156 research outputs found

    Mapping of the current transition of care practice for patients with pituitary disease at Endo-ERN reference centers

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    Rare endocrine conditions present specific diagnostic and management challenges for healthcare providers, one of which is the understudied transition of care. Despite the need for guidance regarding transition, consensus on structured and protocolled approaches is lacking. Therefore, we aimed to map the current clinical practice and identify unmet needs regarding transition of care for patients with pituitary disease in the reference centers (RCs) of the European Reference Network on Rare Endocrine Conditions (Endo-ERN). A survey-based, cross-sectional study using the EU Survey tool was performed and completed by 46 physicians (n) from 30 RCs (N). Transition is a common practice among RCs (n = 44/46), usually accomplished by a multidisciplinary team meeting (N = 20/30). Criteria for start and end of transition were defined in half of the RCs, with 16.7% of centers providing dissimilar answers. Transition readiness was assessed by >75% of the RCs, mostly by unvalidated means (e.g. subjective opinions, informal consultations). Pituitary-specific transition assessment tool was applied in one RC only. Transition protocols were present in only 9% of RCs, while in many RCs, transition decisions were taken in combined adult-pediatric meetings or based on clinicians’ personal judgment. A minority of physicians evaluated the effectiveness of transition-related interventions (n = 11/46) or medical outcomes (n = 8/46). Patient-reported outcome measures were infrequently used (n = 4/46). Identified unmet needs included the development of guidelines (n = 5/46) and EU-wide approach (n = 2/46). This study exemplifies the unmet needs for a structural definition of the transition period and transition management for patients with rare hypothalamic and pituitary conditions from healthcare providers’ perspective

    El Na Savi en Cerrarás los ojos para no ver de Florentino Solano

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    Artículo número 11 de la Sección Tema. 8 páginas. tyvllviiEl presente texto es una reseña crítica del libro de cuentos Cerrarás los ojos para no ver del poeta y narrador de origen Ñuu Savi, Florentino Solano. El autor en este libro de cuentos, a través de la ironía, muestra los conflictos que padece el Na Savi, gente del pueblo de la lluvia: violencia de género, intromisión de los partidos políticos. Estos conflictos se muestran con un humor irónico pues lo que busca el autor es mostrar los problemas del Na savi de manera irrisoria, pues en este sentido el humor devela las monstruosidades que sufre el Na Savi.This text is a critical review of the book of short stories Cerrarás los ojos para no ver by the poet and narrator of origin Ñuu Savi, Florentino Solano. The author in this book of short stories, through irony, shows the conflicts suffered by the Na Savi, people of the town of the rain: gender violence, interference by political parties. These conflicts are shown with an ironic humor because what the author seeks is to show the problems of Na savi in a laughable way, since in this sense humor reveals the monstrosities that Na Savi suffers

    Androgen Levels in Men with Acute and Chronic Coronary Syndrome // Андрогенни нива при мъже с остър и хроничен коронарен синдром

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    Актуалността на проблема за андрогените при мъже с остър (ОКС)и хроничен коронарен синдром (ХКС) е свързана изясняване патогенезата и профилактика на ИБС. Налице са данни за благоприятен ефект на андрогените върху сърдечната мускулатура и васкуларизация, но и повишен риск при субституция. В тази връзка си поставихме за цел да изследваме ролята на андрогените при адаптацията към ОКС както и за развитието на ИБС при мъже със остър и ХКС. Изследвани са 105 пациенти - 72 с ОКС, 32 с ХКС и 35 контроли. Установихме по-ниски стойности на всички фракции на тестостерона (Т), по-висока честота на хипотестостеронемията при пациенти с ОКС . Най- ниски са посочените фракции на Т и ароматизационния индекс в групата на пациентите със ST-елевация, спрямо ОКС без ST-елевация. В групата на ХКС ароматизационния индекс корелира с някои липидни показатели. По-ниските нива на SHBG се свързват с по-лош метаболитен профил в групата ХКС, докато в ОКС по-високите нива на SHBG са параметър отразяващ и допълващ рисковата характеристика. Основни детерминанти на DHEA-S са възрастта и гломерулната филтрация в групите ОКС и АКБ, докато за групата на ХКС това е само възрастта. По-високата стойност на отношението кортизол/DHEA-S се свързва с по-лоша рискова характеристика на пациентите с ОКС. Резултатите от изследването дават основата за провеждане на проучвания, които биха могли да изяснят важни аспекти в регулацията на гонадната функция и екстрагонадните ефекти на стероидните хормони в контекста на ИБС.The problem of androgens in men with acute (ACS) and chronic coronary syndrome (CCS) is relevant to clarify the pathogenesis and prevention of CHD. There is evidence of a beneficial effect of androgens on the cardiac muscle and vascularization and an increased risk with substitution. In this regard, we aim to investigate the role of androgens in adaptation to ACS as well as in the development of CHD. We studied 105 patients, 72 with ACS, 32 with CCS and 35 controls. We found lower values of all testosterone (T) fractions and a higher incidence of hypotestosteronemia in patients with ACS. T fractions and aromatization index were the lowest in the group of patients with ST-elevation compared to non-ST-elevation ACS. In the CCS group, the aromatization index correlates with some lipid parameters. Lower SHBG levels were associated with a worse metabolic profile in the CCS group, whereas in the OCS group, higher SHBG levels were a parameter reflecting and complementing the risk characteristic. The main determinants of DHEA-S were age and glomerular filtration rate in the IHD and ACS groups, whereas for the CCS group, it was only age. A higher value of the cortisol/DHEA-S ratio was associated with a worse risk characteristic of ACS patients. The results of this study provide the basis for studies that could elucidate important aspects in regulating gonadal function and the extragonadal effects of steroid hormones in the context of CHD

