1,720,964 research outputs found
Computational Prediction for the Binding Affinity of Interleukins 3 and 5 and GM- CSF to Cell Surface Receptors on Human Eosinophils
No full textAbstract. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a 14.477 kD glycoprotein comprising 144 amino acids residues. The respective encoding gene is located on chromosome 5 in human. This protein stimulates proliferation and differentiation of macrophages. N-terminally seventeen amino acid residues are serving as a signal peptide while, the rest of 127 amino acids, known to have therapeutics application, is termed Molgramostim. Previous studies have revealed a high affinity of this protein for binding to a heterodimer receptor on surface of the cell. The respective receptor includes α and β chains which the β chain is similar to interleukins 3 and 5 receptors. Due to this similarity, interleukins 3 and 5 are capable to compete with GM-CSF in binding to the shared receptor. In the present study, to evaluate the binding affinity of interleukins 3 and 5 and GM-CSF to the same receptor, a computational prediction study carried out using Modeller, Hex and Molegro softwares. According to the results, interleukin 3 with -517.09 kJ/mole, interleukin 5 with -538.05 kJ/mole and GM-CSF with -606.17 kJ/mole energy could bind to the α and β chains of receptor. In the next step the two chains of the receptor were separated and the affinity of each protein to both chains was studied. Based on the results the binding affinity of all three considered proteins to α chain of the protein was weaker than the binding to β chain. The binding energy of interleukin 3, interleukin 5 and GM-CSF to β chain of receptors was -620.37 kJ/mole,-663.80 kJ/mole and -696.07 kJ/mole respectively. According to the results, interleukin 3 and interleukin 5 strongly compete with GM-CSF in binding to cell surface receptors on human eosinophils
Cardiotoxicity Effects of Herbal Medicine, A Review Article
Get PDFWith the development of human's modern society more and more people tend to use complementary and alternative medicine (CAM). Toxicological studies indicated that many herbal medicines have direct toxic effects on the circulatory system or cardiovascular system and cause harmful effects on the body. Cardiotoxicity or heart damage is a serious issue defined as heart electrophysiology dysfunction, affecting the cardiac structure, and muscle damage that arises from the drug or chemical poisoning agents, that may lead to heart failure. The aim of this review article is to provide various information about the potential adverse effects of herbal medicine on the cardiovascular system and introduce herbs that induced cardiac toxicity. To provide this review, all reported cases of cardiac toxicity induced by herbal medicines and natural products were collected through research articles and documents, and the most relevant articles, and books in various authentic search engines including Scopus, PubMed, SID (scientific information database), Science Direct and Google Scholar, from 1984 to April 2022 were searched, and selected herbs with therapeutic properties which induce toxic effects on the cardiovascular system are introduced. In this review, scientific data regarding cardiotoxicity showed that 16 herbs from 11 families may increase cardiac toxicity. Therefore, it's important to use herbal medicines and natural products under the guidance of medical professionals
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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