26 research outputs found
Can't take the trauma out of my mind and body : a result of classical conditioning processes?
No full textIntrusive memories as conditioned responses to trauma cues: an empirically supported concept? Laila K. Franke, Julina A. Rattel, Stephan F. Miedl, Sarah K. Danböck, Paul-Christian Bürkner, Frank H. WilhelmNeuroscientific evidence for pain being a classically conditioned response to trauma- and pain-related cues in humans Laila K. Franke, Stephan F. Miedl, Sarah K. Danböck, Michael Liedlgruber, Markus Grill, Martin Kronbichler, Herta Flor, Frank H. WilhelmEstradiol during (analogue-)trauma: risk- or protective factor for intrusive re-experiencing? Laila K. Franke, Stephan F. Miedl, Sarah K. Danböck, Johanna Lohse, Michael Liedlgruber, Paul-Christian Bürkner, Belinda Pletzer, Frank H. Wilhelmsubmitted by: Laila K. Franke, MSc.Literaturverzeichnis: Seite 162-175Kumulative Dissertation aus drei ArtikelnDissertation Paris-Lodron-University Salzburg 202
Can't take the trauma out of my mind and body : a result of classical conditioning processes?
No full textIntrusive memories as conditioned responses to trauma cues: an empirically supported concept? Laila K. Franke, Julina A. Rattel, Stephan F. Miedl, Sarah K. Danböck, Paul-Christian Bürkner, Frank H. WilhelmNeuroscientific evidence for pain being a classically conditioned response to trauma- and pain-related cues in humans Laila K. Franke, Stephan F. Miedl, Sarah K. Danböck, Michael Liedlgruber, Markus Grill, Martin Kronbichler, Herta Flor, Frank H. WilhelmEstradiol during (analogue-)trauma: risk- or protective factor for intrusive re-experiencing? Laila K. Franke, Stephan F. Miedl, Sarah K. Danböck, Johanna Lohse, Michael Liedlgruber, Paul-Christian Bürkner, Belinda Pletzer, Frank H. Wilhelmsubmitted by: Laila K. Franke, MSc.Literaturverzeichnis: Seite 162-175Kumulative Dissertation aus drei ArtikelnDissertation Paris-Lodron-University Salzburg 202
High accuracy mantle convection simulation through modern numerical methods
No full textNumerical simulation of the processes in the Earth's mantle is a key piece in understanding its dynamics, composition, history and interaction with the lithosphere and the Earth's core. However, doing so presents many practical difficulties related to the numerical methods that can accurately represent these processes at relevant scales. This paper presents an overview of the state of the art in algorithms for high-Rayleigh number flows such as those in the Earth's mantle, and discusses their implementation in the Open Source code Aspect (Advanced Solver for Problems in Earth's ConvecTion). Specifically, we show how an interconnected set of methods for adaptive mesh refinement (AMR), higher order spatial and temporal discretizations, advection stabilization and efficient linear solvers can provide high accuracy at a numerical cost unachievable with traditional methods, and how these methods can be designed in a way so that they scale to large numbers of processors on compute clusters. Aspect relies on the numerical software packages deal.II and Trilinos, enabling us to focus on high level code and keeping our implementation compact. We present results from validation tests using widely used benchmarks for our code, as well as scaling results from parallel runs. © 2012 The Authors Geophysical Journal International © 2012 RAS.The first author was supported by the Graduate School in Mathematics and Computing (FMB) at Uppsala University, Sweden. The second and third authors are supported in part through the Computational Infrastructure in Geodynamics initiative (CIG), through the National Science Foundation under Award No. EAR-0949446 and The University of California-Davis. This publication is based in part on work supported by Award No. KUS-C1-016-04, made by King Abdullah University of Science and Technology (KAUST). The third author is also supported in part by an Alfred P. Sloan Research Fellowship.Some computations for this paper were performed on the 'Ranger' and 'Lonestar' clusters at the Texas Advanced Computing Center (TACC), and the 'Brazos' and 'Hurr' clusters at the Institute for Applied Mathematics and Computational Science (IAMCS) at Texas A&M University. Ranger was funded by NSF award OCI-0622780, and we used an allocation obtained under NSF award TG-MCA04N026. The authors acknowledge the Texas A&M Supercomputing Facility for providing computing resources on 'Lonestar' useful in conducting the research reported in this paper. Part of Brazos was supported by NSF award DMS-0922866. Hurr is supported by Award No. KUS-C1-016-04 made by King Abdullah University of Science and Technology (KAUST). Some computations were performed on resources provided by SNIC through Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX) under project p2010002
