15 research outputs found
The “History of Mar Yahballaha and Rabban Sawma” as a source for the Ilkhanid history
No full textThe Syriac anonymous narrative known as the History of Mar Yahballaha and Rabban Sawma (written before 1319) consists in the biography of the catholicos of the Church of the East, Mar Yahballaha III (ca. 1248–1317), and his mentor, the monk Sawma (ca. 1225–1294). The author’s interests go beyond the biography of two eminent clergymen of the Church of the East, and his commitment combines with that of a chronicler. The narrative of the journey of Rabban Sawma in Europe as ambassador of the Khan Arghun (1287-1288) elicited the interest of translators, readers and scholars more than the rest of the book. Nevertheless, the author’s interest does not seem to focus on it more than on other episodes: for instance, much more space is devoted to the destiny of the Christians living in the city of Erbil, a case that from his point of view deserved a detailed explanation of the events, as it resulted in the elimination of the Christian population of the city. Church history is apparently a central issue for the author: his reports are abundantly detailed when devoted to the restorations and building of churches and monasteries, and to the relationship with the sovereigns. On the contrary, what pertains to the relations of Mar Yahballaha with Latin Christians, both in the Ilkhanid dominion and in the West, remains largely out of the narrative. Mar Yahballaha’s good relationship with the Latin missionaries, as the Dominican friar Riccoldo da Montecroce, and the contacts with the pope after the mission of Rabban Sawma, are not mentioned at all. The paper focuses on two episodes reported in the History, which provide information about the policy of the Ilkhans towards the Church of the East. The first one relates the events occurring just after the election of Aḥmad/Teguder, when two envious bishops and two Muslim officials defamed Mar Yahballaha and Rabban Sauma with false accusations, as Arghun’s supporters. The author’s qualification of Aḥmad as a persecutor of Christiany does not fit with other evidence (for instance Marco Polo’s report of Aḥmad’s reign), nor combines with the development of the affair in the narrative itself: after an enquiry and a trial, both the catholicos and Rabban Sawma are recognised as innocent, freed and reinstalled in their positions. The second episode is the report of the revolt of the Mongol garrison of the citadel of Erbil, the Christian qayajiyē, “rock climbers”, which marks the end of Christianity in the city. Comparison with the Persian narrative about the same case by Qāshānī shows interesting parallels
マラリア原虫感染において、抗原特異的CD8+ T細胞の活性化と疲弊は、脾臓の異なる領域で惹起される
No full textThe spleen is the major organ in which T cells are primed during infection with malaria parasites. However, little is known regarding the dynamics of the immune responses and their localization within the splenic tissue during malaria infection. We examined murine CD8+ T cell responses during infection with Plasmodium berghei using recombinant parasites expressing a model antigen ovalbumin (OVA) protein and compared the responses with those elicited by Listeria monocytogenes expressing the same antigen. OVA-specific CD8+ T cells were mainly activated in the white pulp of the spleen during malaria infection, as similarly observed during Listeria infection. However, the fates of these activated CD8+ T cells were distinct. During infection with malaria parasites, activated CD8+ T cells preferentially accumulated in the red pulp and/or marginal zone, where cytokine production of OVA-specific CD8+ T cells decreased, and the expression of multiple inhibitory receptors increased. These cells preferentially underwent apoptosis, suggesting that T cell exhaustion mainly occurred in the red pulp and/or marginal zone. However, during Listeria infection, OVA-specific CD8+ T cells only transiently expressed inhibitory receptors in the white pulp and maintained their ability to produce cytokines and become memory cells. These results highlighted the distinct fates of CD8+ T cells during infection with Plasmodium parasites and Listeria, and suggested that activation and exhaustion of specific CD8+ T cells occurred in distinct spleen compartments during infection with malaria parasites.長崎大学学位論文 学位記番号:博(医歯薬)甲第958号 学位授与年月日:平成29年3月21日Author: Ganchimeg Bayarsaikhan, Mana Miyakoda, Kazuo Yamamoto, Daisuke Kimura, Masoud Akbari, Masao Yuda, Katsuyuki YuiCitation: Parasitology International, 66(3), pp.227-235; 201
Halone bucseki Bayarsaikhan & Bucsek & Cha & Le & Kwon & Bae 2022, comb. nov.
