186 research outputs found
Effect of chemical composition on hot cracking susceptibility (HCS) using various hot cracking criteria
No full textThe paper aims to evaluate the effect of chemical composition on the Hot Cracking Susceptibility (HCS) using mechanical and non-mechanical hot cracking criteria during solidification. The criteria were SKK as a mechanical criterion. Feurer, Clyne Davis, and Katgerman as non-mechanical criteria. The criteria were implemented at various parameters to evaluate their abilities in the hot cracking susceptibility (HCS) prediction at varied chemical composition. In this study, The Mg content was varied in Al9Zn (1, 1.5, 2, 2.5 %wt.) Mg2Cu alloys and Cu content in Al9Zn2Mg (1, 1.5, 2, 2.5 %wt.) Cu alloys. The validation of the result is also conducted by comparing with the experimental data. Based on Feurer criterion, The hot cracking initiates at lower temperature and at higher critical rate of feeding and shrinkage with Cu content, and the hot cracking initiates at higher temperature with Mg content, and it initiates at higher critical rate of feeding and shrinkage from 1 up to 1.5 of Mg, and the critical rate of feeding and shrinkage remains constant from 1.5 up to 2.5 of Mg. Based on Clyne & Davies, the HCS decreases with Cu content from 1 up to 2 of Cu, and it increases from 2 up to 2.5 of Cu. The HCS decreases with Mg content from 1 up to 2 of Mg, and it remains constant from 2 up to 2.5 of Mg. Based on Katgerman criterion, the HCS decreases with Cu content from 1 up to 1.5 of Cu, it increases from 1.5 up to 2 of Cu, and it decreases from 2 up to 2.5 of Cu. The HCS decreases sequentially with Mg content. Based on SKK criterion, the HCS curves shift to the right with Cu content which means that the hot cracking initiates at lower temperature, and the HCS curves shift to the left with Mg content which means that the hot cracking initiates at higher temperature with Mg content. The Feurer, Clyne & Davies, and some specific range for SKK criteria are in agreement for the effect of Cu content on HCS of alloys, and Katgerman and some specific range for Clyne&Davies criteria are in agreement for the effect of Mg content on HCS of alloys.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Joris Di
Hospital Colônia Sant'Ana: o saber/poder dos enfermeiros e as transformações históricas (1971-1981)
No full textTese (Doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Enfermagem, Florianópolis, 2010Trata-se de uma pesquisa sócio-histórica com abordagem qualitativa, cujo objetivo foi historicizar as transformações ocorridas no Hospital Colônia Sant'Ana (HCS), em especial na enfermagem, a partir do ingresso dos enfermeiros com seus saberes de 1971 e 1981. A investigação privilegiou a história oral como fonte de consulta buscando confirmar a tese de que os enfermeiros, com seus saberes e poderes, provocaram transformações administrativas, estruturais e nas práticas assistenciais no HCS, em especial na enfermagem, no período compreendido entre 1971 a 1981. A análise se pautou no referencial teórico foucaultiano sobre o saber/poder. Na coleta de dados, realizaram-se entrevistas semiestruturadas com 16 personagens que atuaram direta ou indiretamente no HCS no período do estudo, as quais constituíram as fontes orais. Com o intuito de subsidiar as entrevistas realizadas e complementar os dados, foram pesquisadas outras fontes documentais como livros, jornais, relatórios de governos, de secretários da saúde estaduais, dos diretores da instituição e fotografias do acervo da própria instituição, dos entrevistados e do Grupo de Estudos da História do Conhecimento da Enfermagem e Saúde (GEHCES/UFSC). Os dados foram organizados tendo por base a análise de conteúdo, sendo obtidas as seguintes categorias: 1) O panorama político social e de saúde em Santa Catarina e sua relação com o Hospital Colônia Sant#Ana na década de 1970; 2) O contexto do Hospital Colônia Sant#Ana no início da década de 1970; 3) O processo de profissionalização no Hospital Colônia Sant#Ana: o ingresso dos enfermeiros e de outros profissionais; 4) As transformações no Hospital Colônia Sant#Ana e na enfermagem de 1971 a 1981; 5) As relações de saber/poder no Hospital Colônia Sant#Ana e na enfermagem, no período de 14 1971 a 1981. Os resultados obtidos permitem afirmar que a tese formulada foi comprovada no decorrer do estudo, pois evidenciou que o ingresso dos enfermeiros no HCS, foi marcado por importantes transformações na enfermagem e na instituição, o que lhes conferiu poder. A chegada do primeiro enfermeiro no HCS em 1971, e