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Synthesis, spectroscopic characterization, crystal structure, interaction with DNA, CTAB as well as evaluation of biological potency, docking and Molecular Dynamics studies of N-(3,4,5-trimethoxybenzylidene)-2, 3-dimethylbenzenamine
No full textA novel N-substituted Schiff base ligand: N-(3,4,5-trimethoxybenzylidene)-2,3-dimethylbenzenamine was designed and successfully characterized by several spectroscopic techniques. The formation of the desired compound was confirmed by the appearance of C[dbnd]N peak at 1691 cm−1 in FT-IR spectrum. Similarly, in 1H and 13C NMR spectra, the peaks at 8.22 ppm for azomethine proton (HC[dbnd]N) and 158.8 ppm for azomethine carbon (C[dbnd]N) confirm the formation of the synthesized compound. DNA interaction of the compound was screened by using UV–visible spectroscopy and viscometry measurements confirming an intercalation mode. The interaction of compound with CTAB (Cetyl trimethylammonium bromide) was also studied by conductometric method showing a strong interaction with CTAB. The IC50 value of the current compound was highly efficacious upon comparison with the standard Glucantime used. This activity represents a higher multitude interaction, which might be a cause of enhanced antileishmanial activity. Cytotoxicity results showed that this compound is highly active even at lower concentrations and is biocompatible, making it a promising drug candidate for further investigations in this field. The experimental data were auxiliary supported by molecular docking studies in order to explore their binding behavior and the stability of the molecule due to its interaction within the receptor active site
Designing of homo and heteroleptic zinc(II) carboxylates: synthesis, spectroscopic characterizations, DNA binding study, CTAB interaction and in vitro antimicrobial evaluations
No full textSynthesis of two homoleptic and five heteroleptic zinc (II) carboxylate complexes with two different ligands: HL 1 = 3-chlo-robenzoic acid and HL 2 = 2-(4-chlorophenyl) acetic acid have been reported in this paper. The general formulae of the two homoleptic complexes are: Zn(L 1 ) 2 (1), and Zn(L 2 ) 2 (2). Similarly, the general formulae for two different types of heteroleptic complexes are: (Type-I): [(Zn) 2 (L 1 ) 4 (bipy) 2 (H 2 O)] (3), [Zn(L 2 ) 2 (bipy)(H 2 O)] (4) and (Type-II): [ZnL 1 L 2 ] (5), [ZnL 1 L 2 (py)] (6) and [ZnL 1 L 2 (bipy)] (7). The synthesized complexes were characterized in the solid state by FT-IR, CHN analyses and in solution state by NMR ( 1 H, 13 C) spectroscopy. Complexes 3 and 4 were also characterized by single crystal analysis where data revealed that the geometry around each Zn atom is distorted trigonal bipyramidal and octahedral, respectively. The synthesized complexes were interacted with SS-DNA and CTAB (surfactant). Interaction of the synthesized compounds with SS-DNA was studied by UV–visible spectroscopy and viscometry and intercalative mode of interaction was exhibited. Moreover, the interaction of the synthesized complexes with CTAB was studied by conductometry showing a strong binding that is evident from higher CMC and negative Gibbs free energy of micellization (ΔGm) values. The tested compounds were further screened for in vitro antibacterial and antifungal activities and were found active against the studied strains of bacteria and fungus
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
المعنى المفهومي والترابطي في الشعر "أخبرنا نخبرك" لسراج الدين محمد: دراسة دلالية جيفري ليش
Full text linkمستخلص البحث
يهدف هذا البحث: (1) وصف المعنى المفهومي عند جيفري ليش في الشعر "أخبرنا نخبرك" لسراج الدين محمد، (2) وصف المعنى الترابطي عند جيفري ليش في الشعر "أخبرنا نخبرك" لسراج الدين محمد، و (3) معرفة محتويات المعنى في الشعر "أخبرنا نخبرك" لسراج الدين محمد على أساس نظرية المعنى المفهومي والترابطي عند جيفري ليش. نوع البحث في هذا البحث هو البحث النوعي الكيفي. البيانات الرئيسية في هذا البحث هو الشعر "أخبرنا نخبرك" لسراج الدين محمد. مصادر البيانات الثانوية التي استخدمها الباحثة في هذا البحث هي الكتب والمجلات العلمية والمقالات التي ناقشت المعاني المفهومية والترابطية لجيفري ليش مما سهل تحليل المعنى في الشعر. إن طريقة جمع البيانات في هذا البحث فهي طريقة القراءة والتسجيل. واستخدمت طريقة تحليل البيانات في هذا البحث بتنفيض البيانات، وعرض البيانات، والإستنتاج. يشير نتائج هذا البحث أن (1) المعنى المفهومي للشعر"أخبرنا نخبرك" في ثلاث كلمات، (2) المعنى التربطي للشعر"أخبرنا نخبرك" في أربعة وعشرين كلمات وجمل التي تنقسم إلى خمسة أنواع وهي: ستة المعانى المجازية، وأربعة المعاني الأسلوبية، وعشرة المعاني العاطفية، والمعنيان التأمليان، والمعنيان الطرزيان، و (3) يدل محتويات المعنى في الشعر "أخبرنا نخبرك" على هجاء للبخيلين، للمتغطرسين، للمصريين، للمتكبرين للكسولين، للجاهلين؛ وأمر لتحقيق أقصى استفادة من الوقت.
