130,633 research outputs found
Myrsidea serini
No full textserini species group The three species of this group are characterized as having both sexes with weakly developed hypopharyngeal sclerites (Fig. 40), the females with a strongly spiculate posterior margin of the subgenital plate (Fig. 39), and the males with a well-developed sternite II (Fig. 43) and unusual genital sac sclerites (Fig. 44).Published as part of Price, Roger D. & Dalgleish, Robert C., 2007, Myrsidea Waterston (Phthiraptera: Menoponidae) from the Emberizidae (Passeriformes), with descriptions of 13 new species, pp. 1-18 in Zootaxa 1467 on page 12, DOI: 10.5281/zenodo.17659
Myrsidea serini Seguy
No full textMyrsidea serini (Séguy) (Fig. 39) Menopon serini Séguy 1944: 80. Type host: " Serinus canaria serinus (L.)" = Serinus serinus (L.), European Serin (Fringillidae). Female (3). Gula with 4–5 setae on each side. Metanotum, dorsal abdomen, and ventral terminalia as in Fig. 39. Metanotum not enlarged, with 12–15 marginal setae; metasternal plate with 4–6 setae. Abdominal tergites unmodified, with slight medioposterior curvature associated with III–IV. Tergal setae, with median gap on III– VIII: I, 14–16; II, 17–18; III–V, 14–17; VI, 12–14; VII, 9–11; VIII, 8. Postspiracular setae long on V–VI (0.16–0.21), extremely long on VII (0.34–0.40). Sternal setae: II, 3–4 in each aster, 11–13 marginal between asters, 6–9 anterior; III, 21–24; IV–V, 30–38; VI, 19–26; VII, 12–14; VIII–IX, 16–19. Dimensions: TW, 0.40– 0.42; HL, 0.27–0.30; PW, 0.27–0.28; MW, 0.41–0.46; AWIV, 0.61–0.65; ANW, 0.19–0.24; TL, 1.45–1.56. Male (3). Gula with 4–5 setae on each side. Metanotum and dorsal abdomen much as in Fig. 42. Metanotum with 11–12 marginal setae; metasternal plate with 5 setae. Tergal setae, with median gap on posterior segments: I, 15–16; II, 21–22; III, 19–20; IV, 18–19; V–VII, 16–18; VIII, 12–14. Sternal setae: II, 3–4 in each aster, 10–12 marginal between asters, 8–10 anterior; III, 19–24; IV–V, 35–38; VI, 24–29; VII, 14–16; VIII, 4– 5. Dimensions: TW, 0.37–0.39; HL, 0.27–0.28; PW, 0.24–0.26; MW, 0.35–0.39; AWIV, 0.49–0.52; GL, 0.39– 0.43; TL, 1.20–1.35. Material examined. 3 females, 3 males, ex Emberiza citrinella calliginosa Clancey, NEW ZEALAND (3 collections). Remarks. This is an atypical species of Myrsidea in that it is the only one reported from this genus by Price et al. (2003) to occur on hosts in two different passerine families -- the Fringillidae and the Emberizidae. Klockenhoff (1984) redescribed this species and recorded it from one species of Serinus each from Morocco and New Zealand, one of Carduelis each from Spain and New Zealand, and one of Emberiza from New Zealand. The detailed description is excellent and is accompanied by fine illustrations. Our descriptive details for M. serini are based only on the material we have studied from E. citrinella. Since the other specimens included in this louse taxon by Klockenhoff (1984) are in the Fringillidae and beyond the scope of this paper, we tentatively accept these also as M. serini.Published as part of Price, Roger D. & Dalgleish, Robert C., 2007, Myrsidea Waterston (Phthiraptera: Menoponidae) from the Emberizidae (Passeriformes), with descriptions of 13 new species, pp. 1-18 in Zootaxa 1467 on pages 12-13, DOI: 10.5281/zenodo.17659
ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3
No full textAn interactive crosstalk between tumor and stroma cells is essential for metastatic melanoma progression. We evidenced that ESDN/DCBLD2/CLCP1 plays a crucial role in endothelial cells during the spread of melanoma. Precisely, increased extravasation and metastasis formation were revealed in ESDN-null mice injected with melanoma cells, even if the primary tumor growth, vessel permeability, and angiogenesis were not enhanced. Interestingly, improved adhesion of melanoma cells to ESDN-depleted endothelial cells was observed, due to the presence of higher levels of E-selectin transcripts/proteins in ESDN-defective cells. In accordance with these results, anticorrelation was observed between ESDN and E-selectin in human endothelial cells. Most importantly, our data revealed that cimetidine, an E-selectin inhibitor, was able to block cell adhesion, extravasation, and metastasis formation in ESDN-null mice, underlying a major role of ESDN in E-selectin transcription upregulation, which according to our data, may presumably be linked to STAT3. Based on our results, we propose a protective role for ESDN during the