No full textHalone bucseki (Černý, 2009), comb. nov. (Figs. 11, 12, 13) Eugoa bucseki Černý in Černý & Pinratana, 2009, Moths of Thailand, vol. 6: 27, pl. 4: 53. TL: SW Thailand (Nakhon Si Thammarat, Kao Luang NP). Holotype. 1 ♀, SW Thailand, Nakhon Si Thammarat, Khao Luang NP, Nopphitam env. 70m, 8˚44,043′N, 99˚41,450′E, 6.XII.2007 (leg. K. Černý). Material examined (Paratypes). 1 ♂, SW Thailand, Nakhon Si Thammarat, Khao Luang region, Nopphitam env., 276m, 8˚47,447′N, 99˚43,514′E, 7.˗9.XII.2007 (leg. K. Černý), 1 ♀, SW Thailand, Ranong-prov., Ranong, 380m, 10˚01′32″N, 98˚40′13″E, 3.˗4.XII.2005 (leg. K. Černý). Remarks. This species was described from Thailand as a member of the genus Eugoa by Černý (2009), without illustration and description of its genitalia. The examination of the genitalia structures of this species by the second author led to the conclusion that it belongs to the genus Halone Walker, 1854, and is closely similar to Halone solitus Bucsek, 2014 (illustrated by Bucsek 2014: gen. fig. MalS26)). Thus, here we establish a new combination: Halone bucseki (Černý, 2009), comb. nov. Original description of adult by Černý (2009). (Figs. 11a, 11b). Wingspan 11˗13 mm in males, 13˗15 mm in females. Head and antenna pale brown. Thorax and legs grayish pale brown. Forewing pale brown, covered with dark scales; dark antemedial line angled in cell; a dark disco cellular spot rounded; dark postmedial line indistinct; terminal series of spots dark; and lines of forewing particularly reduced sometimes. Hindwing suffused with gray. Abdomen grayish pale brown. Description of genitalia. Male genitalia (Fig. 12). Uncus stout, with angular apex. Tegumen sclerotized, roundly shouldered posteriorly, with two strongly sclerotized medial spurs. Valva wide basally, slightly taperered to 3/4 and somewhat dilated in distal quarter. Apical process flat with blunt hips, saccular weakly covered with setae, distal plain. Distal costal lobe of valva pronounced. The basal costal process creates a small triangular˗shaped vertex. Juxta weakly sclerotized, arch˗shaped. Vinculum broadly “U”˗shaped. Aedeagus stout, distal half strongly sclerotized and curved, with two apical processes, and vesica with a large (almost half size of aedeagus), tapering cornutus and scobinated. Female genitalia (Fig. 13). Papillae anales weakly covered with setae.Apophysis posterioris and anterioris slender, same sized. Ostium sclerotized, arched. Ductus bursae tubular, membranous. Corpus bursae globular, membranous, with a weakly waved, sclerotized short band covered by the short, stout spines. Distribution. Thailand (Černý & Pinratana, 2009).Published as part of Bayarsaikhan, Ulziijargal, Bucsek, Karol, Cha, Yeong-Bin, Le, Xuanvi, Kwon, Hyung Wook & Bae, Yang-Seop, 2022, A new Halone Walker (Lepidoptera, Erebidae, Arctiinae, Lithosiini) from Vietnam with establishing of a new combination, pp. 385-391 in Zootaxa 5093 (3) on pages 388-389, DOI: 10.11646/zootaxa.5093.3.6, http://zenodo.org/record/590999
