1,721,196 research outputs found
L’epilogo della vicenda insediativa: l’abbandono del centro lucano e le trasformazioni del territorio in età romana
No full textLe recenti campagne di ricognizione di superficie, promosse nel comprensorio di Torre di Satriano (PZ) hanno consentito di gettare nuova luce sugli assetti insediativi di età romana. Il caso preso in esame rappresenta un’ulteriore conferma dell’ inarrestabile processo di destrutturazione del territorio lucano all’epoca del contatto e della guerra con Roma. Al completo abbandono dell’altura fortificata di età lucana fa infatti riscontro una significativa riduzione delle presenze nel territorio circostante. La cesura sembra potersi collocare tra la fine del III e gli inizi del II sec. a.C., in concomitanza con la creazione del nuovo polo urbano di Potentia che determinerà consistenti trasformazioni degli assetti territoriali di tutta l’area centro-occidentale della regione. Da un’ analisi incrociata della orografia, della idrografia e della distribuzione dei siti individuati è stato possibile ricostruire, per il comprensorio di Torre di Satriano, il sistema viario di età romana che sembra ricalcare tracciati di età precedente. Tale acquisizione consente di dare una spiegazione alla pur rarefatta presenza di siti di età romana, che verrebbero così a collocarsi lungo tracciati di collegamento ai principali assi stradali della Lucania romana
Organizzazione dello spazio insediativo e paesaggi agrari in Lucania: il caso di Torre di Satriano
No full textImpact of immunogenetic polymorphisms in bone marrow failure syndromes.
No full textAIM:
To explore whether predisposition to bone marrow failure syndromes (BMF), such aplastic anemia (AA), paroxysmal nocturnal hemoglobinuria (PNH) and myelosysplastic syndromes (MDS), is found in killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) ligand (KIR-L) gene variations or cytokine polymorphisms.
PATIENTS:
We studied a cohort of 77 patients with AA, 129 with MDS and 285 healthy controls for the frequencies of KIR-L and KIR genotypes and 22 selected single nucleotide polymorphisms (SNPs) located within 10 cytokine (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-10, IL12, IFN- γ, TNF- α, TGF- β) and 3 cytokine receptor (IL-1R, IL-1RA, IL-4Rα) genes.
RESULTS:
In AA we found a decreased frequency of inhibitory KIR-2DL3 genes. In MDS, no difference in the frequency of KIR genotype was identified; however, a decreased frequency of 2DL3 was found in hypocellular MDS. Analysis of the KIR genotype in correlation with the corresponding KIR-L profile, revealed a decreased frequency of stimulatory 2DS1/C2 mismatch both in AA and MDS. In AA and MDS cohorts, compared to controls, we found a higher frequency of TT codon 10 variant and of GG codon 25 variant of TGF- β gene, consistent with a high secretory phenotype. This relationship was even more pronounced in PNH and hypocellular MDS. We confirm that the hypersecretory genotype T/T at position -874 of INF-γ gene was overrepresented only in AA and correlates with presence of a PNH clone. Instead in MDS patients, the frequency of G/A polymorphism at position -308 on the TNF- α gene promoter, which correlates with higher TNF- α production, was found significantly higher. Moreover, hypocellular MDS was characterized by a higher prevalence of IL-10 GCC/GCC haplotype, which is functionally associated with a low secretor phenotype.
CONCLUSION:
Our findings suggest that alterations in KIR/KIR-L matching, such as increased 3DL2 and decreased 2DS1 mismatch, and in the polymorphisms of TGFβ1, IFN-γ, TNF- α and IL-10 may account for the propensity to immunemediated killing of hematopoietic stem cells and/or ineffective hematopoiesis characteristic of AA and MDS. Further studies are needed to elucidate whether these immunogenetic traits may be involved in increased risk of developing immune-mediated BMF
All Roads Lead to Interferon-γ: From Known to Untraveled Pathways in Acquired Aplastic Anemia
No full textBone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions with common clinical features including reduced bone marrow cellularity and peripheral blood cytopenias. Acquired aplastic anemia (AA) is caused by T helper(Th)1-mediated immune responses and cytotoxic CD8+ T cell-mediated autologous immune attacks against hematopoietic stem and progenitor cells (HSPCs). Interferon-γ (IFNγ), tumor necrosis factor-α, and Fas-ligand are historically linked to AA pathogenesis because they drive Th1 and cytotoxic T cell-mediated responses and can directly induce HSPC apoptosis and differentiation block. The use of omics technologies has amplified the amount of data at the single-cell level, and knowledge on AA, and new scenarios, have been opened on “old” point of view. In this review, we summarize the current state-of-art of the pathogenic role of IFNγ in AA from initial findings to novel evidence, such as the involvement of the HIF-1α pathway, and how this knowledge can be translated in clinical practice
Ricostruire la memoria, illuminare i silenzi. Esperienze a confronto per la storia dell'educazione nell'area mediterranea
No full textIl Mediterraneo, da sempre crocevia di popoli e luogo di scambi culturali, è il filo conduttore che lega i saggi presentati, nei quali si fa spazio a saperi disciplinari differenti. Comune denominatore è il recupero della memoria e la valorizzazione di esperienze che assumono un ruolo rilevante ai fini di una ricostruzione della storia dell’educazione in area mediterranea. In tale ricostruzione, che parte dall’antichità per arrivare ai nostri giorni, appare centrale la volontà di fare spazio alla nuova veste della ricerca storica, che negli ultimi sessant’anni è andata progressivamente soppiantando il “fare storia ufficiale” — fortemente intriso di un carattere ideologico e persuasivo — per fare posto al recupero di oggetti di studio silenti, che meritavano, appunto, di essere illuminati. In quest’ottica, e nel tentativo di recuperare le storie locali dell’area mediterranea, si sono approfonditi alcuni soggetti “ai margini” della storia dell’educazione, come
le donne e gli anziani, utilizzando nuove fonti storiografiche e archivi cosiddetti “minori”: storie orali, racconti autobiografici, attrezzi di lavoro e arredi, con particolare riferimento a quelli scolastici.
Contributi di Gabriella Armenise, Vittoria Bosna, Antonella Cagnolati, Giovanni U.
Cavallera, Hervé A. Cavallera, Daniela De Leo, Barbara De Serio, Pablo Álvarez Domínguez,
Franca Pinto Minerva
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Mediterraneo: crocevia di storie, culture, progettualità. Note introduttive
No full textBreve introduzione che illustra le finalità del volume ed i contenuti dei sagg
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