3,669 research outputs found
MNT-CURN Seminar Series: Antibody Engineers - Blockchain & Proof of Useful Work
No full textThis video is part of a series from the Micro Nano Technology Education Center's (MNT-EC) Micro Nano Technology Collaborative Undergraduate Research Network (MNT-CURN) Research Program. In this program, students gain hands-on research experience and build nanotechnology technical education skills. Throughout this video series, viewers "... will hear and see nanotechnology and microtechnology professors presenting about their own research and work -- from biosensors to underwater drones to nanomaterials." Each video covers a different specialty that students may want to learn about and pursue as an undergraduate research project.During the presentation, Alejandro Strachan, professor of materials engineering at Purdue University, provides an explanation of blockchain and discusses research aimed at adapting bitcoin mining technology, originally used to solve cryptographic problems for bitcoin, for addressing scientific challenges. Blockchain is the technology underlining Bitcoin and other cryptocurrencies, functioning as a ledger that records bitcoin transactions in the form of blocks. To add another block to the chain, one must solve a cryptographic password, which is done through bitcoin mining. Strachan follows the explanation of blockchain by discussing research related to the usage of this same technology to solve scientific problems, which can help maximize benefits from the energy-intensive process of bitcoin mining.This video runs 32:53 minutes in length. Additional videos from this series are available to view separately
The blind spots of secularization
No full textAccording to several international surveys Spain is among the western countries with the most negative views of Jews. While quantitative data on the topic accumulates, there is a significant lack of interpretative approaches that might explain the particular Spanish case. This paper presents the background, methodology and major results of a discussion group-based study on antisemitism, which was conducted in Spain in the autumn of 2009. The study identifies and locates in different socio-economic and ideological milieus the range of stereotypical discourses on Jews, Judaism and the Arab–Israeli conflict in Spain. Analysis of the group meetings shows that, despite growing secularization in Spanish society, the central explanatory variable for persisting and resurging antisemitism in this country is still religion in a broad cultural sense.N
Métricas de autor Alejandro Gómez Jaramillo
No full textInforme de las métricas de autor del Dr. Alejandro Gómez Jaramillo de las publicaciones indexadas en Google Académico cuyo objetivo es entregar un insumo para el fortalecimiento de las capacidades y potencialidades de los autores de la Universidad Santo Tomás en el posicionamiento y visibilidad de sus publicacionesReport of the author metrics Alejandro Gómez Jaramillo of the publications indexed in Google Scholar whose objective is to provide an input for the strengthening of the capacities and potentialities of the authors of the Santo Tomás University in the positioning and visibility of their publications.http://unidadinvestigacion.usta.edu.c
Author response
No full textDetecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these responses come at a high metabolic price (McKean and Lazzaro, 2011, Kominsky et al., 2010), and avoiding pathogens before infection may be advantageous. The bacterial endotoxins lipopolysaccharides (LPS) are important immune system infection cues (Abbas et al., 2014), but it remains unknown whether animals possess sensory mechanisms to detect them prior to infection. Here we show that Drosophila melanogaster display strong aversive responses to LPS and that gustatory neurons expressing Gr66a bitter receptors mediate avoidance of LPS in feeding and egg laying assays. We found the expression of the chemosensory cation channel dTRPA1 in these cells to be necessary and sufficient for LPS avoidance. Furthermore, LPS stimulates Drosophila neurons in a TRPA1-dependent manner and activates exogenous dTRPA1 channels in human cells. Our findings demonstrate that flies detect bacterial endotoxins via a gustatory pathway through TRPA1 activation as conserved molecular mechanism.sponsorship: Vlaams Instituut voor Biotechnologie Alessia Soldano Luis Franco Guangda Liu Natalia Mora Emre Yaksi Bassem A Hassanr Fonds Wetenschappelijk Onderzoek G.0702.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0077.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0680.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0681.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0503.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0654.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0761.10N Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0596.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0565.07 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven GOA/14/011 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar European Commission IUAP P7/13 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekensr KU Leuven OT/12/091 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven PF-TRPLe Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talavera (Vlaams Instituut voor Biotechnologie, Fonds Wetenschappelijk Onderzoek|G.0702.12, Fonds Wetenschappelijk Onderzoek|G.0077.15, Fonds Wetenschappelijk Onderzoek|G.0680.10, Fonds Wetenschappelijk Onderzoek|G.0681.10, Fonds Wetenschappelijk Onderzoek|G.0503.12, Fonds Wetenschappelijk Onderzoek|G.0654.15, Fonds Wetenschappelijk Onderzoek|G.0761.10N, Fonds Wetenschappelijk Onderzoek|G.0596.12, KU Leuven|GOA/14/011, KU Leuven|OT/12/091, European Commission|IUAP P7/13, KU Leuven PF-TRPLe)status: Publishe
