68 research outputs found
Five Years of Constitutional Jurisprudence in Bosnia and Herzegovina: A First Balance. EDAP 7/2004
No full textThe article reflects the experiences of the author after having served as one of the three international judges of the Constitutional Court of BiH from 1997 to 2002. Based on the relevant case-law of the Constitutional Court it gives a basic overview of the constitutional structure of BiH and analyses the position of the Court vis-à-vis other institutions established under the Dayton-Agreement and the powers of judicial review and human rights protection based on its appellate jurisdiction. Moreover means of interpretation and the elements of constitutional doctrine elaborated through case-law as well as organisational and procedural matters such as the role of dissenting opinions are discussed. In conclusion the article reflects the role of the Constitutional Court in transition from an ethnically divided and war-torn society to democracy and the effective protection of human and minority rights
"PULS." - Ein Blog als Online-Magazin für Medizinstudierende der Goethe-Universität Frankfurt
No full textIm Herbst 2009 forderten Studierende im Rahmen landesweiter Proteste auch am Fachbereich Medizin/Zahnmedizin der Goethe-Universität Frankfurt mehr Transparenz und Kommunikation zu Angelegenheiten ihres Studiums. Einen innovativen Lösungsansatz, um diesen Forderungen nachzukommen, bietet eines der Web 2.0 Werkzeuge: ein auf einer Blog-Software basierendes Online-Magazin für Studierende und andere Mitglieder des Fachbereichs.
Das öffentlich zugängliche Online-Magazin "PULS." (https://newsmagazin.puls.med.uni-frankfurt.de/wp/) wird mit einer freien Blog-Software (wordpress Version 3.1.3.) realisiert und von einer Online-Redakteurin konzipiert und geschrieben. Die Beiträge entstehen nach eigenen Recherchen sowie aus Anregungen und Gesprächen mit verschiedenen Personengruppen des Fachbereichs. Die datenschutzkonforme Auswertung der Zugriffe erfolgt über eine open-source Webanalyse-Software (Piwik). Zusätzlich werden jährlich mit dem Online-Umfrage-Tool Survey Monkey die Nutzer anonym befragt.
"PULS." ist seit dem 14.02.2010 ununterbrochen online und hat seitdem 806 Beiträge (Stand: 27.11.2012) publiziert und wird von ca. 2400 Besuchern monatlich gelesen. Das Themenspektrum ist zentriert auf die Anliegen der Frankfurter Medizin- und Zahnmedizinstudierenden. Die enge Zusammenarbeit mit verschiedenen Gruppierungen des Fachbereichs – Dekanat, Studierende und Lehrende – garantiert darüber hinaus ein fachbereichs-relevantes Themenspektrum. Das Online-Magazin begleitet komplexe Projekte und Entscheidungen mit Hintergrundinformationen und kommuniziert sie verständlich. Eine jährliche Nutzer-Evaluierung zeigt eine wachsende Leserzahl und eine sehr hohe Zustimmung für das Online-Magazin, seine Inhalte und seinen Stil. Das Web 2.0-Medium "Blog" und seine web-typische Sprache entsprechen dem Medienverhalten der Zielgruppe, d.h. den Studierenden des Fachbereichs Medizin.