spread of melanoma and reveal its therapeutic potential.sponsorship: D. Taverna: Compagnia di San Paolo, Torino, 2008.1054, AIRC 2013, 2017 (IG2013-14201DT; IG2017-20258DT), Fondazione Cassa di Risparmio Torino CRT (2018.1311DT); Progetto di ricerca di Ateneo/SanPaolo 2017 Torino; M. Mazzone: supported by a long term structural Methusalem funding from the Flemish Government; M. M. Sadeghi: NIH (R01-HL138567) and Department of Veterans Affairs (I0-BX004038); G. Serini: Fondazione AIRC IG grant #21315; Fondazione AIRC under 5 per Mille 2018 -ID. 21052 program -P.I. Comoglio Paolo, G.L. Guido Serini; D. Valdembri: Fondazione AIRC IG grant #20366; R. Coppo: Telethon fellowship (Grant 2014 GGP14106 to Emilio Hirsch); L. Quirico: FIRCAIRC fellowship (Rif. 24188). (Compagnia di San Paolo, Torino|IG2013-14201DT, Compagnia di San Paolo, Torino|IG2017-20258DT, Fondazione Cassa di Risparmio Torino CRT|2018.1311DT, Progetto di ricerca di Ateneo/SanPaolo 2017 Torino, Flemish Government, NIH|R01-HL138567, Department of Veterans Affairs|I0-BX004038, Fondazione AIRC IG|21315, Fondazione AIRC IG|20366, Fondazione AIRC|21052, Telethon fellowship|2014 GGP14106, FIRCAIRC fellowship|24188)status: Publishe
Search for dark matter cosmic-ray electrons and positrons from the Sun with the Fermi Large Area Telescope
No full textWe use 7 years of electron and positron Fermi-LAT data to search for a possible excess in the direction of the Sun in the energy range from 42 GeV to 2 TeV. In the absence of a positive signal we derive flux upper limits which we use to constrain two different dark matter (DM) models producing e+e-fluxes from the Sun. In the first case we consider DM model being captured by the Sun due to elastic scattering and annihilation into e+e-pairs via a long-lived light mediator that can escape the Sun. In the second case we consider instead a model where DM density is enhanced around the Sun through inelastic scattering and the DM annihilates directly into e+e-pairs. In both cases we perform an optimal analysis, searching specifically for the energy spectrum expected in each case, i.e., a boxlike shaped and linelike shaped spectrum respectively. No significant signal is found and we can place limits on the spin-independent cross section in the range from 10-46 cm2 to 10-44 cm2 and on the spin-dependent cross section in the range from 10-43 cm2 to 10-41 cm2. In the case of inelastic scattering the limits on the cross section are in the range from 10-43 cm2 to 10-41 cm2. The limits depend on the life time of the mediator (elastic case) and on the mass splitting value (inelastic case), as well as on the assumptions made for the size of the deflections of electrons and positrons in the interplanetary magnetic field
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Supplementation with canthaxanthin affects plasma and tissue distribution of and γ-tocopherols in mice
No full textThe effects of oral doses of canthaxanthin on tissue distribution of α- and γ-tocopherols were investigated in three experiments in male and female Balb/c mice. Mice were assigned to receive canthaxanthin [7 or 14 μg/(g body weight. d)] or placebo (olive oil) by gavage for different periods of time (0, 1, 2, 4 and 6 wk). A 2 wk-treatment with canthaxanthin resulted in incorporation of the carotenoid in all tissues analyzed, including liver, spleen, kidney, lung and heart. In liver, the maximum accumulation of the carotenoid was reached after 2 wk of dosing in female mice and after 6 wk in male mice. Canthaxanthin incorporation was accompanied by changes in α- and γ-tocopherol concentrations in plasma and tissues. These included the following: 1) a significant increase (P < 0.001) in α-tocopherol concentration in spleen (21 and 27% in male and female mice, respectively) after 2 wk and in liver (~50% in both male and female mice) after 6 wk; 2) a significant decrease in γ-tocopherol concentration in plasma (P < 0.05) and tissues (P < 0.001) after 2 wk of treatment. In female mice, this decrease was 55% in plasma, 43% in liver, 44% in kidney, 71% in lung and 70% in heart. In male mice, the decrease was observed only in plasma (30%), kidney (54%) and heart (46%). In liver, the decrease in γ-tocopherol concentration was both dose- and time-dependent and significantly (P < 0.001) greater in female than in male mice. We conclude that dietary administration of canthaxanthin modifies tocopherol status in murine tissues
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