Eugoa vasta van Eecke 1920
No full text<i>Eugoa vasta</i> van Eecke, 1920, rest. comb. <p>(Figs. 11, 12, 30, 31, 49)</p> <p> <i>Eugoa vasta</i> van Eecke, 1920, <i>Zool. Meded.</i> 5(13): 125. TL: Java.</p> <p> <i>Philenora vasta</i> van Eecke: Bucsek, 2016, <i>Entomofauna</i> 37(22): 385.</p> <p> <b>Redescription</b> (Figs. 11a, b, 12a, b). Wingspan 15–16 mm in male, 16–17 mm in female. Forewing ground color yellow brownish, covered by dark brown mottling, rectangular, apex truncate, with a faintly dark discal spot and series of dark terminal spots; cilia dark. Male of hindwing pale gray, with pale gray-brown terminal area, cilia dark; female of hindwing dark brown, cilia pale orange. <i>Male genitalia</i> (Figs. 30, 31). Uncus slender, hook-shaped, with weakly setose, almost same length with tegumen. Valvae tapering, apex rounded, with weakly setose; costa of valva with roundly angular projection basally. Saccular process tapering, apex asymmetrically bifurcated, about 2/ 3 length of valva. Juxta “X”-shaped, covered with small spines. Aedeagus stout, about 1/2 length of valva, streaked by sclerotized bands in apical, and with weakly sclerotized, irregular cornutus. <i>Female genitalia</i> (Fig. 49). Lamella antevaginalis with broadly “U”-shaped plate. Ductus bursae short, tube-shaped, membranous. Corpus bursae ovoid, narrower in medially, heavily covered with thin spines near cervix of bursae.</p> <p> <b>Material examined.</b> Cambodia. 1 ♂, 1 ♀, Pursat (N12˚03′46.7″, E103˚14′36.1″), 2.V.2010 (YS Bae, XV Le & DY Chae), Gen. Slide No. INU-1526; 1 ♂, 1 ♀, Cardamom (N11˚58′47″, E103˚22′22″), 29.VI.2011 (YS Bae, YD Ju, U Bayarsaikhan & HJ Lee), Gen. Slide No. INU-1580, 1683; 1 ♂, 2 ♀, Samkos (N12˚12′40″, E102˚52′13″), 23.XII.2014 (YS Bae, YD Ju, MJ Qi, U Bayarsaikhan, BS Park, SM Na, JW Kim & DJ Lee), Gen. Slide No. INU- 1579, 1582, 1584.</p> <p> <b>Distribution.</b> Cambodia (Cardnom, Pursat, Samkos), Sumatra, Java.</p> <p> <b>Remarks.</b> This species was transferred to <i>Philenora</i> author by Bucsek (2016a). But after study of its lectotypes (LECTOTYPES: male, Buitenzorg, Java, RMNH910302; female, Ambarawa, Sumatra, RMNH910301), we re-establishe it in <i>Eugoa</i> based on external and genital characters (Figs. 12a, b, 31). Therefore, <i>Eugoa vasta</i> van Eecke, is newly recorded in Cambodia.</p>Published as part of <i>Bayarsaikhan, Ulziijargal, Bucsek, Karol & Bae, Yang-Seop, 2018, A review of the genus Eugoa Walker (Lepidoptera, Erebidae, Arctiinae, Lithosiini) in Cambodia, with the description of a new species, pp. 469-494 in Zootaxa 4403 (3)</i> on pages 479-480, DOI: 10.11646/zootaxa.4403.3.3, <a href="http://zenodo.org/record/1212899">http://zenodo.org/record/1212899</a>
Survival, CD4 T lymphocyte count recovery and immune reconstitution pattern during the first-line combination antiretroviral therapy in patients with HIV-1 infection in Mongolia.
