10 research outputs found
آئینہ ماہ و سال کے تخصیصی پہلو
No full textThe diverse experiences of life and the emotions related to it have been a central theme in literary works. Urdu literature is adorned with a variety of genres, among which autobiography holds significant prominence. The core and main focus of an autobiography centers on self-expression, allowing the author to shape his own portrait through his writings. Inam ul Haq Javed is a renowned scholar, literary critic, and linguist. He has written extensively on various aspects of Urdu literature, including poetry, fiction, autobiography and criticism. His works are known for his depth, insight, and thorough analysis, and have been widely acclaimed by scholars and literary circles.
As an autobiographer Inam-ul-Haq Javed enhances the charm of autobiography through detailed descriptions, vivid imagery, and the use of metaphors. His work "Aaina-e-Mah-o-Saal" fully adheres to the principles of autobiography. Undoubtedly, it holds a significant position in the tradition of autobiographical writing. In this article, we will explore the intellectual and artistic elements of "Aaina-e-Mah-o-Saal" within the context of the tradition of autobiography
Standardization of Unani Drugs with Modern Analytical Parameters: A Necessary Step
No full textMankind have been always utilized their native flora, not only as a source of food but also use for shelter, fuel, clothing, chemical production and healthcare products since ancient time. Traditional medicine (Ayurveda, Naturopathy, Unani, Siddha, and Homeopathy) and Yoga are gaining more and more attention all over the world, because of their long historic clinical practice and minimum side effects. Unani system of medicine also a part of traditional medicine, it also gaining more acceptability around the world, but to get the quality of the crude drugs and Unani formulations is still facing lacking of standardization. In this respect internationally recognition related with the quality is necessary. This can be achieved only if the herbal products are evaluated and analyzed using modern scientific tool and technologies of standardization.
In this article discuss the various standardization parameters like morphological characters, microscopic evaluation, fluorescence analysis, physicochemical evaluations-proximate analysis (Moisture, ash content), solubility value (alcohol soluble, water soluble and ether soluble), heavy metal analysis and chromatography of botanicals are included. In the present review, various sensory parameters of the plant material (such as colour, odour, size, shape, and taste) were also mentioned of organoleptic evaluation method.
Key words: Herbal medicine, Standardization, Quality control, Chromatograph
Therapeutic Potential of Widely Used Unani Drug Asl-Us-Soos (Glycyrrhiza glabra Linn.): A Systematic Review
No full textPlants have been one of the important sources of therapeutics or other human health benefits since the beginning of human civilization throughout history. Currently, there is increasing awareness and general acceptability of the use of herbs, as a medicines, health products, pharmaceuticals, food supplements, cosmetics etc. Traditional system of medicine including Ayurveda, Unani, and Siddha etc. contributed in Health care dealing worldwide. The Unani system of medicine (USM) is an age old system of medicine which has a holistic approach to treat various kind of disease; most of the time the drugs mentioned in this system has tremendous effects in chronic disease.
Asl-Us-Soos (Glycyrrhiza glabra Linn), is a widely used herb in USM. Although the review articles on this plant are already published, this review article is presented to comply all the updated information on its therapeutic potency based on phytoconstituents and pharmacological activities and the potency which is described by renowned Unani physicians and scholars. The evidence based studies provides strengthen to the concept of Unani physicians as the Unani physician used and recommended the drug since along. Moreover the evidence based studies indicate that Glycyrrhiza glabra Linn possesses antibacterial, antioxidant, antimalarial, antispasmodic, expectorant, aphrodisiac, antimycobacterial activity, antiinflammatory and anti-hyper glycemic properties. Various other effects like antiulcer, antiviral, antihepatotoxic, antifungal and herpes simplex have also been studies. These results are very encouraging and indicate that this Unani drug can be studies more extensively with a well-planned and systematic scientific preclinical and clinical approach to explore the promising outcome. Further this review gives an account of the current knowledge on the morphological characters, microscopic characters, phytochemistry, and pharmacological actions present in root of Glycyrrhiza glabra along with its actions and therapeutic potential in the perspective of USM.
