3,236 research outputs found
Data for Gupta et al., "Estimating the Meridional Extent of Adiabatic Mixing in the Stratosphere using Age-of-Air", JGR:Atmospheres,
No full textModel data and post-processed data supporting the creation of the manuscript "Estimating the Meridional Extent of Adiabatic Mixing in the Stratosphere using Age-of-Air" submitted to JGR:Atmospheres in August 2022.
1) The netCDF files created through post-processing of full model data in FORTRAN are shared in the /data/ directory. These file contains the zonal mean circulation statistics based on Gupta et al. (2020), age-of-air transport diagnostics based on Linz et al. (2021), and the novel \Gamma-\Theta circulation streamfunction introduced in this study. The /data/ directory also contains MATLAB .mat data files for the transport diagnostics obtained from WACCM. 150 days of actual GFDL-FV3 model data in the northern hemisphere, between 0.1 hPa-500 hPa pressure levels is also provided to support external computations and validation.
2) The Jupyter notebook used for final computation and figures production is provided in .ipynb, .html and .pdf formats in /code/. All the files referred to in the notebook are stored in the /data/ directory.
Corresponding author : Aman Gupta, [email protected], [email protected], [email protected]
Corrigendum: Capital Inflows and House Prices: Aggregate and Regional Evidence from China
No full textIn the paper ‘Capital Inflows and House Prices: Aggregate and Regional Evidence from China’ by H. An, et al., printed in the December 2016 issue, there was a missing acknowledgement section for funding resources.
On page 451, the acknowledgement section should appear after the corresponding information as:
“Correspondence: Rakesh Gupta, Department of Accounting, Finance and Economics, Griffith Business School, Griffith University, Nathan Campus QLD 4111. [email protected]
*This work was financially supported by the Humanities and Social Science Foundation of Ministry of Education of China (16YJA790001).”
The author apologises for this error and any confusion it may have caused.No Full Tex
The gamified workplace: managing the geographically dispersed workforce
No full textThe world economy has made it difficult for businesses to survive due to which they create global teams to address strategic issues. These teams use tools such as emailing, videoconferencing and knowledge management systems to access a wide range of human resources worldwide. They provide low-cost customer entry by operating across time zones 24/7. Gamification can be a powerful technique for creating diversity at work. Having a geographically diverse workforce is necessary for organizations doing business globally that want to reach new markets and foster a culture of excellence. It encourages creativity, innovation, and access to different skills, expertise, and experience which provides a competitive edge. This also applies when companies are involved in joint ventures, alliances or mergers. This chapter attempts to review the gamification literature to find appropriate strategies as well as principles for addressing the challenges of managing geographically diverse teams. We bring in the industry perspective by providing examples of some of the practices of using gamification to understand the structural dynamics of managing global teams
Abstract B13: Synthetic vulnerabilities in MLL3 deficient pancreatic tumors
No full textAbstract
Myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3) is a histone 3-lysine 4 methyltransferase, frequently mutated in a variety of solid tumors including pancreatic ductal adenocarcinoma (PDAC), a nearly lethal disease due to our current inability to therapeutically target major oncogenic proteins driving this cancer. Like other tumor suppressor genes, direct targeting of MLL3 is not feasible, and thus our objective was to find biological pathways which are synthetic lethal targets in MLL3-deficient PDAC tumors. Identification of drug targets in such a specific genetic context could potentially dictate stratification of patients based on the mutational profile of their tumor. To achieve this, we generated a novel genetically engineered mouse model (GEMM) of pancreatic cancer, in which targeted mutation of Kras (G12D) and loss of functional MLL3 was driven by Cre-recombination from early pancreatic lineage-specific transcription factor, Pdx1. Our unpublished data suggests that loss of MLL3 function in exocrine pancreas cooperates with mutant Kras to accelerate the progression of invasive pancreatic neoplasia. Using cell lines generated from spontaneous tumors arising in KC (KrasG12D alone) and KMC (KrasG12D; MLL3δ/δ) mice, we performed functional genomic analyses and found several key oncogenic pathways upregulated in MLL3-deficient cells. We selected two well-known oncogenic pathways and through a series of cellular and biochemical assays, further validated their selectively activation in KMC cells, in contrast with KC cells. Next, we picked multiple pharmacological inhibitors of these pathways, which are already approved at various phases of clinical trials, and tested for their efficacy on growth of KC and KMC cells in both two- and three-dimensional growth assays. In agreement with our data showing preferential activation in KMC cells, we found KMC cells to be significantly more sensitive than KC cells to the effect of these inhibitors. Thus, identification of synthetic lethal hits in context of MLL3 functional loss could potentially enable us to design strategies to limit metastasis in patients with surgically-resectable tumors.
