6,514 research outputs found
War of Ghosts: Marshall, Veblen and Bartlett
No full textThe article discusses the historical relationship between economics and the tradition of experimental psychology established at Cambridge University. At the same time, we explore how the Cambridge model of the mind was implemented in the United States by Thorstein Veblen, who claimed instinct theory as a novel foundation for his evolutionary-institutional economics. While Veblen identified Alfred Marshall's economics with an older version of psychology, our comparison of the psychological thought of these two economists, as well as our investigation into the social dimensions and possibilities of the Cambridge psychological tradition as developed in the early twentieth century by F. C. Bartlett, points to substantial common ground
A chart of part of the south coast of Newfoundland [cartographic material] : includingthe islands St. Peters and Miquelon, from an actual survey /
No full textDetailed chart of part of the Newfoundland, Canadian coast with relief shown by hachures and bathymetric soundings.; "Scale to the general chart English and French leagues 20 to a degree"; Accompanied by booklet: Directions for navigating on part of the south coast of Newfoundland, with a chart thereof, including the islands of St. Peter's and Miquelon ... / by James Cook. London : Printed for the author, and sold by J.Mount and T. Page on Tower-Hill, 1766. 32 p. : 24 cm.; Insets: Harbours of St. Laurence; Harbour [of] Briton.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.map-rm423
Nutrient-responsive mTOR signalling grows on Sterile ground
No full textThe control of cell growth, that is cell size, is largely controlled by mTOR (the mammalian target of rapamycin), a large serine/threonine protein kinase that regulates ribosome biogenesis and protein translation. mTOR activity is regulated both by the availability of growth factors, such as insulin/IGF-1 (insulin-like growth factor 1), and by nutrients, notably the supply of certain key amino acids. The last few years have seen a remarkable increase in our understanding of the canonical, growth factor-regulated pathway for mTOR activation, which is mediated by the class I PI3Ks (phosphoinositide 3-kinases), PKB (protein kinase B), TSC1/2 (the tuberous sclerosis complex) and the small GTPase, Rheb. However, the nutrient-responsive input into mTOR is important in its own right and is also required for maximal activation of mTOR signalling by growth factors. Despite this, the details of the nutrient-responsive signalling pathway(s) controlling mTOR have remained elusive, although recent studies have suggested a role for the class III PI3K hVps34. In this issue of the Biochemical Journal, Findlay et al. demonstrate that the protein kinase MAP4K3 [mitogen-activated protein kinase kinase kinase kinase-3, a Ste20 family protein kinase also known as GLK (germinal centre-like kinase)] is a new component of the nutrient-responsive pathway. MAP4K3 activity is stimulated by administration of amino acids, but not growth factors, and this is insensitive to rapamycin, most likely placing MAP4K3 upstream of mTOR. Indeed, MAP4K3 is required for phosphorylation of known mTOR targets such as S6K1 (S6 kinase 1), and overexpression of MAP4K3 promotes the rapamycin-sensitive phosphorylation of these same targets. Finally, knockdown of MAP4K3 levels causes a decrease in cell size. The results suggest that MAP4K3 is a new component in the nutrient-responsive pathway for mTOR activation and reveal a completely new function for MAP4K3 in promoting cell growth. Given that mTOR activity is frequently deregulated in cancer, there is much interest in new strategies for inhibition of this pathway. In this context, MAP4K3 looks like an attractive drug target since inhibitors of this enzyme should switch off mTOR, thereby inhibiting cell growth and proliferation, and promoting apoptosis
Where Participatory Approaches Meet Pragmatism in Funded (Health) Research: The Challenge of Finding Meaningful Spaces
