63 research outputs found

    The Role of Surgery in Pleural Mesothelioma: A Journey through the Evidence, MARS 2 and Beyond

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    Pleural mesothelioma (PM) is a rare incurable disease, predominantly linked to asbestos exposure. Not only is diagnosis difficult, but treatment choices are often limited to systemic anti-cancer treatment with chemotherapy or immunotherapy. Surgery has been employed for decades, but its application has been fiercely debated despite some randomized controlled trials such as the recent Mesothelioma and Radical Surgery 2 (MARS 2) study. We provide a commentary on this controversial topic. © The Author(s) 2025

    Averaged strain energy density estimated rapidly from nodal displacements by coarse fe analyses: cracks under mixed mode loadings

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    The strain energy density (SED) averaged over a structural volume allows to assess the fracture and fatigue behaviour of cracked components under mixed-mode loadings. To rapidly estimate the averaged SED , two approaches have been previously proposed: (i) the direct approach; (ii) the peak stress method (PSM) and nodal stress (NS) approach. In this paper the nodal displacement (ND) approach is presented to rapidly estimate the averaged SED from the nodal displacements by FE analyses. This method combines the advantages of all previous approaches, i.e. the use of coarse meshes able to capture the contributions of both stress intensity factors (SIFs) and higher order terms, without requiring geometrical modelling of the control volume. To validate the method, cracked plates and cracked bars under mixed-mode loadings have been analysed. The averaged SED values estimated by the ND approach agree with those calculated by the direct approach, within a range of applicability

    Calcolo rapido del SED mediato per la verifica strutturale di componenti indeboliti da intagli severi

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    L'approccio SED consente di effettuare la verifica strutturale di componenti indeboliti da intagli, tra cui la maggior parte dei giunti saldati. In questa tesi vengono sviluppati due metodi innovativi per il calcolo del SED mediato in un generico componente intagliato tramite software agli elementi finiti.ope

    Calcolo rapido del SED mediato per la verifica strutturale di componenti indeboliti da intagli severi

    No full text
    L'approccio SED consente di effettuare la verifica strutturale di componenti indeboliti da intagli, tra cui la maggior parte dei giunti saldati. In questa tesi vengono sviluppati due metodi innovativi per il calcolo del SED mediato in un generico componente intagliato tramite software agli elementi finiti

    Relationship between comorbid factors and mortality in patients with necrotizing enterocolitis

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    the Author analyze factors that determine mortality in newborns affected by necrotizing enterocoliti

    Code and Data for Prediction of SARS-Cov-2-positivity from million-scale complete blood counts using machine learning

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    Sample data and code for easy reproducibility of results described in the paper Prediction of SARS-CoV-2-positivity from million-scale complete blood counts using machine learning. Please see the paper for the full author list and more details. https://www.nature.com/articles/s43856-022-00129-0 </p

    Literatura Popular: Análisis de la Leyenda de Cantuña y del cuento “El tesoro del Tres de Mayo”

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    El trabajo de investigación denominado Literatura popular: Análisis de la leyenda de Cantuña y del cuento “El tesoro del tres de mayo”, tiene como objetivo profundizar en el estudio de la literatura popular mediante el análisis de la Leyenda de Cantuña y el cuento “El tesoro del tres de mayo”. Para la realización del mismo, se contó con la participación de la interesada y de la tutora designada por la universidad. Además, se tuvo una importante colaboración del autor del cuento analizado y la guía de un recopilador de obras breves de literatura popular de Morona Santiago. Al ser una investigación cualitativa, para realizarla se utilizó la técnica de la entrevista y el diálogo oral tanto con el recopilador de literatura popular como con el autor del cuento, además de la investigación bibliográfica necesaria para la elaboración del marco teórico. Se llegó a la conclusión de que el estudio de la literatura popular es fundamental para el desarrollo cultural de nuestro país.The research work: “Popular literature: Analysis of the legend of Cantuña and the story ‘The treasure of third of May’”, has like target to penetrate into the study of the popular literature through the analysis of the legend of Cantuña and the story “The treasure of third of May”. For this work, it is attended by the interested person and the tutor appointed by the university. In addition, there was had an important collaboration of the author of the analyzed story and the guide of a reporter of brief works of Morona Santiago's popular literature. To the being a qualitative investigation, to realize it was in use the technique of the interview and the oral dialog both with the reporter of popular literature and with the author of the story, besides the bibliographical investigation necessary for the production of the theoretical framework. It came near to the conclusion that the study of the popular literature is fundamental for the cultural development of our country
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