196,936 research outputs found
Pulmonary arterial hypertension (PAH) from autopsy study: T-cells, B-cells and mastocytes detection as morphological evidence of immunologically mediated pathogenesis.
No full textBackground: Pulmonary arterial hypertension (PAH) is characterized by severe vascular remodelling, resulting in increased pulmonary vascular resistance with cardiac hypertrophy and heart failure. However, the diagnosis of PAH is often inaccurate. Many cases of PAH are incorrectly diagnosed or missed, and they are often associated with death. The aim of this study was to verify the morphological and histological criteria of fatal cases of PAH and evaluate the lymphocytic populations associated to lesions with reactive neo-angiogenesis. Methods: Pulmonary lung sections from 10 cases of sudden unexpected death (SUD) in the absence of previously diagnosed diseases and in an apparent state of well-being, with final histological post autopsy diagnosis of PAH were collected. The pathological findings were compared using ten controls from non-pathological lung from deaths from other causes. The autopsies included 4 males (40%) and 6 females (60%) with an average age of 52.1 ± 10.1 years. Sections stained with hematoxylin and eosin (H&E) were revised for a morphological diagnosis. Subsequently, serial sections were performed and stained with immunohistochemistry for anti-CD20 (B-lymphocytes), anti-CD3 (T-lymphocytes), anti-CD4 (T-helper lumphocytes), anti-CD8 (T-cytotoxic lymphocytes) and anti-CD117/C-Kit (mast cells/MCs) to detect inflammatory infiltrate and different ratios of cell-type. Statistical analysis was conducted using a paired t-test looking at 100 cells in 3 different tissue samples representative of vascular lesion and 3 different random normal lung parenchyma fields without lesion (from 10 normal control lungs), to identify specific lymphocyte subpopulations in inflammatory infiltrates. Results: There was a significant percentage increase of CD20 (p < 0.001), CD8 (p = 0.002), CD4 (p < 0.001), and CD117/C-Kit positive (C-Kit+; p < 0.001) cells mainly detected around wall vessels; while increased MCs positivity and C-Kit+ were observed especially in alveolar septa. In addition, reactive angiomatosis was observed. Conclusions: The inflammatory infiltrate should be included for a correct diagnosis of PAH besides the vascular remodelling. The inflammatory infiltrate seems to be implicated as a main factor in the pathogenesis. This finding is important to rule out secondary pulmonary hypertension, to identify SUDs of unknown causes and to add new elements to the literature that can explain the immunologically related pathogenesis of PAH
Monomeric C-reactive protein and cerebral hemorrhage: From bench to bedside
No full text© 2018 Di Napoli, Slevin, Popa-Wagner, Singh, Lattanzi and Divani. C-reactive protein (CRP) is an important mediator and a hallmark of the acute-phase response to inflammation. High-sensitivity assays that accurately measure levels of CRP have been recommended for use in risk assessment in ischemic stroke patients. Elevation of CRP during the acute-phase response in intracerebral hemorrhage (ICH) is also associated with the outcomes such as death and vascular complications. However, no association has been found with the increased risk of ICH. The aim of this review is to synthesize the published literature on the associations of CRP with acute ICH both as a risk biomarker and predictor of short- and long-term outcomes as well as its role as a pathogenic determinant. We believe before any clinical utility, a critical appraisal of the strengths and deficiencies of the accumulated evidence is required both to evaluate the current state of knowledge and to improve the design of future clinical studies
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
Scanning electron microscopy of blood vascular corrosion casts (SEM on VCC) in mammals
No full textIn this chapter, we will describe the standard technical protocols used to obtain blood vascular cast for the study with SEM, as well as we will briefly review the recent advances in the observation of vascular network through the use of this tool, and its application in the study of angiogenesis mainly according to our experience in the mammalian ovary
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Slevin, Ann M. (Death, 1875-12-10)
No full textAddress: 424 W. 6th St.Age at death: 59 yrsPg 307/1875/243/F W M/Pa./Dr. I. Quinn/Sullivan/St.Joseph'sOriginal record filed in drawer labeled 'SLIVER-SLOMER'
Investigating sources of uncertainty associated with the JULES land surface model
No full textThe land surface is a key component of the climate system and exchanges
energy, water and carbon with the overlying atmosphere. It is the location
of the terrestrial carbon sink and changes in the land surface can impact
weather and climate at various time and spatial scales. It's ability to act
as a source or a sink can influence atmospheric CO2 concentrations. Both
models and observations have shown the reduced ability of the land surface
to absorb increased anthropogenic CO2 emissions with results from the
Coupled Climate-Carbon Cycle Model Intercomparison Project (C4MIP)
and phase 5 of the Coupled Model Intercomparison Project (CMIP5) have
shown that the terrestrial carbon cycle is a major source of model uncertainty.