"PULS." hat sich als ein geeignetes und strategisches Instrument erwiesen, um größere Transparenz, mehr Kommunikation und letztendlich eine stärkere Identifikation der Studierenden mit ihrem Fachbereich voranzutreiben
2011-13_Ederer-MA
No full textIris Ederer – Masterarbeit SS 11
01. A life that’s filled with light (F. Foster, lyrics: I. Ederer) 6:42
02. Sometime ago (S. Michanovich) 7:27
03. Daydream (D. Ellington / B. Strayhorn) 9:19
04. Eclipse (C. Mingus) 6:21
05. Sweet Dulcinea Blue (K. Wheeler) 8:04
06. Iris (W. Shorter, trad. Irish Folksong) 7:08
07. Time all gone (F. Correa, lyrics: M. Murphy) 5:20
08. Winter Sweet (K. Wheeler, lyrics: N. Winstone) 4:38
09. Wild is the Wind (D. Tiomkin) 5:43
Total time 60:47
Instruments played by:
Iris Ederer – voc, Stefan Heckel – pno, Dusan Simovic – b, Klaus Fürstner – dr
Flügelhorn: Axel Mayer
Posaunen: Reinhard Summerer, Stefan Bellada, Karel Eriksson, Johannes Oppel
Recorded by Ulrich Katzenberger, Christian Klotzbücher and Jonathan Schorr at KUG Studio,
Graz, Austria
Mixed by Ulrich Katzenberger (1-5), Christian Klotzbücher (6, 8, 9) and Martin Denda (7) at KUG Studio, Graz, AustriaIris Ederer – Masterarbeit SS 11
01. A life that’s filled with light (F. Foster, lyrics: I. Ederer) 6:42
02. Sometime ago (S. Michanovich) 7:27
03. Daydream (D. Ellington / B. Strayhorn) 9:19
04. Eclipse (C. Mingus) 6:21
05. Sweet Dulcinea Blue (K. Wheeler) 8:04
06. Iris (W. Shorter, trad. Irish Folksong) 7:08
07. Time all gone (F. Correa, lyrics: M. Murphy) 5:20
08. Winter Sweet (K. Wheeler, lyrics: N. Winstone) 4:38
09. Wild is the Wind (D. Tiomkin) 5:43
Total time 60:47
Instruments played by:
Iris Ederer – voc, Stefan Heckel – pno, Dusan Simovic – b, Klaus Fürstner – dr
Flügelhorn: Axel Mayer
Posaunen: Reinhard Summerer, Stefan Bellada, Karel Eriksson, Johannes Oppel
Recorded by Ulrich Katzenberger, Christian Klotzbücher and Jonathan Schorr at KUG Studio,
Graz, Austria
Mixed by Ulrich Katzenberger (1-5), Christian Klotzbücher (6, 8, 9) and Martin Denda (7) at KUG Studio, Graz, Austri
Case report : synergetic effect of ischaemia and increased vagal tone inducing ventricular fibrillation in a patient with Brugada syndrome
No full textBackground
Brugada syndrome (BS) is a hereditary channelopathy associated with syncope, malignant ventricular arrhythmia, and sudden cardiac death. Right ventricular ischaemia and BS have similar underlying substrates precipitating ventricular tachycardia or fibrillation (VF).
Case summary
A 72-year-old woman with BS and a stenosis on the proximal right coronary artery received several subsequent implantable cardioverter-defibrillator shocks due to VF during an episode of extreme nausea with vomiting.
Discussion
This case report emphasizes on the synergetic effect of mild ischaemia and increased vagal tone on the substrate responsible for BS to create pathophysiological changes precipitating VF
Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability
No full textChromothripsis is a frequent form of genome instability, whereby a presumably single catastrophic event generates extensive genomic rearrangements of one or multiple chromosome(s). However, little is known about the heterogeneity of chromothripsis across different clones from the same tumour, as well as changes in response to treatment. Here we analyse single-cell genomic and transcriptomic alterations linked with chromothripsis in human p53-deficient medulloblastoma and neural stem cells (n = 9). We reconstruct the order of somatic events, identify early alterations likely linked to chromothripsis and depict the contribution of chromothripsis to malignancy. We characterise subclonal variation of chromothripsis and its effects on extrachromosomal circular DNA, cancer drivers and putatively druggable targets. Furthermore, we highlight the causative role and the fitness consequences of specific rearrangements in neural progenitors.We thank Peter Lichter and Aurelio Teleman for discussions, Frauke Devens, Michaela Hergt, Brigitte Schoell and Katharina Bauer for technical support, the Sequencing and the Microarray units of the Genomics and Proteomics Core Facility (DKFZ), the EMBL Sequencing Facility, the DKFZ FACS Core Facility and the DKFZ Imaging Facility. David Pellman and his team are acknowledged for kindly sharing their published single-cell DNA sequencing data as a reference dataset. Florian Markowetz and his team are acknowledged for sharing scAbsolute and for support in using it. Thomas Weber and Jan Korbel are acknowledged for their advice regarding strand-seq data analysis. Axel Benner is acknowledged for support with statistical analyses. Daniel Haag