3,093 research outputs found
A saga de um clã Xavier
No full textThe book brings together historical memories of the Xavier family, of which the author is a member, and includes everything from the heroic episode between members of the Xavier family and Lampião's gang, to a Xavier family tree and tributes to the members of this family, as well as photographic records of known members. The author rescues and preserves important memories of the family, reconstructing facts that, if told orally, could gradually be erased. The story told by Maria do Socorro Cardoso Xavier is also a way of preserving the memory of Ipueira, reporting on the social life and historical setting of the place, using family narrative.O livro reúne registros de memórias históricas da família Xavier, da qual a autora é membro,
e traz desde o episódio heróico entre membros da família Xavier e o bando de Lampião, à
uma árvore genealógica dos Xavier e homenagens aos membros dessa famílias, além de
registros fotográficos dos membros conhecidos. A autora resgata e preserva memórias
importantes da família, reconstituindo fatos que, contados oralmente, poderiam se apagar aos
poucos. A história narrada por Maria do Socorro Cardoso Xavier também é uma forma de
preservar a memória de Ipueira, relatando sobre a vida social e cenário histórico do lugar,
utilizando da narrativa familiar
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Sir William Collins and Xavier Herbert
No full textSir William Collins, publisher and Xavier Herbert, author. Hand written comment about the photograph by Xavier Herbert on verso. [Gift of David Rowbotham
Mecanismes implicats en la resposta inflamatòria i noves dianes terapèutiques en la COVID-19
No full text[cat] L'edat avançada o altres comorbiditats no permeten predir amb exactitud quins pacients infectats per SARS-CoV-2 progressaran als estadis més greus de la COVID-19. Calen noves eines que ens permetin entendre millor la gran variabilitat interindividual per emmalaltir greument d’aquesta infecció.
La gravetat de la COVID-19 s'ha associat a variants genètiques rares en components immunitaris que intervenen en el reconeixement i la senyalització de la SARS-CoV-2. TLR7 és un receptor de la immunitat innata que reconeix RNA de cadena simple, com el genoma de SARS-CoV-2, i indueix una resposta d'interferons (IFN) ràpida i potent. En el nostre primer estudi hem identificat dues noves variants germinals al gen TLR7 que probablement causen una funció deficient del receptor i que podrien explicar la COVID-19 greu en els pacients portadors de les mateixes. El diagnòstic de deficiència de TLR7 no només obre la porta a nous tractaments personalitzats per als pacients, sinó que també permeten fer proves presimptomàtiques als familiars homes en risc.
S'han relacionat formes greus de COVID-19 amb autoanticossos neutralitzants davant dels IFNs de tipus I (NautoAbs), la fenocòpia dels errors innats que senyalitzen per aquests IFNs (p.e. TLR7). Sabem que els NautoAbs podrien ser un bon biomarcador de gravetat si es determinen quan es fa el diagnòstic d'infecció per SARS-CoV-2 però es desconeix la utilitat d'aquests NautoAbs quan els pacients ja han desenvolupat una forma greu de la malaltia. En el nostre segon estudi, una cinquena part dels pacients amb COVID-19 ingressats en cures intensives del HUB tenien autoanticossos enfront IFN-α2 i/o IFN-ω, mostrant en la meitat dels casos activitat bloquejant davant de altes concentracions (10 ng/mL) d'aquests IFNs. En aquests pacients la presència d'aquests autoanticossos neutralitzants davant IFN-I va ser notable i significativament superior en homes, es va associar a valors més elevats de paràmetres de laboratori relacionats amb la gravetat de la COVID-19 i també a un risc més gran de desenvolupar insuficiència renal aguda. Per contra, la mortalitat va ser semblant tant en presència com en absència d'aquests autoanticossos.
SARS-CoV-2 té la capacitat d'interferir la producció d'IFNs de l'hoste, mecanisme que permet evadir la resposta immune. Aquest fet podria afectar el rendiment de proves com el
QuantiFERON-TB Gold Plus (QFT-Plus) basat en la detecció IFN-γ després de l'estimulació in vitro de sang completa. Al nostre tercer estudi un terç dels pacients hospitalitzats per COVID-19 al qual es va demanar la prova QFT-Plus va presentar resultats indeterminats. Aquesta prevalença notablement alta posa en dubte la fiabilitat d'aquesta prova com a screening d'infecció tuberculosa latent en aquests malalts. El nostre estudi indica que una concentració plasmàtica elevada de LDH i l’ús de corticosteroides abans de la realització de la prova QFT-Plus podrien ser predictors d’un resultat indeterminat. Es va documentar també una proporció significativament superior de resultats indeterminats als pacients hospitalitzats per COVID-19 que van ser èxitus.
A l'HUB vam realitzar un assaig clínic randomitzat que va concloure que la combinació de polsos de metilprednisolona i tacrolimus, a més de l'Standard of Care, no va millorar significativament el temps fins a l'estabilitat clínica o altres criteris de validació (outcomes) secundaris, en comparació amb el Standard of Care només, en pacients hospitalitzats amb COVID-19 greu. Encara que no va assolir la significació estadística, els pacients que van rebre la teràpia experimental van presentar una mortalitat per totes les causes numèricament inferior que la del grup que només va rebre l'Standard of Care, reforçant els resultats obtinguts prèviament per estudis no aleatoritzats amb inhibidors de la calcineurina.[eng] Advanced age or other comorbidities do not accurately predict which patients infected with SARS-CoV-2 will progress to the most severe stages of COVID-19. Therefore, new tools are needed that allow us to better understand the great inter-individual variability to become seriously ill with this infection.
