1,354,163 research outputs found
Multi-band MEG signatures of BOLD connectivity reorganization during visuospatial attention
No full textThe functional architecture of the resting brain, as measured with the blood oxygenation level-dependent functional connectivity (BOLD-FC), is slightly modified during task performance. In previous work, we reported behaviorally relevant BOLD-FC modulations between visual and dorsal attention regions when subjects performed a visuospatial attention task as compared to central fixation (Spadone et al., 2015). Here we use magnetoencephalography (MEG) in the same group of subjects to identify the electrophysiological correlates of the BOLD-FC modulation found in our previous work. While BOLD-FC topography, separately at rest and during visual attention, corresponded to neuromagnetic Band-Limited Power (BLP) correlation in the alpha and beta bands (8–30 Hz), BOLD-FC modulations evoked by performing the visual attention task (Spadone et al. 2015) did not match any specific oscillatory band BLP modulation. Conversely, following the application of an orthogonal spatial decomposition that identifies common inter-subject co-variations, we found that attention–rest BOLD-FC modulations were recapitulated by multi-spectral BLP-FC components. Notably, individual variability of alpha connectivity between Frontal Eye Fields and visual occipital regions, jointly with decreased interaction in the Visual network, correlated with visual discrimination accuracy. In summary, task-rest BOLD connectivity modulations match multi-spectral MEG BLP connectivity
Spatio-temporal relationships between BOLD and MEG signals at rest or during visuospatial attention
No full textThe relationship between fMRI and MEG signals between different cortical regions (functional connectivity, FC) has been extensively analyzed in the resting state (De Pasquale et al 2010; Brookes et al 2011; Hipp et al 2012). Much less is known about FC modulations from rest to task states, and how they appear respectively in these two imaging modalities. Previously we have shown task-specific alterations of FC in fMRI during a visuospatial attention task (Spadone et al., PNAS, 2015). Specifically, decrements of resting correlation in visual areas were coupled with increments of correlation between visual and dorsal attention regions. Here, we compared fMRI with band-limited power (BLP) correlation obtained with MEG on the same group of subjects. Aim (i) is to measure frequency specific task-related FC modulations in MEG. Aim (ii) is to compare fMRI- and MEG-FC modulations (task-rest)
Interindividual variability in functional connectivity as long-term correlate of temporal discounting.
No full textDuring intertemporal choice (IT) future outcomes are usually devaluated as a function of the delay, a phenomenon known as temporal discounting (TD). Based on task-evoked activity, previous neuroimaging studies have described several networks associated with TD. However, given its relevance for several disorders, a critical challenge is to define a specific neural marker able to predict TD independently of task execution. To this aim, we used resting-state functional connectivity MRI (fcMRI) and measured TD during economic choices several months apart in 25 human subjects. We further explored the relationship between TD, impulsivity and decision uncertainty by collecting standard questionnaires on individual trait/state differences. Our findings indicate that fcMRI within and between critical nodes of task-evoked neural networks associated with TD correlates with discounting behavior measured a long time afterwards, independently of impulsivity. Importantly, the nodes form an intrinsic circuit that might support all the mechanisms underlying TD, from the representation of subjective value to choice selection through modulatory effects of cognitive control and episodic prospection
rTMS affects EEG microstates dynamic during evoked activity
No full textElectrophysiological (EEG) correlates both at time (i.e., event-related potentials, ERP) and frequency (i.e., event-related desynchronization, ERD) domains have been shown to be modulated by external magnetic interference. Parallel studies reported a similar interference also for the EEG microstate at rest and in the period that anticipates a task. Here we investigated whether such interference was prolonged during the evoked activity in the framework of the semantic decision task. To this aim, rTMS was delivered over a core region of both the Default mode network and the language network (i.e., left angular gyrus, AG), previously associated to the current task, and as active control we stimulated the left IPS. When subjects received a non-active stimulation (i.e., Sham), in the period that follows the target onset (i.e., 2 sec after the rTMS) we found an interesting alternation of two dominant microstates (MS1, MS3), previously associated to the phonological network and the Cingulo-Opercular Network (CON), respectively. This dynamic was not altered when TMS was delivered over the left IPS. On the contrary, rTMS over left AG selectively suppressed the phonological-related microstate. These findings provide the first causal evidence of region specificity of the EEG microstates topography during the evoked activity corroborating the idea of a crucial role of AG in the semantic memory. Moreover, the present results might provide insight for understanding the neurophysiological correlates of language disorders e.g., aphasia as well as for planning non-invasive brain stimulation protocols for the rehabilitation
Alpha rhythm modulations in the intraparietal sulcus reflect decision signals during item recognition
No full textThis dataset contains the data presented in Spadone et al. (2022)."Alpha rhythm modulations in the intraparietal sulcus reflect decision signals during item recognition" Neuroimage, 258, 119345.https://doi.org/10.1016/j.neuroimage.2022.119345Please, refer to the manuscript for all details.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
Energy consumption of locomotion with orthosis versus Parastep-assisted gait: a single case study
No full textValidità diagnostica dell’ASQ in un campione italiano di bambini affetti da disturbi pervasivi dello sviluppo
No full textEnergy consumption of locomotion with orthosis versus Parastep-assisted gait: a single case study.
No full textStudy design: Single case study. Objectives: To evaluate the energy expenditure during ambulation with the Advanced Reciprocating Gait Orthosis (ARGO), with and without functional electrical stimulation (FES), and with the Parastep system in a single subject, in order to avoid the effect of intersubject variability. Setting: The Centre of Sport Medicine and Bioengineering Centre 'Don C Gnocchi' Foundation ONLUS IRCCS, Milano, Italy. Methods: A single patient (lesion level T5-T6) was trained specifically for each walking system and was evaluated after each training period. The effects of FES on muscle conditioning, spasticity and bone density were also evaluated. The HR/VO2 relationship and the energy cost of locomotion were measured during wheelchair (WHCH) use, during locomotion with ARGO (with and without FES) and Parastep system at different speeds. Results: The following was observed at the end of the whole training: (a) circumferences of both lower limbs and quadriceps forces were increased, whereas fatigue index was slightly decreased, spasticity and bone density were unchanged; (b) compared to WHCH locomotion, the slope of HR/VO2 curves with ARGO was higher (slope difference = 51.1 b 1O2-1), with ARGO + FES was similar (slope difference = -5.3 b 1O2-1) and with Parastep was smaller (slope difference = -55.6 b 1O2-1); (c) HR increased linearly with all locomotion systems, but did not rise above 125 bpm with Parastep; (d) the cost of locomotion was higher with Parastep than with ARGO (with and without FES), tested at each velocity; (e) Parastep appears to be easier to use for the subject. Conclusions: (a) FES can improve ambulation with orthosis, but the cost of locomotion remains very high; (b) the Parastep assisted gait elicits a higher energy expenditure than other orthoses, probably due to the lower speed of locomotion and to the high isometric effort of the stimulated muscles. Sponsorship: This work has been partially supported by the Italian Minister of Public Health
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