47 research outputs found
Nd-doped polarization maintaining all-fiber laser with dissipative soliton resonance mode-locking at 905 nm
No full textFunding Information: Manuscript received February 15, 2021; revised May 14, 2021; accepted May 27, 2021. Date of publication June 1, 2021; date of current version September 13, 2021. This work was supported by RFBR under Grant 20-32-90233. (Corresponding author: Aram A. Mkrtchyan.) Aram A. Mkrtchyan, Yuriy G. Gladush, and Kirill A. Sitnik are with the Skolkovo Institute of Science and Technology, Moscow 121205, Russia (e-mail: [email protected]; [email protected]; [email protected]). Publisher Copyright: © 1983-2012 IEEE.Moving the fiber laser emission to the region below one micron may provide a cheaper, more compact and robust alternatives to the existing solid state lasers. Here, for the first time we report a neodymium mode-locked fiber laser emitting at 905 nm in the all-fiber polarization maintaining configuration. We obtain a self-starting pulse generation in nonlinear amplifying loop mirror (NALM) cavity configuration. To suppress a dominant emission at 1064 nm corresponding to a 4-level laser scheme, we use an active fiber - 920/1064 division multiplexer - active fiber sandwich-like sequence in the NALM loop. A rectangular shape dissipative soliton had nJ energy, 30 pm spectral width and 80 ÷ 430 ps width linearly depending on the pump power. Excellent agreement with numerical simulation allowed us to recover pulse shape and width for the pulses out of autocorrelation window.Peer reviewe
Risk <inf>in polytrauma</inf> factors and prevention of nosocomial pneumonia
No full textNosocomial pneumonia (NK) is one of the most frequent complications of polytrauma leading to death. Meanwhile, the recommendations on prevention of NK in case of polytrauma have not been specified so far. This is due in large part to the lack of study of the pathophysiology of severe combined trauma. The review presents the results of modern experimental and clinical studies of the effect of shock, immune distress syndrome, posttraumatic immunosuppression, the phenomenon of mutual aggravation of lesions, age, sex, concomitant pathology on the risk of NK in polytrauma. The role of iatrogenic risk factors for NK in polytrauma – intubation of trachea and artificial lung ventilation (AVL), massive hemotransfusions, immobilization, the phenomenon of “second strike” after multiple surgeries has been determined. The most effective measures of NK prevention are reduction of the duration of AVL, prevention of oropharyngeal colonization and aspiration in case of AVL, use of inhalation antibacterial drugs, anti-shock measures, early mobilization of the patient, the earliest possible stable functional osteosynthesis by minimally traumatic methods. The data on the effectiveness of selective decontamination of intestines, probiotics and glucocorticosteroids for the prevention of NK in polytrauma are inconsistent. A promising area of NK prophylaxis may be the development of agents that regulate the complex mechanisms of immune response to polytrauma and prevent secondary acute lung injury and post-traumatic immunosuppression
Adsorption properties of Silochrom chemically modified with nickel acetylacetonate
No full textOne of the areas of development of gas chromatography is the creation of new chromatographic materials that have improved sorption and analytical characteristics. In this work, for the first time, a new sorbent based on Silochrom C-120 modified with nickel acetylacetonate was studied using a complex of physico-chemical methods. It has been established that due to chemical modification of silica gel surface with nickel acetylacetonate the surface area of the specific surface decreases from 112 to 98 m2/g and surface acidity diminishes by 1.2 pH units. Using the thermogravimetric analysis it has been revealed that the obtained sorbent can be used in gas chromatography up to 290°C. Gas chromatography method was used to investigate the adsorption properties of the modified materials. According to the retention data of adsorbates: n-alkanes (C6-C9), benzene, ethanol, nitropropane and butanone-2 the differential molar adsorption energy q̄dif, 1, Henry adsorption constants К1,С, the differential molar entropy ΔS̄S1 and Δ q̄dif, 1 (special) of adsorbates in dispersion and specific interactions were calculated. The influence of the modifying additive on the changings in the thermodynamic retention characteristics of all sorbates because of the manifestation of specific sorbate-sorbent interactions has been shown. The highest values of the thermodynamic parameters were indicative for sorbates forming hydrogen bonds and capable of donor-acceptor interaction
Glomerular filtration and diuresis are related to the state of lipids peroxidation in female rats exposed to water-salt loads accompanied by chronic stress
No full textŻukow Xawery, Zavidnyuk Yuriy V. Glomerular filtration and diuresis are related to the state of lipids peroxidation in female rats exposed to water-salt loads accompanied by chronic stress. Journal of Education, Health and Sport. 2021;11(12):481-491. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.12.039
https://apcz.umk.pl/JEHS/article/view/JEHS.2021.11.12.039
https://zenodo.org/record/6942038
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 1 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 25.11.2021. Revised: 15.12.2021. Accepted: 31.12.2021.