    Re: "Chronic Helicobacter pylori infection and migraine: a case-control study" (Pinessi L, Savi L, Pellicano R, et al. Headache. 2000;40:836-839)

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    Chronic Helicobacter pylori infection and migraine: a case-control study" (Pinessi L, Savi L, Pellicano R, et al. Headache. 2000;40:836-83

    PENERAPAN METODE SAVI PADA MATA PELAJARAN AL QUR’AN DAN HADIS UNTUK MENINGKATKAN KEMAMPUAN MENGHAFAL SURAT PENDEK

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    Abstrak: Penelitian ini bertujuan untuk meningkatkan kemampuan menghapal surat pendek siswa pada mata pelajaran Al Qur’an Hadist melalui penerapan metode SAVI ( Somatis, Auditori, Visual dan Intelektual). Permasalahan yang dibahas adalah bagaimana penerapan metode SAVI dan meningkatkan kemampuan menghafal surat pendek siswa. Jenis penelitian ini adalah penelitian tindakan kelas (PTK). Urutan kegiatan penelitian adalah mencakup (1) perencanaan, (2) pelaksanaan, (3) Observasi dan (4) refleksi. Dalam pengumpulan data,penulis menggunakan tehnik observasi,dokumentasi,pengukur alat tes dan angket. Analisis hasil penelitian menunjukkan bahwa penerapan metode SAVI pada pembelajaran Al-Qur’an Hadist dapat meningkatkan kemampuan menghapal surah pendek siswa. Dalam penilaian hafalan siswa peneliti menggunakan 3 kriteria penilaian yaitu : (1) kefasihan, (2) hafalan terjemahan (3) kelancaran gerakan. Hal itu berdasarkan skor hasil nilai hafalan siswa dalam ketuntasan belajar pada siklus I memperoleh 84 % dan persentase skor yang diperoleh dari hasil nilai hafalan siswa pada siklus II memperoleh 96 %. Abstract:  This research aims to improve students' ability to memorize short letters in the subjects of the Qur'an Hadith through the application of SAVI methods (Somatis, Auditory, Visual and Intellectual). The issues discussed are how to implement the SAVI method and improve students' short letter memorization skills. This type of research is class action research (PTK). The sequence of research activities includes (1) planning, (2) implementation, (3) Observation and (4) reflection. In the data collection, the author uses observation techniques, documentation, test equipment gauges and questionnaires. Analysis of the results showed that the application of SAVI method in the study of the Qur'an Hadith can improve the ability to memorize short surahs of students. In the assessment of memorization of research students using 3 assessment criteria, namely: (1) fluency, (2) memorization of translation (3) smooth movement. It is based on the score of students' memorization in the completion of learning in the first cycle obtained 84% and the percentage of scores obtained from the results of student memorization in the second cycle obtained 96%

    Structured transitions to adult health care and the concept of transition readiness

