1,720,998 research outputs found
The possible role of gut neuroendocrine peptides and amines in the pathogenesis and treatment of colorectal cancer
No full textAbnormalities in colonic neuroendocrine peptides/amines were observed inrats with chemically induced colon carcinoma. This supports the assumption that neuroendocrine peptides and amines of the gut seem to be involved inthe carcinogenesis of colorectal carcinoma. These changes seem to occur prior to the development of colon cancer, since they appear at the dysplasia stage. The nature of the changes in the neuroendocrine peptides/amines inchemically induced carcinoma is, however, different from those observed in patients with colorectal cancer. This difference made this model unsuitable for studying the role of these substances in colorectal carcinoma. Treatment with a single therapy of octreotide or serotonin had no effect on rat colonicadeno carcinoma; galanin, however, reduced the relative volume density of blood vessels. Treatment with a double therapy of octreotide/galanin, octreotide/serotonin, or galanin/serotonin had certain effects on the rat colon cancer but not to the same extent as did the triple therapy. Triple therapy with octreotide, galanin, and serotonin reduced the volume and weight ofthe rat colonic cancer. This seems to have been brought about by increasing the tumor apoptosis and necrosis. The optimal dose for triple therapy with octreotide, galanin, and serotonin was between 10 and 20-ug/kg body weight. Doses under this limit had a marginal effect, while doses above this level did not increase the effect. No apparent side effects were found in mice during the period of treatment.digitalisering@um
The possible role of gut neuroendocrine peptides and amines in the pathogenesis and treatment of colorectal cancer [Elektronisk resurs]
No full textAbnormalities in colonic neuroendocrine peptides/amines were observed inrats with chemically induced colon carcinoma. This supports the assumption that neuroendocrine peptides and amines of the gut seem to be involved inthe carcinogenesis of colorectal carcinoma. These changes seem to occur prior to the development of colon cancer, since they appear at the dysplasia stage. The nature of the changes in the neuroendocrine peptides/amines inchemically induced carcinoma is, however, different from those observed in patients with colorectal cancer. This difference made this model unsuitable for studying the role of these substances in colorectal carcinoma. Treatment with a single therapy of octreotide or serotonin had no effect on rat colonicadeno carcinoma; galanin, however, reduced the relative volume density of blood vessels. Treatment with a double therapy of octreotide/galanin, octreotide/serotonin, or galanin/serotonin had certain effects on the rat colon cancer but not to the same extent as did the triple therapy. Triple therapy with octreotide, galanin, and serotonin reduced the volume and weight ofthe rat colonic cancer. This seems to have been brought about by increasing the tumor apoptosis and necrosis. The optimal dose for triple therapy with octreotide, galanin, and serotonin was between 10 and 20-ug/kg body weight. Doses under this limit had a marginal effect, while doses above this level did not increase the effect. No apparent side effects were found in mice during the period of treatment.</p
The possible role of gut neuroendocrine peptides and amines in the pathogenesis and treatment of colorectal cancer
No full textAbnormalities in colonic neuroendocrine peptides/amines were observed inrats with chemically induced colon carcinoma. This supports the assumption that neuroendocrine peptides and amines of the gut seem to be involved inthe carcinogenesis of colorectal carcinoma. These changes seem to occur prior to the development of colon cancer, since they appear at the dysplasia stage. The nature of the changes in the neuroendocrine peptides/amines inchemically induced carcinoma is, however, different from those observed in patients with colorectal cancer. This difference made this model unsuitable for studying the role of these substances in colorectal carcinoma. Treatment with a single therapy of octreotide or serotonin had no effect on rat colonicadeno carcinoma; galanin, however, reduced the relative volume density of blood vessels. Treatment with a double therapy of octreotide/galanin, octreotide/serotonin, or galanin/serotonin had certain effects on the rat colon cancer but not to the same extent as did the triple therapy. Triple therapy with octreotide, galanin, and serotonin reduced the volume and weight ofthe rat colonic cancer. This seems to have been brought about by increasing the tumor apoptosis and necrosis. The optimal dose for triple therapy with octreotide, galanin, and serotonin was between 10 and 20-ug/kg body weight. Doses under this limit had a marginal effect, while doses above this level did not increase the effect. No apparent side effects were found in mice during the period of treatment.digitalisering@um
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A comparison between double and triple therapies of octreotide, galanin and serotonin on a rat colon carcinoma
No full textSixty female nude mice (C578L/6jBom-nu) were injected with 100µl cell suspension containing 2x106 viable cells of an N-methyl-N-nitroguanidine-induced rat colonic adenocarcinoma. After seven days the animals were divided into five groups. The first group received only saline and served as a control group. The second group received a triple therapy of octreotide, galanin and serotonin (20 µg/kg). The last three groups received double therapies of octreotide/galanin, octreotide/serotonin or galanin/serotonin (20 µg/kg). They were treated twice a day for five days. Tumour volume and weight, relative volume density of tumour-feeding blood vessels and of tumour necrotic tissue, as well as apoptotic and proliferation indices were determined. Animal weight, food consumption, faeces weight and its water content were recorded before and after treatment. Tumour volume was significantly reduced only in the group that received the triple therapy. The volume density of the tumour-feeding blood vessels was significantly reduced in the treated groups with the exception of the group that received octreotide and serotonin. Increased relative volume density of tumour necrotic tissue occurred only in the group treated with triple therapy. Apoptotic indices were significantly increased in all treated groups. No statistical difference was found between treated animals and controls regarding proliferation indices, food consumption, faeces weight and water content or animal weight. In conclusion, double therapy using two of the gastrointestinal bioactive substances, octreotide, galanin and serotonin, has certain effects on colon cancer cells. To cause a considerable tumour necrosis, triple therapy seems to be required. Both double and triple therapy seem to lack obvious side-effects.</p
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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