105,098 research outputs found
Janus kinases are targets of tyrphostin AG17 and HSP90-inhibitor 17-AAG in classical Hodgkin lymphoma
No full textCDC bulletin, vol. X, no. 2, February 1951.
No full textOn cover: Creeping eruption: natural life cycle dog hookworm.Creeping eruption / Alan W. Donaldson, James H. Steele -- A Plan for revising morbidity reporting by states -- Communicable disease center training program in housing / Herbert H. Rogers -- Expansion of housing training by establishing a new regional center / Emil A. Tiboni -- Relationship of housing to public health / Ross W. Buck -- Reported brucellosis in the United States / L. Otis Emik -- Estimates of the true number of human brucellosis cases in the United States / James H. Steele, L. Otis Emik -- Musca publicica: Charleston experiments with a new species of fly publicity / Odom Fanning and Wade H. Bolton -- Entomologic appraisal of fly control programs / H.F. Schoof -- Production of stereographs / Robert E. Bates, Jr. -- Book review: Fundamentals of bacteriology -- Recent publications by CDC personnel -- Rat-borne disease and insect control field training courses -- Morbidity data.Federal Security Agency, Public Health Service, Communicable Disease Center, Atlanta, Ga.32 numbered page
HSP90 is essential for Jak-STAT signaling in classical Hodgkin lymphoma cells
No full textAbstract In classical Hodgkin lymphoma (cHL) chemotherapeutic regimens are associated with stagnant rates of secondary malignancies requiring the development of new therapeutic strategies. We and others have shown that permanently activated Signal Transducer and Activator of Transcription (STAT) molecules are essential for cHL cells. Recently an overexpression of heat-shock protein 90 (HSP90) in cHL cells has been shown and inhibition of HSP90 seems to affect cHL cell survival. Here we analysed the effects of HSP90 inhibition by geldanamycin derivative 17-AAG or RNA interference (RNAi) on aberrant Jak-STAT signaling in cHL cells. Treatment of cHL cell lines with 17-AAG led to reduced cell proliferation and a complete inhibition of STAT1, -3, -5 and -6 tyrosine phosphorylation probably as a result of reduced protein expression of Janus kinases (Jaks). RNAi-mediated inhibition of HSP90 showed similar effects on Jak-STAT signaling in L428 cHL cells. These results suggest a central role of HSP90 in permanently activated Jak-STAT signaling in cHL cells. Therapeutics targeting HSP90 may be a promising strategy in cHL and other cancer entities associated with deregulated Jak-STAT pathway activation.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
The construction of Karen Karnak: The multi-author-function
No full textThis thesis is situated within the comparatively recent developments of Web 2.0 and the emergence of interactive WikiMedia, and explores the mode of authorship within a Read/Write culture compared to that of a Read/Only tradition. The hypothesis of this study is that the role of the audience has become merged with the author, and as such, represents new functions and attributes, distinct from a more conventional concept of authorship, in which the roles of audience and author are more separate. Read/Write and participatory culture, as defined by this study, is focused on collaboration, and includes the influences of D.I.Y. culture, Open-Source practices and the production of text by multiple authors. Multi-authorship presents a re-thinking of several concepts which support the notion of the individual author, since the focus of multi-authorship is not on attribution and ownership of a finished text, but on the continued malleability of a text. Modes of multi-authorship, demonstrated in the use of the pseudonyms Alan Smithee and Karen Eliot, represent declarative authors whose names signify multiple origins, whilst concurrently indicating a distinct body of work. The function of these names form an important context to this study, since primary research involves the construction of an experimental mode of multi-authorship utilising WikiMedia technology and the interaction of thirty nine participants, who are invited to create a body of work under the collective pseudonym Karen Karnak. The data generated by this experiment is analysed using aspects of Michel Foucault's author-function to identify and determine power structures inherent in the WikiMedia context. The interplay of power structures, including concepts such as identity, ownership and the body of work, affect the resulting mode of authorship and contribute to the construction of Karen Karnak, suggesting further areas of research into the emerging multi-author
Contribution of Information and Communication Technology (ICT) in Country’S H-Index
No full textThe aim of this study is to examine the effect of Information and Communication Technology (ICT) development on country’s scientific ranking as measured by H-index. Moreover, this study applies ICT development sub-indices including ICT Use, ICT Access and ICT skill to find the distinct effect of these sub-indices on country’s H-index. To this purpose, required data for the panel of 14 Middle East countries over the period 1995 to 2009 is collected. Findings of the current study show that ICT development increases the H-index of the sample countries. The results also indicate that ICT Use and ICT Skill sub-indices positively contribute to higher H-index but the effect of ICT access on country’s H-index is not clear
The European Social Model and eastern enlargement
No full text"The European Social Model (ESM) is increasingly becoming a model of integration policy. The idea is based on a combination of economic efficiency, in the sense of high productivity, competition and economic growth, and a high level of employment on the one hand together with social cohesion on the other hand. At the same time the ESM is understood as a dynamic model in evolution, whose development is influenced by global, European and national processes, including eastern enlargement. With the accession of the eight Central and Eastern European countries to the European Union, the economic and social disparities between the now 25 EU Member States have grown considerably. On the basis of theoretical and empirical literature this paper develops answers to the following questions in particular: will there be a gradual erosion of the ESM, are there prospects of convergence or are new vectors developing in the enlarged field of power? The authors reach the conclusion that the old and the new Member States, starting out from different historical experiences in the past decades and different levels of production and productivity, will have to withstand structurally similar challenges in the foreseeable future if they wish to achieve economic efficiency and social cohesion simultaneously. From the perspective of the new Member States, which come from an egalitarian tradition, there is every reason to believe that the majority of the population desires social cohesion and will demand it. Together with the diverse integration advantages of enlargement, a successful catching-up process in the new Member States provides good preconditions for the preservation and productive development of the ESM." (Author's abstract, IAB-Doku) ((en))EU-Osterweiterung, regionale Disparität, europäische Sozialpolitik, europäische Integration, Konvergenz, Arbeitsmarktentwicklung, Wirtschaftsentwicklung, Produktivitätsentwicklung, soziale Integration, Integrationspolitik, Leitbild, Europäische Union, Osteuropa, Mitteleuropa
Fully Turbulent Mean Velocity Profile for Purely Viscous non-Newtonian Fluids
No full textThe characteristic near wall behavior of turbulent flow of purely-viscous non-Newtonian fluids is discussed for both power-law (P.-L.) and Herschel-Bulkley (H.-B.) rheological models. A proper scaling is presented for H.-B. fluids to establish an analogy with power-law fluids with same flow index. To provide reference data for turbulent flow of non-Newtonian fluids, DNS simulations of power-law fluids are conducted in a rectangular channel for a large range of power-law indices ( = 0.5, 0.69, 0.75, 0.9, 1, 1.2). The DNS data show that the mean velocity profile in the viscous and logarithmic layers follow expressions of the form and respectively, where shows a logarithmic dependency on the flow index.Comparison with some experimental data shows the above formulation to be valid for Reynolds numbers (based on shear velocity) as high as 1000
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