12 research outputs found
TEHNIK DASAR PENULISAN KARYA ILMIAH PENDIDIKAN
Full text linkThe research was carried out starting from the existence of a problem. Problems are "deviations" from what should be and what happens, deviations between plans and implementation, deviations between theory and practice, and deviations between rules and implementation. The problem appears at a certain time and space. Before conducting research, a researcher must understand the rules of writing scientific papers, namely determining the study area in accordance with the study program, breaking the area into sub-regions, the researcher determining whether to study certain figures, the topic must attract the reader's attention, the topic must be The author knows that the topic should not be too technical. Original, Necessary, Scientific, Consistent and objective. The next step is to prepare a research proposal that broadly includes three main questions, namely: What will be researched?, Why researched?, How will research be done? The research design must be made systematically and logically so that it can be used as a guide that is really easy to follow. The research design, which is often called a research proposal, contains at least four main components, namely the problem, theoretical basis and hypothesis submission, research methods, organization and research schedule
Antigen-coated latex particles as a model system for probing monocyte responses in leprosy
No full textTo study responses to Mycobacterium leprae antigens, we developed an in vitro model system in which latex particles coated with M. leprae sonic extract (MLSON) antigen were presented to monocytes. Uptake and oxidative response as measured by superoxide production to these antigens were investigated. Phagocytosis of MLSON-coated particles was greater than that of control particles in monocytes from both leprosy patients and controls from leprosy-endemic areas; uptake of MLSON-coated particles was higher in monocytes from lepromatous leprosy patients than in cells from tuberculoid leprosy patients and controls. In both patients and controls, uptake of latex particles coated with leprosy antigens triggered very little reduction of nitroblue tetrazolium although the cells were capable of mounting a respiratory burst. Antigen-coated latex particles can therefore be used as a tool to investigate monocyte responses to M. leprae and individual recombinant antigens.Peer reviewedfinal article publishe
Quantitation of IgM antibodies to the M. leprae synthetic dissacharide can predict early bacterial multiplication in leprosy
No full textQuantitative enzyme-linked immunosorbent assays detecting IgM to the soluble Mycobacterium leprae crude sonicate (CD75) and the synthetic disaccharide antigen coupled to bovine serum albumin (ND-BSA) were assessed for their ability to determine early infection in families/household contacts of leprosy patients and employees of a leprosy center working in close contact with leprosy patients. Although IgM to both antigens (CD75 and ND-BSA) correlated with the bacterial index (BI) assessed histologically on skin-biopsy samples, the level of IgM antibodies to ND-BSA was a much more sensitive indicator of low bacterial loads. A 4.4-fold difference in antibody levels was observed between the mean group levels of endemic controls (N = 116) and tuberculoid leprosy patients with a BI of 0 (N = 88), increasing to sevenfold in tuberculoid leprosy patients with a BI of 1 (N = 20). Using a statistical cut off with endemic controls (mean + 2 S.D.), household/family contacts showed 30% seropositivity (N = 180) as compared to staff contacts who showed 17% seropositivity (N = 55). Percent seropositivity in family contacts was not related to the type of leprosy of the index case (lepromatous vs. tuberculoid) or the duration of treatment of the index case. Age of the individual in the family contact group had a significant influence on seropositivity. These results support the hypothesis that, in this community, factors other than the viable bacterial load of the index case, such as genetic susceptibility, may be influencing the high rate of seropositivity in family contacts. IgM ND-BSA antibodies seem to provide a good indicator of low antigenic loads and could prove to be useful in detecting subclinical infection before the onset of dis-ease. Follow-up studies of these seropositive individuals are in progress to understand the relationship between seropositivity and the progress of clinical disease.Peer reviewedfinal article publishe
Lepidópteros de O Courel (Lugo, Galicia, España, N.O. Península Ibérica) XII: Papilionidae, Pieridae y nota adicional sobre Hesperiidae y Lycaenidae. (Insecta: Lepidoptera).
