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Glycans of myelin proteins.
No full textP0 is a myelin glycoprotein of the peripheral nervous system (PNS). It can bind as many as 6
different glycans, all at its one and unique glycosylation site, Asn93.This is in contrast to other
myelin glycoproteins which have also one glycosylation site: PMP22 at Asn36, MOG at
Asn31, but can bind only one glycan type containing usually HNK-1 epitope. The MAG has
10 glycosylation sites, and glycoprotein OMpg has 11 glycosylation sites, some of them
contain HNK-1 epitope. The HNK-1 epitope is involved in cell interactions that controls cell
type-specific neurite outgrowth, regeneration, myelin stability and is target for autoimmune
IgM antibodies in human demyelinating neuropathies of the PNS. Beside myelin P0
glycoprotein, no data are available on other myelin glycoproteins. In this paper we review
and analyze all published data on the chemical structure of glycans containing HNK-1
epitopes or sialic acid of bovine P0, PMP22, MOG and MAG. For bovine P0, the MW of
glycan is in the range of 1294.56(GP3) Da - 2279.94(GP5) Da. The pI of glycosylated P0
protein varies from pH 9.32-9.46. The most charged is a glycan MS2 containing 3 sulfate
groups and one glucuronic acid; the less charged is glycan BA2. All glycans contain 1 fucose
and 1 galactose. The most mannose rich are MS2 and GP4, each has 4 mannoses; OPPE1
contains 5 N-acetylglucosamines and 1 sulfated glucuronic acid, GP4 contains 1 sialic acid
Structure of the P0 glycoprotein purified in the native form from bovine myelin: a circular dichroism study
No full textStructure of the PNS glycoprotein zero (P0) purified in lipid-bound form: a circular dichroism study
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Crystallization of myelin P2 protein purified in the native lipidic environment and in lipid-free form
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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