Glomerular filtration and diuresis are related to the state of lipids peroxidation in female rats exposed to water-salt loads accompanied by chronic stress
Xawery Żukow1, Yuriy V Zavidnyuk2
1Medical University of Bialystok, Bialystok, Poland [email protected]
2IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine [email protected]
Summary
Background. It is known about the existence of close functional link between adequate working kidney nephrons and bone metabolism. Focused monitoring of renal function is able to provide substantial assistance in the organization of preventive measures against latently emerging osteoporosis. Activation of lipoperoxidation is known to inhibit glomerular filtration, whereas antioxidants prevent this. We set ourselves the goal of clarifying correlations between glomerular filtration, as well as tubular water reabsorption and daily diuresis, on the one hand, and lipoperoxidation parameters, on the other hand. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 240-290 g, both intact and exposed to water-salt loads. By the size of the diuresis and the level of creatinine in plasma and urine, glomerular filtration and tubular reabsorption were calculated. The plasma levels of diene conjugates and malondyaldehide as well as catalase of plasma and superoxide dismutase of erythrocytes were determined. The levels of the first three parameters determined in urine too. Results. In conditions of water-salt loads accompanied by chronic stress, glomerular filtration is downregulated by malondialdehyde and superoxide dismutase; diuresis is also downregulated by malondialdehyde, but upregulated by catalase. Lipoperoxidation parameters determine kidney function by 52,8%. Conclusion. The obtained data indicate the role of lipoperoxidation as a accompaniment of chronic stress in the regulation of kidney functions.
Keywords: glomerular filtration, diuresis, lipid peroxidation, relationships, water-salt loads, chronic stress, rats
Features of neuro-endocrine and immune reactions to various water-salt loads in female rats
No full textGozhenko Olena A, Zavidnyuk Yuriy V, Korda Mykhaylo M, Mysula Igor R, Klishch Ivan M, Zukow Walery, Popovych Igor L. FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS. Journal of Education, Health and Sport. 2018;8(9):11-31. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1323491
http://ojs.ukw.edu.pl/index.php/johs/article/view/5729
https://pbn.nauka.gov.pl/sedno-webapp/works/872545
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017).
1223 Journal of Education, Health and Sport eissn 2391-8306 7
© The Author(s) 2018;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 20.06.2018. Revised: 28.06.2018. Accepted: 30.07.2018.
FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS
Olena A Gozhenko1, Yuriy V Zavidnyuk1,2, Mykhaylo M Korda2, Igor R Mysula2,
Ivan M Klishch2, Walery Zukow3, Igor L Popovych4
1Ukrainian Scientific Research Institute of Transport Medicine, Odesa, Ukraine, [email protected]
2IY Horbachevs’kyi State Medical University, Ternopil’, Ukraine, [email protected]
3Nicolaus Copernicus University, Torun, Poland, [email protected]
4OO Bohomolets’ Institute of Physiology, Kyiv, Ukraine, [email protected]
Abstract
Background. Previously, we have shown that the weekly load of rats with water-salt solutions of different chemical compositions causes both general and specific reactions of the parameters of metabolism. The purpose of this study is to identify under these conditions specific neuroendocrine and immune responses. Materials and methods. Experiment was performed on 58 healthy female Wistar rats 240-290 g divided into 6 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Instead, the other rats received the same tap water as well as waters Sophiya, Naftussya, Gertsa and its artificial salt analogue through the probe at a dose of 1,5 mL/100 g of body mass for 6 days. The day after the completion of the drinking course in all rats some neuroendocrine and immune parameters were registered. Results. The method of discriminant analysis revealed 29 parameters of the neuroendocrine-immune complex (10 of them reflect the neuroendocrine regulation, 4 thymus mass and thymocytogram elements, 5 elements of splenocytogram, 10 elements of immunocytogram and leukocytogram of blood and parameters of phagocytosis), according to which the reaction on various water-salt loads are identified with an accuracy of 98.3%. Conclusion. The peculiarities of the reactions of the parameters of the neuroendocrine-immune complex are due to the content of water in sulfate, bicarbonate and magnesium, as well as organic carbon and nitrogen.
Key words. Water-salt loads, neuroendocrine and immune parameters, female rats.Gozhenko Olena A, Zavidnyuk Yuriy V, Korda Mykhaylo M, Mysula Igor R, Klishch Ivan M, Zukow Walery, Popovych Igor L. FEATURES OF NEURO-ENDOCRINE AND IMMUNE REACTIONS TO VARIOUS WATER-SALT LOADS IN FEMALE RATS. Journal of Education, Health and Sport. 2018;8(9):11-31. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1323491
http://ojs.ukw.edu.pl/index.php/johs/article/view/5729
https://pbn.nauka.gov.pl/sedno-webapp/works/87254
Toxicity of Water-Soluble D-g-PNIPAM Polymers in a Complex with Chemotherapy Drugs and Mechanism of Their Action In Vitro
No full textfirst_pagesettingsOrder Article ReprintsOpen AccessArticleToxicity of Water-Soluble D-g-PNIPAM Polymers in a Complex with Chemotherapy Drugs and Mechanism of Their Action In Vitroby Svitlana Prylutska1, Anna Grebinyk2,3 [ORCID] , Stanislav Ponomarenko4, Defne Gövem3, Vasyl Chumachenko4, Nataliya Kutsevol4 [ORCID] , Mykola Petrovsky4, Uwe Ritter5 [ORCID] , Marcus Frohme3 [ORCID] , Jacek Piosik6,* [ORCID] and Yuriy Prylutskyy41Department of Plants Physiology, Biochemistry and Bioenergetics, National University of Life and Environmental Sciences of Ukraine, 03041 Kyiv, Ukraine2Deutsches Elektronen-Synchrotron DESY, Platanenallee 6, 15738 Zeuthen, Germany3Division Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, 15745 Wildau, Germany4Department of Biophysics and Neurobiology, Department of Chemistry, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine5Institute of Chemistry and Biotechnology, Technical University of Ilmenau, 98693 Ilmenau, Germany6Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-307 Gdańsk, Poland*Author to whom correspondence should be addressed.Int. J. Mol. Sci. 2024, 25(5), 3069; https://doi.org/10.3390/ijms25053069Submission received: 13 February 2024 / Revised: 27 February 2024 / Accepted: 3 March 2024 / Published: 6 March 2024(This article belongs to the Special Issue Development, Characterization and Applications of Novel Polymeric Materials and Composites)Downloadkeyboard_arrow_downBrowse FiguresVersions NotesAbstractThe application of a biocompatible polymer nanocarrier can provide target delivery to tumor tissues, improved pharmacokinetics, controlled drug release, etc. Therefore, the proposed strategy was to use the water-soluble star-like copolymers with a Dextran core and