2,139 research outputs found
Who's afraid: Red, Yellow, and Blue - A three-biomarker model to capture neural heterogeneity in the anxious phenotype
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236417.pdf (Publisher’s version ) (Open Access)Radboud University, 30 september 2021Promotores : Fernandez, G., Schene, A.H. Co-promotor : Kohn, N.202 p
Neural mechanisms of negative learning bias. A transdiagnostic approach to mental health
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231206.pdf (Publisher’s version ) (Open Access)Radboud University, 16 april 2021Promotores : Schene, A.H., Cools, R. Co-promotores : Vassena, E., Vrijsen, J.N.185 p
Ambivalent connections: Improving community mental health care for non-psychotic chronic patients perceived as ‘difficult’
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83239.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 14 januari 2011Promotores : Hutschemaekers, G.J.M., Schene, A.H. Co-promotor : Meijel, B.K.G. van199 p
A transdiagnostic, integrative approach to psychiatric heterogeneity: genetics as the starting point
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322707.pdf (Publisher’s version ) (Open Access)Mental health problems affect not only how people feel, but also their school, work, health, and relationships. This thesis shows that genes, environment, lifestyle, and social factors all work together to shape the risk for mental health conditions. We found that genetic risks for disorders like ADHD and depression influence not just symptoms, but also school success, physical health, and social well-being in both children and adults. Traditional diagnoses often don’t reflect real-life diversity: many people have overlapping or shifting problems, and genetic risks span across diagnoses. Sleep, family context, and lifestyle are at least as important as genes—especially for young people. Our findings highlight that mental health cannot be separated from other parts of life. This knowledge can help make mental health care and prevention more personal and effective for everyone.Radboud University, 06 oktober 2025Promotores : Franke, B., Schene, A.H. Co-promotores : Roth Mota, N., Sprooten, E.187 p
Frailty & late-life depression: a delicate balance
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144024.pdf (Publisher’s version ) (Open Access)Depression is the most common psychiatric disease worldwide. With demographic balance shifting towards an older population, the number of older adults with a lifetime history of depression or subthreshold depression will be significant over the next decades. Depression is a serious psychiatric disease that affects not only the person suffering from depression, but also the social environment oft he person. The course of late-life depression is characterized by high recurrence and relapse rates. Little is known about the causes of this adverse course of depression in older persons.
During the last half of the 20th century, life expectancy rapidly increased and marked the appearance and growth of a vulnerable group of older persons. This shift in age distribution resulted in the introduction of the term frailty. Frailty is a condition conferring vulnerability to poor physical health outcomes, due to a loss of reserve capacity oft he aging body.
The associations between late-life depression and frailty are investigated in this thesis.
We found that frailty prevalence is much higher in depressed older persons, than in non-depressed older persons and that physical frailty predicts higher severity of depressive symptoms and a chronic course of depression.
Frailty can be a useful construct to detect a particularly vulnerable group within depressed older persons that are at risk of a more chronic course of late-life depression. Since frailty is a potentially reversible condition that can be targeted with specific interventions such as exercise, vitamin D supplementation and reduction of polypharmacy, it can guide treatment. Therefore screening for frailty deserves a prominent place in the treatment of late-life depression.Radboud Universiteit Nijmegen, 07 oktober 2015Promotores : Oude Voshaar, R.C., Schene, A.H. Co-promotores : Comijs, H.C., Naarding, P
On the conceptual feasibility of a CAAD-CAAI integrated decision support system: A computer aided environment for technical decision-making in architecture
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