The severity of COVID-19 has been associated with rare genetic variants in immune components that are involved in recognizing and signaling SARS-CoV-2. TLR7 is an innate immune receptor that recognizes ssRNA, such as the SARS-CoV-2 genome, and induces a rapid and powerful IFN response. In our first study, we have identified two new germline variants in the TLR7 gene that probably cause impaired function of the receptor and that could explain severe COVID-19 in patients who carry them.
Severe forms of COVID-19 have been related to neutralizing autoantibodies against type I IFNs (NautoAbs), the phenocopy of inborn errors signaled by these IFNs (e.g. TLR7). In our second study, a 9.5% of the patients with COVID-19 admitted to intensive care at the HUB presented these NautoAbs. Mortality was similar both in the presence and absence of these autoantibodies.
SARS-CoV-2 has the ability to interfere with the production of IFNs by the host, a mechanism that allows it to evade the immune response. This fact could affect the performance of tests such as the QuantiFERON-TB Gold Plus (QFT-Plus). In our third study, one-third of patients hospitalized for COVID-19 had indeterminate results. This remarkably high prevalence casts doubt on the reliability of this test as a screening test for latent tuberculosis infection in these patients. A significantly higher proportion of indeterminate results was documented in patients hospitalized for COVID-19 who died.
Finally, we conducted a randomized clinical trial that concluded that the combination of methylprednisolone and tacrolimus pulses, in addition to Standard of Care, did not significantly improve time to clinical stability or other secondary outcomes, compared to the Standard of Care only, in hospitalized patients with severe COVID-19
San Xavier District pedestrian access and safety study : final report
No full textabstract: The San Xavier District of the Tohono O’odham Nation is home to approximately 2,000 people. Numerous others come to the District to visit the San Xavier del Bac Mission Church. The San Xavier District Pedestrian Access and Safety Study is being prepared to improve the walking and bicycling environment on the San Xavier District for Community members and visitors alike. The study is being funded by the Arizona Department of Transportation Multimodal Planning Division’s Planning Assistance for Rural Areas program.Includes bibliographical references
Interview with Xavier Aldana Reyes
No full textXavier Aldana Reyes is Reader in English Literature and Film in Manchester, a founding member of the Manchester Centre for Gothic Studies, and the author of Spanish Gothic: National Identity, Collaboration and Cultural Adaptation (2017) and Gothic Cinema (2019). His publications in Gothic and horror studies include Twenty-First-Century Gothic: An Edinburgh Companion (with Maisha Wester; 2019), Horror: A Literary History (2016) and Digital Horror: Haunted Technologies, Network Panic and the Found Footage Phenomenon (with Linnie Blake; 2015). Aldana Reyes also edited fiction anthologies for the British Library series, Tales of the Weird, including the following titles: The Gothic Tales of H.P. Lovecraft (2018), The Weird Tales of William Hope Hodgson (2019), Promethean Horrors: Classic Tales of Mad Science (2019) and Roarings from Further Out: Four Weird Novellas, by Algernon Blackwood (2019)
Xavier Albó: Memoria, Crónica, Perfil
No full textAuthor historicizes the monumental contribution to the study of Quechua of linguist and anthropologist Xavier Albó. Author recalls Albó's early linguistic and anthropological influence during the late 1960s as a clear inspiration to study Quechua linguistics, the largest indigenous language spoken today in the Americas
Digital Gothic : an interview with Xavier Aldana Reyes
No full textXavier Aldana Reyes is Reader/Associate Professor in English Literature and Film at Manchester Metropolitan University and a founder member of the Manchester Centre for Gothic Studies. He is author of Gothic Cinema (2020), Spanish Gothic (2017), Horror Film and Affect (2016) and Body Gothic (2014), and editor of Twenty-First-Century Gothic: An Edinburgh Companion (with Maisha Wester, 2019), Horror: A Literary History (2016) and Digital Horror (with Linnie Blake, 2015). Xavier is chief editor of the Horror Studies book series at the University of Wales Press, and has edited anthologies of Gothic and horror fiction for the British Library. One of Xavier's research interests is the optical dynamics of found footage horror films. On this topic, he has published an article on narrative framing for Gothic Studies, and chapters on affective immersion in the film [REC] (2007) and viewer involvement and guilt in The Last Horror Movie (2003). More recently, he wrote a chapter on 'Online Gothic' that considers social media found footage horror for the collection The Edinburgh Companion to Globalgothic (2022)
Darkroom/Body/Literature: Valêncio Xavier
No full textEste trabalho se aproxima da obra Minha mãe morrendo e o menino mentido, de Valêncio Xavier, refletindo sobre as relações entre corpo e literatura. Tem como pontos norteadores os conceitos de câmara escura e dorsalidade. Também está em pauta a ambiência nacional, a fornecer elementos para concepção de história apreendida por Xavier. O diálogo com o cinema será tratado nesta dissertação, numa abertura de focos que propiciará uma análise da dimensão-máquina no projeto narrativo do autor.This research approaches the work Minha mãe morrendo e o menino mentido [My mother dying and the boy lied], by Valêncio Xavier, reflecting on the relationship between body and literature. Its guiding points are the concepts of darkroom and dorsality. The national ambience is also on the focus, providing elements for the conception of history apprehended by Xavier. The dialogue with cinema will be dealt with in this dissertation, in an opening of focuses that will provide an analysis of the machine dimension in the author\'s narrative project
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Dr. Xavier Amador Shares His Experiences Addressing Anosognosia
No full textJennifer Cohen interviews Xavier Amador, PhD, the CEO of the Henry Amador Center for Anosognosia. Dr. Amador has 30 years of experience as a clinical psychologist, researcher, author, and caregiver for people suffering with serious mental illnesses. Dr. Amador is the author of several books including, I’m Not Sick, I Don’t Need Help: How to Help
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