ABSTRACT
The study was intended to: (1) Determine the conceptual meaning in the poem Akhbirna Nukhbiruka by Sirajuddin Muhammad based on the perspective of Geoffrey Leech; (2) Knowing the associative meaning in the poem Akhbirna Nukhbiruka by Sirajuddin Muhammad based on the perspective of Geoffrey Leech; (3) Knowing the content of meaning in the poem Akhbirna Nukhbiruka by Sirajuddin Muhammad based on the conceptual and associative meaning of the perspective on Geoffrey Leech. The type used in this study is a descriptive qualitative study method. The primary source of data in this study is poem Akhbirna Nukhbiruka by Sirajuddin Muhammad, while secondary data sources are drawn from books, scientific journals, and articles that discuss the conceptual and subjective perspective of Geoffrey leech. Data collection techniques using read and note techniques. As for the data analysis techniques in this is data reduction, data exposure, and deduction. This study suggests that (1) the conceptual meaning in Akhbirna Nukhbiruka's poetry is contained in three words; (2) the connotative meaning in Akhbirna Nukhbiruka's poetry is contained in 24 words and sentences which are divided into five parts, namely: six connotative meanings, four stylistic meanings, ten affective meanings, two reflective meanings, and two collocative meanings; (3) the content of meaning in Akhbirna Nukhbiruka's poem shows about the satire of the stingy person, arrogant people, Egyptian people, lazy people, stupid people; and contains a command to make the best use of time.
ABSTRAK
Penelitian ini bertujuan untuk: (1) Mengetahui makna konseptual dalam puisi Akhbirna Nukhbiruka karya Sirajuddin Muhammad berdasarkan perspektif Geoffrey Leech; (2) Mengetahui makna asosiatif dalam puisi Akhbirna Nukhbiruka karya Sirajuddin Muhammad berdasarkan perspektif Geoffrey Leech; (3) Mengetahui kandungan makna dalam puisi Akhbirna Nukhbiruka karya Sirajuddin Muhammad berdasarkan makna konseptual dan asosiatif perspektif Geoffrey Leech. Jenis yang digunakan dalam penelitian ini adalah metode penelitian kualitatif deskriptif. Sumber data primer dalam penelitian ini adalah puisi Akhbirna Nukhbiruka karya Sirajuddin Muhammad, sedangkan sumber data sekunder diambil dari buku-buku, jurnal ilmiah, dan artikel yang membahas tentang makna konseptual dan asosiatif perspektif Geoffrey Leech. Teknik pengumpulan data menggunakan teknik baca dan catat. Adapun teknik analisis data dalam penelitian yaitu reduksi data, paparan data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa (1) makna konseptual dalam puisi Akhbirna Nukhbiruka terdapat dalam tiga kata; (2) makna konotatif dalam puisi Akhbirna Nukhbiruka terdapat dalam 24 kata dan kalimat yang terbagi menjadi lima bagian yaitu: enam makna konotatif, empat makna stilistika, sepuluh makna afektif, dua makna reflektif, dan dua makna kolokatif; (3) kandungan makna dalam puisi Akhbirna Nukhbiruka menunjukkan tentang sindiran terhadap orang yang pelit, riya, penduduk Mesir, orang yang sombong, orang yang malas, orang yang bodoh; dan perintah untuk menggunakan waktu sebaik mungkin
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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