1,720,992 research outputs found
Ticagrelor in ST-Elevation Myocardial Infarction.
No full textTicagrelor is a new oral antagonist of the platelet P2Y12 receptor that offers several potential advantages compared to clopidogrel including faster and more effective inhibition of platelet aggregation. Ticagrelor has been compared to clopidogrel in the PLATelet inhibition and patient Outcomes (PLATO) trial in a broad population of patients with acute coronary syndrome showing a reduction of the 12-month risk of death from vascular causes, myocardial infarction and stroke without increasing the overall risk of major bleeding. In a subanalysis of the PLATO trial focusing on patients with ST-elevation myocardial infarction, ticagrelor results were consistent with those of the overall trial. Additionally, possible pleiotropic effects of ticagrelor, including an appealing interaction with adenosine, might constitute a specific advantage in this particular subset of patients
The emerging role of allergic inflammation in adverse reactions after coronary stent implantation
No full textN/
Inflammatory mechanisms of adverse reactions to drug-eluting stents
No full textIn-stent restenosis and stent thrombosis represent the main adverse reactions to coronary stents and individual susceptibility appears to play an important role in their onset. In particular, inflammatory status, classically assessed by C-reactive protein levels, predicts the risk of in-stent restenosis after bare-metal stent implantation but not after drug-eluting stent (DES) implantation. On the other hand, C-reactive protein seems to predict the risk of stent thrombosis after treatment with DES but not with bare-metal stent. If DES have considerably reduced, as compared to bare-metal stent, the rate of adverse reaction in the first year after implantation, concern is emerging about late events that seem to be related to delayed healing and allergic reactions to polymers, a process in which eosinophils play an important role by enhancing restenosis and thrombosi
Non Invasive Evaluation of Coronary Flow Reserve in the Left Anterior Descending Coronary Artery in Patients with Syndrome X
No full textEvolving management of patients treated by drug-eluting stent: prevention of late events
No full textCoronary Flow Reserve Evaluated Non Invasively in the Left Anterior Descending Coronary Artery of Patients with Sindrome X
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