is acknowledged for kindly sharing neural stem cells. P.S. was supported by the Heidelberg-Mannheim Life Science Alliance. D.R.G. was supported with personal grants by the German Academic Scholarship Foundation (Studienstiftung des Deutschen Volkes) and the Mildred Scheel Doctoral Fellowship programme of the German Cancer Aid (Deutsche Krebshilfe). K.W.P. acknowledges funding by the German Childhood Cancer Foundation (DKS2021.02) and the Federal Ministry of Education and Research (01GM2205A). R.G.P. holds a fellowship from Grant IHMC22/00007 funded by the Instituto de Salud Carlos III (ISCIII). The vast majority of the experimental work in this study was supported by grants to A.E. from the DFG, the Wilhelm Sander Foundation and the Fritz Thyssen Foundation. H.S. was supported by the German Federal Ministry of Education and Research (031L069A).Peer Reviewed"Article signat per 26 autors/es: Petr Smirnov, Moritz J. Przybilla, Milena Simovic-Lorenz, R. Gonzalo Parra, Hana Susak, Manasi Ratnaparkhe, John KL. Wong, Verena Körber, Jan-Philipp Mallm, George Philippos, Martin Sill, Thorsten Kolb, Rithu Kumar, Nicola Casiraghi, Konstantin Okonechnikov, David R. Ghasemi, Kendra Korinna Maaß, Kristian W. Pajtler, Anna Jauch, Andrey Korshunov, Thomas Höfer, Marc Zapatka, Stefan M. Pfister, Wolfgang Huber, Oliver Stegle & Aurélie Ernst"Postprint (published version
Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability
No full textChromothripsis is a frequent form of genome instability, whereby a presumably single catastrophic event generates extensive genomic rearrangements of one or multiple chromosome(s). However, little is known about the heterogeneity of chromothripsis across different clones from the same tumour, as well as changes in response to treatment. Here we analyse single-cell genomic and transcriptomic alterations linked with chromothripsis in human p53-deficient medulloblastoma and neural stem cells (n = 9). We reconstruct the order of somatic events, identify early alterations likely linked to chromothripsis and depict the contribution of chromothripsis to malignancy. We characterise subclonal variation of chromothripsis and its effects on extrachromosomal circular DNA, cancer drivers and putatively druggable targets. Furthermore, we highlight the causative role and the fitness consequences of specific rearrangements in neural progenitors.We thank Peter Lichter and Aurelio Teleman for discussions, Frauke Devens, Michaela Hergt, Brigitte Schoell and Katharina Bauer for technical support, the Sequencing and the Microarray units of the Genomics and Proteomics Core Facility (DKFZ), the EMBL Sequencing Facility, the DKFZ FACS Core Facility and the DKFZ Imaging Facility. David Pellman and his team are acknowledged for kindly sharing their published single-cell DNA sequencing data as a reference dataset. Florian Markowetz and his team are acknowledged for sharing scAbsolute and for support in using it. Thomas Weber and Jan Korbel are acknowledged for their advice regarding strand-seq data analysis. Axel Benner is acknowledged for support with statistical analyses. Daniel Haag is acknowledged for kindly sharing neural stem cells. P.S. was supported by the Heidelberg-Mannheim Life Science Alliance. D.R.G. was supported with personal grants by the German Academic Scholarship Foundation (Studienstiftung des Deutschen Volkes) and the Mildred Scheel Doctoral Fellowship programme of the German Cancer Aid (Deutsche Krebshilfe). K.W.P. acknowledges funding by the German Childhood Cancer Foundation (DKS2021.02) and the Federal Ministry of Education and Research (01GM2205A). R.G.P. holds a fellowship from Grant IHMC22/00007 funded by the Instituto de Salud Carlos III (ISCIII). The vast majority of the experimental work in this study was supported by grants to A.E. from the DFG, the Wilhelm Sander Foundation and the Fritz Thyssen Foundation. H.S. was supported by the German Federal Ministry of Education and Research (031L069A).Peer Reviewed"Article signat per 26 autors/es: Petr Smirnov, Moritz J. Przybilla, Milena Simovic-Lorenz, R. Gonzalo Parra, Hana Susak, Manasi Ratnaparkhe, John KL. Wong, Verena Körber, Jan-Philipp Mallm, George Philippos, Martin Sill, Thorsten Kolb, Rithu Kumar, Nicola Casiraghi, Konstantin Okonechnikov, David R. Ghasemi, Kendra Korinna Maaß, Kristian W. Pajtler, Anna Jauch, Andrey Korshunov, Thomas Höfer, Marc Zapatka, Stefan M. Pfister, Wolfgang Huber, Oliver Stegle & Aurélie Ernst"Postprint (published version
Predicting severity and intrahospital mortality in CovID-19: The place and role of oxidative stress