posteriormente de outros profissionais durante uma década, promoveu a sucessiva atualização do saber técnico-científico, possibilitando a diversidade de transformações na enfermagem e na instituição. Esse evento foi decorrente de um processo político e social que já vinha ocorrendo no estado de Santa Catarina e que impulsionou a profissionalização na instituição, em particular na enfermagem. Essa profissionalização permitiu o maior controle no gerenciamento das práticas de enfermagem e resultou no afastamento progressivo das religiosas, que até então, respondiam por todos os serviços lá prestados. Esse processo estabeleceu uma modificação importante nas relações de saber/poder entre os diversos trabalhadores no HCS, em especial, os agentes de enfermagem, cuja prática, foi historicamente centrada na figura dos médicos e das religiosas. Essas transformações foram fundamentais e contribuíram de forma expressiva para o progressivo desenvolvimento da assistência de enfermagem mais humanizada ao doente mental no HCS, com reflexos na assistência em saúde mental de todo o Estado.It is a socio-historical research with a qualitative approach, whose aim was to historicize the transformations of the Sant'Anna Hospital Cologne (HCS), particularly in nursing, from the entry of nurses with their knowledge of 1971 and 1981. The investigation focused oral history as a source of consultation seeking to confirm the thesis that nurses, with their knowledge and power, caused administrative changes, structural and in care practices in HCS, particularly in nursing, in the period 1971 to 1981. The analysis was based on the theoretical framework of the Foucauldian power / knowledge. In collecting data, semi structured interviews were conducted with 16 characters that acted directly or indirectly in the HCS during the study period, which constituted the oral sources. In order to support the interviews and supplementary data were researched documentary sources such as books, journals, reports from governments, the state health secretaries, directors of the institution's collection and photographs of the institution, and the Group of respondents Study of the History of Nursing Knowledge and Health (GEHCES / UFSC). Data were organized based on content analysis, and obtained the following categories: 1) The political background and social health in Santa Catarina and its relationship with the Colony Hospital Sant'Anna in the 1970s, 2) The context of Sant'Anna in the early 1970s; 3) The process of professionalization in the Sant'Anna Hospital Cologne: the inflow of nurses and other professionals, 4) The changes in the Sant'Anna Hospital Cologne and nursing from 1971 to 1981; 5) The relations of power/knowledge in Cologne Sant'Anna Hospital and nursing in the period 1971 to 1981. The results have revealed that the formulated thesis was proven during the study, because it showed that the inflow of nurses in the HCS, was marked by important changes in nursing and in the institution, which gave them power. The arrival of the first nurses in the HCS 18 in 1971, and later from other professionals for a decade, promoted the successive update of technical and scientific knowledge, enabling a variety of changes in nursing and in the institution. This event was due to a political and social process that has been occurring in the state of Santa Catarina, and that boosted the professionalism in the institution, particularly in nursing. This professionalism has allowed greater control in the management of nursing practice and resulted in the gradual removal of the nuns, until then, accounted for all the services provided there. This process has established a significant change in relations of power / knowledge among many workers in the HCS, especially the nursing staff, whose practice has historically focused on the figure of the doctors and nuns. These changes were essential and contributed significantly to the progressive development of more humane nursing care to the mentally ill in the HCS, with reflections on mental health care across the state
MICROWAVE SPECTRA OF THE HCS AND THE HSC RADICALS
