1,017 research outputs found
Introduction by Manuela Gieri
No full textIn the introduction to the volume, the author outlines the development of Italian cinema from its early days to the present
Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
No full textCorrection to: Nature Genetics, 50, 928–936 (2018), https://doi.org/10.1038/s41588-018-0142-8, published online 11 June 2018.
In the version of this article initially published, the name of author Manuela Gago-Dominguez was misspelled as Manuela Gago Dominguez. The error has been corrected in the HTML and PDF version of the article.No Full Tex
Killer Peptide-Containing Polyelectrolytic Nanocomplexes to Fight <i>Toxoplasma gondii</i> Infection
No full textBackground/Objectives: Toxoplasmosis, a zoonotic disease caused by Toxoplasma gondii, typically is asymptomatic in immunocompetent individuals but causes severe complications in immunocompromised subjects and during pregnancy. Current treatments such as pyrimethamine and sulfadiazine are effective for acute infections but cannot eliminate encysted bradyzoites and have significant side effects. The antimicrobial killer peptide (KP) has interesting therapeutic potential, but its intracellular delivery is challenging; hyaluronate-based nanoparticles loaded with KP (KP-NPs) were evaluated to target T. gondii-infected cells that overexpress CD44. Methods: KP-NPs made of chitosan and hyaluronate were produced by microfluidics and were characterized for size, surface charge, encapsulation efficiency, and stability under stress conditions. After excluding their toxicity, their activity was tested in vitro against Candida albicans and T. gondii as free tachyzoite or in infected human foreskin fibroblasts (HFFs). Results: KP was efficiently encapsulated in nanoparticles and protected from harsh acidic conditions at high temperature. Preliminary in vitro testing against C. albicans showed that, at the lowest candidacidal concentration of KP (2.5 μg/mL), KP-NPs killed 90.97% of yeast cells. KP itself proved to be non-toxic for HFFs as host cells and effective against T. gondii. Comparable results were obtained for KP-NPs and blank nanoparticles (BLK-NPs), with no observed toxicity to host cells, confirming that encapsulation did not alter peptide efficacy. The parasiticidal effect of KP alone, as well as KP-NPs at 250 µg/mL and BLK-NPs, was confirmed through tests on free T. gondii tachyzoites. Reduction rates for the number of infected cells ranged from 66% to 90% with respect to control, while the reduction in the number of intracellular tachyzoites ranged from 66% to 80%. Interestingly, KP alone was not effective against intracellular tachyzoite, while KP-NPs maintained an efficacy comparable to the extracellular model, suggesting that particles helped the internalization of the peptide. Conclusions: Encapsulation of KP into hyaluronate/chitosan nanoparticles does not alter its activity and improves its efficacy against the intracellular parasite. Notably, BLK-NPs appeared to exhibit efficacy against the parasite on its own, without the presence of KP
La biografía de Manuela Cambronero
No full textManuela Cambronero’s biography has been a pending issue until now, given that her figure has not aroused interest and no studies which focus on clarifying her origins and chronology have been published. This information is essential as a starting point for any work on the author, which is why elucidating these unknowns through direct archive research is a sine qua non. Consequently, locating Manuela Cambronero’s baptismal, marriage and death certificates is the only reliable way to dispel any doubt about her provenance and to determine the exact places and dates of the trans-cendental events of her life.La biografía de Manuela Cambronero ha sido una cuestión pendiente hasta ahora, pues, como su figura no ha suscitado interés, no se han publicado estudios centrados en esclarecer su origen y su cronología. Esta información es esencial como punto de partida para cualquier trabajo sobre la autora, por lo que dilucidar estas incógnitas a través de la búsqueda directa en archivos se convierte en una condición sine qua non. En consecuencia, la localización de los certificados de bautismo, de matrimonio y de defunción de Manuela Cambronero es la única vía fiable para disipar las dudas sobre su procedencia y para concretar los lugares y fechas exactas de los eventos trascendentales de su vida
