163 research outputs found

    sj-jpg-1-cll-10.1177_09636897221083549 – Supplemental material for The Endoplasmic Reticulum-Stressed Head and Neck Squamous Cell Carcinoma Cells Induced Exosomal miR-424-5p Inhibits Angiogenesis and Migration of Humanumbilical Vein Endothelial Cells Through LAMC1-Mediated Wnt/β-Catenin Signaling Pathway

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    Supplemental material, sj-jpg-1-cll-10.1177_09636897221083549 for The Endoplasmic Reticulum-Stressed Head and Neck Squamous Cell Carcinoma Cells Induced Exosomal miR-424-5p Inhibits Angiogenesis and Migration of Humanumbilical Vein Endothelial Cells Through LAMC1-Mediated Wnt/β-Catenin Signaling Pathway by Zeyu Wang, Pengfei Jiao, Yi Zhong, Huan Ji, Yaqin Zhang, Haiyang Song, Hongming Du, Xu Ding and Heming Wu in Cell Transplantation</p

    Contribuição à deteção de defeitos nos rotores de turboalternadores

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    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.Este trabalho tem como objetivo desenvolver métodos de detecção, localização e caracterização de defeitos em um turboalternador em escala reduzida. Os defeitos estudados neste trabalho são o curto-circuito entre espiras do rotor e as excentricidades rotóricas. Os métodos serão, em seguida, adaptados aos estudos das máquinas de 900 e 1300 MW do parque nuclear da empresa EDF (Electricité de France). Para isto, a máquina em escala reduzida, foi simulada com o auxílio de dois modelos, um analítico e um numérico por elementos finitos. Os métodos para detectar e localizar os defeitos rotóricos foram, em seguida, desenvolvidos. Os resultados das simulações utilizando os dois modelos e os testes experimentais foram analisados e comparados entre si. Uma boa concordância foi verificada, o que confirma o bom funcionamento dos métodos propostos para a detecção dessas anomalias. Vários casos de defeitos, associados a diferentes modos de trabalho da máquina, foram estudados, comprovando a confiabilidade dos métodos de detecção desenvolvidos.The aim of this work is to develop methods to detect, locate and recognise faults in a turbogenerator of reduced scale. In the framework of this study, only short-circuit defects in the rotor windings and rotor eccentricities were investigated. The developed methods would be adapted to the machines of EDF nuclear plant of 900 and 1300 MW. First the studied machine was modelled using an analytical approach and a numerical model based on the finite element method. Then, the methods to detect and locate the rotor faults were developed. The results obtained from simulations using both approaches and experimental measurements were analysed and compared. They showed a good agreement and demonstrated a good capacity of the method proposed to detect and locate the faults. Several fault cases, at different operating points of the machine, were studied and they showed the good reliability of the method

    Tough, rapid self-recovery and responsive organogel-based ionotronic for intelligent continuous passive motion system

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    Continuous passive motion (CPM) is an adjunct therapy to the standard postoperative rehabilitation regimen of joint injuries. The capability of real-time monitoring actual bending angle of knee joints is highly desired for treatment strategies of personalized postoperative rehabilitation and telemedicine. Here we report an intelligent CPM system for personalized rehabilitation and telemedicine based on the flexible and versatile ionotronic that possesses impressive mechanical properties (2.56 MPa tensile strength; 11.63 MJ m −3 toughness), fast self-recovery ability (60 s) and broaden environmental tolerance (−60–45 °C). Especially, the ionotronic responds fast and shows stability for cyclic strain sensing, ensuring the detection of actual joint bending angle with high sensitivity and reliability. The intelligent CPM system assembled with this ionotronic and a wireless transmitter was constructed, opening up a horizon for developing digital intelligent medical that can remotely monitor the movement of hospitalized/at-home patients who use CPM for personalized postoperative rehabilitation

    Temporomandibular Joint Pain is Negatively Correlated to TNF Alpha and Osteoprotegrin Content in Synovial Fluid in Patients with Juvenile Idiopathic Arthritis.