No full text H. Habara, S. Yamamoto, C. Ochsenfeld, M. Head-Gordon. R.I. Kaiser, and Y.T. Lee, J. Chem. Phys. 108, 8859 (1998).Author Institution: Department of Physics, The University of Tokyo rotational transition of the HCS radical in the electronic ground state was observed in our laboratory using the Fourier transform millimeter-wave (FTMW) . The HCS radical was generated in a free expansion molecular gas which was prepared by discharging a hydrogen sulfide and methane mixture diluted in argon. On the basis of the measurements of the transition, we also observed higher-N rotational transitions of HCS using a conventional millimeter-and submillimeter-wave spectrometer combined with a glow discharge cell. In this case, the HCS radical was produced by discharging a gaseous mixture of hydrogen sulfide and carbon monoxide. A series of the a-type R-branch pure rotational transitions with was observed up to 362 GHz. Molecular constants including hyperfine interaction terms were determined accurately from the observed frequencies. The Fermi contact term of the hydrogen nucleus of HCS is found to be 127 MHz, which is much smaller than that of HCO (389 MHz). This implies the quasi-linear nature of HCS. During a search for the lines of HCS, other strong paramagnetic lines that showed the K-structure pattern of an asymmetric free radical were observed. This strong spectrum was observed in the same experimental condition as the HCS radical. Judging from the rotational constants (, and ), we concluded that these lines are due to the HSC radical in its electronic ground state, which is the structural isomer of the HCS radical. There is no experimental study of the HSC radical so far. More than one hundred transitions lines including a-type R-branch and b-type Q-branch rotational transitions were measured for HSC, and nineteen molecular constants were determined accurately
Software Quality Prediction Model with the Aid of Advanced Neural Network with HCS
No full textAbstractSoftware quality is regarded as the highly important factors for assessing the global competitive position of any software product. To assure quality, and to assess the reliability of software products, many software quality prediction models have been proposed in the past decades. In this proposed method we have utilized a hybrid method for quality prediction. The prediction is done with the help of the Advanced Neural network which is incorporated with Hybrid Cuckoo search (HCS) optimization algorithm for better prediction accuracy. The application software is first subjected to test case generation and once the test cases are generated they are applied to advanced neural network for the prediction of quality. The neural network is improved by utilizing HCS which optimizes the weight factor for improving the prediction. The quality metrics like maintainability and reliability are estimated for predicting the software quality and the results are compared with other existing techniques to verify the effectiveness of our proposed method
MoS2 nanosheets supported on hollow carbon spheres as efficient catalysts for electrochemical hydrogen evolution reaction
No full textHybridizing structured carbon materials with MoS2 has
been demonstrated to be an effective method to increase the
electrochemical hydrogen evolution reaction (HER) activity and
durability of MoS2. In this study, we report the growth of MoS2
nanosheets on the surface of uniform hollow carbon spheres (HCS) to
form a hydrangea-like nanocomposite. The HCS were formed through
carbonization of a phenol formaldehyde template, and the MoS2
nanosheets were grown on the HCS surfaces through a hydrothermal
method. The nanocomposites have the advantages of significantly
improved electrical conductivity, ease of varying the MoS2 loading, and
minimizing stacking of MoS2 nanosheets, which are manifested by their
remarkably improved HER performance. The well-tuned carbon−MoS2
composite shows a Tafel slope of 48.9 mV dec−1, an onset potential of
−0.079 V (vs reversible hydrogen electrode), and an overpotential of 126
mV at the current density of 10 mA cm−2 after 1000 potential cycles
Anàlisi genètica i funcional de la migranya hemiplègica i la migranya comuna
No full text[cat] Aquesta tesi es centra en la genètica de la migranya. La migranya comuna és un trastorn neurològic caracteritzat per episodis recurrents de mal de cap. Els criteris de la IHS (International Headache Society) subclasifiquen la malaltia en migranya amb aura (MA) i migranya sense aura (MO). L'aura són símptomes neurològics transitoris que poden acompanyar el mal de cap. Les aures més freqüents són les aures visuals, tot i que també existeixen les aures sensorials essent l'aura hemiplègica la seva forma severa. La nostra investigació es va dividir en dues areas d'acord amb la base genètica dels trastorns, d'una banda, s'ha estudiat la genètica complexa de la migranya comuna, d'altra banda s'ha estudiat una forma rara de la migranya que presenta una herència mendeliana anomenada migranya hemiplègica familiar (FHM).