Manuela Sáenz en varios textos
No full textThis report is an attempt to analyze the narrative discourse order in the novel “La esposa del Dr. Thorne” (Dr. Thorne’s Wife) of the Venezuelan writer Denzil Romero, in the light of ¨Las cuatro estaciones de Manuela” (“The Four Seasons of Manuela”) of the American author Víctor W. von Hagen, and of “Manuela. Sus diarios perdidos y otros papeles”, (Manuela. Lost Diaries and Other Papers) of the Ecuadorian Carlos Álvarez Saá. This paper is a risky comparison between a book of fiction, presumably based on real facts, where Manuela’s eroticism is the central theme in Romero, the large literary chronicles issued by von Hagen and the compilation and discovery of alleged original and historic texts (letters and diaries) produced by Álvarez Saá. It is also a research exercise where, whimsically, what the official discourse says, as it may be viewed by the school of Venezuela or that of Quito, is mixed with the fictionalization of that discourse. It is, too, a possible vindication of Manuela Sáenz as a person and/or predominant character in the fights for the independence of America beyond her ¨circumstantial¨ relationship with Simón Bolívar. It is, to a certain extent, a look into how literary texts and the perceptions of history about a character (Manuela) tend to a “rearrangement” in present times and how there has been an attempt to consolidate the figure of Manuela Sáenz as a heroine, awarding a victory to what von Hagen calls “the school of Quito”.Si prese l’analisi dell’ordine discorsivo narrativo del romanzo dell’autore venezuelano Denzil Romero, La sposa del Dott.re Thorne, attraverso le comparazioni delle opere dell’autore statunitense Víctor W. Von Hagen, Le quattro stagioni di Manuela e dell’ autore ecuadoregno Carlos Álvarez Saá, Manuela, i suoi diari persi ed altre carte. È una comparazione azzardadata tra un libro di finzione, forse basato in fatti reali, dove l’erotismo della donna (Manuela) costituisce la tematica centrale, nell’opera di Romero, con la lunga cronaca letteraria che fa von Hagen e la compilazione e la scoperta di supposti testi originali e storici (lettere, diari) che fa Álvarez Saá. È un esercizio di ricerca dove si mescolano, in modo capriccioso, il campo d’attività del Venezuela o quello del Quito, e la finzione di quello ufficiale. È anche la rivendicazione possibile di Manuela Sáenz come persona e/o personaggio preponderante nelle lotte indipendentistiche dell’America che era aldilà della relazione congiunturale con Simón Bolívar. Si vuole vedere, fino a un certo punto, come i testi letterari e le percezioni della storia su un personaggio (Manuela) tendono a sistemarsi con i tempi attuali e come si ha voluto affiancare la figura eroica di Manuela Sáenz, concedendole il trionfo, forse secondo la tesi di von Hagen: quella che lui definisce la scuola di Quito.Se pretendeu analisar a ordem discursivo-narrativa do romance do venezuelano Denzil Romero, “La esposa del Dr. Thorne”, à luz das obras do americano Víctor W. von Hagen, ¨Las cuatro estaciones de Manuela” e do equatoriano Carlos Álvarez Saá, “Los diários perdidos de Manuela Sáenz y otros papeles”. Este trabalho é a comparação arriscada entre um livro de ficção, baseado aparentemente em fatos reais, no qual o erotismo da mulher (Manuela) é o tema central, em Romero, com a extensa crônica literária que lhe faz von Hagen e a recopilação e a descoberta de aparentes textos originais e históricos (cartas, diários) que faz Álvarez Saá. Também é um exercício de pesquisa em que, de maneira especial, se mistura o que diz o discurso histórico oficial, segundo seja visto pela escola da Venezuela ou a de Quito, com a visão dada pela ficção a esse discurso. É, ao mesmo tempo, um pouco a possível reivindicação de Manuela Sáenz como pessoa e/ou personagem preponderante nas lutas de independência da América que chegavam além do seu ¨controvertido¨ relacionamento com Simón Bolívar. É ver, de certa forma, como os textos literários a as percepções da história sobre uma personagem (Manuela) têm tendência a ¨se readaptar” nos tempos atuais e como se quis dar força à figura de heroína de Manuela Sáenz, dando uma vitória a ela na que, tal vez, von Hagen denomina “a escola de Quito”.Se pretendió el análisis del orden discursivo narrativo de la novela del venezolano Denzil Romero, “La esposa del Dr. Thorne”, a luz de las obras del estadounidense