13 research outputs found
Late Paleozoic to Jurassic tectonic evolution of the Bogda area (northwest China): Evidence from detrital zircon U-Pb geochronology
No full textSince the Cenozoic, the Tian Shan is rejuvenated by crustal shortening related to the ongoing India-Asia collision. However, the tectonic process prior to the Cenozoic remains ambiguous, especially in the Bogda area of the eastern Tian Shan. The continuous Late Paleozoic-Mesozoic sequences in the Bogda area record abundant information about the basin-mountain interaction. U-Pb (LA-ICP-MS) dating of detrital zircons from seven sandstone samples from Permian to Jurassic was used to investigate the changes of provenance and basin-mountain interaction in the Bogda area. During the Permian, proximal and synchronous pyroclastic materials were the major source. The Late Paleozoic magmatic belt in the North Tian Shan (NTS) had gradually become one of the main sources by the Late Permian, which implies the uplift and exhumation in the NTS area. This is interpreted in terms of near-source sedimentation in basin developing in a post-orogenic extension setting. The large range of U-Pb ages of detrital zircons observed in the Early-Middle Jurassic sediments encompasses most of the available sources implying a wide drainage pattern developing on a rather flat topography. Re-emergence of the Early Permian peak in the spectrum implies that the Bogda Mountains has existed as a gentle positive relief and began to provide materials to the submountain regions. The southern Junggar Basin extended towards to the south and evolved as a passively subsiding basin from the Middle Triassic to the Middle Jurassic. However, the synchronous pyroclastic (tuff) and the exhumed late Paleozoic detrital materials from the uplifted Bogda Mountains were the major component of the Upper Jurassic sediments. Associated to the conglomerate in the Kalaza Formation, the basin-range evolution entered a compression uplift stage. The basin pattern evolution of the Bogda area is consistent with that of the southern Junggar Basin. (C) 2014 Elsevier B.V. All rights reserved.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000338615800010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Geochemistry & GeophysicsSCI(E)[email protected]
Mesozoic and Cenozoic uplift and exhumation of the Bogda Mountain, NW China: Evidence from apatite fission track analysis
No full textAbstractApatite fission track (AFT) analysis on samples collected from a Paleozoic series is used to constrain the cooling history of the Bogda Mountain, northwest China. AFT ages range from 136.2 to 85.6 Ma and are younger than rock depositional ages and the mean confined track lengths (11.0–13.2 μm) mostly showing unimodal distribution are shorten, indicating significant track-annealing. Thermal histories modeling based on the distribution of fission-track lengths combined with the regional geological data show that two rapid cooling phases occurred in the latest Jurassic–early Cretaceous and the Oligocene–Miocene. Those new data together with previous published data show that the AFT ages become younger from the southwest to northeast in the western Bogda Mountain and its adjacent areas. The fission-track ages of the southwest area are relatively older (>100 Ma), recording the earlier rapid uplift phase during the late Jurassic–Cretaceous, while the ages in the north piedmont of the Bogda Mountain (namely the northeast part) are younger (<60 Ma), mainly reflecting the later rapid uplift phase in the Oligocene–Miocene. The trend of younger AFT ages towards the northeast might be explained by post-Cretaceous large-scale crustal tilting towards the southwest. In the thrust fault-dominated northern limbs of the Bogda Mountain, AFT ages reveal a discontinuous pattern with age-jumps across the major fault zones, showing a possible strata tilting across each thrust faults due to the thrust ramps during the Cenozoic. The two rapid uplift stages might be related to the accretion and collision in the southern margin of the Asian continent during the late Jurassic and late Cenozoic, respectively
“Эзэн Чингис хааны билиг сургаал”-ын судлагдсан байдал: Studies on “Chingis khaany bilig surgaal”
No full textIn this article, author examines the scientific and research studies on “Chingis khaany bilig surgaal”. The scholars [Sh.Choimaa, E.Purevjav, Kh.Namjil, G.Akim] and source studies have have divided the work into the following: 1. Folklore - intellectual prowess and superiority of proverbs 2. Natural intelligence and wisdom of Ezen bogda 3. Life experience, learning from others and the wise men that use his mind to call upon past teachings. Also professor G.Munkh has classified it: 1. Khutag bilig (his sayings and teachings) 2. Öv bilig (expressed his ideas enriching others teachings) 3. Örgömöl bilig (Chingis khan’s teaching and sayings to his sons, successors, generals and ministers; others’ sayings related to his success and deed) 4. Ish bilig (quotes on Chingis khan’s concepts based on historical source materials) These classifications are helpful to do the further investigations
Closed Strings and Moduli in AdS3/CFT2
No full textString theory on AdS3×S3×T4 has 20 moduli. We investigate how the perturbative closed string spectrum changes as we move around this moduli space in both the RR and NSNS flux backgrounds. We find that, at weak string coupling, only four of the moduli affect the energies. In the RR background the only effect of these moduli is to change the radius of curvature of the background. On the other hand, in the NSNS background, the moduli introduce worldsheet interactions which enable the use of integrability methods to solve the spectral problem. Our results show that the worldsheet theory is integrable across the 20 dimensional moduli space
Shared Care Involving Cancer Specialists and Primary Care Providers - What Do Cancer Survivors Want?