Poly(N-isopropylacrylamide) grafts (D-g-PNIPAM) for conjugation with the widely used chemotherapy drugs in oncology–Cisplatin (Cis-Pt) and Doxorubicin (Dox). The molecular characteristics of the copolymer were received using size-exclusion chromatography. The physicochemical characterization of the D-g-PNIPAM-Cis-Pt (or Dox) nanosystem was conducted using dynamic light scattering and FTIR spectroscopy. Using traditional biochemical methods, a comparative analysis of the enhancement of the cytotoxic effect of free Cis-Pt and Dox in combination with D-g-PNIPAM copolymers was performed in cancer cells of the Lewis lung carcinoma line, which are both sensitive and resistant to Dox; in addition, the mechanism of their action in vitro was evaluated
Estimating Preferred Shares with Regard to the Possibilities of Gaining the Voting Right by their Holders
No full textAbstract This article views the techniques to estimate preferred shares, the holders of which have acquired the voting right for the shareholder's meeting by nonpayment of dividends on these shares. The author of this paper attempts to show regard to the option factor, which reflects the possibilities to gain the voting right by preferred shareholders, directly in special calculation models. In addition, the article proposes the criterion of decision making by majority (controlling) shareholders on the reasonability of either the payment or nonpayment of dividends to minority shareholders. JEL classification numbers: D 460, G 120, G 32
Problems of the Doctrinal Interpretation of Law
No full textThe article observes the problems of understanding of legal hermeneutics and doctrinal interpretation. The author concludes that the issue of interpretation of the law has already developed into the thematic framework of the general theory of law and state, and now is a subject of a specific applied science - legal hermeneutics, which has different ways of interpreting the law. The author focuses of the definition of the object of doctrinal interpretation and its types. After carrying out the analysis the author concludes that the doctrinal interpretation of the objects is very diverse and does not mean only interpretation of the law. Almost all the elements of the legal system can be subjects to scientific analysis and forecasting. In contrary to the opinion affirmed in the literature on the theory of law and state that the doctrinal interpretation is a kind of informal interpretation of the law, the author makes a conclusion that the doctrinal interpretation can be official, unofficial and officious i.e. it can have the semi-official character, such as the conclusion to bills. The author considers that despite the fact that in modern Russia the doctrine is not recognized as an official source of law it has a tremendous impact on the legislator, in particular, his legal mind, his psychology foundations. The best samples of scientific doctrines presented in the first chapter of the Constitution. E.g. it is Montesquieu’s theory on the separation of powers, idea of the federal structure of the Russian state, ideas of a secular and democratic state, which withstood a major test of time. This is idea of Lorenz von Stein of the social character of the state, too. After considering the various approaches to understanding the sources of law the author comes to the conclusion that if the interpretation of the results is prepared by a famous legal scholar, is set out in the field of a recognized theory, a certain concept, the legal paradigm, it must be recognized as the legal source and one needs to refer to it in resolution of legal problems in the administration and courts of various levels
Role of organic carbon and nitrogen of mineral waters in their immunomodulating effects at female rats
No full textPopovych Igor, Mysula Igor, Popovych Andriy, Mysula Yuriy, Sydliaruk Nataliya, Bilas Volodymyra, Zukow Walery. Role of organic carbon and nitrogen of mineral waters in their immunomodulating effects at female rats. Journal of Education, Health and Sport. 2021;11(9):886-894. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.09.104
https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.09.104
https://zenodo.org/record/5856299
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 10.09.2021. Revised: 20.09.2021. Accepted: 30.09.2021.