La colección Enrique Strachan de la Biblioteca de la Universidad Bíblica Latinoamericana y su relación con el Instituto Bíblico (1923-1941)
No full textTesis (licenciatura en bibliotecología y ciencias de la información)--Universidad de Costa Rica. Facultad de Educación. Escuela de Bibliotecología y Ciencias de la Información, 2022Poco después de la muerte de Enrique Strachan en 1945, los libros de su colección personal fueron trasladados a la biblioteca de la Universidad Bíblica Latinoamericana (UBL) e integrados a la colección general. Así permanecieron durante varios años, hasta que el bibliotecólogo a cargo en el período 1982-2017 localizó la mayoría, los separó y los colocó en estantería cerrada, aproximadamente entre los años 2006 y 2016 (A. Pérez, comunicación personal, 2021). Rescató así una colección prácticamente desconocida, convirtiéndola en una colección especial, a la cual denominó Colección Enrique Strachan (CES). Las últimas piezas de esta valiosa colección fueron localizadas recientemente por el actual bibliotecólogo y, con ello, quedó conformada definitivamente en el año 2021. La conformación de dicha colección despertó el interés del investigador por el origen, proceso de formación, función y en general, la historia de la colección. Al situar la pregunta en el origen de la colección destaca el hecho de que el Instituto Bíblico(IB) fue la primera institución a la que perteneció. De forma que al indagar en la historia de la colección se vuelve necesario conocer también la historia del IB. Dicho enfoque permite a esta investigación estudiar la historia de una colección especial en relación con un proyecto educativo concreto. Surge así la pregunta de investigación: ¿Cómo se puede explicar la relación de la Colección Enrique Strachan con el proyecto educativo del Instituto Bíblico? Esta pregunta se despliega en tres elementos de análisis. El primero corresponde a los motivos que llevaron a Enrique Strachan a formar esta colección bibliográfica. El segundo a la CES misma como objeto de investigación y a la vez fuente de información. El tercero se trata de la congruencia entre la colección, su contenido y propósito, con el proyecto educativo del Instituto Bíblico. La metodología utilizada consistió...UCR::Docencia::Ciencias Sociales::Facultad de Educación::Escuela de Bibliotecología y Ciencias de la Informació
Alma, impulso y movimiento según Alejandro de Afrodisia
No full textthis paper discusses Alexander of Aphrodisias’ conception of the soul, paying special attention to a specific aspect distinguishing the Alexandrian view from the Aristotelian one: the impulsive capacity or faculty. Firstly, it considers Alexander’s reformulation of Aristotle’s approach to the soul (as a form of the body), a reformulation that is performed in connection with his original reconstruction of hilemorphism. At this point the author makes a special emphasis upon the manner Alexander develops a ‘terraced model’ of hilemorphic composition. Secondly, the treatment of impulsive faculty, with a special focus on the theoretical performance that Alexander derives from taking the notion of impulse, is developed. Finally, Alexander’s reformulation of the Aristotelian psychology of action is also brie y considered in order to account for the sequence of the process of the production of voluntary movement and of action. This is an explicative model that leaves aside the Aristotelian resource to the structure of the practical syllogism, and incorporates the elements predominantly characteristic of the Stoic conception. This, though, does not entail the abandonment of the basic thesis of Aristotle’s stance regarding motivation, as an opposition to socratic intellectualism: the thesis of the primacy of desire, in all its possible ways, as a factor accounting for the origin of voluntary movement and action.Este artículo se ocupa de la concepción del alma elaborada por Alejandro de Afrodisia, con especial atención a un aspecto específico que la distingue de la concepción aristotélica: la introducción de una facultad o capacidad impulsiva. En primer lugar, se considera la reformulación de la concepción jaristotélica del alma como forma del cuerpo que Alejandro lleva a cabo, en conexión con su original reconstrucción del hilemorfismo. Aquí se pone especial énfasis en el modo en el cual Alejandro