187,866 research outputs found
Subcutaneous Nadroparin Calcium in the Treatment of Recent Onset Retinal Vein Occlusion: A Pilot Study
No full textPurpose: Optimal management of retinal vein occlusion (RVO) is still a
matter of debate. The purpose of this pilot study was to investigate whether
nadroparin calcium may play some role in the treatment of recent onset (≤3 weeks'
duration) RVO. Methods: Twenty-four RVO patients were treated with subcutaneous
nadroparin calcium (200 I.U./kg/day) for 6 weeks. Best corrected visual acuity
(BCVA) and macular thickness in the affected eye were measured at baseline, and
after 3 and 6 months. Twenty-four RVO patients treated with oral pentoxifylline,
matched for age, gender, RVO type, eye involvement, and BCVA at presentation,
randomly selected from the RVO register, were used as controls. Results: Median
BCVAs at baseline, month 3, and month 6 were 20/70 (range: 20/1,000-20/20), 20/40
(range: 20/100-20/20), and 20/30 (range: 20/200-20/20) in cases and 20/70 (range:
20/1,000-20/20), 20/60 (range: 20/320-20/25), and 20/60 (range: 20/500-20/20) in
controls. Differences between groups were statistically significant at months 3
(P=0.025) and 6 (P=0.024). In the study group, the mean macular thickness was
510±207 μm at baseline, 384±198 μm after 3 months, and 313±170 μm after 6 months.
Differences between baseline and months 3 and 6 were statistically significant
(P=0.004 and P<0.001). Conclusions: Results suggest that nadroparin calcium might
become a potential candidate for the treatment of RVO. Larger trials are
necessary to confirm these preliminary findings
Vincens Jean, d'Iribarne A., Simula P. — Populations d'établissements et la prévision de l'emploi
No full textSauvy Alfred. Vincens Jean, d'Iribarne A., Simula P. — Populations d'établissements et la prévision de l'emploi. In: Population, 23ᵉ année, n°4, 1968. pp. 772-773
Vincens Jean, d'Iribarne A., Simula P. — Populations d'établissements et la prévision de l'emploi
No full textSauvy Alfred. Vincens Jean, d'Iribarne A., Simula P. — Populations d'établissements et la prévision de l'emploi. In: Population, 23ᵉ année, n°4, 1968. pp. 772-773
Trust your back : classification-based care for low back pain in primary care
No full textAbstract
Low back pain (LBP), mostly a non-specific symptom, is a leading cause of years lived with disability: multiple biological, psychological, social and lifestyle factors lead to pain-related disability and use of healthcare. Evidence-based care for LBP comprises active treatments that address biopsychosocial factors and focus on improving functioning, self-management, education, and advice to stay active, also at work. The STarT Back Tool (SBT) and the Örebro Musculoskeletal Pain Screening Questionnaire Short Form (ÖMPSQ-SF) were created to enable easy and systematic identification of predictive psychosocial and symptom-related factors. The patient education booklet was designed to support evidence-based care and reduce inappropriate imaging.
The study aim was to evaluate the concordance of the SBT and ÖMPSQ-SF and the accumulation of psychiatric, psychological, lifestyle, and social risk factors in the high-risk groups of both questionnaires among population with LBP. We also aimed to translate and validate the patient education booklet. We separately assessed the effectiveness of the patient education booklet and the classification-based approach to LBP care in primary care and compared it to that of usual care.
SBT and ÖMPSQ-SF were compared in a population-based study using the Northern Finland Birth Cohort 1966. The preliminary evaluation of the patient education booklet was obtained using web-based questionnaires. A cluster randomised study evaluated the effectiveness of the patient education booklet, and a Benchmarking Controlled Trial evaluated the effectiveness of a classification-based approach to LBP care in primary care.
Individual psychological and social risk factors accumulated among the high-risk groups of the SBT and the ÖMPSQ-SF. The education booklet helped patients understand their pain, encouraged them to be physically active, decreased imaging and the number of LBP-related sick leave days. Although classification-based care did not seem to influence physical functioning in the long term, pain was alleviated more quickly, and the use of healthcare services and number of back-related sick leave days decreased in the intervention group.
