126,028 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Progetto I-Log (Industrial Logistics)-Guida Logistica
No full textLa guida Logistica del Progetto I-Log è il risultato finale delle attività progettuali avviate nel gennaio 2003. Il progetto, finanziato nell'ambito del primo bando del Programma Comunitario Interreg IIIB, ha come obiettivo principale quello di dotare le Piccole e Medie Imprese operanti nei sistemi produttivi locali di strumenti innovativi per sostenere la competitività,la razionalizzazione dei sitemi di logistica e dei trasporti e nella riduzione dei problemi connessi alla congstione del traffico
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Structures and Evaluation of Biologically Active Constituents of "Cussonia Zimmermannii" Harms
No full textFor the present thesis 22 samples of seven African medicinal plants, the extracts of which had previously proved to possess an in vitro activity against T. b. rhodesiense and/or P. falciparum and 13 samples of six randomly selected plant species based on availability were collected in Tanzania. Of these 35 samples, 140 crude extracts were produced with four solvents of different polarity, and the extracts were tested for in vitro antitrypanosomal and antiplasmodial activity and for cytotoxicity. In addition the extracts were tested for the affinity to the GABAA receptor performed by radioligand binding experiments. Based on the considerable antitrypanosomal and antiplasmodial activity and the affinity to the GABAA receptor, two extracts were selected for bioassay-guided fractionation : the petroleum ether extract of the stembark of Commiphora fulvotomentosa Engl. because of its promising IC50 value of 2.1 mg/ml against T. b. rhodesiense and the high selectivity index of 21.4, and the petroleum ether extract of the rootbark of Cussonia zimmermannii Harms because of its IC50 value of 4.8 mg/ml against T. b. rhodesiense, its IC50 value of 3.3 mg/ml against P. falciparum, and the potent modulatory effect at the GABAA receptor of 151 %. After three fractionation steps the fractions of the petroleum ether extract of the stembark of Commiphora fulvotomentosa Engl. did not show any inhibitory activity against T. b. rhodesiense and were therefore not investigated further. Bioassay-guided fractionation of the petroleum ether extract of the rootbark of Cussonia zimmermannii Harms lead to the isolation of four polyacetylenes. By the application of MS, HR-MS, UV/VIS and IR methods and NMR experiments (1H-NMR, 13C-NMR, DEPT135, 1H-1H COSY, HMQC and HMBC) the structures of the four novel diynes were established : 8-Hydroxyheptadeca-4,6-diyn-3-yl acetate (MS-1 (25)), 8-Hydroxyheptadeca-1-ene-4,6-diyn-3-yl acetate (MS-2 (26)), 16-Acetoxy-11- hydroxyoctadeca-17-ene-12,14-diynyl acetate (MS-4 (27)), and 11,16-Diacetoxyoctadeca- 17-ene-12,14-diynyl acetate (MS-5 (28)). Additionally, stigmasterol (42) was isolated and identified by comparison of its spectroscopic data with those of an authentic sample. For the determination of the absolute configuration of MS-4 (27) at C(11) the Mosher method was used. The negative d values for the neighbouring protons suggested the S-configuration. But this result could not be confirmed by the 13C-NMR data since both positive and negative d values were obtained for the neighbouring carbons. Due to the fact, that the results for the protons and the carbons were not consistent the S-configuration for C(11) of MS-4 (27) could not be assigned with certainty. The isolated compounds MS-1 (25), MS-2 (26), and MS-4 (27) were tested for in vitro inhibitory activity against additional parasites like T. cruzi and L. donovani (axenic and in infected macrophages). 42 was not tested because it was a well known phytosterol which is ubiquitous in plants. Neither was MS-5 (28) tested, since the isolated amount was not sufficient. It was found that MS-1 (25) showed in all antiparasitic in vitro assays no higher inhibitory activity than the crude extract. MS-2 (26) showed promising activities in the T. cruzi and L. donovani (axenic and in infected macrophages) assay with IC50 values of 0.2, 0.039, and 0.098 mg/ml, respectively. The respective IC50 values of the standard drugs were 0.62, 0.18, and 0.29. The cytotoxicity was relatively high; therefore the selectivity with SI values of 18.0 and 36.7, respectively (T. cruzi, L. donovani in inf. mac.), was in a moderate range. MS-4 (27) showed also interesting activities in the T. cruzi and L. donovani (axenic) assays with IC50 values of 0.15 and 0.054 mg/ml. The SI value of 145.3 (T. cruzi) was high. Compared with the standard drugs the activities of MS-2 (26) and MS-4 (27) against T. b. rhodesiense and P. falciparum were in a moderate range. MS-1 (25), MS-2 (26), and MS-4 (27) were also tested in the GABAA receptor binding assay. Here MS-4 (27) showed the highest relative specific binding of 158 % at a concentration of 20 mg/ml, followed by MS-2 (26) with 152 % and MS-1 (25) with 138 %. In order to investigate whether the modulatory effect at the GABAA receptor leads to a chanel opening, the isolated compounds were investigated electrophysiologically. It was found that MS-1 (25), MS-2 (26), and MS-4 (27) act as potent positive allosteric modulators at GABAA receptors with a half maximal stimulation at a concentration of 0.6-3.5 mM and a maximal stimulation of 110-450 %. The compounds also showed unique subunit selectivity profiles, the stimulation was independend from the presence of the g subunit and resistant to the benzodiazepine antagonist Ro15-1788. These in vitro data suggested that MS-1 (25), MS-2 (26), and MS-4 (27) may be used to treat diseases of the central nervous system, specifically they may be used to treat states of anxiety, as sedatives/hypnotics, as muscle relaxants and as anticonvulsives (e.g. in epilepsy), and in the treatment of drug addiction. Therefore it was decided to patent the compounds for these indications [174]. All data are on the in vitro level. For a pharmaceutical application in vivo data are needed. Therefore MS-1 (25), MS-2 (26), and MS-4 (27) need to be synthesized in order to get more material for subsequent in vivo experiments
Overstating the evidence - double counting in meta-analysis and related problems
No full textBackground: The problem of missing studies in meta-analysis has received much attention. Less attention has been paid to the more serious problem of double counting of evidence.
Methods: Various problems in overstating the precision of results from meta-analyses are described and illustrated with examples, including papers from leading medical journals. These problems include, but are not limited to, simple double-counting of the same studies, double counting of some aspects of the studies, inappropriate imputation of results, and assigning spurious precision to individual studies.
Results: Some suggestions are made as to how the quality and reliability of meta-analysis can be improved. It is proposed that the key to quality in meta-analysis lies in the results being transparent and checkable.
Conclusions: Existing quality check lists for meta-analysis do little to encourage an appropriate attitude to combining evidence and to statistical analysis. Journals and other relevant organisations should encourage authors to make data available and make methods explicit. They should also act promptly to withdraw meta-analyses when mistakes are found
Aménagement touristique et transformation de l’espace urbain: les risques di développement du secteur a travers le cas comparé de Venise et Marrakech
No full textBedürfnisgerecht pflegen in der Gynäkologie: Ein Symptom-Tagebuch für Frauen nach vulvären chirurgischen Eingriffen
No full textHow cancer research could benefit from the Complex Intervention Framework : students' experiences of the European Academy of Nursing Science summer school
No full textSENN B., KIRSCH M., SANZ C.C., KARLOU C., TULUS K., DE LEEUW J., RINGNÉR A., GOOSSENS G.A. & CLEARY V. (2011) European Journal of Cancer Care20, 1-4
How cancer research could benefit from the Complex Intervention Framework: students' experiences of the European Academy of Nursing Science summer school.status: Publishe
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