Per entendre més la base genètica de la migranya comuna es va utilitzar un estudi d'associació tipus cas-control amb gens candidats. Amb aquesta finalitat es van seleccionar al voltant de 550 pacients amb migranya (MA i MO) i el seu corresponent grup de control. Per tal d'analitzar la seva implicació en la susceptibilitat genètica a la migranya, es van triar gens que codifiquen per als canals de la superfamília heterogeni de potencial receptor transitori (Transient Receptor Potential- TRP) que se sap que estan implicats en les vies nociceptives. Aquesta feina ha donat lloc a una publicació (Carreño et al. SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population. Am J Med Genet B Neuropsychiatr Genet. 2012).
En el cas particular de les formes monogèniques de FHM es coneixen tres gens involucrats en la malatia (CACNA1A, ATP1A2 i SCN1A), les proteïnes codificades per aquests gens tenen un paper rellevant en la neurotransmissió del glutamat. L'anàlisi funcional de les mutacions que causen FHM han mostrat en última instància un augment de l'alliberament de la neurotransmissió. En el cas de mutacions al CACNA1A s'ha vist un efecte de guany de funció, a diferència de les mutacions al ATP1A2 que presenten un efecte de pèrdua de funció. En aquest treball s'ha fet un screening mutacional per identificar mutacions en pacients per seqüenciació directa. Quan les mutacions eren suficientment interessants s'han generat construccions en vectors d'expressió per subseqüents estudis funcionals en cèl·lules eucariotes. Aquesta feina ha donat lloc a tres publicacions. A la primera (Serra et al. A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis. Proc Natl Acad Sci. 2010) es va identificar un canvi que modula la funció del canal de CACNA1A. Aquest estudi ajuda a explicar la contribució genètica en la heterogeneïtat clínica d'una família i a entendre millor el mecanisme molecular dels canals de calci tipus P/Q. El segon (Carreño et al. Acute striatal necrosis in hemiplegic migraine with the novo CACNA1A mutation. Headache. 2011) és un informe d'un pacient que presenta una necrosi aguda stratial. Té una rellevància clínica a causa de l'aparició primerenca dels símptomes neurològics previs als atacs hemiplègics. El tercer i últim treball (Carreño et al. Screening of the ATP1A2 and CACNA1A genes in patients with hemiplegic migraine: clinical, genetic and functional studies. [work in progress]) recull l'screening mutacional al gens ATP1A2 i CACNA1A en 19 pacients amb FHM. Es van identificar 5 mutacions prèviament descrites i dues mutacions noves.[eng] This Thesis is focused in migraine genetics, migraine is a prevalent neurological disorder characterized by recurrent episodes of headache. This research was divided in two areas according to the genetic basis of the disorders; on the one hand we studied the common migraine with a complex genetics, on the other hand we studied the rare mendelian forms of familial hemiplegic migraine (FHM).
To understand more the genetic basis of the common migraine a case-control association study approach was used with candidate genes. For that purpose, around 550 patients with migraine and their corresponding control group were selected. In order to analyze their involvement in the genetic susceptibility to migraine, we chose genes encoding for channels of the heterogeneous superfamily of Transient Receptor Potential (TRP) which are known to be involved in the nociceptive pathway.