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    The transition period between adolescence and adulthood is crucial for ensuring long-term health outcomes for patients with chronic diseases. Key principles of a successful transition include early preparation, effective coordination between medical professionals and patients, and adequate patient readiness. Several challenges, such as lack of follow-up, insufficient patient knowledge and skills, and organizational barriers within the healthcare system, are identified. A significant factor is the variability among different diseases, such as diabetes mellitus and rare endocrine pathologies. Additionally, cultural and socio-economic factors play a critical role in shaping the transition process.An essential aspect of the transition process is the definition and measurement of transition readiness. The variety of tools developed for this purpose underscores its complexity and the difficulties associated with evaluating this multifaceted concept. Early planning, a multidisciplinary approach, and individualized interventions are vital for improving transition outcomes.Organized transitions to adult care remain a challenge for healthcare systems worldwide. Detailed research and structured planning are critical to their success, and endocrine diseases are no exception to this rule

    Croatian Philanthropist Ladies’ Society in Brod na Savi, 1895-1941.

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    Autor je u radu, na temelju Spomenice društva koja je objavljena 1935. i onodobnog tiska, Pravila društva te nekih manjih izvornih ostataka iz Muzeja Brodskog Posavlja i privatne ostavštine, dao pregled djelovanja Hrvatskog dobrotvornog gospojinskog društva u Brodu na Savi od 1895. do 1941. godine. Osim presjeka cjelokupnog djelovanja društva, naglasak je stavljen na njegovom humanitarnom radu i utjecaju na svekoliki društveni i kulturni život Broda i njegovih građana.On the basis of the Society’s Memorial (Spomenica društva) published in 1935 and the contemporary press, the Society’s Rule Book and some minor original artifacts from the Museum of Brodsko Posavlje or private legacy, the author of this paper gives an overview of the activities of the Croatian Philanthropist Ladies’ Society (Hrvatsko dobrotvorno gospojinsko društvo) in Brod na Savi (now Slavonski Brod) from 1895 to 1941. Besides the presentation of its entire sphere of activities, focus is placed on its humanitarian action and on its impact on the social and cultural life of Brod and its citizens. On the basis of preserved historical records, we may stress that during its active work „sine ira et studio“ the Society very successfully implemented the programs and missions laid down in its Rules. It also successfully and proudly persisted in stressing the attribute Croatian in its title from its very inception all through its termination

    Tracing for the problem-solving ability in advanced calculus class based on modification of SAVI model at Universitas Negeri Semarang

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    There were many ways of solving the problem offered by the experts. The author combines various ways of solving the problem as a form of novelty. Among the learning model that was expected to support the growth of problem-solving skills was SAVI. The purpose, to obtain trace results from the analysis of the problem-solving ability of students in the Dual Integral material. The research method was a qualitative approach. Its activities include tests was filled with mathematical connections, observation, interviews, FGD, and triangulation. The results were: (1) some students were still experiencing difficulties in solving the problems. (2) The application of modification of SAVI learning model effective in supporting the growth of problem-solving abilities. (3) The strength of the students related to solving the problem, there were two students in the excellent category, there were three students in right classes and one student in the medium group

    Multi-temporal analysis of morphological changes in an Alpine proglacial area and their effect on sediment transfer

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    Proglacial areas in high-mountain environments are among the most dynamic landscape zones in terms of morphological, sedimentological, and hydrological changes. In fact, in such areas both glacial and paraglacial dynamics exert a strong control on water fluxes (and thus on bedload transport capacity) and on sediment supply. Because of the rapid changes undergoing in these environments, the understanding of the dynamics of sediment transfer and the prediction of how this will change in future still remain a challenge. In this study, we used four different high-resolution topographic surveys to quantitatively analyse the spatio-temporal patterns of sediment transport that occurred in the proglacial area of the Sulden glacier (South Tirol, Italy). The topographic surveys covered the period 2013–2019 and – by building DEMs of difference (DoDs) – we calculated the volumes of erosion and deposition occurring at the glacier terminus and along its outflow channels. Our results indicate that, within the analysed time-period and for different areas, erosion and deposition generally show similar values, suggesting that the analysed proglacial areas has been acting both as a sediment trap and as a sediment source for the downstream river reaches. In addition, the results indicate a complex morphological dynamics, which have strongly impacted coarse sediment connectivity in the upper catchment. In particular, high temperatures and the recent and rapid glacier melt, have promoted a direct control on the structural connectivity within the proglacial area. Morphological changes have increased or decreased sediment connectivity depending on pre-existing morphological features. In contrast, extreme precipitation events, both in term of rainfall and snowfall, have locally and temporally increased the functional connectivity, sometimes leading to long-term modifications in the proglacial area. Overall, in the analysed time-period sediment transfer has been extremely dynamic, suggesting that sediment in the downstream river channel may have been supplied with irregular pulses associated with the morphological changes taking place in the proglacial area

