1,720,957 research outputs found
The Unconventional Growth Factors Cerebral Dopamine Neurotrophic Factor and Mesencephalic Astrocyte–Derived Neurotrophic Factor Promote Post-ischemic Neurological Recovery, Perilesional Brain Remodeling, and Lesion-Remote Axonal Plasticity
No full textTürkiye Bilimler AkademisiTürkiye Bilimsel ve Teknolojik Araştirma Kurum
Circadian clock protein Bmal1 protects against transient focal cerebral ischemia in mice by regulating master signals controlling cell survival and metabolism
No full texthttp://dx.doi.org/10.13039/501100004410 Scientific and Technological Research Council of Turkeyhttp://dx.doi.org/10.13039/501100004412 Turkish Academy of Science
Investigation of the role of BMAL1 in acute and subacute period traumatic brain injury
No full textTravmatik beyin hasarı, her yıl dünya çapında 50 milyondan fazla bireyi etkilemekle beraber bireylerde kalıcı ve geçici fiziksel etkilerin, nörolojik ve psikolojik sorunların da başlıca nedenlerinden biridir. İnsidansı yüksek olmasına rağmen şu anda Amerikan Gıda ve İlaç Dairesi (FDA) onaylı bir tedavi metodu bulunmamaktadır. Bmal1, sirkadiyen ritmin düzenlemesinde merkezi rol oynayan bir transkripsiyon faktörüdür. Parkinson, beyin felci gibi nörodejeneratif hastalıklarda etkili olan Bmal1'in, beyin hasarı ile meydana gelen mekanizmaların oluşmasını engellemeye yardımcı olduğu düşünülmektir. Bmal1'in travma sonrası meydana gelen moleküler mekanizmalar üzerine etkisi henüz tam aydınlatılamamıştır. Bu tezde Bmal1'in travmatik beyin hasarı patofizyolojisindeki rolünün gösterilmesi amaçlanmıştır. Bu amaçla lentivirüslerle Bmal1 ifadesi arttırılan veya azaltılan farelere soğuk ile indüklenen travmatik beyin hasarı uygulanmıştır. Bmal1 ifadesinin arttılmasının nöronal sağkalımı arttırdığı, apoptotik hücre ölümünü, hasar hacmini ve beyin ödemini azalttığı; Bmal1 ifadesinin azaltılmasının ise nöronal sağkalımı azalttığı, apoptotik hücre ölümünü, hasar hacmini ve beyin ödemini arttırdığı gösterilmiştir. Bmal1'in travmatik beyin hasarı sonrası p-Akt, p-Erk 1/2, p-SAPK/JNK 1/2, Bax, Bcl-XL, eNOS gibi hücresel sağkalımda, stres yanıtlarında, apoptotik mekanizmalarda görev alan ve Gap43, Brevican, Versican gibi aksonal büyüme ile ilgili proteinlere istatiksel anlamlı bir etkisinin olduğu, depresyon, lokomotor aktivite ve motor koordinasyon üzerine ise herhangi istatiksel anlamlı bir etkisi olmadığı gösterilmiştir. Elde edilen sonuçların literatürde lentiviral vektörler aracılığıyla protein ifadesi arttırılmış ve azaltılmış olan Bmal1'in hem akut dönem hem de subakut dönem travmatik beyin hasarı sonrası etkisinin aydınlatılmasına katkı sağlaması beklenilmektedir.Traumatic brain injury affects more than 50 million individuals worldwide each year, and is one of the main causes of permanent and temporary physical effects, neurological and psychological problems in individuals. Despite the incidence is high, there is currently no specific treatment method approved by the US Food and Drug Administration (FDA). Bmal1 is a transcription factor that plays a central role in the regulation of the circadian rhythm. Bmal1 is known to play a role in neurodegenerative diseases such as Parkinson's and stroke, it is thought to help prevent the formation of mechanisms that occur with brain damage. The effect of Bmal1 on the molecular mechanisms that occur after trauma has not yet been fully elucidated. In this thesis, it is aimed to show the role of Bmal1 in the pathophysiology of traumatic brain injury. For this purpose, cold-induced traumatic brain injury was applied to mice which have increasing or decreasing Bmal1 expression induced by lentiviruses. According to the results, increased Bmal1 expression increased neuronal survival, decreased apoptotic cell death, injury volume, and brain edema; it has been observed that decreasing Bmal1 expression decreases neuronal survival, increases apoptotic cell death, injury volume and brain edema. A statistically significant effect of Bmal1 on proteins that play a role in cellular survival, stress responses and apoptotic mechanisms such as p-Akt, p-Erk 1/2, p-SAPK/JNK 1/2, Bax, Bcl-XL, eNOS after traumatic brain injury. It has been shown that it has a statistically significant effect on axonal growth-related proteins such as Gap43, Brevican, Versican, but has no statistically significant effect on depression, locomotor activity and motor coordination. It is expected that the results obtained will contribute to the elucidation of the effect of Bmal1, whose protein expression is increased and decreased by lentiviral vectors in the literature, after both acute and subacute traumatic brain injury
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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