3,584 research outputs found
Snieder et al. Genetic Epidemiology 16:426--446 (1999) 1999 Wiley-Liss, Inc.
No full textGenet. Epidemiol. 16:426-- 446, 1999. 1999 Wiley-Liss, Inc. Key words: heritability; twins; insulin resistance; truncated data; assay batch effects; reciprocal causation model *Correspondence to: Dr. Harold Snieder, Twin Research & Genetic Epidemiology Unit, St Thomas' Hospital, Lambeth Palace Road, London, UK SE1 7EH. E-mail: [email protected] Received 5 December 1997; Revised 29 July 1998; Accepted 2 October 1998 Contract grant sponsor: Netherlands Heart Foundation; Contract grant number: 90.313. INTRODUCTION Resistance to insulin-stimulated glucose uptake, also called insulin resistance or impaired insulin sensitivity, is considered a major risk factor for progression to both coronary heart disease (CHD) and non-insulin-dependent diabetes mellitus (NIDDM) [Reaven, 1988; Groop and Eriksson, 1992; Beck-Nielsen and Groop, 1994; Pierce et al., 1995]. At first, insulin-resistant individuals are able to keep a normal glucose homeostasis by developing hyperinsulinemia [Reaven,
Letter from Carl Hayden to Harold Greene
No full textLetter from Carl Hayden to Harold Greene regarding the progress of the national park bill
Letter from Harold Greene, Tusayan National Forest to Carl Hayden
No full textLetter from Harold Greene to Carl Hayden regarding the proposed boundaries for the national park bill
Harold Palmer
Full text linkHarold E. Palmer (1877-1949), was a London-born early twentieth century linguist, phonetician, language educator, and author of over a hundred books, research papers and monographs. A school dropout, he started work as a learner- teacher at a school in Verviers, Belgium where he taught and experimented with teaching methods, and learnt several languages, both living and artificial
Broad thinking: An interview with Harold Kalant
No full textIn this interview, Dr. Harald Kalant, Professor Emeritus at the University of Toronto, talks about his career in addiction science, his professional associations with E.M. Jellinek, Griffith Edwards and other luminaries, the growth of the addiction field, and the issue of cannabis legalization in Canada, among other things. The interview was made by Judit H. Ward and William Bejarano on May 16, 2016 in Toronto.Peer reviewe
A Principal Component Informed Approach to Address Polygenic Risk Score Transferability Across European Cohorts
Full text linkOne important confounder in genome-wide association studies (GWASs) is population genetic structure, which may generate spurious associations if not properly accounted for. This may ultimately result in a biased polygenic risk score (PRS) prediction, especially when applied to another population. To explore this matter, we focused on principal component analysis (PCA) and asked whether a population genetics informed strategy focused on PCs derived from an external reference population helps in mitigating this PRS transferability issue. Throughout the study, we used two complex model traits, height and body mass index, and samples from UK and Estonian Biobanks. We aimed to investigate 1) whether using a reference population (1000G) for computation of the PCs adjusted for in the discovery cohort improves the resulting PRS performance in a target set from another population and 2) whether adjusting the validation model for PCs is required at all. Our results showed that any other set of PCs performed worse than the one computed on samples from the same population as the discovery dataset. Furthermore, we show that PC correction in GWAS cannot prevent residual population structure information in the PRS, also for non-structured traits. Therefore, we confirm the utility of PC correction in the validation model when the investigated trait shows an actual correlation with population genetic structure, to account for the residual confounding effect when evaluating the predictive value of PRS
Harold Dudley papers
No full textHarold Dudley (1896-1970) was a poet, author, and founder of the Washington Pilgrimage, later known as Religious Heritage of America. The organization actively promoted the Judeo-Christian heritage of the United States. Dudley was instrumental in lobbying Congress to add "under God" to the official text of the Pledge of Allegiance. He also wrote The Populist Movement, American Women in Public Life, This New America, Thoughts of Love and You, a volume of poetry to his wife; and the music to "Lead My America," a patriotic anthem. The collection consists of biographical materials documenting Dudley's life, as well as selected poems and other of Dudley's publications
Letter from Harold Johnson to Tsuneo Iwata, April 16, 1942
No full textLetter from Harold Johnson field representative of Federal Reserve Bank of San Francisco to Tsuneo Iwata, president of the Turlock social Club, in regards to mass removal preparation.The Nisaburo Aibara Collection features materials from the Turlock Social Club, a local Japanese-American community group active between 1939 and 1970. It contains documents regarding the Stockton, Turlock and Merced Assembly Centers and Japanese American Citizens League chapters. The Collection also features correspondences with reactions, responses, and preparations for the forced evacuation. Additionally, the Collection has records on the Central California Cantaloupe Company, Turlock Farm Corporation, Turlock Japanese Society, and family records and funeral service programs of Japanese-American residents of Turlock
Genetic influence on age at first birth of female twins born in the UK, 1919-68
No full textUsing a sample of monozygotic (945, 42 per cent) and dizygotic (1,329, 58 per cent) twin pairs born 1919–68 in the UK, we applied innovative tobit models to investigate genetic and environmental influences on age at first birth (AFB). We found that a substantial part (40 per cent) of the variation in AFB is caused by latent family characteristics. Genetic dispositions (26 per cent) play a more important role than the shared environment of siblings (14 per cent), with the non-shared environment/measurement error having the strongest influence (60 per cent). Like previous studies, this study reveals marked changes in estimates over time, and supports the idea that environmental constraints (war or economic crisis) suppress and normative freedom (sexual revolution) promotes the activation of genetic predispositions that affect fertility. We show that the exclusion of censored information (i.e., on the childless) by previous studies biased their results
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