169 research outputs found
A randomized phase II study of radiation induced immune boost in operable non-small cell lung cancer (RadImmune trial)
Get PDFBackground: Lung cancer is the leading cause of cancer deaths worldwide. Surgery, radiotherapy at conventional and high dose and chemotherapy are the mainstay for lung cancer treatment. Insufficient migration and activation of tumour specific effector T cells seem to be important reasons for inadequate host anti-tumour immune response. Ionizing radiation can induce a variety of immune responses. The goal of this randomized trial is to assess if a preoperative single fraction low dose radiation is able to improve anti-tumour immune response in operable early stage lung cancer. Methods/Design: This trial has been designed as an investigator-initiated, prospective, randomized, 2-armed phase II trial. Patients who are candidates for elective resection of early stage non-small cell lung cancer will be randomized into 2 arms. A total of 36 patients will be enrolled. The patients receive either 2 Gy or no radiation prescribed to their primary tumour. Radiation will be delivered by external beam radiotherapy using 3D radiotherapy or intensity-modulated radiation technique (IMRT) 7 days prior to surgical resection. The primary objective is to compare CD8+ T cell counts detected by immunohistochemistry in resected tumours following preoperative radiotherapy versus no radiotherapy. Secondary objectives include the association between CD8+ T cell counts and progression free survival, the correlation of CD8+ T cell counts quantified by immunohistochemistry and flow cytometry, local tumour control and recurrence patterns, survival, radiogenic treatment toxicity and postoperative morbidity and mortality. Further, frequencies of tumour reactive T cells in blood and bone marrow as well as whole blood cell transcriptomics and plasma-proteomics will be correlated with clinical outcome. Discussion: This unique intervention combining preoperative low dose radiation and surgical removal of early stage non-small cell lung cancer is designed to address the problem of inadequate host anti-tumour immune response. If successful, this study may affect the role of radiotherapy in lung cancer treatment. Trial registration: NCT02319408; Registration: December 29, 2014
The dynamic pattern of recurrence in curatively resected non-small cell lung cancer patients: Experiences at a single institution
No full textTo investigate the hazard function of tumor recurrence in patients with completely (R0) resected non-small cell lung cancer
Maintaining the Presumption of Innocence in Date Rape Trials Through the Use of Language Orders: State v. Safi and the Banning of the Word Rape
Get PDFThis note evaluates the use of language orders in date rape trials in which the defense is consent through a case study of State v. Safi, in which Tory Bowen claims that Pamir Safi date raped her. In that case, the trial judge granted a motion by the defense to prevent the prosecution and any of their witnesses from using words such as rape and sexual assault. Using State v. Safi as a starting point, the author examines the use of such trial orders from the perspective of both defendants and victims. The author concludes that a modified version of such language orders would effectively preserve the presumption of innocence afforded to all criminal defendants without sacrificing a fair opportunity for victims to see their attackers convicted
Problems of Ontology in the Heritage of Ali Safi
Get PDFThis article focuses on fundamental ontological and philosophical views of the representative of the Central Asian Renaissance Ali Safi, who in their writings have found a «consensus» between the official theology of Sunni Islam and the philosophical teachings of the «Greek Sciences» and their Eastern representatives. The fundamental features of the philosophical Outlook of the scientist are given: true commitment to Sunnism, objective idealism. In addition, the author seeks to show Ali Mafia as a tolerant representative of his society.The author found out that the entire medieval concept of Islamic philosophy, as well as the objective monism of Sufism based on idealism, was based on Ali Safi’s worldviews. It is established that the scientist in his analyses was not limited to the definitions and conclusions of Sufis and philosophers, but provided his own conclusion in relation to being, cited materials from ancient Oriental works, expressing skepticism towards them
Lifting effect of sequential autologous fat injection (SAFI) in three patients with small and flat malar bones
No full textVarious fat grafting techniques are commonly performed to restore the facial volume deficiency in the soft tissue. Generally, the purified fat is evenly injected into the whole layer in the volume deficit area. The sequential autologous fat injection (SAFI) technique is known to have a volumetric lifting effect. In patients with small and flat malar bones, the soft tissue foundation becomes weak; hence, the soft tissue overlying the bone easily sags even in young patients. Therefore, the author tried to apply the SAFI technique to correct the sagging face. The fat was harvested and purified by the Coleman’s method, and sequentially injected into each defective region in the superolateral to anteroinferior direction. Furthermore, the fat was injected consequently in the deep, middle, and superficial layers to increase the skeletal support for the soft tissue using the SAFI technique. An increase in the volume in the malar and sub-malar areas and decrease in the volume in the deep nasolabial folds and jowls were simultaneously observed. Moreover, the facial contour changed from square to inverted triangle type with shallow nasolabial folds and lifted appearance of the jowls in these 3 cases. The results indicated that the SAFI technique could be used for volumetric face lifting, because it focuses on the correction of the skeletal deformity in order to improve the soft tissue foundation
4D SignWordNet: Building a Comprehensive Video Dataset for Bengali Sign Word Recognition Model and Language Model
No full textThis dataset contains videos illustrating Bengali Sign Language. 6 Bangladeshi adults created this dataset with the specific goal of addressing the absence of a comprehensive video dataset for Bengali Sign Language. This dataset serves as a bridge to fill this gap by offering a rich resource to develop real-life expert systems. This dataset aims to include all aspect of practical sign language usage, addressing the critical need for variety. This dataset comprises two parts as word and sentences each of which includes two sections. The first section involves Raw Video Data and the second involves the Masking Data. Within the Masking Video Data, there are two types of videos: with background and without background. For the word part, each section and sub section contain 102 classes with approximately 300 videos per class, resulting in a total of approximately 30,600 videos in each section and approximately 91,800 videos overall. And for the sentence part, each section and sub section comprise 20 classes with approximately 100 videos per class, resulting in a total of approximately 2000 videos in each section and approximately 6000 videos overall. Notably, both sections of the dataset prioritize diversity by capturing videos in various backgrounds and lighting conditions, ensuring its suitability for real-world applications. This dataset is made available through a data use agreement.