No full textMongolia has a low incidence of human immunodeficiency virus (HIV) infection, with 281 cases reported at the end of 2019 and an estimated incidence rate of 50 cells/μL indicated CD4 T cell count recovery, and a cell count of ≥500 cells/μL in patients with a baseline cell count of 500 cells/μL in 95 of 145 (65.5%) patients with a baseline cell count of <500 cells/μL after 36 months of ART. The baseline CD4 T cell count was found to be a sensitive indicator for immune reconstitution. An advanced pretreatment clinical stage of HIV infection (as classified by the WHO classification), a low CD4 T cell count in the peripheral blood, and a high viral load before the initiation of the first-line ART accurately predicted survival, CD4 T cell count recovery, and immune reconstitution in Mongolian patients with HIV/AIDS
Correction: Survival, CD4 T lymphocyte count recovery and immune reconstitution pattern during the first-line combination antiretroviral therapy in patients with HIV-1 infection in Mongolia.
No full text[This corrects the article DOI: 10.1371/journal.pone.0247929.]
Phenology of Stipa krylovii Roshev. and Stipa tianschanica var. klemenzii Roshev., species dominating the vegetation communities of Hustai National Park
No full textIncludes bibliographical references.Presented at the Building resilience of Mongolian rangelands: a trans-disciplinary research conference held on June 9-10, 2015 in Ulaanbaatar, Mongolia.Hustai National Park (HNP), which is one of the important parts of the Mongolian Special Protection Areas network, was founded in 1992 with the purpose of reintroducing the Takhi horse (Equus ferus przewalskii). HNP vegetation phenology research was first done in 1999 and since 2003 has been conducted each year between 24th of April and 24th of September, every 10 days. The purpose of this study is to identify, with the help of dominant species, the response of vegetation growing period to climate changes and to clarify features of species' phenology changes. As a result of the research we identified and recorded general trends of dominant vegetation phenology stages and how these changes respond to environmental factors (air temperature and precipitation). Comparison of the phenology stages of the two grasses dominant in the mountain steppe and steppe communities, Stipa tianschanica var. klemenzii Roshev. and Stipa krylovii Roshev. identified that the May and June precipitation amount had a significant effect on the beginning of the species' spring growing period (p<0.027). The results show that the vegetation growing period of the species has been increasing in the mountain steppe communities
γδ T cell-mediated activation of cDC1 orchestrates CD4+ Th1 cell priming in malaria
No full textNagasaki University (長崎大学)博士(医学)γδ T cells facilitate the CD4+ T helper 1 (Th1) cell response against Plasmodium infection by activating conventional dendritic cells (cDCs), although the underlying mechanism remains elusive. Our study revealed that γδ T cells promote the complete maturation and production of interleukin-12 and CXCR3-ligands specifically in type 1 cDCs (cDC1), with minimal impact on cDC2 and monocyte derived DCs (Mo-DCs). During the initial infection phase, γδ T cell activation and temporal accumulation in the splenic white pulp, alongside cDC1, occur via CCR7-signaling. Furthermore, cDC1/γδ T cell interactions in the white pulp are amplified through CXCR3 signaling in γδ T cells, optimizing Th1 cell priming by cDC1. We also demonstrated how transitional Th1 cells arise in the white pulp before establishing their presence in the red pulp as fully differentiated Th1 cells. Additionally, we elucidate the reciprocal activation between γδ T cells and cDC1s. These findings suggest that Th1 cell priming is orchestrated by this reciprocal activation in the splenic white pulp during the early phase of blood-stage Plasmodium infection.長崎大学学位論文 学位記番号:博(医歯薬)甲第1695号 学位授与年月日:令和7年3月19日Author: Yarob Ibraheem, Ganchimeg Bayarsaikhan, Maria Lourdes Macalinao, Kazumi Kimura, Katsuyuki Yui, Taiki Aoshi and Shin-Ichi InoueCitation: Frontiers in Immunology, 15, art. no. 1426316; 2024Nagasaki University (長崎大学), 博士(医学) (2025-03-19)doctoral thesi
