS* the S*lr»t la Aatattcs.
Tin Htwie el tke Oteatatt Sleek
..AND . .
, Intli saw Pt.retefrw.rl. thai'* a*orta r*lss
s sssaraa ■!!•* ts aa*.
YOU WONT BE SORRY
GOt GO! GOI
Do you know bow to sell goodsf
Toor clerka, of course, know how to
sell goods wben people call and aak i
for tban.
Hut when people do not call and aak :
fur wbat tbey want and what you bav*
tn stock, what then?
Let tb* people know what you bav-*.
Our columns ar* open to advsrUaors
wltb bargains wbo want bl connect
wltb bargain buatera.
pimtMisntriaimisixfira
SAN FRANCISCO
"CHRONICLE"
. IjUl SSS pSSJSt «S Wttm amtarmm.tm*
aa«-_stt*Bmaf
MAI SUBSCmPTTON RATES
NOTICE OF BPKCIAL ELECTION
TO ADOPT OR REJECT FREEHOLDERS' CHARTER.
"Notice la hereby given to lh*
qualified electors of the Town of
Palo Alto, County of Santa Clara.
Slate of California, tbat a apeclal
Municipal Election will be bald In
aald municipality according to law,,
on Thursday. January 81, 1808, at.
wblcb aald election the question to
im voted upon ahall be th* ratification or rejection or tbe propo**d
Froeholddra' Chartar.
"Rallota aball b* naed whan voting npon the ratification or rejection.
or said Freeholders' Cbartar, aald
bsllots ahall be entitled 'Charter
Prepared and Propoaed ror th* City ■
or Palo Alto by the Board or Free-
holdtrs oo tba 80th day of November. A.D. 1908.' Undarneatb said-
tltl* th* ballot* aball contain tha
worda, 'I'ur the Fi-r*-lml«)■*.■*.' Charter,' with « square after aald words.
In which scjuar* voter* dealrlng to
vote for apd In fs,vor of the Charter
will stamp a rroaa. on a Un* below
and act out In opposition, tb* bal-t
lots shall contain the worda. 'Against
the Kr<-< imltlt-m* Chart er.' wltb a'
at) us re after the worda: tha voters
desiring to vote agalnat the charter;
will stamp a croaa ln th* aquare op-,
poslie the worda 'Against tbe Free.-
holders' Cliarter.'
"At the nam* time aod on the same'
ballote shall be printed lh a space
below the apnea on aald ballot* fori
votlog for or sgaln.t tb* Charter,
the title of the additional proposition aa follows:
Proposition 1. Article X. Alcoholic Liquors.
"On tb* ballot below the title shall
appear th* word*. 'For r>oposlilo«
1,' with a square aft*r tb* aame: j
voter* dealrlng to vot* for Propoal-
tlon 1 will stamp a croaa ta this]
square. Underneath and In oppoal-:
tlon. aball appear th* worda,
•Again*! Proprisiu-* I.' with al
aquare afler th* aame: vot*ra deslr-j
log to vote agalnat Proposition 1 j
will sump a croaa In tbla aquare. <
"For the purpoae of said apeclal'
election all election precincts of aald.
Town ahall be consolidated and coo-
atltut* one voting precinct and tho!
place of voting aball be at the Town j
Hall on Ramona street, between1
t'nlverslty avenue and Lytton ave-j
nue In aald Town. The Board of;
Election for auch consolidated al*c-j
tlon precinct shall consist or two
judge*, two clerk*, two ballot darks,
and two Inspectors, wbo shall ap-j
portion among themselves tb* work > -
and labor required to conduct such
•lection.
"Said election officers ar* hereby
appointed as.follow*:
"Judge*—C. Thompson, Frank
Co_d*n.
"Clerks—-A. A. Qulnn, F. K. Saunders. -""*"
"Ballot Clerks—Ed Vandervoort,
Frank Kaaaon.
"Inspector---L. Welchselfelder. 0.!
C. Bill*.
"In caae any of tbe officers above
appointed to conduct aald election
do oot attend at the opening of thai
polls, on the morning ot aald •lection, tb* electors of th* precinct
present at that boor may appoint and j
supply a competent person from
among ihemselfe* to nil th* place-
of aach absent member thereof.
"At aald election the polls shall j
Tte Weekly "ClneJele"
TBS —If *Mt WBBBJJ B.WSBSB—
-kOsaa* k *• a—ra Wa-
$1.50 a Year
tt* Bvaststt Mar-rt tt ail **«*i**i Is
thaaa t-v-vtrt**. tnry Ha* ae-iaa* avtl-as
wfc* *r* ta trtSBB Mac* wit*
SrtSC
I* ..Bdlss la tout rsbserlptlaa,
ddreas
K.H.de YOUNO,
Saa rn-MriMe -t-*kr*aia.,-
-— Fraartssi, CaL
CTacin-iTioa sgr-gTvzirr.
Golden
Gate
Coffee
The kind thai makes fhe brcik-
fast—real Coffa* throujh sod
tbroujb — slwsys tb* same.
Your grocer will grind it-
better If ground at horn*—not
too fine.
OO YEARe*
CXPEIUENCS
Patent