A combination of education for healthcare professionals, classification-based care using the SBT, and systematic use of the patient education booklet seems to bring value to LBP care in primary healthcare. Original papers Simula, A. S., Ruokolainen, O., Oura, P., Lausmaa, M., Holopainen, R., Paukkunen, M., Auvinen, J., Linton, S. J., Hill, J. C., & Karppinen, J. (2020). Association of STarT Back Tool and the short form of the Örebro Musculoskeletal Pain Screening Questionnaire with multidimensional risk factors. Scientific Reports, 10(1), 290. https://doi.org/10.1038/s41598-019-57105-3 https://doi.org/10.1038/s41598-019-57105-3 Self-archived version Simula, A. S., Jenkins, H. J., Holopainen, R., Oura, P., Korniloff, K., Häkkinen, A., Takala, E.-P., Hancock, M. J., & Karppinen, J. (2019). Transcultural adaption and preliminary evaluation of “understanding low back pain” patient education booklet. BMC Health Services Research, 19(1), 1010. https://doi.org/10.1186/s12913-019-4854-y https://doi.org/10.1186/s12913-019-4854-y Self-archived version Simula, A. S., Jenkins, H. J., Hancock, M. J., Malmivaara, A., Booth, N., & Karppinen, J. (2021). Patient education booklet to support evidence-based low back pain care in primary care – a cluster randomized controlled trial. BMC Family Practice, 22(1), 178. https://doi.org/10.1186/s12875-021-01529-2 https://doi.org/10.1186/s12875-021-01529-2 Self-archived version Simula, A. S., Malmivaara, A., Booth, N., & Karppinen, J. (2020). A classification-based approach to low back pain in primary care – protocol for a benchmarking controlled trial. BMC Family Practice, 21(1), 61. https://doi.org/10.1186/s12875-020-01135-8 https://doi.org/10.1186/s12875-020-01135-8 Self-archived version Simula, A. S., Malmivaara, A., Booth, N., & Karppinen, J. (2024). Effectiveness of a classification-based approach to low back pain in primary care – a benchmarking controlled trial. Journal of Rehabilitation Medicine, 56, jrm28321. https://doi.org/10.2340/jrm.v56.28321 https://doi.org/10.2340/jrm.v56.28321 Self-archived version Tiivistelmä
Alaselkäkipu on yleisin haittaa aiheuttava vaiva, enimmäkseen epäspesifi oire, jossa monet biologiset, psykologiset, sosiaaliset ja elintapatekijät vaikuttavat kipuun liittyvään haittaan ja terveyspalveluiden käyttöön. Näyttöön perustuva alaselkäkivun hoito on aktiivista ja huomioi biopsykososiaaliset tekijät. Hoidon keskiössä on toimintakyvyn parantaminen, omahoito, ohjaus ja neuvonta sekä ohje pysyä aktiivisena työ mukaan lukien. STarT-selkäkysely (SBT) ja Örebro-kipukysely (ÖMPSQ-SF) on kehitetty auttamaan ennustavien psykososiaalisten ja oireeseen liittyvien tekijöiden tunnistamisessa. Uusi potilasopas on kehitetty tukemaan näyttöön perustuvaa hoitoa ja vähentämään tarpeetonta kuvantamista.
Tavoitteemme oli arvioida SBT ja ÖMPSQ-SF yhdenmukaisuutta sekä psykiatristen, psykologisten, elintapaan liittyvien ja sosiaalisten riskitekijöiden kasautumista molempien kyselyiden korkeaan riskiryhmään alaselkäkipuisessa väestössä. Tavoitteena oli myös kääntää ja validoida uusi potilasopas suomeksi. Lisäksi arvioimme erikseen potilasoppaan vaikuttavuutta ja luokitteluun perustuvan hoitomallin vaikuttavuutta alaselkäkipupotilaiden hoidossa perusterveydenhuollossa.