Land surface models (LSMs) represent the interaction between the
biosphere and atmosphere in earth system models (ESMs) and are important
for simulating the terrestrial carbon cycle. In the context of land
surface modelling, uncertainty arises from an incomplete understanding of
land surface processes and the inability to model these processes correctly.
As LSMs become more advanced, there is a need to understand their accuracy.
In this thesis, the ability of the Joint UK Land Environment Simulator
(JULES), the land surface scheme of the UK Met Office United Model, to
simulate Gross Primary Productivity (GPP)
fluxes is evaluated at various
spatial scales (point, regional and global) in order to identify and quantify
sources of uncertainty in the model. This thesis has three main objectives.
Firstly, JULES is evaluated at the point scale across a range of biomes and
climatic conditions using local (site-specific), global and satellite datasets.
It was found that JULES is biased with total annual GPP underestimated
by 16% and 30% across all sites compared to observations when using local
and global data, respectively. The model's phenology module was tested
by comparing results from simulations using the default phenology model
to those forced with leaf area index (LAI) from the MODIS sensor. Model
parameters were found to be a minor source of uncertainty compared to the
meteorological driving data at the point scale as was the default phenology
module in JULES. Secondly, in addition to evaluating simulated GPP fluxes at the point scale, the ability of JULES to simulate GPP at the global
and regional scale for 2000-2010 was investigated with being able to simulate
interannual variability and simulated global GPP estimates were found
to be greater than the observation-based estimates, FLUXNET-MTE and
MODIS, by 8% and 25%, respectively. At the regional scale, differences in
GPP between JULES, FLUXNET-MTE and MODIS were observed mostly
in the tropics and this was the reason for differences at the global scale.
Simulating tropical GPP was found to be a major source of uncertainty
in JULES. JULES was found to be insensitive to spatial resolution and
when driven with the PRINCETON meteorological dataset, differences between
model simulations driven using WFDEI-GPCC and PRINCETON
occurred in the tropics (at 5°N-5°S) and extratropics (at 30°N-60°N). Finally,
the response of JULES to changes in climate (surface air temperature,
precipitation, atmospheric CO2 concentrations) was explored at the global
and regional scale. Simulated GPP was found to have greater sensitivity
to changes in precipitation and CO2 concentrations than air temperature
at the global scale while LAI was sensitive only to changes in temperature
and insensitive to changes in precipitation and CO2 concentrations. It was
found that model sensitivity to climate at the global scale was determined
by its behaviour at the regional scale
The chick embryo chorioallantoic membrane assay.
No full textDuring avian development the mesodermal layers of the allantois and chorion fuse to form the chorioallantoic membrane (CAM). This structure rapidly expands generating a rich vascular network that provides an interface for gas and waste exchange. The CAM allows to study tissue grafts, tumor growth and metastasis, drugs delivery and toxicologic analysis, and angiogenic and anti-angiogenic molecules. The CAM is relatively simple, quick, and low-cost model that allows screening of a large number of pharmacological samples in a short time; does not require administrative procedures for obtaining ethics committee approval for animal experimentation. Moreover, being naturally immunodeficient, the chick embryo may receive transplantations from different tissues and species, without immune responses
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