    PENGEMBANGAN BAHAN AJAR DIGITAL BAHASA INDONESIA DENGAN MODEL SAVI UNTUK PEMELAJAR BIPA 4 EKSPATRIAT JERMAN

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    Penyebaran bahasa Indonesia melalui pembelajaran merupakan upaya peningkatan fungsi bahasa Indonesia sebagai salah satu bahasa yang digunakan secara internasional. Hal tersebut dapat menjadi kebanggaan sekaligus tantangan. Tantangan yang dihadapi yakni kualitas mutu pengajaran BIPA harus lebih ditingkatkan lagi. Hasil penulisan terdahulu memperlihatkan pengembangan bahan ajar BIPA saat ini masih pada tahap analisis kebutuhan belajar berdasarkan kompetensi berbahasa Indonesia secara umum tanpa melihat kebutuhan secara rinci yakni berdasarkan maksud dan tujuan pemelajar asing datang ke Indonesia. Terkait dengan hal tersebut, penulis mengembangkan bahan ajar digital bahasa Indonesia dengan model SAVI untuk pemelajar BIPA 4 ekspatriat Jerman menggunakan silabus BIPA Permendikbud Nomor 27 Tahun 2017 yang mengarah pada CEFR (Common European Framework of Reference for Languanges) level B2 (BIPA 4). Penelitian ini menggunakan metode R & D (Research and Development) dengan model 4D yang terdiri dari 4 tahapan, yaitu Define (Pendefinisian), Design (Perencanaan), Develop (Pengembangan), dan Desseminate (Penyebaran). Bahan ajar ini memuat unsur SAVI (Somatic, Auditory, Visual, Intellectualy) yang melibatkan seluruh panca indera pemelajar dalam pembelajaran yang dapat meningkatkan kemampuan pemelajar belajar bahasa Indonesia. Berdasarkan penilaian validator, aspek isi/materi mendapat penilaian rata-rata 92.5%, aspek penyajian mendapat penilaian rata-rata 96.5%, aspek bahasa mendapatkan penilaian rata-rata 92%, dan aspek media mendapatkan hasil penilaian rata-rata 90%. Terkait dengan hal tersebut, dapat disimpulkan bahwa kelayakan bahan ajar digital bahasa Indonesia dengan model SAVI untuk pemelajar BIPA 4 ekspatriat Jerman secara keseluruhan memiliki kriteria sangat baik dan layak untuk digunakan. Bahan ajar ini direkomendasikan untuk pemelajar dan pengajar. Kata Kunci : Analisis Kebutuhan, BIPA, Bahan Ajar. DEVELOPMENT OF INDONESIAN DIGITAL TEACHING MATERIALS USING THE SAVI MODEL FOR BIPA 4 STUDENT GERMAN EXSPATRIATES NELLITA SIPINTE 1706340 ABSTRACT The spread of Indonesian through learning is an effort to improve the function of Indonesian as one of the languages used internationally. This can be both a source of pride and a challenge. The challenge faced is that the quality of BIPA teaching must be further improved. The result of previous writings show that the development of BIPA teaching materials is currently still at the stage of analyzing learning needs based on Indonesian language competence in general without looking at the needs in detail, namely based on the aims and objectives of foreign students coming to Indonesia. Related to this, the author develops Indonesian digital teaching materials with the SAVI model for German expatriate BIPA 4 students using the BIPA syllabus Permendikbud Number 27 of 2017 which leads to CEFR (Common European Framework of Reference for Languages) level B2 (BIPA 4). This study uses the R & D (Research and Development) method with a 4D model consisting of 4 stages, namely, Define, Design, Develop, and Desseminate. This the teaching material contains elements of SAVI (Somatic, Auditory, Visual, Intellectual) which involves all five senses of students in learning which can improve students ability to learn Indonesia. Based on the validator’s assessment, the content/material aspect gets an average rating of 92.5%, the presentation aspect gets an average rating of 96.5%, the language aspect gets an average rating of 92%, and the media aspect gets an average rating of 90%. Related to this, it can be concluded that the feasibility of Indonesian digital teaching materials with the SAVI model for German expatriat BIPA 4 students as a whole has very good criteria and is feasible to use. This teaching material is recommended for students and teachers. Keyword: Needs Analysis, BIPA, Theacing Materials
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