SBT ja ÖMPSQ-SF vertailtiin väestöaineistossa käyttäen Pohjois-Suomen syntymäkohortti 1966 aineistoa. Alustava arvio potilasoppaasta tehtiin nettikyselyillä. Ryvässatunnaistetussa asetelmassa tutkittiin potilasoppaan vaikuttavuutta ja vertaiskontrolloidussa asetelmassa luokitteluun perustuvan hoitomallin jalkauttamisen vaikuttavuutta alaselkäkivun hoidossa perusterveydenhuollossa.
Yksilölliset psykologiset ja sosiaaliset riskitekijät kasautuivat SBT ja ÖMPSQ-SF korkean riskin ryhmiin. Potilasopas auttoi potilaita ymmärtämään heidän kipuansa, rohkaisi heitä olemaan fyysisesti aktiivisia ja vähensi alaselän kuvantamistutkimuksia sekä sairauslomapäiviä. Vaikka luokitteluun perustuva hoitomalli ei vaikuttanut fyysiseen toimintakykyyn pitkällä aikavälillä, kipuoireet näyttivät paranevan nopeammin, terveyspalvelujen käyttö oli vähäisempää ja selkäkipuun liittyvien sairaslomapäivien määrä oli pienempi interventioryhmässä.
Yhdessä terveydenhuollon ammattilaisten koulutus, luokitteluun perustuva alaselkäkipupotilaiden hoito STarT-selkäkyselyä käyttäen ja systemaattinen potilasoppaan käyttö näytti edistävän alaselkäkipupotilaiden hoitoa perusterveydenhuollossa. Osajulkaisut Simula, A. S., Ruokolainen, O., Oura, P., Lausmaa, M., Holopainen, R., Paukkunen, M., Auvinen, J., Linton, S. J., Hill, J. C., & Karppinen, J. (2020). Association of STarT Back Tool and the short form of the Örebro Musculoskeletal Pain Screening Questionnaire with multidimensional risk factors. Scientific Reports, 10(1), 290. https://doi.org/10.1038/s41598-019-57105-3 https://doi.org/10.1038/s41598-019-57105-3 Rinnakkaistallennettu versio Simula, A. S., Jenkins, H. J., Holopainen, R., Oura, P., Korniloff, K., Häkkinen, A., Takala, E.-P., Hancock, M. J., & Karppinen, J. (2019). Transcultural adaption and preliminary evaluation of “understanding low back pain” patient education booklet. BMC Health Services Research, 19(1), 1010. https://doi.org/10.1186/s12913-019-4854-y https://doi.org/10.1186/s12913-019-4854-y Rinnakkaistallennettu versio Simula, A. S., Jenkins, H. J., Hancock, M. J., Malmivaara, A., Booth, N., & Karppinen, J. (2021). Patient education booklet to support evidence-based low back pain care in primary care – a cluster randomized controlled trial. BMC Family Practice, 22(1), 178. https://doi.org/10.1186/s12875-021-01529-2 https://doi.org/10.1186/s12875-021-01529-2 Rinnakkaistallennettu versio Simula, A. S., Malmivaara, A., Booth, N., & Karppinen, J. (2020). A classification-based approach to low back pain in primary care – protocol for a benchmarking controlled trial. BMC Family Practice, 21(1), 61. https://doi.org/10.1186/s12875-020-01135-8 https://doi.org/10.1186/s12875-020-01135-8 Rinnakkaistallennettu versio Simula, A. S., Malmivaara, A., Booth, N., & Karppinen, J. (2024). Effectiveness of a classification-based approach to low back pain in primary care – a benchmarking controlled trial. Journal of Rehabilitation Medicine, 56, jrm28321. https://doi.org/10.2340/jrm.v56.28321 https://doi.org/10.2340/jrm.v56.28321 Rinnakkaistallennettu versio Academic dissertation to be presented with the assent of the Doctoral Programme Committee of Health and Biosciences of the University of Oulu for public defence in MKS Auditorium (Mikkeli), on 13 December 2024, at 12 noonAbstract
Low back pain (LBP), mostly a non-specific symptom, is a leading cause of years lived with disability: multiple biological, psychological, social and lifestyle factors lead to pain-related disability and use of healthcare. Evidence-based care for LBP comprises active treatments that address biopsychosocial factors and focus on improving functioning, self-management, education, and advice to stay active, also at work. The STarT Back Tool (SBT) and the Örebro Musculoskeletal Pain Screening Questionnaire Short Form (ÖMPSQ-SF) were created to enable easy and systematic identification of predictive psychosocial and symptom-related factors. The patient education booklet was designed to support evidence-based care and reduce inappropriate imaging.