No full textAn updated and annotated list of the Rhopalocera families Papilionidae and Pieridae (Lepidoptera: Papilionoidea) known to occur in O Courel (Lugo, Galicia, Spain, NW Iberian Peninsula) is made, compiling the existing bibliographical records and adding new ones as a result of the fieldwork undertaken by the author since the year 1989 to present. With the new data, the Papilionidae catalogue of O Courel is increased in two species: Papilio machaon Linnaeus, 1758 and Zerynthia rumina (Linnaeus, 1758); and in one that of Pieridae: Gonepteryx cleopatra (Linnaeus, 1767). An additional note concerning to the catalogues of Hesperiidae and Lycaenidae from O Courel is also included.Se elabora un listado comentado y puesto al día de las familias de ropalóceros Papilionidae y Pieridae (Lepidoptera: Papilionoidea) presentes en O Courel (Lugo, Galicia, España, N.O. Península Ibérica), recopilando los datos bibliográficos existentes, a los que se añaden otros nuevos como resultado del trabajo de campo del autor llevado a cabo desde el año 1989 a la actualidad. Con los nuevos datos se incrementa el catálogo de Papilionidae de O Courel en dos especies: Papilio machaon Linnaeus, 1758 y Zerynthia rumina (Linnaeus, 1758); y en una el de Pieridae: Gonepteryx cleopatra (Linnaeus, 1767). Incluimos también una nota adicional concerniente a los catálogos de Hesperiidae y Lycaenidae de O Courel
Literary Dimensions of National Identity: The Historical Novel of the Late Soviet Period (1960s--1980s)
No full text233 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.The dissertation examines the changes that took place in the popular and ideologically "safest" genre of historical novel in the post-Stalin period in two Soviet literatures, Russian and Ukrainian. In this comparative study the author analyzes a set of novels by Russian and Ukrainian writers which center on Kievan Rus', medieval Muscovy, and the period of imperial expansion. These texts are analyzed within several interrelated theoretical frameworks. In particular, the author's approach is informed by Benedict Anderson's theory of the nation as an "imagined community", Clifford Geertz's concept of "local knowledge", and Rumina Sethi's postcolonial interpretation of the historical novel. This theoretical grounding allows conceptualizing the Soviet historical novel as an active element in a state-sponsored identity construction process where the official doctrines of the existing political system often played only minor roles. The theoretical tools of cultural anthropology highlight the possibilities that are offered by such an approach for the study of popular literary genres, particularly historical fiction. This methodology provides the basis for the main argument that historical novels in Russian and Ukrainian literatures culturally and ideologically were moving in different directions, thereby subverting one of the core principles of the Soviet identity model---the notion of a common transnational past. The dissertation helps in better understanding of how popular fictional texts about the past shaped national and cultural identities of the last Soviet generation.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD
A successful UN high-level meeting on antimicrobial resistance must build on the 2023 UN high-Level meeting on tuberculosis
No full textAbstract is not provided by the author/publisher
Literary Dimensions of National Identity: The Historical Novel of the Late Soviet Period (1960s--1980s)
No full text"The dissertation examines the changes that took place in the popular and ideologically ""safest"" genre of historical novel in the post-Stalin period in two Soviet literatures, Russian and Ukrainian. In this comparative study the author analyzes a set of novels by Russian and Ukrainian writers which center on Kievan Rus', medieval Muscovy, and the period of imperial expansion. These texts are analyzed within several interrelated theoretical frameworks. In particular, the author's approach is informed by Benedict Anderson's theory of the nation as an ""imagined community"", Clifford Geertz's concept of ""local knowledge"", and Rumina Sethi's postcolonial interpretation of the historical novel. This theoretical grounding allows conceptualizing the Soviet historical novel as an active element in a state-sponsored identity construction process where the official doctrines of the existing political system often played only minor roles. The theoretical tools of cultural anthropology highlight the possibilities that are offered by such an approach for the study of popular literary genres, particularly historical fiction. This methodology provides the basis for the main argument that historical novels in Russian and Ukrainian literatures culturally and ideologically were moving in different directions, thereby subverting one of the core principles of the Soviet identity model---the notion of a common transnational past. The dissertation helps in better understanding of how popular fictional texts about the past shaped national and cultural identities of the last Soviet generation."Made available in DSpace on 2015-09-28T16:22:13Z (GMT). No. of bitstreams: 2
