117,342 research outputs found

    Anoxic persistence of lumbar respiratory bursts and block of lumbar locomotion in newborn rat brainstem-spinal cords

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    The tolerance of breathing in neonates to oxygen depletion is reflected by persistence of inspiratory-related motor output during sustained anoxia in newborn rat brainstem preparations. It is not known whether lumbar motor networks innervating expiratory abdominal muscles are, in contrast, inhibited by anoxia similar to locomotor networks in neonatal mouse lumbar cords. To test this, we recorded inspiratory-related cervical/hypoglossal plus pre/postinspiratory lumbar/facial nerve activities and, sometimes simultaneously, locomotor rhythms in newborn rat brainstem–spinal cords. Chemical anoxia slowed 1 : 1-coupled cervical and lumbar respiratory rhythms and induced cervical burst doublets associated with depressed preinspiratory and augmented postinspiratory lumbar activities. Similarly, anoxia evoked repetitive hypoglossal bursts and shifted facial activity toward augmented postinspiratory bursting in medullas without spinal cord. Selective lumbar anoxia augmented pre/postinspiratory lumbar bursting without slowing the rhythm. This suggests a medullary origin of both anoxic inspiratory double bursts and preinspiratory depression, but a mixed medullary/lumbar origin of boosted postinspiratory lumbar activity. Lumbar respiratory rhythm is likely to be generated by the parafacial respiratory group expiratory centre as indicated by lack of normoxic and anoxic bursting following brainstem transection between the facial motonucleus and the more caudal pre-B¨otzinger complex inspiratory centre. Opposed to sustained respiratory activities, anoxia reversibly abolished non-rhythmic spinal discharges and electrically or chemically evoked lumbar locomotor activities, followed by pronounced postanoxic spinal hyperexcitability. We hypothesize that (i) the anoxia tolerance of neonatal breathing includes pFRG-driven lumbar expiratory networks, (ii) the anoxic respiratory pattern transformation is due to disturbed inspiratory–expiratory centre interactions, and (iii) postanoxic lumbar hyperexcitability contributes to spasticity in cerebral palsy

    La Secchia rapita di Alessandro Tassoni

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    La Secchia rapita di Alessandro Tassoni / Elettra Messana. - Palermo : A. Trimarchi, 1915 Dedica manoscritta dell\u27autore: Al Chiar.mo Prof. E. Bodrero / omaggio dell\u27a. https://galileodiscovery.unipd.it/discovery/fulldisplay?context=L&vid=39UPD_INST:VU1&search_scope=MyInst_and_CI&tab=Everything&docid=alma99000150801020604

    The triassic evaporites of Sassalbo and secchia valley (Tuscan-Emilian Apennines): geometric and kinematic data

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    The trending of Triassic evaporites cropping out at Sassalbo (Tuscany) and in Secchia Valley (Emilia Romagna) represents one of the most important trans-Apennines lineaments to gain informations about the structural evolution of the apenninic chain from the collisional to the more recent extensional tectonic phases. Two groups of outcrops have been distinguished: 1) Sassalbo - Cerreto Pass group; 2) Secchia Valley group. Taking into account abundant published data and new field observations some considerations on their tectonic evolution and emplacement are proposed. These deposits, with their associated sedimentary sequence, belong to the internal Tuscan realm. In spite to the common origin and provenance, at a certain time of the geological history (Tertiary) from diapiric structure evolved into flattened salt tongue and finally they have been dismembered and a more external portion has been translated towards the external adriatic-padan zone, originating the salt outcrops of Secchia Valley, the most external Tuscan allochthonous triassic evaporites nucleus of the Northern Apennine mountain building

    A proposito di Re Enzo: un personaggio tassiano nella "Secchia rapita"

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    Si intende dimostrare come nella Secchia rapita la strategia dello straniamento comico passi anche attraverso personaggi dalla caratterizzazione apparentemente tradizionale. è il caso di re Enz

    Foraminiferal biostratigraphical and paleobathymetric constraints in geohistory analysis: the example of the Epiligurian Succession of the Secchia Valley (Northern Apennines, Mid Eocene-Late Miocene)

