1,721,249 research outputs found
Diagnostic strategy for analytical scanning of BRCA1 gene by Fluorescence-Assisted Mismatch Analysis using large bifluorescently labeled amplicons
No full textDiagnostic strategy for analytical scanning of BRCA1 gene by fluorescence-assisted mismatch analysis using large, bifluorescently labeled amplicons
No full textDiagnostic strategy for analytical scanning of BRCA1 gene by Fluorescence Assisted Mismatch Analysis using large, bifluorescently labeled amplicons.
No full text
Clinical service development for familial breast cancer in European Countries; the role and training of genetic councellors in this service, and educational provision in cancer genetics
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Ethical, social and economic issues in familial breast cancer: a compilation of views from the EC biomed II demonstration project
Full text linkABSTRACT:
Demand for clinical services for
familial breast cancer is continuing to rise across
Europe. Service provision is far from uniform and, in
most centres, its evolution has been determined by
local conditions, specifically by local research
interests, rather than by central planning. However, in
a number of countries there is evidence of progress
towards co-ordinated development and audit of clinics
providing risk assessment, counselling, screening and,
in some cases, prophylactic intervention. Much
important information should emerge from continued
observation and comparative assessment of these
developments.
In most countries for which relevant data are
available, there is a distinct bias towards higher social
class among those who avail themselves of clinic
facilities (in line with findings from many other
health-promotion initiatives). This should be
addressed when considering future organisation of
clinical services.
Molecular genetic studies designed to identify the
underlying mutations responsible for familial breast
cancer are not generally regarded as part of the clinical
service and are funded through research grants (if at
all). Economic considerations suggest that there is a
case for keeping this policy under review.
Familial cancers throw into sharp relief certain ethical
and legal issues that have received much recent
attention from government advisory bodies, patients
’
representatives, professional commentators and the
popular media. Two are of particular importance;
first, the right to gain access to medical records of
relatives, in order to provide accurate risk assessment
for a given family member, versus the right to privacy
in respect of personal medical information and,
second, the obligation (or otherwise) to inform family
members of their risk status if they have not actively
sought that knowledge. The legal position seems to
vary from country to country and, in many cases, is
unclear. In view of pressures to establish uniform
approaches to medical confidentiality across the EC, it
is important to evaluate the experience of participants
in this Demonstration Programme and to apply the
principle of
“
non-malfeasance
”
in formulating regu-
lations that should govern future practice in this field.
Data on economic aspects of familial breast cancer are
remarkably sparse and outdated. As evidence accrues
on the influence of screening and intervention
programmes on morbidity and mortality, there is a
strong case for evaluating the cost-effectiveness of
different models of service provisi
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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