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    Objective: Temporomandibular joint (TMJ) involvement occurs in up to 80% of children with juvenile idiopathic arthritis (JIA). Little is known with regard to the complexity of the protein profile in synovial fluid (SF) from JIA arthritis during growth as compared to both JIA and rheumatoid arthritis (RA) of adults. Design: Synovial fluid was collected from 54 joints/30 patients with TMJ arthritis (JIA 35 joints/20 patients, JIA adults 9 joints/5 patients, RA 10 joints/5 patients). Three cytokines and seven bone markers were quantified using Luminex multiplex assays and compared to demographic and clinical data of function and pain. Results: Pain (spontaneous and upon palpation) and duration of pain were all negatively correlated with the TMJ SF content of tumor necrosis factor (TNF)-α. The level of Adrenocorticotropic hormone (ACTH) was negatively correlated to TMJ pain upon palpation and post-treatment pain and function. The concentration of ACTH was significantly lower in SF in JIA (1.4 ± 2.8 pg/ml) compared to adults with JIA (4.7 ± 12.2 pg/ml) and significantly higher compared to adults with RA (0.8 ± 1.5 pg/ml). Osteoprotegerin (OPG) was negatively correlated to spontaneous pain. Conclusions: Our results indicate that the local concentrations of TNF-α, ACTH and OPG in TMJ fluid may not contribute to TMJ pain and tissue destruction in JIA/RA patients. © 2014 Olsen-Bergem H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

    Damage detection in semiconductor devices by non-linear elastic wave spectroscopy

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    Semiconductor devices can be found everywhere in our daily lives, for example in self-driving cars, bank cards and personal devices such as smart phones or notebooks. Once part of these personal devices, one does not want them to show failure. Although reliability of such devices is taken into account in the design, the fabrication process might lead to the emergence of small damages in the product. Since these damages or their propagation might cause failure of the device, a series of visual inspections and functional tests is part of the fabrication process. The obtained resolution by optical microscopy, currently the state of the art inspection method, is not sufficient for the detection of small damages such as microcracks or damages located inside a sample. To keep improving the reliability of semiconductor devices, these damages need to be detected in another high speed, low cost way.As semiconductor devices shrink in size, their natural vibration frequencies increase and approach theMHz-range. Vibration based damage detection methods might therefore offer an alternative high speed in-situ inspection method. The main goal of this thesis is to identify and experimentally verify vibration characteristics that indicate the presence of damage, with a focus on microcracks, in semiconductor devices. While linear vibration based damage methods have proven to be insensitive to small damages such as microcracks, non-linear vibration based damage detection methods show much higher sensitivities to this type of damage. The non-linear elastic wave spectroscopy (NEWS) of several damaged materials have shown two characteristic phenomena: amplitude dependent natural frequency shifts and the generation of higher harmonics. Both are explained by a phenomenological non-linear hysteric elastic model. While the applicability of NEWS is proven for several materials, its performance for silicon, in particular at microscale, is still unknown.Mechanical Engineering | Micro and Nano Engineerin

    A geometric flow on noncompact affine Riemannian manifolds

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    In this paper, we obtain the existence criteria for a geometic flow on noncompact affine Riemannian manifolds. Our results can be regarded as a real version of Lee-Tam [19]. As an application, we prove that a complete noncompact Hessian manifold with nonnegative Hessian sectional curvature and bounded geometry is diffeomorphic to Rn\mathbb{R}^n if its tangent bundle has maximal volume growth.Comment: arXiv admin note: text overlap with arXiv:math/0504422, arXiv:1708.00141 by other author

    Creativity and Its Necessity in Teaching and in the Administration of Schools

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    As a research exercise, the study of creativity has long been the province of psychologists. In recent y ears, administrators have researched the creativity literature and have encouraged administrative practitioners to accelerate discovery and increase effectiveness of their organizations through more efficient use of their personnel. The author discusses why and how school administrators must manage schools creatively if creativity is to be fostered in the classroom
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