*** Data Usage Agreement (DUA)***
This Data Usage Agreement (DUA) is made between the Authors and the Readers for the use of the “4D SignWordNet: Building a Comprehensive Video Dataset for Bengali Sign Word Recognition Model and Language Model”. By requesting and using this dataset, reader agree to comply with the terms and conditions outlined below.
1. Purpose
The dataset is provided with the specific goal of addressing the absence of a comprehensive video dataset for Bengali sign language. It aims to support the development of real-life expert systems and other research or applications that require a rich resource of Bengali sign language videos.
2. Access Request Procedure
To request access to the dataset, Readers must:
2.1. Submit a written request to the corresponding author, Nasima Begum, at
[email protected], including:
• Name and affiliation of the requester.
• Purpose of the data request, including a brief description of the intended use.
• Agreement to the terms and conditions of this DUA.
2.2. Await approval from the Authors. The Authors reserve the right to deny access requests at their discretion.
3. Terms and Conditions of Use
By accessing and using the dataset, Readers agree to the following terms:
• Non-Commercial Use: The dataset shall be used solely for academic, research, and educational purposes. Commercial use is strictly prohibited.
• Data Integrity: Readers shall not modify or alter the dataset except as necessary for analysis purposes.
• Confidentiality: Readers must keep the dataset secure and not share it with unauthorized individuals or third parties.
• Credit and Attribution: Any publication or presentation resulting from the use of the dataset must properly credit the Authors and cite the original source of the dataset.
4. Compliance and Reporting
• Readers agree to comply with all applicable laws and regulations regarding data use and privacy.
• Readers must report any findings, publications, or derivative works resulting from the dataset to the corresponding author, Nasima Begum, at [email protected].
5. Termination
The Authors reserve the right to terminate this agreement and the Reader's access to the dataset at any time if the Reader is found to be in violation of the terms and conditions outlined in this DUA.
6. Liability
The dataset is provided "as is" without any warranties, express or implied. The Authors shall not be liable for any damages arising from the use or inability to use the dataset.
7. Amendments
This agreement may be amended by the Authors at any time. Any amendments will be communicated to the Readers via email.
By requesting and using the dataset, you acknowledge that you have read, understood, and agreed to the terms and conditions of this Data Usage Agreement.
Contact information:
Dr. Nasima Begum
[email protected]
Safi Ullah Chowdhury
[email protected]</a
Chirurgie beim lokalisierten nichtkleinzelligen Lungenkarzinom in den Frühstadien I und II : Von der Tradition zu neuen modernen Methoden der Thoraxchirurgie
No full textCrime Masala : Ibne Safi and South Asian crime fiction writing
No full textNurt detektywistyczny w literaturze pisanej w języku urdu stanowi przykład niezwykłego fenomenu literackiego. To właśnie po książki pisane w tym stylu najchętniej sięgają czytelnicy w Indiach i w Pakistanie. Co więcej, twórczość pisarzy związanych z nurtem detektywistycznym – przez krytyków i historyków literatury najczęściej pomijana milczeniem – odegrała znaczącą rolę w życiu literackim Indii i Pakistanu. Jednym z najciekawszych reprezentantów owego nurtu był, tworzący w języku urdu, Ibne Safi. Jego książki ukazywały się równocześnie w Indiach i w Pakistanie, a każda z nich z miejsca stawała się bestsellerem. A mimo to, postać Ibne Safiego nieobecna jest na kartach historii literatury tworzonej w urdu.
Głównym celem niniejszego artykułu jest prezentacja nurtu detektywistycznego w urdu poprzez postać jednego z najciekawszych pisarzy tworzących w tym stylu - Ibne Safiego. Tekst skupia się na stylu autora oraz inspiracjach, które miały wpływ na jego pisarstwo. Konkretne przykłady podparte są cytatami z powieści Safiego, które nigdy wcześniej nie były tłumaczone na język polski.Crime fiction written in Urdu language is an example of an extraordinary literary phenomenon. Books written in that genre are extremely popular amongst the readers in both India and Pakistan. Yet, in those countries novels by prolific crime fiction writers are not even included on best-seller lists, even though their selling reaches thousands of copies. Moreover, crime fiction is absent from works of literary critics and scholars dealing with vernacular writing of India and Pakistan. The main aim of this article is to present the crime scene of Urdu literature through the profile of Ibne Safi – the most interesting writer of this genre. The text focuses on the style of the author and inspirations that have shaped his writing. Arguments are based on excerpts from his novels that have not been translated into Polish before
Safi, Capital of the Western Atlantic during the XVI century. A rehabilitation proposal
No full textWhat is the role of architecture when enhancing tourism in a region? How can the architect’s vision help reactivate under performing regions, considering the relationship between design, heritage, tourism and landscape? How can design’s architectural and landscape processes contribute to the reinvention of marginal areas, reflect upon the sense of place and the needs expressed by visitors, while prioritizing the region’s aims and its inhabitants? This text unveils historical and architectural surveys that were realized in recent years by the author and within a multidisciplinary team, on the city of Safi. It presents historical analysis as well a rehabilitation master plan for the city of Safi.CIHDEUS, Iuav Venezi
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