No full textThis article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving'. Copyright (2017) John Wiley & Sons, Inc. All rights reserved.
This author accepted manuscript is made available following 12 month embargo from date of publication (May 2017) in accordance with the publisher’s archiving policyBackground
Cancer survivors are living longer, prompting greater focus on managing cancer as a chronic condition. Shared care between primary care providers (PCPs) and cancer specialists, involving explicit partnership in how care is communicated, could ensure effective transitions between services. However, little is known about cancer patients' and survivors' preferences regarding shared care.
Objective
To explore Australian cancer survivors' views on shared care: what cancer survivors need from shared care; enablers and barriers to advancing shared care; and what successful shared care looks like.
Setting and Participants
Community forum held in Adelaide, Australia, in 2015 with 21 participants: 11 cancer survivors, 2 family caregivers, and 8 clinicians and researchers (members of PC4-Primary Care Collaborative Cancer Clinical Trials Group).
Intervention
Qualitative data from group discussion of the objectives.
Results
Participants stressed that successful shared care required patients being at the centre, ensuring accurate communication, ownership, and access to their medical records. PCPs were perceived to lack skills and confidence to lead complex cancer care. Patients expressed burden in being responsible for navigating information sharing and communication processes between health professionals and services. Effective shared care should include: shared electronic health records, key individuals as care coordinators; case conferences; shared decision making; preparing patients for self-management; building general practitioners' skills; and measuring outcomes.
Discussion and Conclusions
There was clear support for shared care but a lack of good examples to help guide it for this population. Recognizing cancer as a chronic condition requires a shift in how care is provided to these patients
Evaluating the efficacy of a self-guided Web-based CBT intervention for reducing cancer-distress: a randomised controlled trial.
No full textThe author manuscript is made available following 12 months embargo from date of publication (Aug 7 2015) in accordance with publisher copyright policy. “The final publication is available at Springer via http://dx.doi.org/10.1007/s00520-015-2867-6."Purpose
This study evaluated the efficacy of a self-guided Web-based cognitive behaviour therapy (CBT) intervention compared to an attention control in improving cancer-related distress, health-related quality of life (HRQOL), and maladaptive coping, among people recently diagnosed with cancer.
Methods
Sixty individuals with cancer diagnosed in the previous 6 months and receiving treatment with curative intent were randomised to receive either the 6-week intervention Cancer Coping Online (CCO: n = 30) or the 6-week Web-based attention control (n = 30). Outcome measures, including cancer distress (the Posttraumatic Stress Scale—Self-Report), general distress (Depression Anxiety Stress Scale), quality of life (EORTC QLQ-C30), and coping (mini-MAC), were administered at baseline, immediately post-intervention, and at 3 and 6 months post-intervention.
Results
Significant main effects for time were found for cancer distress, global QOL, physical function, role function, social function, and anxious preoccupation. Post hoc between-group comparisons showed CCO participants had statistically significantly higher physical functioning compared to controls at 3 months of follow-up (d = −0.52, p = 0.02). Furthermore, compared to controls, post hoc comparisons found moderate between-group effect sizes favouring CCO post-intervention for cancer distress (d = 0.43) and anxious preoccupation (d = 0.38), and at 6 months of follow-up for global QOL (d = −0.43).
Conclusions
These results provide preliminary support for the potential efficacy of a self-guided Web-based CBT programme in improving aspects of HRQOL, cancer-related distress, and anxious preoccupation after cancer diagnosis. This paper provides justification for, and will help inform the development of, subsequent larger multi-site studies
A qualitative exploration of barriers and facilitatorsto adherence to an online self-help intervention for cancer-related distress
No full textThis author accepted manuscript is made available following 12 month embargo from date of publication (March 2017) in accordance with the publisher’s copyright policyObjective
This study qualitatively explored barriers and facilitators of adherence to an online psychological intervention for cancer-related distress.
Methods
Semi-structured interviews were conducted with 13 adults with cancer, randomised to receive either a 6-week intervention (n = 8) or attention control (n = 5) as part of a larger RCT. Transcripts were coded for themes and subthemes, and recruitment ceased when saturation of themes occurred.
Results
Adherence overall was high: six participants completed all six modules, three completed five modules, two completed four modules, one completed one module, and one did not access the program. The total numbers of barriers (n = 19) and facilitators (n = 17) identified were equivalent and were categorised into five overarching themes: illness factors, psychological factors, personal factors, intervention factors and computer factors. However, the prevalence with which themes were discussed differed: illness factors (specifically cancer treatment side effects) were the main reported barrier to adherence; intervention factors (email reminders, program satisfaction, ease of use, program content) were the most common facilitators.