Keywords: Glycyrrhiza glabra, therapeutic potential, US
Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat
No full textAbstract Rumex vesicarius hasbeen extensively used for the management of diabetes in the traditional system of medicine. The current study was designed to investigate antidiabetic and antihyperlipidemic effects of R.vesicarius and also to explore metabolomic profiling using UPLC-QTOF-MS. The effect of extracts was observed by checking the biochemical and histopathological parameters in diabetic rats. The results had shown a significant dose- dependent inhibition potential of aqueous extract of R. vesicarius seed against α-amylase and α-glucosidase along with significant inhibition in DPPH free-radical scavenging activity. Oral administration of R. vesicarius to diabetic rats significantly ( p< 0.05) ameliorated blood glucose level. It also improved the function of the liver and kidney as well as ameliorated dyslipidemia in diabetic rats. Histopathological examination of the treatment groups reversed the damage of the pancreas, liver, and kidney tissues confirming the antidiabetic efficacy of R. vesicarius. UPLC- QTOF-MS analysis of the extract revealed a total of 42 bioactive compounds, which might contribute to the antidiabetic activity. Based on our findings, we can conclude that R. vesicarius might be a promising candidate for the management of diabetes
Standardization and Development of Standard Operating Procedures (SOPs) of a Polyherbal Unani Formulation Qurṣ-i Bawāsīr
No full textQurṣ-i Bawāsīr (QB) is a highly potent compound Unani formulation as it has synergistic effect in the treatment of Bawāsīr (Piles). Its ingredients act as anti- inflammatory, analgesics, purgative and emollient. The present study aims at identification and authentication of the crude ingredients of QB, development of SOPs and HPTLC fingerprinting by modern analytical techniques to comprehend its quality. QB in its three different batches was evaluated for organoleptic parameters, microscopic studies, physicochemical parameters, phytochemical screening, TLC and HPTLC profile, aflatoxin, microbial load and heavy metal analysis. QB was successfully standardized with all the parameters such as total ash, acid insoluble ash, water and alcohol soluble matter and loss of weight on drying. Further, TLC and HPTLC fingerprinting profile was developed and detected under various detection systems, viz. UV 366nm, UV 254nm, exposure to iodine vapours and anisaldehyde sulphuric acid. The present study ensured authenticity of the Unani formulation and furnished referential facts for its identification and purity thereby substantiating a validated scientific data.
Keywords: Qurṣ-i Bawāsīr, Unani formulation, Standardization, HPTL
Safūf-i Aslussūs: A time-tested polyherbal formulation for the management of Premature Ejaculation- A comprehensive review
Get PDFPremature Ejaculation (PE) is the most prevalent male sexual complaint worldwide. The ability to control the timing of ejaculation is very important to get pleasure and to maintain the couple’s sexual health. PE is believed to have a multifactorial etiology which mainly includes psychogenic and biogenic factors. Currently available conventional drugs are based on mere assumptions and their use in PE is considered off-label as they have not been approved by the regulatory bodies. On the other hand, Unani System of Medicine has a holistic approach to the prevention and treatment of diseases and provides a line of treatment for PE which is mainly focused on the internal and external use of specific drugs for the restoration of lost powers, elimination of morbid humor and strengthening of organs, muscles, and nerves. In classical Unani literature, PE/Surʻat-i-Inzāl are described in detail under the heading of Amrāz-i-Bāh. In the series of drug therapy a polyherbal Unani formulation, Safūf-i Aslussūs mentioned in different Unani Pharmacopoeias for the management of PE, and Spermatorrhoea is widely prescribed and recommended for a long time by Unani physicians and it is a time-tested drug. This manuscript is an attempt to summarize scientific studies in support of the claim made by Unani physicians regarding Safūf-i Aslussūs.
