1,721,057 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the ESC , the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases
No full textAbstract Gene therapy has recently become a reality in the treatment of cardiovascular diseases. Strategies to modulate gene expression using antisense oligonucleotides or small interfering RNA are proving to be safe and effective in the clinic. Adeno‐associated viral vector‐based gene delivery and CRISPR‐Cas9‐based genome editing have emerged as efficient strategies for gene delivery and repair in humans. Overall, gene therapy holds the promise not only of expanding current treatment options, but also of intervening in previously untackled causal disease mechanisms with little side effects. This scientific statement provides a comprehensive overview of the various modalities of gene therapy used to treat heart failure and some of its risk factors, and their application in the clinical setting. It discusses specifically the possibilities of gene therapy for hereditary heart diseases and (non)‐genetic heart failure. Furthermore, it addresses safety and clinical trial design issues and challenges for future regulatory strategies.Deutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659Deutsche Krebshilfe https://doi.org/10.13039/501100005972H2020 European Research Council https://doi.org/10.13039/100010663H2020 Excellent Science - European Research Council https://doi.org/10.13039/100010663British Heart Foundation https://doi.org/10.13039/501100000274Deutsches Zentrum für Herz-Kreislaufforschung https://doi.org/10.13039/100010447Instituto de Salud Carlos III https://doi.org/10.13039/501100004587Norges Forskningsråd https://doi.org/10.13039/501100005416Ministero della Salute https://doi.org/10.13039/50110000319
Plättchen-SDF-1 reguliert die Rekrutierung, Proliferation und Differenzierung von humanen CD34+ Progenitorzellen : Implikationen bei Patienten mit akutem Myokardinfarkt
No full textThe chemokine stromal cell derived factor-1 (SDF-1) regulates the homing of hematopoietic stem cells. The aim of this study was to examine the platelet surface expression of SDF-1 in patients with acute myocardial infarction (AMI) and to investigate the role of platelet-derived SDF-1 for homing and differentiation of CD34+ progenitor cells.
In a consecutive cohort of 450 patients with coronary artery disease, flow cytometric analysis demonstrated a significantly increased platelet-surface expression of SDF-1 in patients with AMI (n=144) compared to patients with stable angina (n=306) (P=0.021). Platelet surface expression was dependent on platelet activation and correlated with degranulation of P-selectin. Platelet-derived SDF-1 regulated adhesion of CD34+ cells to immobilized platelets and endothelium under static and dynamic flow conditions. Moreover, platelets induced formation of macrophages/foam cells and maturation to endothelial cells from CD34+ cells in co-culture experiments via SDF-1.
These findings imply that platelet-derived SDF-1 regulates recruitment and differentiation of progenitor cells and may play a central role for regeneration of ischemic myocardium.Das Chemokin SDF-1 reguliert unter anderem die Rekrutierung von hämatopoetischen Stammzellen. Im Rahmen dieser Arbeit wurde die Oberflächenexpression von SDF-1 auf humanen Thrombozyten von Patienten mit akutem Myokardinfarkt untersucht. Von besonderem Interesse war dabei der Einfluß von thrombozytärem SDF-1 auf das 'Homing' und die Diffferenzierung von CD34-positiven Progenitorzellen.
In einer Kohorte von 450 konsekutiven Patienten mit koronarer Herzerkrankung zeigte die Durchflußzytometrie, dass bei Patienten mit akutem Myokardinfarkt (n=144) die Oberflächenexpression von SDF-1 auf den Thrombozyten im Vergleich zu Patienten mit stabiler Angina pectoris signifikant erhöht ist. Die thrombozytäre SDF-1 Oberflächenexpression korreliert zum Ausmaß der Thrombozytenaktivierung und Degranulierung. Unter statischen und unter Flussbedingungen regulierte thombozytäres SDF-1 die Adhäsion von CD34-positiven Progenitorzellen an immobilisierte Thrombozyten und an das Endothel. Dabei induzierte die Adhärenz an Thrombozyten die Differnzierung von CD34-positiven Progenitorzellen zu Makrophagen / Schaumzellen oder Endothelzellen.
Aus diesen Daten kann man schließen, dass das Chemokin SDF-1 eine zentrale Rolle in physiologischen Regenerationsprozessen des Myokards spielen kann
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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