7 research outputs found
Variations in dermatoglyphic patterns in oral submucous fibrosis and leukoplakia patients with and without adverse oral habits
No full textIntroduction: The present study was conducted to determine the comparative variations in dermatoglyphic patterns in patients without oral submucous fibrosis (OSMF) and leukoplakia and those having lesions, as well as to predict the occurrence of these diseases and initiate preventive measures in these high-risk patients. Materials and Methods: Dermatoglyphic patterns were collected from randomly selected 120 patients using 3M™ CSD200i. Single-digit Optical Scanner (3M™, Canada, 2015) with automatic capture mechanism was applied to capture finger prints of all the 10 fingers of patients, who were divided in control and test group with respective subgroups of leukoplakia and OSMF. Qualitative analysis of dermatoglyphic patterns in the different groups showed loops, arches, and whorls. Results: The collected data was subjected to analysis using Chi-square test for comparison between the groups; significant difference in P value was observed on comparison between dermatoglyphic patterns in patients with leukoplakia and those with adverse oral habits but without oral lesions (P = 0.00005), patients with OSMF and individuals with adverse oral habits but without oral lesions (P = 0.03), patients with OSMF and individuals without adverse oral habits and without oral lesions (P = 0.004), leukoplakia and OSMF (P = 0.007). Quantitative analysis including total finger ridge count was done by counting the number of ridges in all 10 fingers for all the patients in all the groups. Conclusion: The present study showed weak association in the loop pattern of patients with OSMF than leukoplakia, whorl pattern with adverse oral habits, without oral lesions, and arch pattern with OSMF. More controlled prospective trials are needed to affirm the association, if any, at larger homogeneous Indian sample in future to validate the finding
Comparison of mean total ridge count and mean ATD angle in OSMF and oral Leukoplakia patients
No full textIntroduction: Palm prints formed once does not change throughout life and is not influenced by environment. Palmar Dermatoglyphics can indicate the development of potentially malignant and malignant lesions and help in identifying persons at high risk of developing Oral submucous fibrosis (OSMF) and Oral squamous cell carcinoma (OSSC). Materials and Methods: Dermatoglyphic patterns were collected from randomly selected 120 patients using 3M™ CSD200i. Single-digit Optical Scanner (3M™, Canada, 2015) with automatic capture mechanism was applied to capture finger prints of all the 10 fingers of patients, who were divided in control and test group with respective subgroups of leukoplakia and OSMF. Mean total ridge count and ATD angle were measured in all patients and comparison was done between control group and patients with OSMF and leukoplakia. Results: The collected data was subjected to analysis using Chi-square test for comparison between the groups. The mean ATD angle in patints with osmf is 43.38, leukoplakia is 43.53, patients without lesion but with habit is 44.78, and patients without habit is 45.65
Role of platelet count in diagnosis of oral potentially malignant disorders and oral squamous cell carcinoma
No full textIntroduction: Platelets play an important role in the metabolic functions of malignant tissues. Platelet count is the major marker for malignancy and their increase in number can depict stages, severity and metastasis of cancer. Increase in number of platelet count can be used in early diagnosis of cancer. However, use of some chemotherapeutic agents is associated with low platelet count. Therefore, the platelet to cancer cell ratio varies through the course of the disease and is highly affected by treatment. Aim: To assess correlation between platelet count and progression of malignancy. Materials and method: Platelet counts were retrieved from patients diagnosed oral potentially malignat disorders and oral squamous cell carcinoma based on clinical data. The collected data is analyzed to correlate the platelet count in oral potentially malignat disorders and oral squamous cell carcinoma compared to healthy control patients. Result: Nonsignificant differnce was noted in platelet count in oral potentially malignat disorders and oral squamous cell carcinoma compared to healthy control patients. Conclusion: Thrombocystosis is a poor predicator for malignancy, platelet count alone cannot determine the severity of malignancy, correlation with histopathologic data can better establish the grading of malignancy
Hydrolysis improves the inhibition efficacy of bovine lactoferrin against infection by SARS-CoV-2 pseudovirus
No full textThe entry of SARS-CoV-2 into host cells may involve the spike protein cleavage by cathepsin L (CTSL). Certain food proteins such as lactoferrin (Lf) inhibit CTSL. The current study investigated the impact of hydrolysis (0–180 min) by proteinase K on electrophoretic pattern, secondary structure, cathepsin inhibitory and SARS-CoV-2 pseudovirus infectivity inhibitory of bovine Lf. Gel electrophoresis indicated that hydrolysis cut Lf molecules to half lobes (∼40 kDa) and produced peptides ≤18 kDa. Approximation of the secondary structural features through analysis of the second-derivative amide I band collected by infra-red spectroscopy suggested a correlative–causative relationship between cathepsin inhibition and the content of helix-unordered structures in Lf hydrolysate. The half maximal inhibitory concentration (IC(50)) of Lf hydrolysed for 90 min (H90) against CTSL was about 100 times smaller than that of the Lf hydrolysed for 0 min (H0). H90 had also double activity against SARS-CoV-2 pseudo-types infectivity compared with H0
Correlation Between Of Lipid Profile And Progression Of Oral Cancer In The Population Of Madhya Pradesh
No full textOral cancer is the rising public health concern in India, particularly in central state of India; Madhya Pradesh where tobacco consumption is prevalent and this habit is common among both males and females. Alterations in lipid profile have been associated with tobacco consumption and cancer pathogenesis, which could be potentially served as biomarkers for oral cancer risk
Advances In Bioactive Dental Composites
No full textBackground: The introduction of bioactive dental composites has revolutionized restorative dentistry with features like remineralization, antibacterial activities, and prolonging the lifespan of dental restorations. Adoption in clinical practice, however, is still quite limited due to their costs, difficulty in material handling, and absence of long-term clinical evidence. This study attempts to determine the awareness and adoption of bioactive dental composites as well as their effectiveness and shortcomings among dental professionals.
Methods: A cross-sectional survey using quantitative methods was administered to 250 dental practitioners including general dentists, prosthodontists, endodontists, periodontists, orthodontists, dental researchers, and dental students. Data was gathered through a structured questionnaire focusing on bioactive dental composites’ awareness, use, effectiveness, and the barriers surrounding it. Descriptive statistics, Shapiro-Wilk normality test, Cronbach’s Alpha reliability test, and regression analysis were the statistical methods performed to compute the data distribution and internal consistency as well as the relationship of years of experience to the frequency of use.
Results: The Shapiro-Wilk normality test performed with the data also noted the variation (p <0.05) in responses, showcasing that the data did not follow the expected normal distribution. The Cronbach’s Alpha reliability test showcased a value of -0.148 which indicates awful internal consistency of the decision-making factors. Regression analysis gave an R² value of 0.00016, which confirms that Despite the number of years of experience one has had, there are no significant shifts in the adoption of bioactive dental composites. In addition, other significant obstacles included great material expense, difficult handling, and a lack of sufficient clinical proof.
Conclusion: The findings show that the more experience clinicians have with composites, the lower the adoption of bioactive dental composites tends to be, suggesting that the transition is more dependent on external variables like material properties and cost. There is an urgent call to enhance education and training to improve material handling and cost-effectiveness to enable the use of these composites. Further studies are needed to address other possible influencing variables, clinical studies, and patient-oriented approaches toward using bioactive composites in everyday dental practice. Solving these issues will ensure that bioactive dental composites increase the efficiency in modern restorative dentistry, which in turn will decrease the cost of treatment increase the longevity of dental materials, and improve patient satisfaction