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    ABSTRACT A geohistory analysis has been proposed for the Mid Eocene- Late Miocene Epiliguran succession cropping out in the Enza, Secchia end Reno Valleys (Northern Apennines) in order to quantify the evolution of the studied areas in terms of both vertical motions (subsidence/ uplift) and sedimentary infill. The three curves integrate and complete the geohistory scenario proposed by DI GIULIO et alii (2002) in order also to discriminate local events from large-scale episodes related to the Northern Apennine orogenesis. New biostratigraphic and paleobathymetric data were collected for the late Bartonian-early Burdigalian Epiligurian succession from the Secchia Valley, conversely, literature data have been used for the youngest investigated units (Pantano, Cigarello and Termina Formations; Burdigalian-Tortonian), which were not sampled for this work. Both chronostratigraphic and bathymetric data have been wholly derived from the literature for the Enza and Reno Valleys (MANCIN & PIRINI, 2001; 2002). From a paleobathymetric point of view, the Secchia Valley Epiligurian deposition began in the earliest Bartonian in a very deep marine environment (average depth 1900 m). After a deepening phase during late Bartonian-Priabonian, with a shift of the bottom (average depth 2200 m) to probably close to the calcite compensation depth, an overall shallowing trend was recorded culminating in Burdigalian shelf deposits (Pantano Fm., average depth 50 m). Finally, during Mid-Late Miocene, a second, lesser, deepening phase occurred, ending with the Tortonian sediments of the marly Termina Fm. (average depth 200 m). This paleobathymetric evolution has been related to the vertical motion and sedimentary infill undergone by the Secchia Valley area during the time interval considered. The results described highlight the occurrence of large-scale episodes involving the whole analysed area (from the Enza to the Reno Valleys), alternating with periods of quite different growth for each sector recording the existence of independently evolving domains of the Ligurian orogenic wedge in the geodynamic context of a mobile belt

    Insediamenti dell'età del bronzo fra Secchia e Reno. Formazione, affermazione e collasso delle terramare

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    The research focuses on the analysis of the settlement system between Secchia and Reno rivers (Emilia – Po Plain). A detailed analysis of the archaeological evidences (settlements, farms and cemeteries) offers a reconstruction of the demographic consistency of the communities and their organization. The integration of archaeological, archaeobotanical and archaeozoological data has added information about land productivity. Differences are highlighted between mountain, hill and plain areas during the Middle and Recent Bronze Age

    A1 adenosine receptor modulation of chemically and electrically evoked lumbar locomotor network activity in isolated newborn rat spinal cords

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    It is not well-studied how the ubiquitous neuromodulator adenosine (ADO) affects mammalian locomotor network activities. We analyzed this here with focus on roles of 8-cyclopentyl-1,3-dipropylxanthine (DPCPX)-sensitive A(1)-type ADO receptors. For this, we recorded field potentials from ventral lumbar nerve roots and electrically stimulated dorsal roots in isolated newborn rat spinal cords. At ≥ 25μM, bath-applied ADO slowed synchronous bursting upon blockade of anion-channel-mediated synaptic inhibition by bicuculline (20 μM) plus strychnine (1 μM) and this depression was countered by DPCPX (1 μM) as tested at 100 μM ADO. ADO abolished this disinhibited rhythm at ≥ 500 μM. Contrary, the single electrical pulse-evoked dorsal root reflex, which was enhanced in bicuculline/strychnine-containing solution, persisted at all ADO doses (5 μM-2 mM). In control solution, ≥ 500 μM ADO depressed this reflex and pulse train-evoked bouts of alternating fictive locomotion; this inhibition was reversed by 1 μM DPCPX. ADO (5 μM-2 mM) did not depress, but stabilize alternating fictive locomotion evoked by serotonin (10 μM) plus N-methyl-d-aspartate (4-5 μM). Addition of DPCPX (1μM) to control solution did not change either the dorsal root reflex or rhythmic activities indicating lack of endogenous A(1) receptor activity. Our findings show A(1) receptor involvement in ADO depression of the dorsal root reflex, electrically evoked fictive locomotion and spontaneous disinhibited lumbar motor bursting. Contrary, chemically evoked fictive locomotion and the enhanced dorsal root reflex in disinhibited lumbar locomotor networks are resistant to ADO. Because ADO effects in standard solution occurred at doses that are notably higher than those occurring in vivo, we hypothesize that newborn rat locomotor networks are rather insensitive to this neuromodulator

    Ricostruzione ambientale del paesaggio vegetale nella bassa pianura modenese-mantovana in età medievale

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    Gli scavi condotti in una cava di argilla a Concordia sul Secchia hanno permesso di ricostruire il paesaggio vegetale in un'area localizzata fra le provincie di Modena e Mantova. In età Alto Medievale nell'are è presente un folto di bosco di olmi e querce. Nella fase successiva il bosco viene sommerso da una alluvione e si forma un bosco di salici con la presenza di numerose aree palustri. Nell'ultima fase l'ambiente è aperto e caratterizzato da na comunità erbacee di cicorioidee, craminacee spontanee accompagnate da chenopodiacee, i luoghi frequentati dall'uomo appaiono sullo sfondo

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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