Correction: Differential expression of MicroRNAs in Alzheimer’s disease: a systematic review and meta-analysis (Molecular Psychiatry, (2022), 10.1038/s41380-022-01476-z)
No full textIn this article the affiliation details for Author JAE IL SHIN were incorrectly given as ‘Department of Psychiatry, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea’ but should have been ‘Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea’. The original article has been corrected
Author Correction: Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions
No full textNeural processing of audiovisual and painful analogue trauma and its relationship with subsequent audiovisual and pain intrusions
No full textFunctional connectivity during a social emotion task in adolescents and in adults
No full textIn this fMRI study we investigated functional connectivity between components of the mentalising system during a social emotion task, using psychophysiological interaction (PPI) analysis. Ten adults (22–32 years) and 18 adolescents (11–18 years) were scanned while thinking about scenarios in which a social or a basic emotion would be experienced. Unlike basic emotions (such as disgust and fear), social emotions (such as embarrassment and guilt) require the representation of another's mental states. In both adults and adolescents, an anterior rostral region of medial prefrontal cortex (arMPFC) involved in mentalising showed greater connectivity with the posterior superior temporal sulcus (pSTS) bordering on the temporo-parietal junction (TPJ) and with anterior temporal cortex (ATC) during social than during basic emotion. This result provides novel evidence that components of the mentalising system interact functionally during a social emotion task. Furthermore, functional connectivity differed between adolescence and adulthood. The adolescent group showed stronger connectivity between arMPFC and pSTS/TPJ during social relative to basic emotion than did the adult group, suggestive of developmental changes in functional integration within the mentalising system
Neural processing of audiovisual and painful analogue trauma and its relationship with subsequent audiovisual and pain intrusions
No full textBackground: Posttraumatic stress disorder and medically unexplained pain frequently co-occur. While pain is common during traumatic events, the processing of pain during trauma and its relation to audiovisual and pain intrusions is poorly understood.Objective: Here we investigate neural activations during painful analogue trauma, focusing on areas that have been related to threat and pain processing, and how they predict intrusion formation. We also examine the moderating role of cumulative lifetime adversity.Methods: Sixty-five healthy women were assessed using functional magnetic resonance imaging. An analogue trauma was induced by an adaptation of the trauma-film paradigm extended by painful electrical stimulation in a 2 (film: aversive, neutral) x 2 (pain: pain, no-pain) design, followed by 7-day audiovisual and pain intrusion assessment using event-based ecological momentary assessment. Intrusions were fitted with Bayesian multilevel regression and a hurdle lognormal distribution.Results: Conjunction analysis confirmed a wide network including anterior insula (AI) and dorsal anterior cingulate cortex (dACC) being active both, during aversive films and pain. Pain resulted in activation in areas amongst posterior insula and deactivation in a network around ventromedial prefrontal cortex (VMPFC). Higher AI and dACC activity during aversive>neutral film predicted greater audiovisual intrusion probability over time and predicted greater audiovisual intrusion frequency particularly for participants with high lifetime adversity. Lower AI, dACC, hippocampus, and VMPFC activity during pain>no-pain predicted greater pain intrusion probability particularly for participants with high lifetime adversity. Weak regulatory VMPFC activation was associated with both increased audiovisual and pain intrusion frequency.Conclusions: Enhanced AI and dACC processing during aversive films, poor pain vs. no-pain discrimination in AI and dACC, as well as weak regulatory VMPFC processing may be driving factors for intrusion formation, particularly in combination with high lifetime adversity. Results shed light on a potential path for the etiology of PTSD and medically unexplained pain
Neuroscientific evidence for pain being a classically conditioned response to trauma- and pain-related cues in humans
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