Víctor W. von Hagen, ¨Las cuatro estaciones de Manuela” y del ecuatoriano Carlos Álvarez Saá, “Manuela. Sus diarios perdidos y otros papeles”. Este trabajo es la comparación riesgosa entre un libro de ficción, basado presumiblemente en hechos reales, donde el erotismo de la mujer (Manuela) es el tema central, en Romero, con la larga crónica literaria que hace von Hagen y la recopilación y descubrimiento de presuntos textos originales e históricos (cartas, diarios) que hace Álvarez Saá. Es también un ejercicio de investigación donde de manera caprichosa se mezcla lo que dice el discurso histórico oficial, según sea visto por la escuela de Venezuela o de Quito, y la ficcionalización de ese discurso. Es también un poco la posible reivindicación de Manuela Sáenz como persona y/o personaje preponderante en las luchas independentistas de América que iban más allá de la ¨coyuntural¨ relación con Simón Bolívar. Es ver, hasta cierto punto, cómo los textos literarios y las percepciones de la historia sobre un personaje (Manuela) tienden a ¨reacomodarse” en los tiempos actuales y cómo se ha querido afianzar la figura de heroína de Manuela Sáenz, dándole el triunfo, tal vez, a lo que llama von Hagen “la escuela de Quito”
Is this an effective way to annotate irony activators?
No full textIn this article we describe the first steps of the annotation process of specific irony activators in TWITTIRÒ-UD, a treebank of Italian tweets annotated with fine-grained labels for irony on one hand, and according to the Universal Dependencies scheme on the other. We discuss in particular the annotation scheme adopted to identify irony activators and some of the issues emerged during the first annotation phase. This helped us in the design of the guidelines and allowed us to draw future research directions
La biografía de Manuela Cambronero
No full textLa biografía de Manuela Cambronero ha sido una cuestión pendiente hasta ahora, pues, como su figura no ha suscitado interés, no se han publicado estudios centrados en esclarecer su origen y su cronología. Esta información es esencial como punto de partida para cualquier trabajo sobre la autora, por lo que dilucidar estas incógnitas a través de la búsqueda directa en archivos se convierte en una condición sine qua non. En consecuencia, la localización de los certificados de bautismo, de matrimonio y de defunción de Manuela Cambronero es la única vía fiable para disipar las dudas sobre su procedencia y para concretar los lugares y fechas exactas de los eventos trascendentales de su vida.Manuela Cambronero’s biography has been a pending issue until now, given that her figure has not aroused interest and no studies which focus on clarifying her origins and chronology have been published. This information is essential as a starting point for any work on the author, which is why elucidating these unknowns through direct archive research is a sine qua non. Consequently, locating Manuela Cambronero’s baptismal, marriage and death certificates is theonly reliable way to dispel any doubt about her provenance and to determine the exact places and dates of the trans-cendental events of her life
Computational linguistics against hate: Hate speech detection and visualization on social media in the “Contro L’Odio” project
No full textThe paper describes the Web platform built within the project “Contro l’odio”, for monitoring and contrasting discrimination and hate speech against immigrants in Italy. It applies a combination of computational linguistics techniques for hate speech detection and data visualization tools on data drawn from Twitter. It allows users to access a huge amount of information through interactive maps, also tuning their view, e.g., visualizing the most viral tweets and interactively reducing the inherent complexity of data. Educational courses for high school students and citizenship has been developed which are centered on the platform and focused on the deconstruction of negative stereotypes against immigrants, Roma, and religious minorities, and on the creation of positive narratives
Author Correction:Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
No full textIn the version of this article initially published, the name of author Manuela Gago-Dominguez was misspelled as Manuela Gago Dominguez. The error has been corrected in the HTML and PDF version of the article.</p
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