1,720,954 research outputs found
Perbandingan Kadar PGE2 pada Mikroenkapsulasi MSC dan HSC-CD34 sebagai Potensial Terapi Seluler MDR-TB
Full text linkLatar belakang penelitian ini untuk melawan Tuberkulosis (TB) telah digunakan obat-obatan selama puluhan tahun, namun selama perjalanannya juga telah menghasilkan strain yang resistan terhadap satu atau lebih obat-obat ini, yang disebut dengan multidrug-resistant tuberculosis (MDR-TB). Terapi konvensional untuk MDR-TB sangat menantang dan membutuhkan waktu yang panjang sehingga dapat menyebabkan efek merugikan yang signifikan terhadap pasien. Selama satu dekade terakhir, pengobatan untuk penyakit degeneratif, infeksi dan metabolik telah berkembang ke arah terapi seluler, khususnya penggunaan terapi stem cell. Stem cell akan mengeluarkan parakrin yang berperan sebagai immunomodulator dan antiinflamasi salah satunya PGE2. Masih belum diketahui bagaimana kadar parakrin PGE2 yang dihasilkan oleh mikroenkapsulasi yang akan digunakan sebagai studi preliminari untuk terapi seluler MDR-TB. Tujuan penelitian ini untuk mengembangkan terapi seluler MDR TB dengan menggunakan parakrin kapsulasi mesenchymal stem cell dan hematopoietic stem cell asal tali pusat. Metode penelitian ini terdiri atas 2 tahap, dimana pada tahap pertama merupakan isolasi, kultur dan enkapsulasi mesenchymal stem cell dan hematopoietic stem cell. Tahap kedua merupakan uji kadar PGE2 pada stem cell yang dimikroenkapsulasi pada hari ke-7, ke-14, dan ke-21. Hasilnya menunjukkan Kadar PGE2 yang dihasilkan oleh mikroenkapsulasi MSC meningkat secara lebih signifikan dibandingkan dengan yang dihasilkan oleh mikroenkapsulasi HSC-CD34. Dengan menggunakan mikroenkapsulasi membuat PGE2 tidak dapat berdifusi keluar sehingga akan menjadi sarana penghantaran yang baik menuju organ yang bermasalah
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Antibacterial Activity of Sweet Orange (Citrus sinensis) Peel Tea against Enterobacteriaceae Isolated from a Water Depot
Full text linkMost orange peels are not utilized and become useless waste that is thrown away. Orange peels contain many nutrients and compounds, such as flavonoids, terpenoids, alkaloids, and essential oils, which are secondary metabolites that act as antibacterial agents. This study intends to investigate the antibacterial activity of sweet orange peel tea against isolated Enterobacteriaceae from a random water depot sample around Universitas Prima Indonesia. This experiment used disc diffusion for antibacterial assay. Meanwhile, the sweet orange peel was brewed using two different methods, including infusion and decoction, in two different masses (3 grams and 5 grams). These sweet orange peel tea formulations were compared to standard (chloramphenicol) and control (distilled water). Enterobacteriaceae was isolated and identified from a random water depot sample around Universitas Prima Indonesia, which included colony identification in EMB agar and MacConkey agar, gram staining, and biochemical test. This study showed that a random water depot sample contaminated by Enterobacteriaceae had properties similar to Citrobacter sp. Sweet orange tea formulation inhibited this isolated Enterobacteriaceae growth (P-Value: 0.010). Antibacterial activity was observed in 3-gram infusion, 5-gram infusion, and 5-gram decoction. However, the antibacterial activity was not better than the standard (chloramphenicol). Overall, it can be concluded that the sweet orange peel tea as infusion or decoction has weak antibacterial activity against Enterobacteriaceae bacteria isolated from water depots, which had some properties similar to Citrobacter sp
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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