122,218 research outputs found
Performance for 'Fifty Years of Twenty Sites in 'n' Years': Tom Phillip's graphic scores, live improvisation
No full textSouth London Gallery, Clore Studio, artist,Tom Phillips commemorative event: 'Fifty Years of 20 sites in ‘n’ years,’ seminar and commissioned performance event, April 16th 2023. Live performance with ensemble devised and led by Tansy Spinks, playing graphic scores: 'Ornamentik' (1966), solo violin and 'Music for ‘n’ Musicians' (1973), with Kate Ryder (prepared and toy pianos, Tom Mills (theremin), Daniel Ross (Tom Phillip’s studio objects), Nick Rampley (experimental bassoon) and Tansy Spinks (electric violin). Ticketed public event. https://www.southlondongallery.org/events/tom-phillips-20-sites-n-years
Recording of electromyogram activity in the monkey during skilled grasping
No full textThis chapter provides a brief presentation of the available techniques for electromyogram (EMG) recordings in the awake monkey using chronically implanted electrodes. We illustrate how this technique can be used for the analysis of the monkey's motor behavior during dexterous grasp. We also investigate how the grasp specificity of EMG activity can be related to the activity of a population of pyramidal tract neurons (PTNs) recorded from the hand area of the primary motor cortex (M1).: Introduction: The ability to grasp and manipulate objects of various sizes and shapes is essential for a large range of human activities. The debilitating loss of skilled hand movements following stroke, spinal injury and many other pathological disorders results in a marked loss of autonomy for the affected patient. The characteristic structure of the human hand provides this organ with a unique combination of motor and sensory capacities that underpin the control of manual dexterity. The anatomy of the hand includes some 27 different bones, and some 39 different muscles located either in the forearm (extrinsic muscles) or in the hand itself (intrinsic muscles; Tubiana, 1981). Special features of bony structures in the hand contribute directly to dexterity, and are important for rotation of the human thumb during precision grip (Tallis, 2004). The muscular control of the multi-articulate hand presents some demanding biomechanical solutions
Bryan D. Spinks, The sanctus in the eucharistie prayer, Cambridge, Cambridge University Press, 1991
No full textPrigent Pierre. Bryan D. Spinks, The sanctus in the eucharistie prayer, Cambridge, Cambridge University Press, 1991. In: Revue d'histoire et de philosophie religieuses, 72e année n°3, Juillet-septembre 1992. p. 321
Structural control of volcanism and caldera development in the transtensional Taupo Volcanic Zone, New Zealand
No full textThe Taupo Volcanic Zone (TVZ), New Zealand, comprises several segments with variable components of extension, and is characterised by longitudinal segmentation into a central zone dominated by rhyolitic calderas and extremities with only andesitic composite volcanoes. Modern (< 300ka) TVZ was investigated to define (a) the overall relationship between regional structures and volcanism and (b) the structural control on the evolution of calderas. New remote sensing and field structural data have been combined with previously published data for TVZ. The results show a general correlation between the amount of extension and the volume and style of eruption in each segment. The segments with the greatest extension coincide with the highly active Taupo and Okataina caldera complexes; conversely, the segments with the greatest dextral transtension correspond to volumetrically less active andesitic stratovolcanoes. Within Modern TVZ, two types of caldera are distinguished based on their structure and development. Calderas within the main zone of rifting (Taupo, Okataina) are multiple (two or more major eruptions) collapse structures with rectilinear margins, overprinted by younger volcanism and faulting. Their complexity is related to the proximity (and influence) of active faulting within TVZ. In contrast, calderas peripheral to the main rift (Rotorua, Reporoa) are sub-circular monogenetic collapse structures, with minor post-collapse volcanism. Their simpler evolution and structure is a attributable to their location away from the main rift zone. Thus, TVZ exemplifies the situation where firstly, magma is erupted as a function of the extension rate along the axial rift zone, and secondly, volcanism is manifest as distinctive caldera structures according to their proximity to the axial rift zone
Simultaneous recording of macaque premotor and primary motor cortex neuronal populations reveals different functional contributions to visuomotor grasp
