523 research outputs found
The Route of the Malignant Plasma Cell in Its Survival Niche: Exploring “Multiple Myelomas”
No full textSIMPLE SUMMARY: Multiple Myeloma is a hematological neoplasia originating from malignant plasma cells in the bone marrow. Despite improved therapies, this cancer is still considered incurable due to the occurrence of relapse and the development of drug resistance over time. Apart from cell-intrinsic oncogenic features such as genetic alterations and clonal evolution that promote tumor growth and survival, increasing evidence demonstrates that the bone marrow microenvironment plays a pivotal role in disease relapse and immune evasion by providing protected bone marrow niches in which dormant myeloma cells are able to reside and survive. This review summarizes the ways of the bone marrow micromilieu to nurture and interact with the malignant plasma cells, and provides insights into the vicious cycles arising from the interplay between myeloma cells and their surrounding tumoral stroma. Knowledge about these mechanisms and how to disrupt them may provide novel approaches to targeting and tackling multiple myeloma. ABSTRACT: Growing evidence points to multiple myeloma (MM) and its stromal microenvironment using several mechanisms to subvert effective immune and anti-tumor responses. Recent advances have uncovered the tumor-stromal cell influence in regulating the immune-microenvironment and have envisioned targeting these suppressive pathways to improve therapeutic outcomes. Nevertheless, some subgroups of patients include those with particularly unfavorable prognoses. Biological stratification can be used to categorize patient-, disease- or therapy-related factors, or alternatively, these biological determinants can be included in a dynamic model that customizes a given treatment to a specific patient. Genetic heterogeneity and current knowledge enforce a systematic and comprehensive bench-to-bedside approach. Given the increasing role of cancer stem cells (CSCs) in better characterizing the pathogenesis of solid and hematological malignancies, disease relapse, and drug resistance, identifying and describing CSCs is of paramount importance in the management of MM. Even though the function of CSCs is well-known in other cancer types, their role in MM remains elusive. With this review, we aim to provide an update on MM homing and resilience in the bone marrow micro milieu. These data are particularly interesting for clinicians facing unmet medical needs while designing novel treatment approaches for MM
Entwicklung einer schnellen Pulsformanalyse für asymmetrische AGATA-Germanium-Detektoren
No full textOnTEAM metadata: GDSID: DOC-2007-May-32; Attribute ID: LIBRARY-thesis_diss-2007-005; Title: [GSI Diss 2007-05] Entwicklung einer schnellen Pulsformanalyse für asymmetrische AGATA-Germanium-Detektoren; Author(s): Beck, Torsten; Corporate author(s): ; Publication date: 20070501; Creator: manton; Creation date: 15.05.2007 16:02:12; Change date: 29.10.2008 16:29:34; Access: nur berechtigte Gruppen; Attribute type: Text.Thesis.Diss; Directory path: ['GSI Publications', 'GSI as Publisher']; Attribute path: ['Infrastructure', 'Library and Documentation', 'thesis_diss', 'Added in 2007']; File name(s): ['DOC-2007-May-32-1.pdf']; File title(s): ['']; File access: ['nur berechtigte Gruppen'
Manifolds, sheaves, and cohomology
No full textThis book explains techniques that are essential in almost all branches of modern geometry such as algebraic geometry, complex geometry, or non-archimedian geometry. It uses the most accessible case, real and complex manifolds, as a model. The author especially emphasizes the difference between local and global questions. Cohomology theory of sheaves is introduced and its usage is illustrated by many examples. Content Topological Preliminaries - Algebraic Topological Preliminaries - Sheaves - Manifolds - Local Theory of Manifolds - Lie Groups - Torsors and Non-abelian Cech Cohomology - Bundles - Soft Sheaves - Cohomology of Complexes of Sheaves - Cohomology of Sheaves of Locally Constant Functions - Appendix: Basic Topology, The Language of Categories, Basic Algebra, Homological Algebra, Local Analysis Readership Graduate Students in Mathematics / Master of Science in Mathematics About the Author Prof. Dr. Torsten Wedhorn, Department of Mathematics, Technische Universität Darmstadt, Germany
James Watson, Maclyn McCarty, and Torsten Wiesel
No full textTorsten Wiesel (right) with Professor Emeritus Maclyn McCarty (center), co-author of the paper with Oswald Avery and Colin MacLeod, and James D. Watson, director of Cold Spring Harbor Laboratory, 1994
Photo by Leif Carlsson
To commemorate the fiftieth anniversary of the discovery at The Rockefeller University that genes are made of DNA - considered by many to be the single most important biological discovery of the twentieth century - the university has kicked off a year-long series of events that were running through May 1994. The celebration was formally inaugurated in November 1993 with a lecture by Nobel laureate James D. Watson, best known for discovering the double-helical structure of DNA.
See also Search Winter 1994, vol. 4, no. 1https://digitalcommons.rockefeller.edu/group-portraits/1013/thumbnail.jp
Seltsame Schauspiele. Torsten Fogelqvists Deutschlandreise 1934
No full textIn 1934 Torsten Fogelqvist, a prominent member of the Swedish Academy and a well-known journalist and intellectual, visits Nazi Germany. He writes about his visit to the Third Reich in 17 articles published in the Stockholm daily newspaper Dagens Nyheter. The author, highly critical of the Hitler regime, scrutinizes several aspects of the nazified German society such as the attempts to re-educate the German citizen in accordance with the ideology of the new regime, the hero cult in the Nazi movement, and the relationship between the German state and the churches. In order to further an understanding of political and social developments in Germany Fogelqvist uses a specific strategy. He “translates” them into an imaginary Swedish context. This paper compares his views with those of other Swedish visitors
PISM glacial cycle sensitivity experiments of the Antarctic Ice Sheet
No full textThis dataset contains PISM simulation results (http://www.pism-docs.org) of the Antarctic Ice Sheet based on code release v1.0-paleo-ensemble (https://doi.org/10.5281/zenodo.3574033). PISM is the open-source Parallel Ice Sheet Model developed mainly at UAF, USA and PIK, Germany.
