324,125 research outputs found
Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors
No full textThe selenoprotein S (SELS) is a putative receptor for serum amyloid A, and recent studies have suggested that SELS may be a link between type 2 diabetes mellitus and inflammation. Genetic studies of SELS polymorphisms have revealed associations with circulating levels of inflammatory markers and hard end points of cardiovascular disease. In this study, we analyzed SELS expression in subcutaneous adipose tissue and SELS genotype in relation to metabolic risk factors. DNA microarray expression analysis was used to study the expression of SELS in lean and obese siblings from the Swedish Obese Subjects Sib Pair Study. TaqMan genotyping was used to analyze 3 polymorphisms, previously found to be associated with circulating levels of inflammatory markers, in the INTERGENE case-control study of myocardial infarction and unstable angina pectoris. Possible associations between SELS genotype and/or expression with anthropometry and measures of metabolic status were investigated. Real-time polymerase chain reaction was used to analyze the SELS expression in isolated human adipocytes incubated with insulin. In lean subjects, we found correlations between SELS gene expression in subcutaneous adipose tissue and measures of obesity (waist, P = .045; sagittal diameter, P = .031) and blood pressure (diastolic, P = .016; systolic P = .015); and in obese subjects, we found correlations with measures of obesity (body mass index, P = .03; sagittal diameter, P = .008) and glycemic control (homeostasis model assessment of insulin resistance, P = .011; insulin, P = .009) after adjusting for age and sex. The 5227GG genotype was associated with serum levels of insulin (P = .006) and homeostasis model assessment of insulin resistance (P = .007). The expression of SELS increased after insulin stimulation in isolated human adipocytes (P = .008). In this study, we found an association between both SELS gene expression in adipose tissue and SELS genotype with measures of glycemic control. In vitro studies demonstrated that the SELS gene is regulated by insulin in human subcutaneous adipocytes. This study further supports a role for SELS in the development of metabolic disease, especially in the context of insulin resistance
The impact of upper and lower echelon human capital and HR practices on innovation in start-ups.
No full textAbstract Innovative start-ups have become the center of attention in government policy. They are considered to be the driving force of economic growth and international competitive advantage. Despite this growing interest, little is known about firm internal determinants of and critical success factors for innovation in newly established firms. Innovation is a function of a firm's ability to create, manage and maintain knowledge. Since knowledge is created by and stored within individuals, human resources as well as HR practices may play an important role as drivers of innovation in start-ups. We expect that start-ups having superior human resources (both owners/managers and employees) and an intensive HRM, are more able to innovate. Results show that unless employees' human capital is managed, it provides little benefit to start-ups in terms of innovation. Moreover, the impact of HRM intensity is higher in start-ups with high human capital as compared to newly established firms with low human capital. Next, innovation is indirectly (through the mediating effect of employees' human capital and/or HRM) and positively affected by the owners/managers' educational level and the appeal to certified experts. Industry experience, in turn, has an indirect negative impact. The number of independent board members directly and positively influences innovation.Employees; Human capital; Human resource management; Innovation; Startups;
EDITING MEDIAEVAL TEXTS FROM A DIFFERENT ANGLE: SLAVONIC AND MULTILINGUAL TRADITIONS. TOGETHER WITH FRANCIS J. THOMSON’S BIBLIOGRAPHY AND CHECKLIST OF SLAVONIC TRANSLATIONS, To Honour Francis J. Thomson on the Occasion of His 80th Birthday Together with Proceedings of the ATTEMT Workshop held at King’s College, London, 19-20 December 2013and the ATTEST Workshop held at the University of Regensburg, 11-12 December 2015
No full textEditing Mediaeval Texts from a Different Angle contains a selection of papers delivered at two workshops devoted to particular cases of text editing: the ATTEMT Workshop held at King’s College, London (19-20 December 2013) explored issues involved in the edition of texts with a multilingual tradition (covering Greek, Latin, Syriac, Arabic, and Slavonic), while the ATTEST Workshop (University of Regensburg, 11-12 December 2015) dealt with tradition and innovation in the field of palaeoslavistic text editing. Central to the discussions reflected in this volume are general questions on variability, textual dependency and transformation, as well as methodological issues raised by the encounter of different scholarly traditions in ecdotics and by the advent of the digital.