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Previous issue date: 2008Embargo set by: Seth Robbins for item 88934
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Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDsRestricted to the U of I community idenfinitely during batch ingest of legacy ETDsU of I Only233 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008
Admission inflammation and coagulation biomarkers as early predictors of COVID-19-associated acute kidney injury
Full text linkIntroduction: Acute kidney injury (AKI) is a common and high-risk complication of COVID-19. Serum creatinine rises with delay, which limits early recognition of renal involvement (7,9). Inflammatory and coagulation biomarkers measured at hospital admission may provide an earlier indication of AKI (1,4,10–12).Materials and Methods: We analysed 436 hospitalisations with PCR-confirmed COVID-19 (01.2021–12.2022) at St. Marina University Hospital, Varna. AKI was defined according to KDIGO 2012 (by serum creatinine; the urine-output criterion was unavailable) (7). First-hour measurements included CRP, D-dimer, fibrinogen, ferritin, and LDH. ROC curves and Youden’s J were used to determine optimal cut-offs; an additional combined model was constructed from the three markers (CRP > 150 mg/L; D-dimer > 0.75 mg/L; fibrinogen > 6 g/L). Multivariable logistic regression was adjusted for age, sex, arterial hypertension, and diabetes (6,8,14).Results: 94/436 (21.6%) developed AKI. At admission, CRP, D-dimer, and fibrinogen were higher in patients who subsequently developed AKI; ferritin and LDH showed trends without independent predictive value. Individual AUCs: CRP 0.69, D-dimer 0.74, fibrinogen 0.62; the combined model achieved AUC 0.82. At the chosen threshold, sensitivity was 72% and specificity 76%. In the multivariable model, D-dimer > 0.75 mg/L (OR 2.3; 95% CI 1.4–3.8), CRP > 150 mg/L (OR 1.9; 95% CI 1.2–3.0), fibrinogen > 6 g/L (OR 1.6; 95% CI 1.1–2.6), and age > 70 years (OR 1.7; 95% CI 1.1–2.8) were independent predictors. A negative result on the combined assessment virtually rules out AKI (residual risk ≈ 9%), whereas a positive result indicates that nearly one in two patients will develop this complication (≈ 45%).Conclusion: A triad of CRP, D-dimer, and fibrinogen available within the first hour of admission provides early and inexpensive risk stratification for COVID-19-associated AKI, consistent with published evidence on the roles of inflammation and coagulopathy (1,4,10–13). Its implementation may support nephroprotective strategies and prioritisation for early consultation (9,10)
Author Correction: Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase
No full textTerrestrial snails and slugs of Nevada, USA: an overview of taxa, biogeography, and habitat affinities
Full text linkThe biogeography and habitat affinities of the Recent taxa of terrestrial mollusks of Nevada, western USA, are discussed herein. A total of 52 land snails and slug species were found in Nevada, of which 21 are newly reported records. Two native land snails found previously were not found by this author, and 6 additional species are possible for the state. Of the 47 species of land snail found in the state, 42 are considered native, while 5 are introduced. Only one slug, Deroceras laeve, is considered native, while 4 others are introduced. Land mollusks in eastern and central Nevada are derived from the Rocky Mountain Molluscan Province, such as Pupilla hebes, Microphysula ingersolli, and Oreohelix strigosa depressa (9 species, 18%), while southern Nevada supports species derived from the Southwestern Province, such as Gastrocopta spp., Striatura meridionalis, and Eremarionta rowelli (8 species, 16%). A Californian and Oregonian influence includes Pristiloma chersinella and Punctum californicum. Introduced land snails and slugs such as Deroceras reticulatum, Lehmannia valentiana, Cepaea nemoralis, and Rumina decollata are found in