In the particular case of FHM, a monogenic form of the disorder, there are three genes known to be involved in the FHM (CACNA1A, ATP1A2 and SCN1A), whose encoded proteins are playing a relevant role in the neurotransmission of the glutamate. Functional analysis of the mutations causing FHM have shown ultimately an increased neurotransmission release. CACNA1A previous studies reveled a gain-of-function effect from FHM mutations, unlike mutations on ATP1A2 that present a loss-of-function effect. Our work consisted on identifying mutations in patients by direct sequencing. If the mutations were interesting enough vector constructions were generated for functional studies in eukaryotic cells. This work gave rise to three publications: First; the identification of a change that modulates the function of the CACNA1A channel. This study contributes to explain the genetic contribution in the clinical heterogeneity of one family and to know more about the molecular mechanism of the P/Q calcium channel. Second; a report of a patient that presents an acute stratial necrosis that had clinical relevance because of the early onset of the neurological symptoms previous to the hemiplegic attacks. Third; a mutational screening of ATP1A2 and CACNA1A genes in 19 patients with FHM. 5 previously described mutations and two new mutations were found. Functional studies were carried out for the newly mutations
Constraints on the formation of Pliocene hummocky cross- stratification in Calabria (southern Italy) from consideration of hydraulic and dispersive equivalence, grain-flow theory, and suspended-load fallout rate
No full textHummocky cross-stratification (HCS) occurs in two Pliocene progradational nearshore-marine to fluvial sequences. The HCS is notable because of its shallow depth of deposition (~2-5m) and its coarse grain size (up to coarse sand). Individual units of HCS consist of, in ascending order, three subfacies which are characterized by distinctive internal structure: a massive subfacies; a centimeter-scale laminated (meso-laminated) subfacies; and a millimeter-scale laminated (micro-laminated) subfacies. Preservation of the Guardavalle HCS in a very shallow-marine environment was promoted by the microtidal, storm-wave-dominated character of the Pliocene Ionian coast of Calabria. -from Author
The Private Cost of Long-Term Care in Canada: Where You Live Matters
No full textCanadians expect the same access to health care whether they are rich or poor, and wherever they live, often without direct charge at the point of service. However, we find that the private cost of long-term care differs greatly across the country, and within provinces, we find substantial variation, depending on income level, marital status, and, in Quebec alone, on assets owned. A non-married person with average income would pay more than twice as much in the Atlantic provinces as in Quebec, while a couple with one in care would pay almost four times as much in Newfoundland as in Alberta.long-term care, private cost
Physiologie du risque face à l’Histoire, or, Health, Culture and Society: The possibilities of anthropology and policy
No full textThis review of published research (Health, Culture and Society – Rawat Publications, India, 2000) seeks to introduce the reader to the driving themes of a work establishing the link between human physiological functions and social represetations. In doing so the author articulates the topic of prevention within a broad and complex social, historical and anthropological framework.</jats:p
Functional hemichannels formed by human connexin 26 expressed in bacteria
No full textCentro de Fisiología Celular e IntegrativaGap-junction channels (GJCs) communicate the cytoplasm of adjacent cells and are formed by head-to-head association of two hemichannels (HCs), one from each of the neighbouring cells. GJCs mediate electrical and chemical communication between cells, whereas undocked HCs participate in paracrine signalling because of their permeability to molecules such as ATP. Sustained opening of HCs under pathological conditions results in water and solute fluxes that cannot be compensated by membrane transport and therefore lead to cell damage. Mutations of Cx26 (connexin 26) are the most frequent cause of genetic deafness and it is therefore important to understand the structure-function relationship of wild-type and deafness-associated mutants. Currently available connexin HC expression systems severely limit the pace of structural studies and there is no simple high-throughput HC functional assay. The Escherichia coli-based expression system presented in the present study yields milligram amounts of purified Cx26 HCs suitable for functional and structural studies. We also show evidence of functional activity of recombinant Cx26 HCs in intact bacteria using a new growth complementation assay. The E. coli-based expression system has high potential for structural studies and high-throughput functional screening of HCs
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