The volume opens with a honorary section for Prof. Francis J. Thomson, who in his influential scholarly work has focused on mediaeval Slavonic translation literature. The section not only contains his rich academic bibliography, but also a chronological Checklist of Slavonic Translations from the 9thcentury up to the immediate post-Petrine period (1725-1730)
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
On-line treatment of chromium waste water with metallic iron
No full textSels D., Mulleman B., Pelsmaekers J., Van Hove S., Van Ostaeyen, S., Vleminx, S., Cornelis, G. and Van der Bruggen B.http://library.wur.nl/WebQuery/artik/lang/186876
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Vieillissement du tuffeau en présence de sels
No full textL objectif principal de cette thèse est d étudier expérimentalement le comportement hydromécanique du Tuffeau en présence de sels et de simuler numériquement le degré d altération du Tuffeau en fonction de la cristallisation et du degré de saturation en sel. A cet effet, sont réalisés des tests d imbibition, de rétention d eau, de résistance mécanique sur des échantillons contenant différents pourcentages de sels. Sont également examinée les rôles de la température, de l humidité et de la concentration en sel lors des tests de vieillissement accéléré en laboratoire afin de simuler expérimentalement l altération du Tuffeau. L évolution du comportement et la localisation du sel dans les éprouvettes testées permettent de déterminer l altération provoquée en fonction des cycles humidification-séchage imposés. Les analyses s appuient sur la caractérisation morphologique et sur les changements texturaux et structuraux des réseaux poreux dans la pierre avec et sans sels. Enfin, les dégradations obtenues en laboratoire et celles observées in situ sont comparées. La simulation numérique de l altération du tuffeau est basée sur différentes hypothèses du remplissage des espaces poraux lors de la précipitation des sels et sur une méthode d homogénéisation de la pression locale appliquée à l interface cristal / paroi du pore. La formulation proposée a été validée en comparant la pression effective globale à la résistance en traction du Tuffeau. L'application de cette simulation vise à estimer la durabilité des pierres soumises à l action des sels et à aider le diagnostique des dégradations in situ lors des opérations de restauration-conservation.ORLEANS-BU Sciences (452342104) / SudocSudocFranceF
Etude du codepot d'U/Pu sur cathode solide inerte en milieux sels fondus
No full textNational audienceLes procedes de separation pyrometallurgiques developpes en sels fondus a haute temperature presentent un interet pour la recuperation selective d'actinides issus des combustibles nucleaires metalliques ou matrices presentant des difficultes de dissolution dans les procedes hydrometallurgiques. Les differentes methodes de separation An/PFs actuellement etudiees en sels fondus reposent soit - sur des techniques de recuperation electrochimiques, par electroraffinage de combustible ou par electrolyse d'elements dissous dans des sels chlorures. Le procede est bien maitrise pour la recuperation d'uranium metallique pur sur une cathode solide inerte,- sur des techniques d'extraction liquide/liquide, par contact entre un sel fluorure fondu contenant les elements issus du combustible et un metal reducteur liquide
Semiclassical echo dynamics in the Sachdev-Ye-Kitaev model
No full textThe existence of a quantum butterfly effect in the form of exponential sensitivity to small perturbations has been under debate for a long time. Lately, this question has gained increased interest due to the proposal to probe chaotic dynamics and scrambling using out-of-time-order correlators. In this work we study echo dynamics in the Sachdev-Ye-Kitaev model under effective time reversal in a semiclassical approach using the truncated Wigner approximation, which accounts for nonvanishing quantum fluctuations that are essential for the dynamics. We demonstrate that small imperfections introduced in the time-reversal procedure result in an exponential divergence from the perfect echo, which allows us to identify a Lyapunov exponent lambda(L). In particular, we find that lambda(L) is twice the Lyapunov exponent of the semiclassical equations of motion. This behavior is attributed to the growth of an out-of-time-order double commutator that resembles an out-of-time-order correlator
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