the gardens and parks of urban areas in Nevada. The present native land snail distributions in Nevada result from Miocene and Pliocene dispersal and establishment in the mountains of the Great Basin followed by Pleistocene and Holocene fragmentation and isolation. Xeric habitats such as sagebrush steppe, Pygmy conifer woodlands, and dry alkaline lake beds dominate much of the state and support very few or no land mollusks. Nine habitats are identified as being used by terrestrial mollusks in Nevada. Mountain woodlands, springs, and chaparral support 71% of the total fauna, which includes 36 land snail species and the slug Deroceras laeve where water, coniferous and deciduous vegetation, and moist litter are available between 1400 and 2800 m elevation. The more xeric Mojave Desert in the south (165–1100 m) and sagebrush steppe of the Great Basin (800–2000 m) support 3 and 4 species, respectively. The Pygmy coniferous woodlands occasionally support 2 species, except when the woodlands are associated with limestone cliffs and shrubs, where 5 species may be present (1600–2200 m). River valleys, perennial streams, and meadows (800–2000 m) make up only 1% of the state’s land area but support 19 species of land mollusks. Subalpine and alpine habitats in the high mountains (2800–3400 m) support 13 species of land snails. Urban areas with greenhouses, parks, and casino gardens support 9 species of introduced land snails and slugs.A continuación, analizamos la biogeografía y las afinidades del hábitat de los taxones recientes de moluscos terrestres de Nevada, oeste de los EE.UU. Se encontraron un total de 52 especies de caracoles terrestres y babosas en Nevada, de los cuales 21 son registros recién reportados. El autor, no encontró dos caracoles terrestres nativos que se habían reportado anteriormente. No obstante, registró seis posibles especies adicionales en el estado. De las 47 especies de caracoles terrestres que se encuentran en el estado, 42 se consideran nativas, mientras que cinco fueron introducidas. Sólo una babosa, Deroceras laeve se considera nativa mientras que las otras cuatro fueron introducidas. Los moluscos terrestres en el este y centro de Nevada se derivan de la Provincia de Moluscos de las Montañas Rocosas (Rocky Mountain Molluscan Province), tales como Pupilla hebes, Microphysula ingersolli y Oreohelix strigose depressa (nueve especies, 18%), mientras que el sur de Nevada sustenta especies derivadas de la Provincia Suroeste (Southwestern Province), tales como la especie Gastrocopta, Striatura meridionalis y Eremarionata rowelli (ocho especies, 16%). La influencia de California y de Oregon incluye Pristiloma chersinella y Punctum californicum. Los caracoles y las babosas terrestres introducidos, tales como Deroceras reticulatum, Lehmannia valentiana, Cepaea nemoralis y Rumina decollata se encuentran en los jardines y parques de las áreas urbanas de Nevada. Las distribuciones de caracoles terrestres nativos que se encuentran ahora en Nevada son el resultado de la dispersión y el establecimiento del Mioceno y Plioceno en las montañas de la Gran Cuenca, seguido de la fragmentación y el aislamiento del Pleistoceno y el Holoceno. Los hábitats xéricos, tales como la estepa de artemisa, los bosques de coníferas pigmeas y los lechos de lagos secos alcalinos dominan gran parte del estado y sustentan muy pocos o prácticamente ningún molusco terrestre. Se identificaron nueve hábitats utilizados por moluscos terrestres en Nevada. Los bosques de montaña, manantiales y chaparral albergan el 71% de la fauna total, que incluye 36 especies de caracoles terrestres y la babosa Deroceras laeve, donde el agua, la vegetación de coníferas y caducifolios y la hojarasca húmeda están disponibles entre los 1400 y 2800 metros de altura. El desierto de Mojave más xérico en el sur (165–1100 m) y la estepa de artemisa de la Gran Cuenca (800–2000 m) albergan tres y cuatro especies respectivamente. Los bosques de coníferas pigmeos ocasionalmente sustentan dos especies, excepto cuando se asocian con acantilados de piedra caliza y arbustos, donde se pueden encontrar hasta cinco especies (1600–2200 m). Las cuencas del río, los arroyos perennes y los prados (800–2000 m) representan sólo el 1% de la superficie terrestre del estado, pero albergan 19 especies de moluscos terrestres. Los hábitats subalpinos y alpinos en las altas montañas (2800–3400 m) albergan 13 especies de caracoles terrestres. Las áreas urbanas con invernaderos, los parques y los jardines de casinos albergan nueve especies introducidas de caracoles terrestres y babosas