No full textSARS-CoV-2 virus causes infection which led to a global pandemic in 2020 with the development of severe acute respiratory syndrome. Therefore, this study was aimed at examining its possible role in predicting severity and intrahospital mortality of COVID-19, alongside with other laboratory and biochemical procedures, clinical signs, symptoms, and comorbidity. This study, approved by the Ethical Committee of Clinical Center Kragujevac, was designed as an observational prospective cross-sectional clinical study which was conducted on 127 patients with diagnosed respiratory COVID-19 viral infection from April to August 2020. The primary goals were to determine the predictors of COVID-19 severity and to determine the predictors of the negative outcome of COVID-19 infection. All patients were divided into three categories: patients with a mild form, moderate form, and severe form of COVID-19 infection. All biochemical and laboratory procedures were done on the first day of the hospital admission. Respiratory (p < 0:001) and heart (p = 0:002) rates at admission were significantly higher in patients with a severe form of COVID-19. From all observed hematological and inflammatory markers, only white blood cell count (9:43 ± 4:62, p = 0:001) and LDH (643:13 ± 313:3, p = 0:002) were significantly higher in the severe COVID-19 group. We have observed that in the severe form of SARS-CoV-2, the levels of superoxide anion radicals were substantially higher than those in two other groups (11:3 ± 5:66, p < 0:001) and the nitric oxide level was significantly lower in patients with the severe disease (2:66 ± 0:45, p < 0:001). Using a linear regression model, TA, anosmia, ageusia, O , and the duration at the ICU are estimated as predictors of severity of SARS-CoV-2 disease. The presence of dyspnea and a higher heart rate were confirmed as predictors of a negative, fatal outcome. Results from our study show that presence of hypertension, anosmia, and ageusia, as well as the duration of ICU stay, and serum levels of O are predictors of COVID-19 severity, while the presence of dyspnea and an increased heart rate on admission were predictors of COVID-19 mortality. 2 2 -
IS A FAMILY HISTORY OF CORONARY HEART DISEASE AN INDEPENDENT CARDIOVASCULAR RISK FACTOR?
No full textBackground: Although a family history (FHx) is an accepted risk factor for cardiovascular (CV) disease, few studies have examined the predictive strength of a positive FHx after adjusting for other conventional risk factors and medications
Methods: We analyzed 12,922 patients with ACSs, without evidence of prior CV disease enrolled in the ISACS-TC registry between January 2010 to January 2021. Main outcome measures were the adjusted rates of STEMI and 30-day mortality from STEMI using multivariable logistic regression models
Results: Overall, 3,147 patients (24,4%) self-reported an FHx of CV disease, defined as first-degree relative with premature CV events (men, age<55 years; women, age<65 years). There were 214 (17.4%) patients with FHx of CV, but without CV risk factors and 2,933 (28.3%) patients with FHx of CV associated with one or more CV risk factors. After adjusting for age, sex, cigarette smoking, obesity,
and history of diabetes, hypertension and hypercholesterolemia, FHx of CV disease was associated with a significantly lower incidence of STEMI in patients with CV risk factors, but not in those without (ORs: 0.71; 95% Cl: 0.61 to 0.83 vs 0.87; 95% Cl: 0.52 to 1.48; interaction p=0.02). The magnitude of this protective association was weaker in younger than older patients (OR 0.81; 95% CI 0.66 to 0.98 vs 0.59; 0.45 to 0.76, interaction p=0.02). Prior use of evidence-based medications (aspirin, beta-blockers, ACE inhibitors/ARBs and statins) did not consistently change prior estimates on FHx of CV disease (OR: 0.79; 95% Cl: 0.65 to 0.96). Patients who presented with STEMI had a twofold excess risk of 30-day mortality (OR: 2.03; 95% CI: 1.36 to 3.11; p<0.001) compared with controls
Conclusion: There is little evidence to consider a positive self-reported FHx of CV disease as a significant risk factor for development of STEMI and related high rate of CV mortality. Paradoxically, FHx of CV disease is associated with reduced severity CV disease outcomes in patients with the four primary CV risk factors, diabetes, cigarette smoking, hypertension, and hypercholesterolemia. Further investigation on the relation between FHx of CV and behavioral risk factors known to affect cardiovascular health is require
Factors affecting carbon monoxide diffusion capacity in early convalescence phase of severe COVID19 patients
No full text
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