Citation Format: Sonal Gupta, Sammy Ferri-Borgogno, Mary R. Reisenauer, Anvita k. Gupta, Anirban Maitra. Synthetic vulnerabilities in MLL3 deficient pancreatic tumors [abstract]. In: Proceedings of the AACR Precision Medicine Series: Opportunities and Challenges of Exploiting Synthetic Lethality in Cancer; Jan 4-7, 2017; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2017;16(10 Suppl):Abstract nr B13.</jats:p
First person – Akash Gupta
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Akash Gupta is first author on ‘A novel and cost-effective ex vivo orthotopic model for the study of human breast cancer in mouse mammary gland organ culture’, published in BiO. Akash conducted the research described in this article while a PhD Scholar in Rajendra Mehta's lab at IIT Research Institute, Chicago, USA. He is now an assistant research scientist in the lab of Syreeta L. Tilghman at the University of Arizona, Department of Medicine, Tucson, USA, investigating drug efficacy modeling using human organoids culture for the treatment of cancers
Engineering materials : research, applications and advances / author, K.M. Gupta.
No full text"A CRC title."Includes bibliographical references and index.596 p.
Universal Statistical Properties of Inertial-particle Trajectories in Three-dimensional, Homogeneous, Isotropic, Fluid Turbulence
No full textWe obtain new universal statistical properties of heavy-particle trajectories in three-dimensional, statistically steady, homogeneous, and isotropic turbulent flows by direct numerical simulations. We show that the probability distribution functions (PDFs) P(Φ), of the angle Φ between the Eulerian velocity u and the particle velocity v, at a point and time, scales as P(Φ) ∼Φ−, with a new universal exponent ≃ 4
Mutual-Friction Coefficients in Two-Dimensional Superfluids: From the Gross-Pitaevskii equation to the Hall-Vinen-Bekharevich-Khalatnikov Two-fluid Model
No full textWe start from the two-dimensional Gross-Pitaevskii equation (GPE) and develop algorithms for the ab-initio determination of the temperature (T) dependence of the mutual-friction coefficients, α and α, and the normal-fluid density Pn, which appear as parameters in the Hall-Vinen-Bekharevich-Khalatnikov (HVBK) two-fluid model for a superfluid. In the second part of our study, we elucidate the statistical properties of two-dimensional, homogeneous, isotropic superfluid turbulence in the simplified HVBK model, with values for the mutual-friction coefficients that are comparable to those we obtain from the first part of our study
Sonal Appliance an innovative space maintainer in management of early loss of first permanent molar: A Rare Case Report
No full textIntroduction: In preventative and interventional dentistry, keeping deciduous teeth until their natural exfoliation is critical. An early tooth or group of teeth loss might have a variety of effects. The first molar is the largest tooth in the mouth, it carries the most occlusal stress, and it affects the vertical distance between the mandible and the maxilla. Adolescent patients who have lost a permanent first molar (PFM) require early space maintenance. Case report: In this case report a successful use of modified distal shoe appliance was made in a patient whose 1st permanent molar was lost before the eruption of 2nd permanent molar. In circumstances when the permanent first molar is lost before the emergence of the permanent mandibular second molar, a unique device is described in this publication. The distal extension of a normal distal shoe appliance was extended distally along with a fixed bilateral appliance, a modified band and loop, and other components in this design. Conclusion: For individuals with bilateral molar loss, a modified distal shoe appliance is a promising option
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