With the help of added python scripts, all figures can be reproduced as in the journal publication:
- Albrecht et al., 2020, doi:10.5194/tc-14-599-2020.
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Data:
Find PISM results as netCDF data. See 'README.md' for a list of all performed experiment.
All forcing input data for the experiments and plots can be downloaded and remapped via https://github.com/pism/pism-ais. Some of the original input data files are freely available, for others please contact the author or the corresponding data publisher.
Figure plotting scripts (jupyter notebook based on python, see https://jupyter.org) in 'plot_scripts' access the uploaded PISM results in 'model_data' and save the plots to 'final_figures'. Jupyter notebook can be run in the browser and shared, see https://nbviewer.jupyter.org/url/www.pik-potsdam.de/~albrecht/notebooks/paleo_paper/paleo_paper_final.ipynb.
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Contact:
Albrecht, Torsten ([email protected]) ; Potsdam-Institute for Climate Impact Research (PIK), Potsdam, German
Die Erfolgsfaktoren für unternehmerisches E-Mail-Marketing nach Dr. Torsten Schwarz am Praxisbeispiel ERGOTOPIA GmbH
No full textThis scientific document reveals the results of an empirical examination within the realm of entrepreneurial e-mail-marketing which is based on a literature review by technical author Dr. Torsten Schwarz. Using the start-up company ERGOTOPIA as a practical example, the author of the master thesis investigates whether the explanations of Dr. Schwarz match with the practical implementation of ERGOTOPIA.
Precisely, the scientific paper focuses on the examination of the four aspects lead generation, newsletter-design, software-requirements and performance measurement through monitoring with regard to successful realization of e-mail-marketing campaigns. The empirical part of this examination is made of the introduction as well as the analysis of two conducted so called split-tests that compare specific aspects of the newsletter-design and measure data-driven results to show which kind of aspect produced the more successful campaign.
This way the author proves whether the recommendations by Dr. Schwarz are practically relevant for the company ERGOTOPIA
Invitation to Dialogue - A Progress Report
No full textFragmentation of knowledge and life milieux, so often associated with specialization in science and planning, provided the broad challenge in science and planning, provided the broad challenge for a DIALOGUE PROJECT initiated by Torsten Hägerstrand and Anne Buttimer in Sweden during the Academic Years 1977-1979. The initial incentive for confronting such a wide-ranging set of issues arose from a paper on Values in Geography (Buttimer, 1974), after which the author was invited as a Fulbright lecturer to offer a series of seminars in Lund on problems of knowledge and experience. More than forty participants from ten widely different disciplines took part in this seminar, and foundations were laid for an experientially-grounded approach to the problems of communication across disciplines. The present project was initiated when Anne Buttimer was invited to accept a full time position in Sweden by the Humanistisk-Samhällsvetenskapliga Forskningsrådet (Council for Humanities and Social Science) in 1977. Financial support for this pilot phase of the Dialogue Project was granted by the Swedish Committee for Future Oriented Research and the Bank of Sweden Tercentenary Foundation. The geography department at the University of Lund continues to provide material and administrative help, with Torsten Hägerstrand as Co-Director
Invitation to Dialogue - A Progress Report
No full textFragmentation of knowledge and life milieux, so often associated with specialization in science and planning, provided the broad challenge in science and planning, provided the broad challenge for a DIALOGUE PROJECT initiated by Torsten Hägerstrand and Anne Buttimer in Sweden during the Academic Years 1977-1979. The initial incentive for confronting such a wide-ranging set of issues arose from a paper on Values in Geography (Buttimer, 1974), after which the author was invited as a Fulbright lecturer to offer a series of seminars in Lund on problems of knowledge and experience. More than forty participants from ten widely different disciplines took part in this seminar, and foundations were laid for an experientially-grounded approach to the problems of communication across disciplines. The present project was initiated when Anne Buttimer was invited to accept a full time position in Sweden by the Humanistisk-Samhällsvetenskapliga Forskningsrådet (Council for Humanities and Social Science) in 1977. Financial support for this pilot phase of the Dialogue Project was granted by the Swedish Committee for Future Oriented Research and the Bank of Sweden Tercentenary Foundation. The geography department at the University of Lund continues to provide material and administrative help, with Torsten Hägerstrand as Co-Director
Living labs as a concept and place for holistic sustainability education
No full textThis chapter has its origins in the authors’ activities in the field of teaching and research of solar energy in buildings at the Vallès School of Architecture (ETSAV) of Universitat Politècnica de Catalunya (UPC), which started as early as in 2003. In 2008 the author initiated and directed the first Solar Decathlon project of UPC, leading a team of 100 students and 50 companies in a 2-year process of the design, construction and operation of the energy self-sufficient solar house LOW3. This unique and transformational teaching and learning experience (for all student participants, but also for the author) led to the author’s conviction that experience-based, collaborative and transdisciplinary project-based learning in non-formal learning environments is highly effective and deeply necessary in the education of future architects, offering immense possibilities for a disciplinary as well as holistic approach to sustainability education.Objectius de Desenvolupament Sostenible::4 - Educació de QualitatObjectius de Desenvolupament Sostenible::7 - Energia Assequible i No ContaminantObjectius de Desenvolupament Sostenible::11 - Ciutats i Comunitats SosteniblesObjectius de Desenvolupament Sostenible::13 - Acció per al ClimaObjectius de Desenvolupament Sostenible::12 - Producció i Consum ResponsablesPostprint (published version
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