No full textSimultaneous recording of macaque premotor and primary motor cortex neuronal populations reveals different functional contributions to visuomotor grasp. J Neurophysiol 98: 488-501, 2007. First published February 28, 2007; doi: 10.1152/ jn.01094.2006. To understand the relative contributions of primary motor cortex ( M1) and area F5 of the ventral premotor cortex (PMv) to visually guided grasp, we made simultaneous multiple electrode recordings from the hand representations of these two areas in two adult macaque monkeys. The monkeys were trained to fixate, reach out and grasp one of six objects presented in a pseudorandom order. In M1 326 task- related neurons, 104 of which were identified as pyramidal tract neurons, and 138 F5 neurons were analyzed as separate populations. All three populations showed activity that distinguished the six objects grasped by the monkey. These three populations responded in a manner that generalized across different sets of objects. F5 neurons showed object/grasp related tuning earlier than M1 neurons in the visual presentation and premovement periods. Also F5 neurons generally showed a greater preference for particular objects/ grasps than did M1 neurons. F5 neurons remained tuned to a particular grasp throughout both the premovement and reach-to-grasp phases of the task, whereas M1 neurons showed different selectivity during the different phases. We also found that different types of grasp appear to be represented by different overall levels of activity within the F5-M1 circuit. Altogether these properties are consistent with the notion that F5 grasping-related neurons play a role in translating visual information about the physical properties of an object into the motor commands that are appropriate for grasping, and which are elaborated within M1 for delivery to the appropriate spinal machinery controlling hand and digit muscles
Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults
No full textSummaryBackground & aimsMortality resulting from influenza (flu) virus infections occurs primarily in the elderly through declining immunity. Studies in mice have suggested beneficial effects of selenium (Se) supplementation on immunity to flu but similar evidence is lacking in humans. A dietary intervention study was therefore designed to test the effects of Se-supplementation on a variety of parameters of anti-flu immunity in healthy subjects aged 50–64 years.MethodsA 12-week randomized, double-blinded, placebo-controlled clinical trial (ClinicalTrials.gov NCT00279812) was undertaken in six groups of individuals with plasma Se levels <110 ng/mL. Four groups were given daily capsules of yeast enriched with 0 μg Se/day (SeY-0/d; n = 20), 50 μg Se/d (SeY-50/d; n = 18), 100 μg Se/d (SeY-100/d; n = 21) or 200 μg Se/d (SeY-200/d; n = 23). Two groups were given onion-containing meals with either <1 μg Se/d (SeO-0/d; n = 17) or 50 μg Se/d (SeO-50/d; n = 18). Flu vaccine was administrated at week 10 and immune parameters were assessed until week 12.ResultsPrimary study endpoints were changes in cellular and humoral immune responses. Supplementation with SeY and SeO affected different aspects of cellular immunity. SeY increased Tctx-ADCC cell counts in blood (214%, SeY-100/d) before flu vaccination and a dose-dependent increase in T cell proliferation (500%, SeY-50/100/200/d), IL-8 (169%, SeY-100/d) and IL-10 (317%, SeY-200/d) secretion after in vivo flu challenge. Positive effects were contrasted by lower granzyme B content of CD8 cells (55%, SeY-200/d). SeO (Se 50 μg/d) also enhanced T cell proliferation after vaccination (650%), IFN-γ (289%), and IL-8 secretion (139%), granzyme (209%) and perforin (190%) content of CD8 cells but inhibited TNF-α synthesis (42%). Onion on its own reduced the number of NKT cells in blood (38%). These effects were determined by comparison to group-specific baseline yeast or onion control groups. Mucosal flu-specific antibody responses were unaffected by Se-supplementation.ConclusionSe-supplementation in healthy human adults with marginal Se status resulted in both beneficial and detrimental effects on cellular immunity to flu that was affected by the form of Se, supplemental dose and delivery matrix. These observations call for a thorough evaluation of the risks and benefits associated with Se-supplementation
Expressional and functional analyses of epididymal SPINKs in mice
No full textEpididymal maturation is critical for acquisition of motility and fertilizing capacity by sperm. During epididymal transit, the surface of sperm undergoes prominent sequential changes through interactions with secreted proteins, including protease inhibitors. In the present study, we characterized three epididymis-specific SPINKs (serine protease inhibitors, Kazal-type): SPINK8, SPINK11, and SPINK12. We found that these epididymal SPINKs are expressed in an epididymal region-specific manner and their expression is developmentally regulated. Remarkably, cellular analyses revealed that SPINK8 and SPINK12 are transferred to the sperm. To investigate the in vivo properties of SPINK12, we analyzed knockout mice generated by CRISPR/Cas9-mediated genome editing. Loss of SPINK12 did not alter epididymal tubule structure or sperm phenotypes. Spink12 mutant mice exhibited normal fertility, suggesting that SPINK12 is functionally redundant in the epididymis. ? 2018 Elsevier B.V.FALSEsciescopu
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The vanishing author in computer-generated works: a critical analysis of recent Australian case law
No full textAbstract
The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals
- …