construye lo que puede llamarse un “modelo escalonado” de composición hilemórfica. En segundo lugar, se considera el tratamiento de la facultad impulsiva, atendiendo especialmente al rendimiento teórico que extrae Alejandro de la adopción de la noción de impulso. Por último, se considera brevemente el modelo reformulado de psicología de la acción que elabora Alejandro, para dar cuenta de la secuencia del proceso de producción del movimiento voluntario y la acción. Se trata de un modelo explicativo que deja de lado el recurso aristotélico a la estructura del silogismo práctico e incorpora, en cambio, los elementos más característicos de la concepción estoica. Ello no implica, sin embargo, el abandono de la tesis básica de la concepción aristotélica de la motivación, por oposición al intelectualismo socrático, a saber: la tesis de la primacía del deseo, en todas sus posibles formas, como factor que da cuenta del origen del movimiento voluntario y la acción
Author-level metrics. Technical Manual. 2.0 Version
No full textBecerril-García, Arianna, Aguado-López, Eduardo, & Macedo-García, Alejandro. (2023). Author-level metrics. Technical Manual. Zenodo. https://doi.org/10.5281/zenodo.79165
Molecular dynamics characterization of the contact between clean metallic surfaces with nanoscale asperities
No full textWe use molecular dynamics (MD) simulations to characterize the tensile strength of contacts formed between various clean platinum surfaces with nanoscale asperities. Both commensurate contacts between (001) and (111) surfaces and incommensurate (001) ones are considered over a wide range of asperity sizes. In cyclic closing and opening, fresh asperities that form contacts for the first time show significant plastic deformation; this leads to a reduction in the effective contact area during the first few cycles, after which steady state is achieved both in terms of contact size and the pull-out force necessary to open the contacts. As is the case for commensurate surfaces [H. Kim and A. Strachan, Phys. Rev. Lett. 104, 215504 (2010)], the strength of the metallic bridges that form in incommensurate contacts exhibit strong size effects; their strength increases with decreasing size until a length of similar to 5 nm, below which weakening is observed. Commensurate contacts lead to stronger bridges than incommensurate ones but only during the initial closing events; after steady state is achieved, commensurate and incommensurate (001) surfaces lead to bridges of similar strengths
Molecular dynamics predictions of thermal and mechanical properties of thermoset polymer EPON862/DETDA
No full textWe use molecular dynamics (MD) to perform an extensive characterization of the thermo-mechanical response of a thermoset polymer composed of epoxy EPON862 and curing agent DETDA. Our simulations, with no adjustable parameters, show that atomistic simulation can capture non-trivial behavior of amorphous thermosets including the role of polymerization degree, thermal history, strain rate and temperature on the glass transition temperature (T(g)) and mechanical response (including ultimate properties) and lead to predictions in quantitative agreement with experiments. We find a significant increase in T(g), Young\u27s modulus and yield stress with degree of polymerization while yield strain is significantly less sensitive to it. For structures cured beyond the gel point (percolation of a 3D network) conversion degree and temperature affect yield stress in a similar way with yield stress linearly dependent on T T(g): however, we find non-linear and non-universal relationship below the gel point. Our results show that a relative small variation in polymerization degree (similar to 5%) can explain the spread in experimental measurements of T(g) and elastic constants available in the literature. (c) 2011 Elsevier Ltd. All rights reserved
Coarse grain modeling of spall failure in molecular crystals: role of intra-molecular degrees of freedom
No full textWe use a recently developed thermodynamically accurate mesodynamical method (Strachan and Holian 2005 Phys. Rev. Lett. 94 014301) where groups of atoms are represented by mesoparticles to characterize the shock compression and dynamical failure (spall) of a model molecular crystal. We characterize how the temperature rise caused by the shockwave depends on the specific heat of the degrees of freedom (DoFs) internal to the mesoparticles (C-int) and the strength of the coupling between the internal DoFs and the mesoparticles. We find that the temperature of the shocked material decreases with increasing C-int and decreasing coupling and quantify these effects. Our simulations also show that the threshold for plastic deformation (the Hugoniot elastic limit) depends on the properties of the internal DoFs while the threshold for failure is very insensitive to them. These results have implications on the results of all-atom MD simulations, whose classical nature leads to a significant overestimation of the specific heat of molecular materials
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