1,721,058 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
MEFV mutation screening in familial mediterranean fever (FMF)
Full text linkBu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır. Yayınlanma izni olmayan tezlerin basılı kopyalarına Üniversite kütüphaneniz aracılığıyla (TÜBESS üzerinden) erişebilirsiniz.vın ÖZET Ailevi Akdeniz Ateşi (FMF) Sefardik Yahudiler, Araplar, Ermeniler ve Türkleri etkileyen otozomal resesif kalıtımlı bir hastalıktır. FMF'den sorumlu gen klonlanmış ve gen üzerinde 84 mutasyon tanımlanmıştır. Belirlenen mutasyonlardan yaygm olan beş tanesi hasta bireylerin %85'ini kapsamaktadır. Bu araşürmada, Tıbbi Biyoloji Anabilim Dalına başvuran, FMF teşhisi konmuş 15 olgunun 30 kromozomunda PCR-ELISA yöntemi kullanılarak beş MEFV mutasyonu değerlendirildi. Çalışılan alellerin %36.67'sinde M694V aleli belirlendi. Olgulann %13.3'ünün yalmzca bu mutasyon açısmdan homozigot olduğu saptandı. V726A, M680I, E148Q ve M694I mutasyonlanmn alel frekansları sırasıyla %23.33, %6.67, %6.67 ve %3.33 olarak hesaplandı. Hasta alellerde iki yaygın mutasyon olan M694V ve V726A %78.3 oramnda belirlendi. Olgulann %80'inin bu iki mutasyonun bir veya ikisini taşıdığı saptandı. Üç mutasyon açısmdan birleşik heterozigot (M694V / M694I / V726A) durumu yalmzca bir olguda belirlendi. Olgularımızda dokuz farklı genotip ortaya kondu.IX SUMMARY Familial Mediterranean Fever (FMF) is a autosomal recessive inherited disorder affecting Sephardic Jews, Arabs, Armenians and Turks. The gene responsible for FMF was cloned and 84 mutations have been described. The about eigthy-five percent of patient individuals have common five mutations in identified mutations. In this research, we have evaluated five MEFV mutations in 30 chromosomes of 15 patients with FMF diagnosis which were referred to Medical Biology Deparment, using PCR-ELISA methods. The M694V allele accounted for 36.67% of the allels studied and 13.3% of the patients were only homo2ygous. The allel frequency of V726A, M680I, E148Q and M694I mutations calculated as 23.33%, 6.67%, 6.67% and 3.33% of the patients, respectively. The 78.3% of the disease allels were attributed to two common mutations: M694V and V726A. The 80% of the patients carried one and two of the two mutations. The compound heterozygote case for three mutations (M694V / M694I / V726A) was determined in one patient. Nine different genotypes were determined in our cases
Cyp27b1 gene polymorphi·si·ms vitamin d levels and relationship with multiple sclerosis
Full text linkBu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır.Yayınlanma izni olmayan tezlerin basılı kopyalarına üniversite kütüphaneniz aracılığı ile (TÜBESS üzerinden) erişebilirsiniz.Çalışmamızda CYP27B1 geninin rs703842 polimorfizmi ve Vitamin D düzeyinin Multipl Skleroz hastalığı ile ilişkisini araştırılmıştır.Bu araştırmada, multiple skleroz tanısı almış 18-55 yaş arası 99 olgudan ve 99 kontrolde serum Vitamin D düzeyleri ve CYP27B1 geni rs703842 polimorfizmi genotiplemesi yapılmıştır..CYP27B1 genine ait rs703842 polimorfizmi genotip frekansları hasta ve kontrol grupları arasında karşılaştırıldığında, CC, CT ve TT genotipleri açısından, iki grup arasında fark belirlendi (p<0.05). Ayrıca vitamin D düzeyi karşılaştırıldığında iki grup arasında fark belirlendi (p<0.05). Vaka grubunda vitamin D düzeyi kontrolden yüksek olarak belirlendi. MS hastaların Serum Vitamin D düzeyleri literatürdeki ile benzer şekilde kontrol grubuna göre düşük saptandı. CYP27B1 genine ait rs703842 polimorfizmi alel frekansı literatürün aksine T alleli kontrol grubunda daha yüksek oranda belirlendi.In our study, rs703842 polymorphism of the gene CYP27B1 and vitamin D levels were investigated the relationship between the Multiple Sclerosis disease. In this research, multiple sclerosis had been diagnosed 18 to 55 years old 99 cases and 99 control serum vitamin D levels and CYP27B1 gene rs703842 polymorphism genotyping was carried out. CYP27B1 gene belongs to the rs703842 polymorphism genotype frequencies patient and control groups compared, CC, CT and TT genotypes in terms of the difference between the two groups respectively (p <0.05). Also, vitamin D levels were compared between two groups (p <0.05). In the case group were significantly higher vitamin D level checked. MS patients' serum vitamin D levels in a similar manner in the literature were lower than the control group. CYP27B1 gene allele frequency of polymorphism rs703842 contrast to the literature of the T allele at a higher rate in the control group was determined
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Molecular Biology and Genetic : Advanced Applications in Health and Biotechnology
No full textMoleküler Biyoloji ve Genetik bilim alanında yeni teknolojiler, baş döndüren yeni gelişmeler, moleküler bakış açısını sağlık ve yaşam bilimlerinin merkezine oturtmuştur. Kitap bu alandaki temel bilgiler ile birlikte, güncel yaklaşımlar ve uygulama alanları hakkında da bilgi vermektedir. Moleküler biyoloji ve Genetik dünyasına giriş anahtarı olan DNA molekülünden başlayarak, hücrede meydana gelen moleküler süreçler genetik uygulamaların anlatımında her başlığın kendi içinde organize bir akış sağlaması hedeflenmiştir.
Kitap temel kavramlardan yeni nesil dizileme teknolojilerine, İnsan genom projesinden bireysel tıp uygulamalarına, omik yaklaşımlardan epigenetik mekanizmalara, yapay zekanın tıptaki uygulamalarına biyogüvenlik süreçlerinden kanser genetiğine kadar 29 başlıkta, ülkemizin değerli bilim insanlarının tecrübelerini ve literatürdeki son bilgileri sade bir dil ile okuyucuya sunmaktadır. Elbette ki bilgiye ulaşmanın bir tuş uzakta olduğu bir çağdayız. Ancak konunun uzmanları tarafından güvenilir bir süzgeçten geçirilerek metodolojik olarak derlenmiş böylesi bir içeriğin kıymetli olduğuna inanıyor ve kaynağa başvuran her okuyucu için pozitif katkı sunacaktır.
Bu eser, lisans ve lisans üstü öğrenciler, uzmanlar, klinisyen ve akademisyenler dahil olmak üzere Moleküler Biyoloji ve Genetik biliminin insan sağlığı üzerindeki uygulamalarına ilişkin bilgi arayan herkes için bir kaynak oluşturacaktır
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