The study aim was to evaluate the concordance of the SBT and ÖMPSQ-SF and the accumulation of psychiatric, psychological, lifestyle, and social risk factors in the high-risk groups of both questionnaires among population with LBP. We also aimed to translate and validate the patient education booklet. We separately assessed the effectiveness of the patient education booklet and the classification-based approach to LBP care in primary care and compared it to that of usual care.
SBT and ÖMPSQ-SF were compared in a population-based study using the Northern Finland Birth Cohort 1966. The preliminary evaluation of the patient education booklet was obtained using web-based questionnaires. A cluster randomised study evaluated the effectiveness of the patient education booklet, and a Benchmarking Controlled Trial evaluated the effectiveness of a classification-based approach to LBP care in primary care.
Individual psychological and social risk factors accumulated among the high-risk groups of the SBT and the ÖMPSQ-SF. The education booklet helped patients understand their pain, encouraged them to be physically active, decreased imaging and the number of LBP-related sick leave days. Although classification-based care did not seem to influence physical functioning in the long term, pain was alleviated more quickly, and the use of healthcare services and number of back-related sick leave days decreased in the intervention group.
A combination of education for healthcare professionals, classification-based care using the SBT, and systematic use of the patient education booklet seems to bring value to LBP care in primary healthcare.Tiivistelmä
Alaselkäkipu on yleisin haittaa aiheuttava vaiva, enimmäkseen epäspesifi oire, jossa monet biologiset, psykologiset, sosiaaliset ja elintapatekijät vaikuttavat kipuun liittyvään haittaan ja terveyspalveluiden käyttöön. Näyttöön perustuva alaselkäkivun hoito on aktiivista ja huomioi biopsykososiaaliset tekijät. Hoidon keskiössä on toimintakyvyn parantaminen, omahoito, ohjaus ja neuvonta sekä ohje pysyä aktiivisena työ mukaan lukien. STarT-selkäkysely (SBT) ja Örebro-kipukysely (ÖMPSQ-SF) on kehitetty auttamaan ennustavien psykososiaalisten ja oireeseen liittyvien tekijöiden tunnistamisessa. Uusi potilasopas on kehitetty tukemaan näyttöön perustuvaa hoitoa ja vähentämään tarpeetonta kuvantamista.
Tavoitteemme oli arvioida SBT ja ÖMPSQ-SF yhdenmukaisuutta sekä psykiatristen, psykologisten, elintapaan liittyvien ja sosiaalisten riskitekijöiden kasautumista molempien kyselyiden korkeaan riskiryhmään alaselkäkipuisessa väestössä. Tavoitteena oli myös kääntää ja validoida uusi potilasopas suomeksi. Lisäksi arvioimme erikseen potilasoppaan vaikuttavuutta ja luokitteluun perustuvan hoitomallin vaikuttavuutta alaselkäkipupotilaiden hoidossa perusterveydenhuollossa.
SBT ja ÖMPSQ-SF vertailtiin väestöaineistossa käyttäen Pohjois-Suomen syntymäkohortti 1966 aineistoa. Alustava arvio potilasoppaasta tehtiin nettikyselyillä. Ryvässatunnaistetussa asetelmassa tutkittiin potilasoppaan vaikuttavuutta ja vertaiskontrolloidussa asetelmassa luokitteluun perustuvan hoitomallin jalkauttamisen vaikuttavuutta alaselkäkivun hoidossa perusterveydenhuollossa.
