106,526 research outputs found
Christian Heinrich Spiess and Bohemia
No full textTématem této bakalářské práce je Christian Heinrich Spiess a Čechy.
V první kapitole se autorka věnuje obecné historii v Českých zemích v 18. století. Ve druhé kapitole se specializuje na literární historii v Českých zemích. Třetí kapitola je ještě konkrétnější, neboť popisuje historii hororové literatury v Českých zemích. Ve čtvrté kapitole je definován pojem horor. Pátá kapitola je biografická. V této kapitole se autorka zabývá životem a dílem Ch. H. Spiesse. V této kapitole je kladen důraz na regionální kontext. V poslední - šestí kapitole se autorka soustředí na odkaz, který Spiess v Českých zemích zanechal.Obhájeno621/5000
The topic of this bachelor thesis is Christian Heinrich Spiess and Bohemia.
In the first chapter, the author deals with the general history of Bohemia in the 18th century. In the second chapter she specializes in literary history in Bohemia. The third chapter is even more specific, as it describes the history of horror literature in Bohemia. The fourth chapter defines the concept of horror. The fifth chapter is biographical. In this chapter, the author deals with the life and work of Ch. H. Spiess. This chapter emphasizes the regional context. In the last - sixth chapter, the author focuses on the legacy that Spiess left in Bohemia
Image of Mary Stuart in Tragedies of C. H. Spiess and F. Schiller
No full textFeatures of the interpretation of events related to the life and death of the Queen of Scotland, Mary Stuart (1542-1587), in the works of the outstanding German playwright F. Schiller (1759-1805) and his contemporary, the famous writer Christian Heinrich Spiess (Spiess, 1755-1799) is considered. The originality in the image of the last days of Mary by C. H. Spiess and F. Schiller is emphasized. The question is raised about the various literary and aesthetic positions of both German writers. Attention is paid to the review of works in various genres and genres of art dedicated to Mary Stuart by Spiess and Schiller. First, an analysis of the work of the author, which is secondary in the framework of German and European literature, is presented, since Spiess wrote his tragedy many years before the great German playwright. It is shown that Schiller’s tragedy was written with a characteristic thirst for epic coverage of reality, while the stage play of Spiess is more focused on the events of the last days of Mary Stuart’s life and turns into a chamber work. The results of the study can be used when giving lecture courses on foreign literature of the XVIII-XXI centuries, special courses on the literature of Western European countries, on the problems of classical literature in Germany, as well as literature of the Western European Enlightenment and pre-romanticism
Corticotropin-releasing factor receptors couple to multiple g-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning
No full textCorticotropin-releasing factor (CRF) exerts a key neuroregulatory control on stress responses in various regions of the mammalian brain, including the hippocampus. Using hippocampal slices, extracts, and whole animals, we investigated the effects of human/rat CRF (h/rCRF) on hippocampal neuronal excitability and hippocampus-dependent learning in two mouse inbred strains, BALB/c and C57BL/6N. Intracellular recordings from slices revealed that application of h/rCRF increased the neuronal activity in both mouse inbred strains. Inhibition of protein kinase C (PKC) by bisindolylmaleimide I (BIS-I) prevented the h/rCRF effect only in hippocampal slices from BALB/c mice but not in slices from C57BL/6N mice. Inhibition of cAMP-dependent protein kinase (PKA) by H-89 abolished the h/rCRF effect in slices from C57BL/6N mice, with no effect in slices from BALB/c mice. Accordingly, h/rCRF elevated PKA activity in hippocampal slices from C57BL/6N mice but increased only PKC activity in the hippocampus of BALB/c mice. These differences in h/rCRF signal transduction were also observed in hippocampal membrane suspensions from both mouse strains. In BALB/c mice, hippocampal CRF receptors coupled to Gq/11 during stimulation by h/rCRF, whereas they coupled to Gs, Gq/11, and Gi in C57BL/6N mice. As expected on the basis of the slice experiments, h/rCRF improved context-dependent fear conditioning of BALB/c mice in behavioral experiments, and BIS-I prevented this effect. However, although h/rCRF increased neuronal spiking in slices from C57BL/6N mice, it did not enhance conditioned fear. These results indicate that the CRF system activates different intracellular signaling pathways in mouse hippocampus and may have distinct effects on associative learning depending on the mouse strain investigated
Ocular Diseases of Companion Animals (Diagnosis, Medical and Surgical Therapy)
No full textThis electronic book was created to facilitate veterinarians and students of veterinary medicine in their pursuit of knowledge regarding the diagnosis and medical and surgical therapy of ocular diseases in companion animals. The electronic format allows several features that bound books lack which is exciting for us as authors and teachers in the Universities and continuing education class rooms across the world. The challenges are numerous for the ophthalmology professor in establishing a curriculum and providing a reference that is current, illustrated with color photos, videos, and illustrations, and within a student’s budget. In addition the text needs to be easily updated and should allow for self directed learning. We have focused our thoughts on these challenges as we developed and wrote this electronic book
TEITELBAUM'S EXCEPTIONAL ZERO CONJECTURE
No full textTeitelbaum formulated a conjecture relating first derivatives of the Mazur-Swinnerton-Dyer -adic -functions attached to modular forms of even weight to certain -invariants arising from Shimura curve parametrizations. This article formulates an analogue of Teitelbaum's conjecture in which the cyclotomic _p\Bbb Q\Bbb{Z}-extension of an imaginary quadratic field. This analogue is then proved by using the Cerednik-Drinfeld theory of -adic uniformisation of Shimura curves
A single amino acid serves as an affinity switch between the receptor and the binding protein of corticotropin-releasing factor: Implications for the design of agonists and antagonists
No full textIn view of the observation that corticotropin-releasing factor (CRF) affects several brain functions through at least two subtypes of G protein-dependent receptors and a binding protein (CRFBP), we have developed synthetic strategies to provide enhanced binding specificity. Human/rat CRF (h/rCRF) and the CRF-like peptide sauvagine (Svg), differing in their affinities to CRFBP by two orders of magnitude, were used to identify the residues determining binding to CRFBP. By amino acid exchanges, it was found that Ala22 of h/rCRF was responsible for this peptide's high affinity to CRFBP, whereas Glu21 located in the equivalent position of Svg prevented high affinity binding to CRFBP. Accordingly, [Glu22]h/rCRF was not bound with high affinity to CRFBP in contrast to [Ala21]Svg, which exhibited such high affinity. Furthermore, the affinity of both peptides to either CRF receptor (CRFR) subtype was not reduced by these replacements, and their subtype preference was not changed. Thus, exchange of Ala and Glu and vice versa in positions 22 and 21 of h/rCRF and Svg, respectively, serves as a switch discriminating between CRFBP and CRFR. On the basis of this switch function, development of new specific CRF agonists and antagonists is expected to be facilitated. One application was the modification of the CRF antagonist astressin (Ast), whose employment in animal experiments is limited by its low solubility in cerebrospinal fluid. Introduction of Glu residues into Ast generated with [Glu11,16]Ast an acidic astressin, which efficiently antagonized in vivo the CRFR1-dependent reduction of locomotion induced by ovine CRF without detectable binding to CRFBP
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dipolar spectroscopy and spin alignment in electron paramagnetic resonance
No full textJeschke G, Pannier M, Godt A, Spiess HW. Dipolar spectroscopy and spin alignment in electron paramagnetic resonance. Chemical Physics Letters. 2000;331(2-4):243-252
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