No full textThe term participatory research is now widely used as a way of categorising research that has moved beyond researching "on" to researching "with" participants. This paper draws attention to some confusions that lie behind such categorisation and the potential impact of those confusions on qualitative participatory research in practice. It illuminates some of the negative effects of "fitting in" to spaces devised by other types of research and highlights the importance of forging spaces for presenting participatory research designs that suit a discursive approach and that allow the quality and impact of such research to be recognised. The main contention is that the adoption of a variety of approaches and purposes is part of the strength of participatory research but that to date the paradigm has not been sufficiently articulated. Clarifying the unifying features of the participatory paradigm and shaping appropriate ways for critique could support the embedding of participatory research into research environments, funding schemes and administration in a way that better reflects the nature and purpose of authentic involvement
7_18-0122_Supplementary_Material_1_final_rpw_(1) - A Multidisciplinary Survey to Assess Facilitators and Barriers to Successful Organ Donation in the Intensive Care Unit
No full text7_18-0122_Supplementary_Material_1_final_rpw_(1) for A Multidisciplinary Survey to Assess Facilitators and Barriers to Successful Organ Donation in the Intensive Care Unit by Simon J. W. Oczkowski, Pamela Durepos, John Centofanti, Erika Arsenau, Sonny Dhanani, Deborah J. Cook, and Maureen O. Meade in Progress in Transplantation</p
8_18-0122_Supplementary_Material_2_final_rpw_(2) - A Multidisciplinary Survey to Assess Facilitators and Barriers to Successful Organ Donation in the Intensive Care Unit
No full text8_18-0122_Supplementary_Material_2_final_rpw_(2) for A Multidisciplinary Survey to Assess Facilitators and Barriers to Successful Organ Donation in the Intensive Care Unit by Simon J. W. Oczkowski, Pamela Durepos, John Centofanti, Erika Arsenau, Sonny Dhanani, Deborah J. Cook, and Maureen O. Meade in Progress in Transplantation</p
Synthesis and structures of potassium bisdithiocarbamate salts
No full textTwo structurally related dipotassium bisdithiocarbamate salts: K2[(S2CNRCH2)2](EtOH)2; R = Me, i-Pr, were synthesised from the corresponding diamines. X-ray structure determinations were performed on single crystals grown from ethanolic solutions. The different alkyl substituents have a profound affect upon the solid-state structures, with the methyl derivative possessing a complex a 3-D network and the isopropyl derivative a 2-D lamellar structure
Xystodesmidae Cook 1895
No full textFamily Xystodesmidae Cook, 1895 <p> <b>Subfamily Xystodesminae Cook, 1895</b></p> <p> <b>Tribe Xystocheirini Hoffman, 1980</b></p> <p> Hoffman (1999) mistakenly attributed tribal authorship to Cook without a date, perhaps because he confused this name with Xystodesmidae /inae, which Cook (1895) did author, or because Cook (1904) subsequently authored the genus. However, the first usage of <i>Xystocheir</i> at the family-group level was by Hoffman (1980), as he then noted, and authorship is properly attributed to him.</p>Published as part of <i>Shelley, Rowland M., Smith, Jamie M. & Ross, Deren J., 2014, Variation and pigmentation in the milliped, Xystocheir brachymacris Shelley, 1996, from the northern Sierra Nevada foothills, California, USA (Polydesmida: Xystodesmidae: Xystocheirini), pp. 1-6 in Insecta Mundi 2014 (371)</i> on page 2, DOI: <a href="http://zenodo.org/record/5179327">10.5281/zenodo.5179327</a>
COOK, George
No full textTitle: Papers, 1855-1931 Description: .5 linear ft.
Notes: Author, educator. Includes correspondence, manuscripts, addresses, biographical sketches, memorials, photographs, a scrapbook and a song composed by William Weston Patton, President of Howard University. Gift, 1958.
Subjects: Business; Education; Washington (DC). Childers, Lulu V. Du Bois, W. E. B. (William Edward Burghardt), 1868-1963; As correspondent Funeral rites and ceremonies; Cook, George William Howard University; Administration Howard University; Faculty; Cook, George William Howard University; Presidents; Patton, William Weston Howard University; Students; Cook, George William Howard University, Washington (DC); Faculty members\u27 papers Howard University, Washington (DC); School of Commerce and Finance Patton, William Weston Roosevelt, Theodore, 1858-1919; As correspondent Spingarn, J. E. (Joel Elias), 1875-1939 Tunnell, W. V. White, Walter F. (Walter Francis), 1893-1955; As correspondent Wilkinson, F. D. Woodson, Carter G. (Carter Godwin), 1875-1950
Location: Howard University, Moorland-Spingarn Research Center (Washington, DC) NIDS Fiche #: 4.72.22 NUCMC Number: MS 83-122
Contemporaneity of Clactonian and Acheulean flint industries at Barnham, Suffolk
No full textNew field evidence challenges an old-established fundamental of the Lower Palaeolithic sequence in Britain
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