Yksilölliset psykologiset ja sosiaaliset riskitekijät kasautuivat SBT ja ÖMPSQ-SF korkean riskin ryhmiin. Potilasopas auttoi potilaita ymmärtämään heidän kipuansa, rohkaisi heitä olemaan fyysisesti aktiivisia ja vähensi alaselän kuvantamistutkimuksia sekä sairauslomapäiviä. Vaikka luokitteluun perustuva hoitomalli ei vaikuttanut fyysiseen toimintakykyyn pitkällä aikavälillä, kipuoireet näyttivät paranevan nopeammin, terveyspalvelujen käyttö oli vähäisempää ja selkäkipuun liittyvien sairaslomapäivien määrä oli pienempi interventioryhmässä.
Yhdessä terveydenhuollon ammattilaisten koulutus, luokitteluun perustuva alaselkäkipupotilaiden hoito STarT-selkäkyselyä käyttäen ja systemaattinen potilasoppaan käyttö näytti edistävän alaselkäkipupotilaiden hoitoa perusterveydenhuollossa
Neutron electric dipole moment on the lattice: a theoretical reappraisal
No full textWe present a strategy for a lattice evaluation of the neutron electric dipole moment induced by the strong CP violating term of the QCD lagrangian. Our strategy is based on the standard definition of the electric dipole moment, involving the charge density operator J(0), in case of three flavors with non-degenerate masses. We present a complete diagrammatic analysis showing how the axial chiral Ward identities can be used to replace the topological charge operator with the flavor-singlet pseudoscalar density P-S. Our final result is characterized only by disconnected diagrams, where the disconnected part can be either the single insertion of P-S or the separate insertions of both P-S and J(0). The applicability of our strategy to the case of lattice formulations that explicitly break chiral symmetry, like the Wilson and Clover actions, is discussed
K ->pi l nu semileptonic form factors from two-flavor lattice QCD
No full textWe present new lattice results of the K ->pi l nu semileptonic form factors obtained from simulations with two flavors of dynamicaltwisted-mass fermions, using pion masses as light as 260 MeV. Our main result is f(+)(0)=0.9560(84), which, combined with the latest experimental data for Kl3 decays, leads to |Vus|=0.2267(5)(exp)(20)(f+(0)). Using the PDG(2008) determinations of|Vud| and |Vub| our result implies for the unitarity relation |Vud|^2+|Vus|^2+|Vub|^2=1.0004(15). For the O(p^6) term of the chiral expansion of f+(0) we get Delta f = f+(0)-1-f2=-0.0214(84)
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Muscle spindle and periodontal trigeminal afferents modulate the hypoglossal motoneuronal activity.
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The carboxyterminal peptide of chorionic gonadotropin facilitates activation of the marmoset LH receptor
No full textLuteinizing hormone (LH) and chorionic gonadotropin (CG) are heterodimeric glycoprotein hormones acting on the luteinizing hormone receptor (LHR). In the LHR, which is genomically encoded by eleven exons, exon 10 encodes for the hinge region and its elimination impairs LH action, while CG maintains normal activity. The two gonadotropins differ in the carboxyterminal peptide (CTP) present in CG but absent in LH. Since the marmoset monkey (Callithrix jacchus) LHR naturally lacks exon 10 (LHR type II), we generated two recombinant marmoset gonadotropin preparations, one consisting of the wild type CG and one of truncated CG lacking the CTP (CG (-CTP)). After calibration in a mouse Leydig cell bioassay against the WHO LH80/522 standard, the ED (50) of the CG preparation on a COS7 cell line permanently expressing the marmoset LHR was 4.25 +/- 0.21 IU/L (n = 3). Stimulation of the COS7 cell line with equipotent concentrations of CG and CG (-CTP) resulted in significantly different formation of cAMP (two-way ANOVA, p < 0.001). In particular, cAMP production stimulated by CG (-CTP) was 3 - 4 times lower compared to CG at the saturating CG concentration (8 IU/L). We conclude, supplementing one current model of LHR activation, that exon 10 might play a permissive role in releasing the constraint of the receptor upon hormone binding, resulting in receptor activation. We speculate that, when exon 10 is lacking, the CTP can overcome its absence and facilitates the opening of the receptor, resulting in normal activation.T. Müller, J. Gromoll, A. P. Simula, R. Norman, R. Sandhowe-Klaverkamp, M. Simon
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