1,721,037 research outputs found
Innate immune responses against Coxiella burnetii - human versus goat
No full textContains fulltext :
159476.pdf (Publisher’s version ) (Open Access)RU Radboud Universiteit, 12 september 2016Promotor : Joosten, L.A.B. Co-promotores : Sprong, T., Rebel, A., Roest, H.I.J
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Onderzoek van menging bij dichtheidsverschillen
No full textMathematisch model voor het berekenen van zoutindringing in een estuarium of zeetgat. Numerieke modellering van de zouttong en de dichtheidsstroming. Effect van menging op de dichtheidsstroom.Environmental Fluid DynamicsHydraulic EngineeringCivil Engineering and Geoscience
The immune response in Q fever.
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145305.pdf (Publisher’s version ) (Open Access)Q fever is an infection caused by the bacterium Coxiella burnetii. A large outbreak of Q fever occurred in the Netherlands between 2007 and 2010, in which infected goats and sheep were the source of human infections. In some people, so-called ‘chronic Q fever’ develops, which mainly manifests as endocarditis, infection of vascular prosthesis or aortic aneurysms, or both. We studied the immune response against C. burnetii in blood of healthy individuals, chronic Q fever patients and people with a past Q fever infection. Immune cells of chronic Q fever patients showed an increased production of ‘interferon-gamma’, a key signalling molecule. We concluded that, in contrast to what had generally been assumed, the interferon-gamma mediated immune response is not defect in chronic Q fever.
Subsequently, we used the measurement of interferon-gamma production and other cell-signalling molecules (‘cytokines’) in blood in-vitro for diagnostic purposes. We found that these kind of blood tests can accurately detect a past or chronic Q fever infection. This valuable new diagnostic tool is currently being developed to a commercial blood test for Q fever infection.
In a screening-study among patients with rheumatoid arthritis (RA) with immunomodulating drugs, we studied the risk for chronic Q fever. We found that RA patients are at increased risk for chronic Q fever compared to the general population. We advised to carefully check for chronic Q fever in these patients when they have been exposed to C. burnetii.
We alse studied the unique Q fever vaccination campaign in the Netherlands in 2011, in which 1370 people with increased risk for chronic Q fever were vaccinated. This was the first time worldwide that such a large population at risk was being vaccinated against Q fever. We could conclude that vaccination was safe, but many vaccinees reported local skin reactions. We measured the immune response in blood of vaccinees 6 and 12 months after vaccination and found overall only a limited immune reaction to C. burnetii. We calculated retrospectively that only 11% of people at risk have been vaccinated in this 2011 campaign.Radboud Universiteit Nijmegen, 02 november 2015Promotores : Meer, J.W.M. van der, Netea, M.G. Co-promotores : Deuren, M. van, Sprong, T
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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