196,325 research outputs found
Optimization of Transportation Costs Using the Sirisha Viola Method
No full textDistribution is the process of channeling goods or products produced from producers to consumers. In the era of Industry 5.0, which is the era of collaboration between humans and technology in production and intense competition in cost efficiency, distribution has become a success target for companies. One of the problems in the distribution process is the high transportation costs and improper delivery routes to each destination. The implementation of this transportation model aims to solve the product distribution problems from the source to the destination by minimizing transportation costs. The distribution of each product must be arranged as well as possible because there are different distribution costs from m sources to n different destinations. This research uses a case study in the form of unbalanced data where the supply (ai)≤ demand (bj) is resolved using the Sirisha-Viola method, characterized by adjacent even-odd row and column exchanges according to demand and supply. Then, its optimality is tested using Modified Distribution (MODI). Based on calculations carried out on the case study of Perum Bulog in the North Sumatra Regional Office, the results are the optimal solution provided directly by the Sirisha - Viola method. Which is where the results obtained are smaller than the initial expenditure by the company where the company saves costs by 1.48%. The Sirisha - Viola method is proven to minimize transportation costs for unbalanced data cases.61 PagesSkripsi Sarjan
Metabolic disorders in young people around the world
Get PDFYouth-onset metabolic diseases, including obesity and type 1 and type 2 diabetes, and their associated cardiometabolic complications represent a major global health challenge. The incidence and prevalence of these conditions vary across regions, with rising trends and a heavier burden observed in middle- and low-income countries. Diet, physical activity and lifestyle choices are key factors in the development and progression of metabolic diseases during childhood and adolescence, along with additional risk factors such as genetic predisposition, ancestry, ethnicity, lifetime events (i.e. puberty) and other environmental factors. Disparities in access to healthcare, diagnostic and management capabilities and treatment options across the world affect outcomes, contributing to high morbidity and mortality rates, particularly in low-resource settings. Compared with onset during adulthood, an early diagnosis of metabolic diseases is associated with a higher risk and severity of complications, including adverse vascular outcomes and premature mortality. Although clinical signs of cardiovascular complications typically appear in adulthood, they are the result of a long, subclinical disease process that can begin in childhood and adolescence. This underscores the need for early prevention strategies and effective treatments to reduce the short- and long-term health impacts of these conditions. Addressing the rising prevalence of metabolic diseases, especially among vulnerable populations, requires comprehensive, culturally tailored actions that consider the available resources in diverse settings
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
Get PDFFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
E-cadherin Mediated Homotypic Cell–cell Interaction Confers Cytokine Independence in Human Leukemia Ut-7 Cell Line
No full textAcute myeloid leukemia (AML) is an aggressive hematopoietic stem cell cancer and 10,590 deaths from AML are estimated in 2017. The lack of knowledge regarding pathways that lead to cytokine independence of leukemia cell progression results in poor prognosis. Since cytokine signals parental leukemogenesis, we hypothesized that cytokine independence confers survival and proliferative advantages to AML progenitor cells. To test this hypothesis, we established a novel erythropoietin (Epo) independent UT-7/EN cell line from UT-7/Epo, an Epo-dependent megakaryocytic leukemia cell line. The UT-7/EN cells survived and proliferated without Epo whereas Epo was indispensable for the survival of parental UT-7/Epo cells (p \u3c 0.0001). Moreover, UT-7/EN cells formed cell aggregates as they proliferated, suggesting the formation of cell-cell adhesion. The gene expression profiles of UT-7/Epo and UT-7/EN cells were compared using HumanHT-12 v4 BeadChip array and by validation with qRT-PCR. Validation of E-cadherin (CDH1) upregulation at both the transcriptional level by RT-qPCR and the translation level by immunoblot (3.7 fold) and immunostaining (p \u3c 0.01) suggested E-cadherin mediated cell-cell interactions in UT-7/EN cells. Furthermore, UT-7/EN lost the characteristic of cell aggregates in calcium stripped media using EDTA (5mM) relative to untreated UT-7/EN, suggesting E-cadherin induced cell-cell interactions. Stabilization of cell adhesion complex by co-localization of β-catenin with E-cadherin was supported by immuno co-staining of β-catenin and E-cadherin. Additionally, Epo supplementation suppressed the E-cadherin gene expression significantly (p \u3c 0.001) in UT-7/EN at the transcription level while concurrently upregulating CDH1 transcriptional repressor SNAIL2 (p \u3c 0.01), whereas β-catenin gene expression remained non-significant at 24, 48, and 72 hours relative to un-supplemented UT-7/EN cells. Epo supplementation also significantly upregulated vimentin gene expression (p \u3c 0.001) relative to Epo un-supplemented UT-7/EN cells. In summary, the results indicate that E-cadherin induced cell-cell interactions confer cytokine independence in UT-7/EN in the absence of Epo
Intern experience at CH���M Hill, Inc.: an internship report
Get PDFIncludes author's vita"Submitted to the College of Engineering of Texas A&M University in partial
fulfillment of the requirement for the degree of Doctor of Engineering."Includes bibliographical referencesA review of the author's internship experience with CH���M HILL, Inc.
during the period September 1975 through May 1976 is presented. During this nine month
internship the author worked as an Engineer II in the Industrial Processes discipline of this
large consulting engineering firm... The author's prime responsibility was as one of three
lead design engineers on the design of a large wastewater treatment facility for a pulp mill
in Hoquiam, Washington owned by ITT Rayonier Inc. The work generally consisted of the design
of individual treatment units and associated piping and pumping. The purpose of the project
was to provide wastewater treatment capabilities that would satisfy the effluent limitations
(standards) imposed upon the mill by the State of Washington Department of Ecology and the
U.S. Environmental Protection Agency. The author's assignment also entailed necessary
interaction with the project manager and other CH���M HILL design engineers and support staff
members, the client's representatives, and representatives of two other consulting engineering
firms working on the project. Thus, the internship position at CH���M HILL provided considerable
experience coordinating the author's work with the work of other engineers, guiding the design
and administrative efforts of a support staff, and interacting regularly with the client and
other consulting firms. This broad exposure to a variety of engineering and organizational
problems provided a valuable educational experience
Transition to turbulence in a qblique shock-wave/boundary-layer interaction at M=15
No full textDirect numerical simulations are carried out for different forcing techniques to trigger transition during the interaction between an oblique shock-wave and a laminar boundary-layer at M = 1.5. Three forcing methods are used: a) forcing of oblique unstable modes, whose shape and behaviour are determined by the local linear stability theory, b) broadband free-stream acoustic disturbances, and c) a cold plasma flow control device. While the oblique-mode breakdown is dominant for low-amplitude forcing, long streaky structures drive the transition process in a high-amplitude disturbance environment. LES are also performed on the experimental setup by the Institute of Theoretical and Applied Mechanics (ITAM) from Novosibirsk State University with cold plasma actuation. As well as the disturbance type, the effect of Reynolds number and forcing amplitude will be investigated
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