Conclusion
While some factors were cited as both facilitating and barring adherence, and therefore reflective of personal preferences and circumstances, a number of recommendations were derived regarding (i) the best timing for online interventions and (ii) the need for multi-platform programs
The use of patient reported outcome measures in oncology clinical practice across Australia and New Zealand
No full textBackground: While there is increasing evidence on the benefits of PROMs in cancer care, the extent of routine collection and use of PROMs in clinical cancer practice across Australia and New Zealand (ANZ) is unknown. This study examined the prevalence and characteristics of PROMs use in routine clinical cancer care in ANZ. Methods: An online survey was designed and disseminated via professional societies and organisations using a snowball sampling approach to clinical and health administration professionals managing cancer care in ANZ. A poster advertising the study was also circulated on professional social media networks via LinkedIn and Twitter inviting health professionals from ANZ to participate if they were using or intending to use PROMs in clinical cancer practice. Responders opted into the survey via the survey link. Results: From 132 survey views, 91(response rate, 69%) respondents from 56 clinical practices across ANZ agreed to participate in the survey, and of these 55 (n = 55/91, 60%) respondents reported collecting PROMs within their clinical practice. The majority of the respondents were from the State of New South Wales in Australia (n = 21/55, 38%), hospital (n = 35/55, 64%), and a public setting (n = 46/55, 83%). PROMs were collected in all cancer types (n = 21/36, 58%), in all stages of the disease (n = 31/36, 86%), in an adult population (n = 33/36, 92%), applied in English (n = 33/36, 92%), and used to facilitate communication with other reasons (27/36, 75%). A geospatial map analysis provided insights into the variation in PROMs uptake between the two countries and in certain jurisdictions within Australia. This study also highlights the limited resources for PROMs implementation, and a lack of systematic priority driven approach. Conclusion: PROM use across Australia and New Zealand seems variable and occurring predominantly in larger metropolitan centres with limited standardisation of approach and implementation. A greater focus on equitable adoption of PROMs in diverse cancer care settings is urgently needed.Policy Analysi
Late characterisation of cardiac effects following anthracycline and trastuzumab treatment in breast cancer patients
No full text© 2018 Elsevier B.V.. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/
This author accepted manuscript is made available following 12 month embargo from date of publication (March 2018) in accordance with the publisher’s archiving policyBackground
Anthracycline (A) and trastuzumab (T) chemotherapy have well-recognized cardiac toxicity, potentially leading to significant morbidity and mortality. Our previous work in 46 prospectively enrolled breast cancer patients showed early left ventricular (LV) and right ventricular (RV) function decline at 1 and 3 months, but only persistent RV dysfunction at 12 months which correlated with myocardial oedema observed early (1 and 3 months) after administration of chemotherapy regimes.
Method
To investigate late cardiac effects, the same cohort were re-imaged with advanced Cardiovascular Magnetic Resonance (CMR) imaging including T1 mapping 5 ± 1 year post chemotherapy.
Results
Twenty-six out of 46 (50%) patients underwent follow-up imaging. A statistical but non-clinically significant decrease was observed in LV ejection fraction (EF) from baseline to 5 years (72.2 ± 6.6 to 65.4 ± 9.3, p 10% at 3 months (n = 5) or at 12 months (n = 3) did not demonstrate any difference in LV or RVEF at 5 years. No correlation was observed between myocardial oedema and LV or RVEF at 5 years. At 5 years, T1 values were within normal limits overall (935 ± 48 ms). One patients had significantly elevated (>1000 ms) T1 values with no correlation to LV or RVEF. No subjects demonstrated replacement myocardial fibrosis at 5 years.
Conclusion
Using advanced CMR, contemporary chemotherapy regimes demonstrate minimal long-term cardiac toxicity. There is minimal diffuse and no replacement fibrosis as demonstrated by LGE, following chemotherapy. This study suggests limiting serial imaging in these patients at 12 months post chemotherapy
Returning to work following curative chemotherapy: a qualitative study of return to work barriers and preferences for intervention
No full textAuthor version under embargo for a period of 12 months from the date of publication, in accordance with the Publisher's policy. The final publication is available at Springer via http://dx.doi.org/10.1007/s00520-014-2324-yPurpose This study aimed to explore barriers to return to work (RTW) and preferences for intervention and support for cancer patients treated with curative intent from the perspectives of cancer survivors and oncology health professionals. Methods Participants attended a focus group (N = 24) or an individual interview (N=14). A topic guide and a semi-structured recorded interview format were used to gather data, which were later transcribed and analysed for global themes and subthemes. Results With regard to barriers, the global theme ‘work capacity’ captured an array of barriers encompassing financial pressure, preparedness for work, lack of confidence as well as other key physical, practical and psychosocial barriers. Participants expressed a preference for RTW models that focus on objective and structured assessment whilst allowing for flexibility to address individual needs. Conclusions Cancer survivors perceive multiple barriers when attempting to RTW. These barriers were perceived to impact upon work-capacity, where ‘capacity’ was defined broadly to include practical, physical and psychosocial concerns. RTW is an important concern for cancer survivors and structured RTW interventions should be incorporated into the care of cancer survivors
