5,129 research outputs found
Contro la funzionalizzazione della contrattazione collettiva. Riflessioni sul pensiero di Mario Rusciano
No full textL'autore riflette sul pensiero di Mario Rusciano in punto di funzionalizzazione della contrattazione collettiva.The author reflects on the thought of Mario Rusciano in relation to the subject of the functionalisation of collective bargaining
I danni punitivi. Riflessioni in chiave comparatistica sui sistemi di common law e di civil law.
No full textLa tesi ha ad oggetto l’istituto del risarcimento punitivo, del quale indaga natura, presupposti applicativi e profili funzionali nell’ambito degli ordinamenti di common law, con particolare riferimento all’ordinamento inglese e a quello statunitense. La parte finale del lavoro si occupa di individuare, in chiave comparatistica, punti di collegamento con le esperienze dei sistemi di responsabilità civile continentali, tentando di avviare una rilettura degli stessi in chiave polifunzionale ed assumendo, a tal fine, come banco di prova il risarcimento del danno non patrimoniale.The thesis deals with punitive damages, investigating their nature, applicative requirements and functions, among common law jurisdictions, with particular reference to England and U.S. law. The final part of the work aims at identifying, in a comparative light, connection points with the law of torts of the European jurisdictions, proposing a multi-functional framework and using, for this purpose, damages for non-pecuniary losses as a test case
Fibril aggregation inhibitory activity of the β-sheet breaker peptides: a molecular docking approach
No full textIl diritto penale nel canone di Mario Romano
No full textThis paper deals with the extension and the extraordinary scientific value of the works written by a great Master in Criminal Law, such as Mario Romano. The Author briefly presents some of the most relevant contributions given by Professor Mario Romano to the Criminal Science, first of all his "Commentario sistematico del codice penale" (Systematic Commentary on the penal code), a unique work. Finally, the paper talks about some topics which have been developed inside the work "Studi in onore di Mario Romano" (Studies in Honour of Mario Romano)
CuI-Catalyzed Azideâ Alkyne Intramoleculari-to-(i+4) Side-Chain-to-Side-Chain Cyclization Promotes the Formation of Helix-Like Secondary Structures
No full textAbstract: A solid-phase assembly of model peptides derived from human parathyroid. hormone-related protein (11-19) containing omega-azido- and omega-yl-alpha-amino acid residues in positions i and i+4 was cyclised in solution by an intramolecular Cu-I-catalyzed azide-alkyne 1,3-dipolar Huisgen cycloaddition These series of heterodetic cyclo-nonapeptides varied in the size of the disubstituted 1,2,3-triazolyl-containing bridge, the location and the orientation of the 1,2,3-triazolyl moiety within the bridge The 1,2,3-triazolyl moiety, presented at either 1,4- or 4,1-orientation, is flanked by side chains containing 1-4 CH2 groups that result in bridges comprised from 4-7 CH2 groups connecting residues 13 and 17 Comprehensive conformational analysis employing CD, NMR and molecular dynamics reveals the conformational propensities of these heterodetic cvclo-nonapeptides Cyclo-nonapeptides containing either the 7 methylene bridge (VII and VIII) or the 4 methylene bridge (II) are unstructured in structure-promoting solvent Cyclo-nonapeptide I in which the 1,4-disubstituted 1,2,3-triazolyl is flanked by 3 and 1 CH2 groups in proximity to the respective residues 13 and 17, is stabilized in a non-canonical structure. All the other heterodetic cyclo-nonapeptides (III-VI) in which the 1,2,3-triazolyl is flanked by a total of 5 or 6 CH2 groups nicely accommodate alpha-helical structures and reproduce very closely the helical structure stabilized by the analogous cyclo-nonapeptide in which Lys(13) and Asp(17) are bridged by the isosteric lactam These studies suggest that the bioorthogonal i-to-(i+4) side-chain-to-side-chain cyclization via the prototypic "click reaction" offers a new and powerful approach for generating stable helix mimetic structures
Introduzione, a Mario Tobino, Il Clandestino
No full textL'introduzione presenta il libro più ambizioso di Mario Tobino, Il Clandestino, dedicato al racconto della sua esperienza con i gruppi clandestini della Resistenza Viareggina, libro con cui l'autore vinse il Premio Strega, nel 1962, imponendosi all'attenzione del grande pubblico dopo il successo dei libri manicomiali. Una nuova edizione in cui Paola Italia valorizza i materiali inediti dell'Archivio Tobino conservato presso l'Archivio Contemporaneo A. Bonsanti del Gabinetto GP Vieusseux di Firenze,Paola Italia presents an Introduction to the new edtion of Il Clandestino, the most ambitious of Mario Tobino's novels, dedicated to the story of his experience with the groups of the Tuscan Resistance when he was a psichiatric doctor ar Lucca. With this book the author won the Strega Prize, in 1962, attracting the attention of a wide public after the success of his psichiatric books. A new edition where Paola Italia enhances the unpublished material of Tobino Archive preserved in A. Bonsanti Contemporary Archive of G.P. Vieusseux Cabinet of Florence
L'uno e il molteplice: su Catull. 5
No full textIn Catull. 5, the author cleverly works out two ancient topoi (‘let’s love, because the night/death is coming’; ‘kisses are the joy of lovers’), gaining a well balanced structure of the poem. In comparison with contemporary Graeco-Roman poetry (erotic epigrams – such as Philod. AP 9, 570 –, the Epitaph of Bion), both themes are handled with a remarkable taste for originality, especially in their ‘numerical’ aspects, in order to put special emphasis on the basic contrast between nox una and basia mille
Stacking Interactions between Adenines in Oxidized Oligonucleotides
No full textThe effects of stacking interactions on the oxidation potentials of single strand oligonucleotides containing up to four consecutive adenines, alternated with thymines and cytosines in different sequences and ratios, have been determined by means
of differential pulse voltammetry. Voltammetric measurements point toward the establishment in solution of structured oligonucleotide conformations, in which the nucleobases are well stacked altogether. Molecular dynamics simulations confirm that
finding, indicating that single strands assume geometrical parameters characteristic of the B-DNA form. The analysis of the voltammetric signals in terms of a simple effective tight
binding quantum model leads one to infer a robust set of parameters for treating hole transfer in one-electron-oxidized DNA containing adenines and thymines
Binding of the hemopressin peptide to the cannabinoid CB(1) receptor: structural insights
No full textHemopressin, a bioactive nonapeptide derived from the α1 chain of hemoglobin, was recently shown to possess selective antagonist activity at the cannabinoid CB(1) receptor [Heimann, A. S., et al. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 20588-20593]. CB(1) receptor antagonists have been extensively studied for their possible therapeutic use in the treatment of obesity, drug abuse, and heroin addiction. In particular, many compounds acting as CB(1) receptor antagonists have been synthesized and subjected to experiments as possible anti-obesity drugs, but their therapeutic application is still complicated by important side effects. Using circular dichroism and nuclear magnetic resonance spectroscopy, this work reports the conformational analysis of hemopressin and its truncated, biologically active fragment hemopressin(1-6). The binding modes of both hemopressin and hemopressin(1-6) are investigated by molecular docking calculations. Our conformational data indicate that regular turn structures in the central portion of hemopressin and hemopressin(1-6) are critical for an effective interaction with the receptor. The results of molecular docking calculations, indicating similarities and differences in comparison to the most accepted CB(1) pharmacophore model, suggest the possibility of new chemical scaffolds for the design of new CB(1) antagonist lead compounds
- …