Keywords: Safoof-i Aslussoos, Surʻat-i-Inzāl, Premature ejaculation, Unani System of Medicin
Nematicidal activity of plant extracts against the root-knot nematode, Meloidogyne incognita
No full textNematicidal activity of extracts from plants was assayed against Meloidogyne incognita. In laboratory assays extracts from tobacco (Nicotiana tabacum L), clove (Syzygium aromaticum L), betelvine (Piper betle L), and sweet flag (Acorus calamus L) were most effective in killing the nematode, with an EC50 that was 5-10 times lower than the EC50 of the synthetic pesticides chlorpyrifos, carbosulfan and deltamethrin. The shapes of the dead nematodes differed in a characteristic way, and groups of pesticides and plant extracts could clearly be distinguished based on this phenomenon, which may be an indicator for the modes of action of the tested pesticides. In a greenhouse bioassay clove bud and betelvine were tested as mulch. Experiments revealed that the total number of live nematodes on roots of pepper plants treated with mulch of the clove bud was 7% of that of the controls and did not differ significantly from that of plants treated with the recommended synthetic pesticide carbofuran. The application of clove buds as a botanical pesticide for future use against nematodes is highly promising since clove is the 6th major plant grown on Bangka Island, and the market value of clove has decreased sharply over the last year
Comparative toxicity study on classical and modified version of Jawarish Jalinoos (a traditional Unani formulation) in rats
No full textBackground: Jawarish Jalinoos (JJ) is a classical semisolid traditional Unani formulation clinically used for the treatment of weakness of vital organs, liver, and stomach. Although JJ has been widely used clinically for several decades, no scientific report is available for its safety.
Methods: JJ and its sugar-free tablet version (SFJJ; formulated to target diabetic population) were assessed for safety in rats. Ninety-day repeated dose oral toxicity study was performed as per the Organisation for Economic Co-operation and Development Guideline 408. JJ was orally administered at the dose of 2000 mg/kg bw/d, whereas SFJJ was orally administered at the doses of 506 mg/kg body weight (bw)/d, 1012 mg/kg bw/d, and 2024 mg/kg bw/d for 90 days. The animals were periodically observed for clinical signs of toxicity, mortality, morbidity, body weight changes, and feed consumption. At the end of the study, hematology, clinical biochemistry, electrolytes, gross pathology, relative organ weight, and histological examination were performed.
Results: Treatment with SFJJ and JJ showed no significant differences in body weight gain, feed consumption, hematology, clinical biochemistry, and serum electrolytes. No gross pathological findings and differences in relative organ weights were observed between control and drug treated rats. Histological examination revealed no toxicologically significant abnormalities related with SFJJ or JJ treatment.
Conclusion: The 90-day repeated dose oral toxicity study demonstrates that the no observed adverse effect level of SFJJ and JJ is greater than 2024 mg/kg bw/d and 2000 mg/kg bw/d (p.o.) in rats, respectively. Both formulations were found to be safe up to the tested dose levels and experimental conditions, and therefore safe for clinical use as specified in the literature
Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat
No full textAbstract Rumex vesicarius hasbeen extensively used for the management of diabetes in the traditional system of medicine. The current study was designed to investigate antidiabetic and antihyperlipidemic effects of R.vesicarius and also to explore metabolomic profiling using UPLC-QTOF-MS. The effect of extracts was observed by checking the biochemical and histopathological parameters in diabetic rats. The results had shown a significant dose- dependent inhibition potential of aqueous extract of R. vesicarius seed against α-amylase and α-glucosidase along with significant inhibition in DPPH free-radical scavenging activity. Oral administration of R. vesicarius to diabetic rats significantly ( p</div
Quality control and HPTLC analysis of a polyherbal Unani formulation Habb-i-Shahtara recommended for skin diseases
Get PDFThe Unani system of medicine (USM) is one of the popular traditional systems of medicine. World widely, this system of medicine becomes an important health care system. Since many years back Unani medicines were used by the Unani physicians for treating the diseases ailments. In USM most of the drugs are of plant origin and their therapeutic effects are due to the presence of active phytochemicals. The proper standardization methods must be necessary for preparation of formulations otherwise secondary metabolites or active constituents might not be up to the quality. The standard operating procedures (SOP’s) are adopted for the preparation of Unani formulation. This study evaluated the quality of polyherbal unani formulation Habb-i-Shahtara, which is used in the treatment of skin diseases. The standardization parameters which were used for the development of quality standard of the study formulation were pharmacognostical studies, physicochemical and phytochemical parameters, HPTLC analysis, microbial load, aflatoxins, heavy metals and pesticide residues determination to evaluate the pharmacopoeial standard. The polyherbal Unani formulation Habb-i-Shahtara have been successfully standardized and the data and procedures which were used may serve the guidelines and standard reference in future for the preparation of formulation and for further study