Regulation of memory CD4+ T cell generation by intrinsic and extrinsic IL-27 signaling during malaria infection
No full textThe generation and maintenance of memory T cells are regulated by various factors, including cytokines. Previous studies have shown that IL-27 is produced during the early acute phase of Plasmodium chabaudi chabaudi AS (Pcc) infection and inhibits the development of Th1-type memory CD4+ T cells. However, whether IL-27 acts directly on its receptor on Plasmodium-specific CD4+ T cells or indirectly via its receptor on other immune cells remains unclear. We aimed to determine the role of IL-27 receptor signaling in different immune cell types in regulating the generation and phenotype of memory CD4+ T cells during Plasmodium infection. We utilized Plasmodium-specific T-cell antigen receptor (TCR) transgenic mice, PbT-II, and Il27rα−/− mice to assess the direct and indirect effects of IL-27 signaling on memory CD4+ T-cell generation. Mice were transferred with PbT-II or Il27rα−/− PbT-II cells and infected with Pcc. Conditional knockout mice lacking the IL-27 receptor in T cells or dendritic cells were employed to discern the specific immune cell types involved in IL-27 receptor signaling. High levels of memory in PbT-II cells with Th1-shift occurred only when both PbT-II and host cells lacked the IL-27 receptor, suggesting the predominant inhibitory role of IL-27 signaling in both cell types. Furthermore, IL-27 receptor signaling in T cells limited the number of memory CD4+ T cells, while signaling in both T and dendritic cells contributed to the Th1 dominance of memory CD4+ T cells. These findings underscore the complex cytokine signaling network regulating memory CD4+ T cells during Plasmodium infection.長崎大学学位論文 学位記番号:博(医歯薬)甲第1638号 学位授与年月日:令和6年9月4日Author: Sanjaadorj Tsogtsaikhan, Shin-Ichi Inoue, Ganchimeg Bayarsaikhan, Maria Lourdes Macalinao, Daisuke Kimura, Mana Miyakoda, MasahiroYamamoto, Hiromitsu Hara, Hiroki Yoshida, and Katsuyuki YuiNagasaki University (長崎大学), 博士(医学) (2024-09-04
Regulation of memory CD4+ T cell generation by intrinsic and extrinsic IL-27 signaling during malaria infection
No full textNagasaki University (長崎大学)博士(医学)The generation and maintenance of memory T cells are regulated by various factors, including cytokines. Previous studies have shown that IL-27 is produced during the early acute phase of Plasmodium chabaudi chabaudi AS (Pcc) infection and inhibits the development of Th1-type memory CD4+ T cells. However, whether IL-27 acts directly on its receptor on Plasmodium-specific CD4+ T cells or indirectly via its receptor on other immune cells remains unclear. We aimed to determine the role of IL-27 receptor signaling in different immune cell types in regulating the generation and phenotype of memory CD4+ T cells during Plasmodium infection. We utilized Plasmodium-specific T-cell antigen receptor (TCR) transgenic mice, PbT-II, and Il27rα−/− mice to assess the direct and indirect effects of IL-27 signaling on memory CD4+ T-cell generation. Mice were transferred with PbT-II or Il27rα−/− PbT-II cells and infected with Pcc. Conditional knockout mice lacking the IL-27 receptor in T cells or dendritic cells were employed to discern the specific immune cell types involved in IL-27 receptor signaling. High levels of memory in PbT-II cells with Th1-shift occurred only when both PbT-II and host cells lacked the IL-27 receptor, suggesting the predominant inhibitory role of IL-27 signaling in both cell types. Furthermore, IL-27 receptor signaling in T cells limited the number of memory CD4+ T cells, while signaling in both T and dendritic cells contributed to the Th1 dominance of memory CD4+ T cells. These findings underscore the complex cytokine signaling network regulating memory CD4+ T cells during Plasmodium infection.長崎大学学位論文 学位記番号:博(医歯薬)甲第1638号 学位授与年月日:令和6年9月4日Author: Sanjaadorj Tsogtsaikhan, Shin-Ichi Inoue, Ganchimeg Bayarsaikhan, Maria Lourdes Macalinao, Daisuke Kimura, Mana Miyakoda, MasahiroYamamoto, Hiromitsu Hara, Hiroki Yoshida, and Katsuyuki YuiNagasaki University (長崎大学), 博士(医学) (2024-09-04)doctoral thesi