ROLE OF ORGANIC CARBON AND NITROGEN OF MINERAL WATERS IN THEIR IMMUNOMODULATING EFFECTS AT FEMALE RATS
Igor Popovych1, Igor Mysula2, Andriy Popovych1, Yuriy Mysula2, Nataliya Sydliaruk2, Volodymyra Bilas1, Walery Zukow3*
1OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine
2IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine
3Nicolaus Copernicus University, Torun, Poland
*[email protected]
Abstract
Background. Drinking mineral water is one of the ethnopharmacologic factors. Organic substances, despite their presence in all drinking mineral waters, are still considered to be active only in the water of Naftussya type (which, due to mineralization less than 1 g/L, are not formally mineral), whereas the physiological activity of true mineral waters (which mineralization is greater than 1-2 g/L) are associated with electrolytes and trace elements. Previously, we identified the role of organic carbon and nitrogen of mineral waters in their effects on certain metabolic and neuro-endocrine parameters. The purpose of this study is to clarify the role of organic substances of same mineral waters in their effects on immunity parameters. Material and methods. Experiment was performed on 48 healthy female Wistar rats 240-290 g divided into 5 groups. Animals of the first group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. In the second group we administered the water Naftussya from the Truskavets’ layer (Galychyna, Ukraine), in the third group the water Sophiya of the Truskavets’ field. The rats of the fourth group received the native water from the Hertsa (Bucovyna, Ukraine) field, and the last group received its artificial salt analogue. The day after the completion of the drinking course in all rats immunne parameters were registered. Results. On the basis of the correlation analysis with step-by-step exclusion, 9 immune parameters (Endotheliocytes of Thymus, Spleen Mass Index, Entropy of Splenocytogram, Natural Killers, B- and 0-Lymphocytes, Rod-shaped Neutrophils, Phagocytic Index and Microbian Count of Monocytes of Blood) are included in the regressive model for organic nitrogen (R=0,818) and 6 parameters (Endotheliocytes of Thymus, Fibroblastes and Reticulocytes of Spleen, Pan-Lymphocytes, Microbian Count of Neutrophils and Phagocytic Index of Monocytes of Blood) for organic carbon (R=0,690). Together, the organic components of the chemical composition of loading fluids determine their effect on the immune parameters by 77%. Conclusion. Organic substances of mineral waters play an essential role in their effects on the immune parameters of female rats.
Key words: Mineral waters, organic carbon and nitrogen, female rats, immunity
Canonical analysis of neuroendocrine-metabolic and neuroendocrine-immune relationships at female rats
No full textMel’nyk Oksana I., Zukow Walery, Hrytsak Myroslava V., Popovych Dariya V., Zavidnyuk Yuriy V., Bilas Volodymyra R., Popovych Igor L. Canonical analysis of neuroendocrine-metabolic and neuroendocrine-immune relationships at female rats. Journal of Education, Health and Sport. 2021;11(5): 356-369. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.05.038
https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.05.038
https://zenodo.org/record/6099322
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 15.05.2021. Revised: 21.05.2021. Accepted: 28.05.2021.
CANONICAL ANALYSIS OF NEUROENDOCRINE-METABOLIC AND NEUROENDOCRINE-IMMUNE RELATIONSHIPS AT FEMALE RATS
Oksana I. Mel’nyk1, Walery Zukow2, Myroslava V. Hrytsak3, Dariya V. Popovych4, Yuriy V. Zavidnyuk3,4, Volodymyra R. Bilas5, Igor L. Popovych3,5
1Danylo Halyts’kyǐ National Medical University, L’viv, Ukraine [email protected]
2Nicolaus Copernicus University, Torun, Poland [email protected]
3Ukrainian Scientific Research Institute of Medicine for Transport, Odesa, Ukraine
[email protected]
4IY Horbachevs’kyi State Medical University, Ternopil’, Ukraine
[email protected]
5OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine [email protected]
Abstract
Background. It has been shown before that drinking mineral waters of different composition has a significant effect on the neuroendocrine, metabolic and immune parameters of healthy rats. We analyzed the canonical correlations between neuroendocrine parameters, on the one hand, and metabolic and immune parameters, on the other hand. Materials and Methods. Experiment was performed on 58 healthy female Wistar rats 240-290 g. HRV parameters, major adaptation hormones, metabolism and immunity parameters were recorded. Results. The method of canonical correlation analysis revealed causal relationships between neuroendocrine and metabolic and neuroendocrine and immune parameters of the organism. The degree of neuroendocrine determination of individual sets of metabolic parameters ranges from 60% to 92%, and immune status from 87% to 96,5%. Conclusion. Effects of mineral waters on metabolism and immunity are realized through nervous and hormonal mechanisms.
Keywords. HRV, hormones, metabolites, immunity, relationships, female rats
